Article
Biochemistry & Molecular Biology
Hyun Jung Park, Sung Won Lee, Jae Geun Song, Luc Van Kaer, Jae Hee Cheon, Soo-Jeong Lim, Hyo-Kyung Han, Seokmann Hong
Summary: Study found that aminoclay nanoparticles have anti-inflammatory effects on murine dendritic cells (DCs) and can attenuate inflammatory responses and inhibit the production of specific cytokines, which has therapeutic potential for controlling inflammatory disorders.
Review
Immunology
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
Summary: The lungs have an immune defense mechanism that uses various cells to eliminate harmful pathogens and activate T cell immune response. In addition to immune cells, other lung cells also participate in antigen presentation and T cell activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ashu Singh, Dayasagar Das, Santosh Kurra, Sudheer Arava, Somesh Gupta, Alpana Sharma
Summary: Vitiligo is a progressive autoimmune skin disorder, and this study found that the frequency and levels of DCs and their associated cytokines were significantly elevated in patients, potentially contributing to defective antigen presentation of DCs and involvement in the pathogenesis of GV.
Article
Biochemistry & Molecular Biology
Agnes Ulfig, Verian Bader, Marharyta Varatnitskaya, Natalie Lupilov, Konstanze F. Winklhofer, Lars Leichert
Summary: Studies have shown that N-chlorinated HSA can significantly impair the ability of macrophages to present antigens to T cells via MHC class II proteins at multiple stages, potentially preventing antigen processing by immune cells at the initial stage of infection and leading to chronic infection and inflammation.
Article
Chemistry, Multidisciplinary
Hejin Jiang, Rui Liu, Lu Wang, Xinyue Wang, Mengmeng Zhang, Sisi Lin, Zhenping Cao, Feng Wu, Yingbin Liu, Jinyao Liu
Summary: Chirality plays a critical role in biological systems, and this study demonstrates the potential of using supramolecular chiral polymer micelles (SCPMs) to activate the immune system for disease prevention and treatment.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Jue Zhang, Jackie Chang, Mirza Ahmar Beg, Wenxin Huang, Yiqiong Zhao, Wen Dai, Xiaopeng Wu, Weiguo Cui, Sneha S. Pillai, Hari Vishal Lakhani, Komal Sodhi, Joseph I. Shapiro, Daisy Sahoo, Ze Zheng, Roy L. Silverstein, Yiliang Chen
Summary: This study found that NKA alpha 1 plays a role in suppressing LPS-induced pro-inflammatory signaling through the inhibition of Lyn.
Article
Multidisciplinary Sciences
Haiyin Liu, Kayla R. Wilson, Ashley M. Firth, Christophe Macri, Patrick Schriek, Annabelle B. Blum, Javiera Villar, Samuel Wormald, Mitch Shambrook, Bangyan Xu, Hui Jing Lim, Hamish E. G. McWilliam, Andrew F. Hill, Laura E. Edgington-Mitchell, Irina Caminschi, Mireille H. Lahoud, Elodie Segura, Marco J. Herold, Jose A. Villadangos, Justine D. Mintern
Summary: This study reveals the critical role of ubiquitin-like protein 3 (UBL3) in the trafficking process controlled by MARCH1. UBL3 has wide-ranging immunological consequences and is essential for immune responses.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Xianmei Liu, Xue Xia, Xifu Wang, Jing Zhou, Lanping Amy Sung, Jinhua Long, Xueyu Geng, Zhu Zeng, Weijuan Yao
Summary: Tropomodulin1 (Tmod1) is a critical regulator of dendritic cell (DC) maturation and immune functions, controlling actin cytoskeleton and TLR4 signaling pathways. Deficiency of Tmod1 impairs DC maturation, migration, T-cell stimulation, and immune responses, suggesting Tmod1 as a potential target for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Thi Mai Nguyen, Syaghalirwa N. M. Mandiki, Jean M. A. J. Salomon, Joel Bondekwe Baruti, Nang Thu Tran Thi, Thu Hang Nguyen, Truong Quynh Nhu, Patrick Kestemont
Summary: The study evaluated how to maximize the utilization of dietary plant oil for an efficient inflammatory response in common carp head kidney leukocytes (HKLs) exposed to a gram-negative bacterial endotoxin, Escherichia coli lipopolysaccharides (LPS). The results showed that fish fed plant oil mixture had immune competence comparable to those fed fish oil diet, and supplementation of ARA or DHA induced similar immunomodulation in common carp.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Immunology
Ray A. Ohara, Kenneth M. Murphy
Summary: Cross-priming, initially recognized in cytotoxic T lymphocyte (CTL) responses, involves the presentation of minor histocompatibility antigens by antigen presenting cells (APCs) derived from immunizing cells. As understanding of T cell receptor antigen recognition progressed, cross-priming was redefined as cross-presentation and expanded to include different forms of antigens and APCs not involved in in vivo CTL priming. In vitro cell models have been utilized for studying cross-presentation, but recent studies have shown differences between these models and in vivo APCs. Current research focuses on validating in vivo pathways and gene candidates for cross-presentation, and evaluating their contributions to CTL responses across different antigens and immunologic settings.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Amanda Mara Teles, Gabriel Silva Xavier, Wendel Fragoso de Freitas Moreira, Carla Junqueira Moragas-Tellis, Maria do Socorro dos Santos Chagas, Maria Dutra Behrens, Ana Lucia Abreu-Silva, Geusa Felipa de Barros Bezerra, Katia da Silva Calabrese, Maria do Desterro Soares Brandao Nascimento, Fernando Almeida-Souza
Summary: This study aims to investigate the chemical composition and anti-inflammatory effects of Talaromyces purpurogenus isolated from a marine-polluted environment. The results showed that the ethyl acetate extract of T. purpurogenus culture broth had a rich chemical composition and inhibited the production of cytokines and nitrites, demonstrating its anti-inflammatory properties.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Immunology
Yuehan Gao, He Li, Zhaohuai Li, Lihui Xie, Xiuxing Liu, Zhaohao Huang, Binyao Chen, Xianchai Lin, Xianggui Wang, Yingfeng Zheng, Wenru Su
Summary: The study identified different subtypes within human moDCs and blood DCs, revealing their transcriptomic differences and differentiation trajectories, which will enable more accurate functional and developmental analyses of human cDC2s and moDCs.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Yinyan Yin, Nuo Xu, Tao Qin, Bangyue Zhou, Yi Shi, Xinyi Zhao, Bixia Ma, Zhengzhong Xu, Chunmei Li
Summary: The study showed that astaxanthin exhibits strong antioxidant properties by increasing cellular reductive status, upregulating antioxidant enzyme activities, and inhibiting cytokine secretions, which could potentially alleviate DC-related inflammatory responses and serve as a promising approach for sepsis treatment.
Review
Biochemistry & Molecular Biology
Anna Ciesielska, Marta Matyjek, Katarzyna Kwiatkowska
Summary: This article discusses the role of TLR4 in promoting inflammatory responses, including internalization and intracellular trafficking of exogenous endotoxin and bacteria. The authors emphasize the significant impact of internalization rate and endo-lysosomal compartment transport rate on inflammatory responses.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'Dowd, Laura O'Doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'Halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm Bergin, Sean P. Kennelly, Seamas C. Donnelly, Nollaig M. Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh, Padraic G. Fallon
Summary: Clinical outcomes of SARS-CoV-2 infection show a wide range, from asymptomatic cases to severe pneumonia and death. This variability is influenced by differences in the immune response to the virus. A study measured inflammatory markers in patients with acute COVID-19 and found that most pro-inflammatory markers were significantly elevated, and specific markers were associated with disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Ji Yeon Lee, Eun-Koung An, Juyoung Hwang, Jun-O. Jin, Peter C. W. Lee
Summary: This study identifies UBA6 as a critical regulator of IFN-gamma production in T cells by modulating the NF-kappa B p65 activation pathway. UBA6 deficiency leads to increased production of IFN-gamma in T cells and exacerbates the development of multi-organ inflammation. Moreover, UBA6 levels are significantly lower in lupus patients compared to healthy individuals.
Article
Chemistry, Multidisciplinary
Juyoung Hwang, Eun-Koung An, So-Jung Kim, Wei Zhang, Jun-O Jin
Summary: In this study, Escherichia coli-mimetic nanomaterials named E. coli mimetic AuNRs (ECA) were synthesized for combination therapy against cancer and its recurrence. ECA treatment with laser irradiation showed a photothermal effect in eliminating tumors and inducing immune cell activation. The preventive effect of ECA against tumor growth in the lung metastatic form was aided by cancer antigen-specific T cell immunity.
Article
Engineering, Biomedical
Juyoung Hwang, Eun-Koung An, Wei Zhang, Hae-Bin Park, So -Jung Kim, Dhananjay Yadav, Jihoe Kim, Inho Choi, Minseok Kwak, Peter CW. Lee, Xiaoyan Zhang, Jianqing Xu, Jun-O Jin
Summary: This study found that recombinant murine programmed death-1 (rmPD-1) protein can function as an immune checkpoint blockade for cancer treatment. Additionally, thermal responsive hybrid nanoparticles (piHNPs) decorated with rmPD-1 have a promoting effect on anti-cancer immunity and can prevent cancer metastasis and recurrence.
Review
Cell Biology
Dhananjay Yadav, Ji Yeon Lee, Nidhi Puranik, Pallavi S. Chauhan, Vishal Chavda, Jun-O Jin, Peter C. W. Lee
Summary: Multiple sclerosis is an autoimmune neurodegenerative disease associated with the central nervous system. Ubiquitination, an important cellular modification process, plays a vital role in protein turnover and immune regulation. Dysfunction in the ubiquitin-proteasome system can disrupt cellular homeostasis and lead to various diseases.
Article
Chemistry, Multidisciplinary
Hyosung Choi, Banyu Firdaus Soeriawidjaja, Sang Hak Lee, Minseok Kwak
Summary: Temperature is a crucial factor in chemical experiments, as it can affect the properties and shape of materials. Existing temperature measurement devices used in experiments are unable to simultaneously measure temperature and process data. We present a low-cost and convenient platform that can address both issues, with the capability to automatically set different measurement time intervals for each experiment and display processed data in real-time on the Internet.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Jun-O Jin, Dhananjay Yadav, Kajal Madhwani, Nidhi Puranik, Vishal Chavda, Minseok Song
Summary: Marine natural products provide a promising avenue for the development of future medications for various ailments. The search for low-toxicity marine drugs to prevent and treat cancer is a current research priority. Fucoidan, a marine-origin polysaccharide, has shown potential as a therapeutic lead candidate against cancer, with diverse biological activities and safety. This review highlights the molecular and cellular aspects, immunomodulatory effects, and anticancer actions of fucoidan, as well as the potential anticancer marine drugs derived from specific fucoidan and membranaceous polysaccharides.
Article
Cell Biology
Jeong Ho Lim, Khurshid Ahmad, Hee Jin Chun, Ye Chan Hwang, Afsha Fatima Qadri, Shahid Ali, Syed Sayeed Ahmad, Sibhghatulla Shaikh, Jungseok Choi, Jihoe Kim, Jun-O Jin, Myunghee Kim, Sung Soo Han, Inho Choi, Eun Ju Lee
Summary: This study reveals that immunoglobulin-like cell adhesion molecule (IgLON4) is highly expressed in mouse muscles and plays a role in muscle regeneration and differentiation. Inhibition of IgLON4 affects myotube alignment and is involved in lipid raft accumulation during myogenic differentiation.
Review
Biodiversity Conservation
Bhupendra Koul, Baveesh Pudhuvai, Chelsi Sharma, Arvind Kumar, Vinay Sharma, Dhananjay Yadav, Jun-O Jin
Summary: Carica papaya, also known as papaya, is a tropical fruit tree with significant commercial and medicinal value. It is rich in bioactive components that provide antioxidant, digestive, and nutraceutical benefits. Papaya is high in vitamins, minerals, and fiber, offering various health benefits such as cholesterol reduction and disease prevention. Papaya leaf extract shows potential in treating cancer and viral diseases. Genetic modification has been used to enhance papaya's resistance and shelf life, but further research is needed to ensure stability and yield.
Article
Engineering, Biomedical
Haejoo Kim, In-ho Jeong, Yeol Kyo Choi, Yeon Kyung Lee, Eunyoung Moon, Yang Hoon Huh, Wonpil Im, Jun-O Jin, Minseok Kwak, Peter Chang-Whan Lee
Summary: UBA6-specific E2 conjugation enzyme 1 (USE1) is frequently overexpressed in lung cancer patients and plays a critical role in the progression of human lung cancer. Researchers aim to develop USE1-targeted therapeutic agents based on RNA interference (RNAi). They introduce a lipid-modified DNA carrier, U4T, to enhance the cell permeability of siRNA targeting USE1. The siSNA created using U4Ts can effectively inhibit tumor growth in vivo and suppress lung cancer cell proliferation, migration, and invasion.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
So-Jung Kim, Hae-Bin Park, Eun-Koung An, Hee-Yun Eom, Wei Zhang, Jihoe Kim, Inho Choi, Minseok Kwak, Peter C. W. Lee, Jun-O Jin
Summary: Induction of immunogenic cell death (ICD) using lipid nanoparticles (LNPs) decorated with ICD indicators effectively targets and activates dendritic cells (DCs) to elicit antigen-specific T-cell immunity and inhibit tumor growth and metastasis.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Environmental
Jun Yong Oh, Eun-Koung An, Batakrishna Jana, Hansol Kim, Seongeon Jin, Gyeongseok Yang, Jinsoo Kim, Eunshil Choi, Jun-O Jin, Ja-Hyoung Ryu
Summary: In order to improve drug delivery with nanoparticles, antibodies are used due to their high affinity to the target site. However, the traditional method of conjugating antibodies to nanoparticles can damage the antibody's ability to recognize its target. This study presents a simple approach to create a targeted delivery platform by coating the nanoparticle surface with a fusion protein consisting of glutathione-S-transferase (GST) and the antibody-binding domain (ABD) called Z domain. The antibody-plugged nanoparticle exhibits excellent stability and target-specific behavior, significantly enhancing drug delivery efficiency in various therapeutic applications both in vitro and in vivo.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Nanoscience & Nanotechnology
So-Jung Kim, Nidhi Puranik, Dhananjay Yadav, Peter C. W. Lee, Jun -O Jin
Summary: Despite ongoing developments in various treatments, lung cancer continues to have high mortality rates, with many cases showing reduced survival rates due to treatment resistance. Cancer nanotechnology, specifically the use of lipid-based nanocarriers, has shown promise in enhancing drug delivery, overcoming absorption barriers, and targeting specific areas for lung cancer treatment and vaccine development.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Engineering, Biomedical
Eun-Koung An, Wei Zhang, Hae-Bin Park, So-Jung Kim, Hee-Yun Eom, Juyoung Hwang, Minseok Kwak, Ji Yeon Lee, Peter Chang-Whan Lee, Jun-O Jin
Summary: In this study, recombinant murine PD-L1 (rmPD-L1) was used to control T cell immunity and treat multi-organ inflammation. Hybrid nanoparticles (HNPs) were developed by incorporating the anti-inflammatory drug methotrexate and decorating the surface with rmPD-L1, resulting in immunosuppressive HNPs (IsHNPs). IsHNP treatment effectively targeted PD-1-expressing CD4 and CD8 T cells, promoted the production of regulatory T cells, and inhibited the activation of CD4 and CD8 T cells. This study demonstrates the therapeutic potential of IsHNPs for multi-organ inflammation and other inflammatory diseases.
Article
Biotechnology & Applied Microbiology
Naz Fathma Tumpa, Mingyeong Kang, Jiae Yoo, Sunju Kim, Minseok Kwak
Summary: In this study, engineered nanoparticles consisting of two different types of rylene derivatives encapsulated in polymeric micelles were used for the elimination of harmful red-tide dinoflagellates. The nanoparticles were found to be effective in reducing cell survival through fluorescence labeling and photothermal effect.
BIOENGINEERING-BASEL
(2022)
