Review
Biochemistry & Molecular Biology
Daniel Sojka, Pavla Snebergerova, Luise Robbertse
Summary: Selective protease inhibitors have been found to provide effective therapeutic solutions for the two most impacting infectious diseases nowadays - malaria and COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Mireia Medrano-Bosch, Blanca Simon-Codina, Wladimiro Jimenez, Elazer R. Edelman, Pedro Melgar-Lesmes
Summary: Monocytes are circulating leukocytes that interact with endothelial cells to regulate inflammation, angiogenesis, and tissue remodeling under physiological and pathophysiological conditions. They transdifferentiate into macrophages and release various substances that induce vascular and tissue remodeling or propagate inflammatory responses. The interactions between infiltrating monocytes and endothelial cells contribute to pathophysiological conditions such as cardiovascular and chronic liver diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Christina Kassiteridi, Jennifer E. Cole, Thibault Griseri, Mika Falck-Hansen, Michael E. Goddard, Anusha N. Seneviratne, Patricia A. Green, Inhye Park, Annelie G. Shami, Tanyaporn Pattarabanjird, Aditi Upadhye, Angela M. Taylor, Ashok Handa, Keith M. Channon, Esther Lutgens, Coleen A. McNamara, Richard O. Williams, Claudia Monaco
Summary: The study demonstrates the significant role of CD200 in atherosclerosis, where CD200 deficiency increases atherosclerotic lesion formation. The CD200/CD200R pathway restrains macrophage activation and monocyte recruitment, limiting the progression of atherosclerosis.
CIRCULATION RESEARCH
(2021)
Article
Immunology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Juan Vladimir de la Rosa, Barbara Alonso, Enrique Capa-Sardon, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kroeger, Miguel A. Vega, Antonio Castrillo, Angel L. Corbi
Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Ki-Wook Kim, Stoyan Ivanov, Jesse W. Williams
Summary: Atherosclerotic lesions progress due to the recruitment and differentiation of circulating monocytes into macrophages within plaques, forming foam cells. Recent studies have used single-cell gene expression profiling to investigate the roles of macrophages and monocytes in inflammatory mechanisms, motility, and proliferation within lesions, but questions remain about tissue-specific regulation and the contribution of recruited monocytes during disease progression. Further research is needed to advance therapeutic strategies for cardiovascular disease based on these findings.
Article
Cell Biology
Jianrui Song, Diana Farris, Paola Ariza, Smriti Moorjani, Mita Varghese, Muriel Blin, Judy Chen, Daniel Tyrrell, Min Zhang, Kanakadurga Singer, Morgan Salmon, Daniel R. Goldstein
Summary: This study reveals that aging enhances atherosclerosis through the increased inflammation of visceral fat. The transplantation of aged fat onto the carotid artery of mice resulted in larger atherosclerotic plaques with increased macrophage numbers. Inflammatory factors secreted by adipose tissue macrophages, including TNF alpha, CXCL2, and CCL2, were found to contribute to the enhancement of atherosclerosis in aging fat transplants.
Article
Biochemistry & Molecular Biology
Luciana Muratori Costa, Michel Mualem de Moraes Alves, Lucas Moreira Brito, Erika de Araujo Abi-chacra, Jose Maria Barbosa-Filho, Stanley Juan Chavez Gutierrez, Humberto Medeiros Barreto, Fernando Aecio de Amorim Carvalho
Summary: Riparin E showed good inhibitory effects against promastigotes and internalized amastigotes of Leishmania amazonensis in vitro. It exhibited low cytotoxicity against BALB/c murine macrophages and also demonstrated immunomodulatory activity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Biochemistry & Molecular Biology
Shirley Pei Shan Chia, Sharleen Li Ying Kong, Jeremy Kah Sheng Pang, Boon-Seng Soh
Summary: The COVID-19 pandemic has led to the adoption of efficient and reliable models in the scientific community to combat infectious diseases. Three dimensional human organoid technology, which closely mimics the structure and function of organs, has emerged as an essential tool in infectious disease research. This article compares conventional systems with organoid models, highlights the role of organoids in modeling infectious diseases and understanding the molecular mechanisms behind them, and presents the limitations of current organoid models and innovative strategies to overcome them.
Article
Cardiac & Cardiovascular Systems
Giuseppe Rizzo, Julius Gropper, Marie Piollet, Ehsan Vafadarnejad, Anna Rizakou, Sourish Reddy Bandi, Panagiota Arampatzi, Tobias Krammer, Nina DiFabion, Oliver Dietrich, Anahi Paula Arias-Loza, Marco Prinz, Matthias Mack, Kai Schlepckow, Christian Haass, Jean Sebastien Silvestre, Alma Zernecke, Antoine Emmanuel Saliba, Clement Cochain
Summary: The study utilized single-cell immune profiling to map the transition of monocyte/macrophage populations in the infarcted heart, revealing the origin and dynamic changes of cardiac macrophages. In summary, the research provides valuable insights into how these cells can be potentially modulated to enhance post-ischaemic heart repair.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Michael E. Rusiniak, Patrick R. Punch, Nitai C. Hait, Aparna Maiti, Robert T. Burns, Digantkumar Chapla, Kelley W. Moremen, Peng Zhao, Lance Wells, Karin Hoffmeister, Joseph T. Y. Lau
Summary: Interaction between immune cells and the systemic environment is crucial for the coordinated development and execution of immune responses. This study reveals that extracellular ST6GAL1 plays a profound role in monocyte-macrophage lineage cells, promoting cell development and survival by activating essential cell surface receptors and initiating intracellular signaling.
Article
Cardiac & Cardiovascular Systems
Alan J. Mouton, Nikaela M. Aitken, Sydney P. Moak, Jussara M. do Carmo, Alexandre A. da Silva, Ana C. M. Omoto, Xuan Li, Zhen Wang, Alexandra C. Schrimpe-Rutledge, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, John E. Hall
Summary: Metabolic reprogramming from glycolysis to the mitochondrial TCA cycle and oxidative phosphorylation may mediate macrophage polarization from M1 to M2 phenotype after myocardial infarction. Changes in cardiac macrophage glucose metabolism reflect polarization status, mainly in monocyte-derived but not resident macrophages.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Rheumatology
Meredyth G. Ll Wilkinson, Dale Moulding, Thomas C. R. McDonnell, Michael Orford, Chris Wincup, Joanna Y. J. Ting, Georg W. Otto, Restuadi Restuadi, Daniel Kelberman, Charalampia Papadopoulou, Sergi Castellano, Simon Eaton, Claire T. Deakin, Elizabeth C. Rosser, Lucy R. Wedderburn
Summary: This study identifies a novel pathway in which altered mitochondrial biology in CD14+ monocytes of Juvenile dermatomyositis (JDM) patients leads to the production of oxidized mitochondrial DNA (oxmtDNA) and stimulates the expression of interferon (IFN) type 1 signature genes. Targeting this pathway has therapeutic potential in JDM and other IFN type 1-driven autoimmune diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Mohamed Amer Musrati, Patrick De Baetselier, Kiavash Movahedi, Jo A. Van Ginderachter
Summary: The liver has important metabolic and immune-regulatory functions, acting as a target site for pathogens while also filtering the blood and containing infections. Kupffer cells (KCs) are the major liver-resident macrophages responsible for scavenging pathogens and play a crucial role in the severity and outcome of infections. Infections can also have long-lasting effects on the KC population. This review discusses the biology and roles of liver macrophages during infections, as well as the potential of infection history to impact macrophages.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Victor D. Cuevas, Miriam Simon-Fuentes, Emmanuel Orta-Zavalza, Rafael Samaniego, Paloma Sanchez-Mateos, Maria Escribese, Francisco J. Cimas, Matilde Bustos, Mario Perez-Diego, Alberto Ocana, Angeles Dominguez-Soto, Miguel A. Vega, Angel L. Corbi
Summary: During inflammatory responses, monocytes can differentiate into monocyte-derived macrophages with distinct transcriptional profiles, which are partially regulated by IL-10. This specific gene expression signature may provide potential targets for macrophage-centered therapeutic strategies.
JOURNAL OF INNATE IMMUNITY
(2022)
Article
Physiology
Peter K. Moore, Kelsey C. Anderson, Shannon A. McManus, Ting -Hui Tu, Emily M. King, Kara J. Mould, Elizabeth F. Redente, Peter M. Henson, William J. Janssen, Alexandra L. McCubbrey
Summary: This study characterized the subtypes and transcriptomic profiles of interstitial macrophages (IMs) in the lung during homeostasis and acute lung inflammation induced by lipopolysaccharide (LPS). The results show that IMs can be divided into distinct subsets based on the expression of folate receptor I3 (FRI3), and during inflammation, there are recruited monocyte-derived IMs with unique gene expression profiles. These findings suggest that IMs have different functions during inflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Immunology
Xinying Li, Jocelyn Darby, A. Bruce Lyons, Gregory M. Woods, Heinrich Korner
IMMUNOLOGICAL INVESTIGATIONS
(2019)
Article
Immunology
Xinming Wang, Xiaoyun Chen, Wei Huang, Pengying Zhang, Yawei Guo, Heinrich Korner, Huaxun Wu, Wei Wei
INFLAMMOPHARMACOLOGY
(2019)
Review
Pharmacology & Pharmacy
Jiajie Tu, Yawei Guo, Wenming Hong, Yilong Fang, Dafei Han, Pengying Zhang, Xinming Wang, Heinrich Korner, Wei Wei
FRONTIERS IN PHARMACOLOGY
(2019)
Review
Oncology
Weijia Mao, Jie Zhang, Heinrich Korner, Yong Jiang, Songcheng Ying
FRONTIERS IN ONCOLOGY
(2019)
Article
Immunology
Miaomiao Li, Yang Dong, Zhangming Chen, Lei Meng, Xingyun Liu, Xinhui Zhang, Huimin Wang, Weijia Mao, Jie Zhang, Zhe Jiang, Ting Huang, Jie Hu, Panquan Luo, Heinrich Korner, Songcheng Ying, Jun Li
IMMUNOLOGICAL INVESTIGATIONS
(2019)
Review
Neurosciences
Yawei Guo, Wenming Hong, Xinming Wang, Pengying Zhang, Heinrich Korner, Jiajie Tu, Wei Wei
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Review
Immunology
Qi Liu, Heinrich Korner, Huaxun Wu, Wei Wei
Article
Immunology
Xiaoyun Chen, Pengying Zhang, Qi Liu, Qiaolin Zhang, Fang Gu, Shixia Xu, Heinrich Korner, Huaxun Wu, Wei Wei
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Review
Cell Biology
Adrian Y. S. Lee, Heinrich Korner
IMMUNOLOGY AND CELL BIOLOGY
(2020)
Article
Medicine, Research & Experimental
Huaxun Wu, Xiaoyun Chen, Fang Gu, Pengying Zhang, Shixia Xu, Qi Liu, Qiaolin Zhang, Xinming Wang, Chun Wang, Heinrich Koerner, Wei Wei
Summary: The study demonstrated that CP-25 therapy inhibits the JAK1-STAT1/2-CXCL13 signaling pathway in HSGEC, preventing B cell migration into the salivary gland. CP-25 showed potential therapeutic effects in alleviating symptoms of Sjogren's syndrome and modulating immune responses in patients.
LABORATORY INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Ma Junaliah Tuazon Kels, Esther Ng, Zahrah Al Rumaih, Pratikshya Pandey, Sigrid R. Ruuls, Heinrich Korner, Timothy P. Newsome, Geeta Chaudhri, Gunasegaran Karupiah
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Microbiology
Xinying Li, Heinrich Koerner, Xiaoying Liu
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Immunology
Xinying Li, Chen Chen, Lianjun Zhang, Xiaomin Cheng, Huiwu Geng, Qiang Ji, Chao Li, Huili Chen, Heinrich Korner, Xiaoying Liu
Summary: Research has shown that TNF plays a crucial role in immunity against Listeria monocytogenes, supporting the M1 phenotype and blocking M2 polarization in macrophages. TNF promotes the transition from M2 to M1 phenotype, with involvement of the NF-kappa B pathway and PPAR gamma receptor agonists. Competing signaling mechanisms are essential for macrophages to defeat Listeria monocytogenes infections, with TNF driving M1 polarization being a key factor.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Article
Immunology
Xinming Wang, Jiajie Tu, Ji Jiang, Qiaolin Zhang, Qi Liu, Heinrich Korner, Jingjing Wu, Huaxun Wu, Wei Wei
JOURNAL OF IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Jie Zhang, Weijia Mao, Yongzheng Dai, Chengwei Qian, Yang Dong, Zhangming Chen, Lei Meng, Zhe Jiang, Ting Huang, Jie Hu, Panquan Luo, Heinrich Korner, Yong Jiang, Songcheng Ying
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2019)