Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening
Authors
Keywords
Fragment-based screening, Differential scanning fluorimetry, Glutaminyl cyclase, Fragment linking
Journal
MOLECULAR DIVERSITY
Volume 21, Issue 1, Pages 175-186
Publisher
Springer Nature
Online
2017-01-09
DOI
10.1007/s11030-016-9717-4
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The impact of binding thermodynamics on medicinal chemistry optimizations
- (2015) György G Ferenczy et al. Future Medicinal Chemistry
- Accurate Binding Free Energy Predictions in Fragment Optimization
- (2015) Thomas B. Steinbrecher et al. Journal of Chemical Information and Modeling
- siRNA screen identifies QPCT as a druggable target for Huntington's disease
- (2015) Maria Jimenez-Sanchez et al. Nature Chemical Biology
- Structure–activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template
- (2013) Phuong-Thao Tran et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Structure–Activity Relationships of Benzimidazole-Based Glutaminyl Cyclase Inhibitors Featuring a Heteroaryl Scaffold
- (2013) Daniel Ramsbeck et al. JOURNAL OF MEDICINAL CHEMISTRY
- The 'rule of three' for fragment-based drug discovery: where are we now?
- (2013) Harren Jhoti et al. NATURE REVIEWS DRUG DISCOVERY
- Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry
- (2012) Alan Nadin et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Fragment-Based Approaches in Drug Discovery and Chemical Biology
- (2012) Duncan E. Scott et al. BIOCHEMISTRY
- Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
- (2012) Justin M. Nussbaum et al. NATURE
- Finding the sweet spot: the role of nature and nurture in medicinal chemistry
- (2012) Michael M. Hann et al. NATURE REVIEWS DRUG DISCOVERY
- Vemurafenib: the first drug approved for BRAF-mutant cancer
- (2012) Gideon Bollag et al. NATURE REVIEWS DRUG DISCOVERY
- Fragment-based lead discovery grows up
- (2012) Monya Baker NATURE REVIEWS DRUG DISCOVERY
- Structures of Glycosylated Mammalian Glutaminyl Cyclases Reveal Conformational Variability near the Active Center
- (2011) David Ruiz-Carrillo et al. BIOCHEMISTRY
- Inhibitors for Human Glutaminyl Cyclase by Structure Based Design and Bioisosteric Replacement
- (2009) Mirko Buchholz et al. JOURNAL OF MEDICINAL CHEMISTRY
- The rise of fragment-based drug discovery
- (2009) Christopher W. Murray et al. Nature Chemistry
- Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β†
- (2008) Holger Cynis et al. BIOCHEMISTRY
- Inhibition of glutaminyl cyclase prevents pGlu-A formation after intracorticalhippocampal microinjectionin vivoin situ
- (2008) Stephan Schilling et al. JOURNAL OF NEUROCHEMISTRY
- Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology
- (2008) Stephan Schilling et al. NATURE MEDICINE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now