Identification of Drug Targets Related to the Induction of Ventricular Tachyarrhythmia Through a Systems Chemical Biology Approach

Identification of Drug-Induced Myocardial Infarction-Related Protein Targets through the Prediction of Drug–Target Interactions and Analysis of Biological Processes

(2014) Sergey M. Ivanov et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Prediction of the Biological Activity Spectra of Organic Compounds Using the Pass Online Web Resource

(2014) D. A. Filimonov et al.   Chemistry of Heterocyclic Compounds

Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias

(2014) Mark J. Shen et al.   CIRCULATION RESEARCH

Risk of Cardiac Arrhythmias During Hypoglycemia in Patients With Type 2 Diabetes and Cardiovascular Risk

(2014) Elaine Chow et al.   DIABETES

The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization

(2013) Angelica Lopez-Izquierdo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiovascular Safety of Tyrosine Kinase Inhibitors: With a Special Focus on Cardiac Repolarisation (QT Interval)

(2013) Rashmi R. Shah et al.   DRUG SAFETY

Systematic identification of proteins that elicit drug side effects

(2013) M. Kuhn et al.   Molecular Systems Biology

The role of acute hyperinsulinemia in the development of cardiac arrhythmias

(2013) László Drimba et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Cardiac ion channel trafficking defects and drugs

(2013) Kathy C.G. de Git et al.   PHARMACOLOGY & THERAPEUTICS

Safety pharmacology — Current and emerging concepts

(2013) Junnat Hamdam et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

(2013) Jian-Bo Pan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ion Channel Phosphorylopathy: a Link between Genomic Variation and Human Disease

(2012) Saverio Gentile   ChemMedChem

Absence of glucose transporter 4 diminishes electrical activity of mouse hearts during hypoxia

(2012) Kwanghyun Sohn et al.   EXPERIMENTAL PHYSIOLOGY

Large-scale prediction and testing of drug activity on side-effect targets

(2012) Eugen Lounkine et al.   NATURE

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

(2012) Joanne Bowes et al.   NATURE REVIEWS DRUG DISCOVERY

The relation of ventricular arrhythmia electrophysiological characteristics to cardiac phenotype and circadian patterns in hypertrophic cardiomyopathy

(2011) Constantinos O'Mahony et al.   EUROPACE

Cardiac mitochondria and arrhythmias

(2010) D. A. Brown et al.   CARDIOVASCULAR RESEARCH

Multi-Targeted Natural Products Evaluation Based on Biological Activity Prediction with PASS

(2010) Alexey Lagunin et al.   CURRENT PHARMACEUTICAL DESIGN

A side effect resource to capture phenotypic effects of drugs

(2010) Michael Kuhn et al.   Molecular Systems Biology

Systems Pharmacology of Arrhythmias

(2010) S. I. Berger et al.   Science Signaling

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Cardiac Metabolism and Arrhythmias

(2009) Andreas S. Barth et al.   Circulation-Arrhythmia and Electrophysiology

Cardiac Ion Channels

(2009) Augustus O. Grant   Circulation-Arrhythmia and Electrophysiology

Gaining Insight into Off-Target Mediated Effects of Drug Candidates with a Comprehensive Systems Chemical Biology Analysis

(2009) Josef Scheiber et al.   Journal of Chemical Information and Modeling

Prediction of drug-related cardiac adverse effects in humans—A: Creation of a database of effects and identification of factors affecting their occurrence

(2009) Edwin J. Matthews et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

In silicomethod for identification of promising anticancer drug targets

(2009) O.N. Koborova et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Harvesting Candidate Genes Responsible for Serious Adverse Drug Reactions from a Chemical-Protein Interactome

(2009) Lun Yang et al.   PLoS Computational Biology

Remodelling of gap junctions and connexin expression in diseased myocardium

(2008) N. J. Severs et al.   CARDIOVASCULAR RESEARCH

ExPlain™: finding upstream drug targets in disease gene regulatory networks

(2008) A. Kel et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Computer-aided prediction of QT-prolongation1

(2008) O. Filz et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH