Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening
出版年份 2017 全文链接
标题
Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening
作者
关键词
Fragment-based screening, Differential scanning fluorimetry, Glutaminyl cyclase, Fragment linking
出版物
MOLECULAR DIVERSITY
Volume 21, Issue 1, Pages 175-186
出版商
Springer Nature
发表日期
2017-01-09
DOI
10.1007/s11030-016-9717-4
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The impact of binding thermodynamics on medicinal chemistry optimizations
- (2015) György G Ferenczy et al. Future Medicinal Chemistry
- Accurate Binding Free Energy Predictions in Fragment Optimization
- (2015) Thomas B. Steinbrecher et al. Journal of Chemical Information and Modeling
- siRNA screen identifies QPCT as a druggable target for Huntington's disease
- (2015) Maria Jimenez-Sanchez et al. Nature Chemical Biology
- Structure–activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template
- (2013) Phuong-Thao Tran et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Structure–Activity Relationships of Benzimidazole-Based Glutaminyl Cyclase Inhibitors Featuring a Heteroaryl Scaffold
- (2013) Daniel Ramsbeck et al. JOURNAL OF MEDICINAL CHEMISTRY
- The 'rule of three' for fragment-based drug discovery: where are we now?
- (2013) Harren Jhoti et al. NATURE REVIEWS DRUG DISCOVERY
- Lead-Oriented Synthesis: A New Opportunity for Synthetic Chemistry
- (2012) Alan Nadin et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Fragment-Based Approaches in Drug Discovery and Chemical Biology
- (2012) Duncan E. Scott et al. BIOCHEMISTRY
- Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
- (2012) Justin M. Nussbaum et al. NATURE
- Finding the sweet spot: the role of nature and nurture in medicinal chemistry
- (2012) Michael M. Hann et al. NATURE REVIEWS DRUG DISCOVERY
- Vemurafenib: the first drug approved for BRAF-mutant cancer
- (2012) Gideon Bollag et al. NATURE REVIEWS DRUG DISCOVERY
- Fragment-based lead discovery grows up
- (2012) Monya Baker NATURE REVIEWS DRUG DISCOVERY
- Structures of Glycosylated Mammalian Glutaminyl Cyclases Reveal Conformational Variability near the Active Center
- (2011) David Ruiz-Carrillo et al. BIOCHEMISTRY
- Inhibitors for Human Glutaminyl Cyclase by Structure Based Design and Bioisosteric Replacement
- (2009) Mirko Buchholz et al. JOURNAL OF MEDICINAL CHEMISTRY
- The rise of fragment-based drug discovery
- (2009) Christopher W. Murray et al. Nature Chemistry
- Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β†
- (2008) Holger Cynis et al. BIOCHEMISTRY
- Inhibition of glutaminyl cyclase prevents pGlu-A formation after intracorticalhippocampal microinjectionin vivoin situ
- (2008) Stephan Schilling et al. JOURNAL OF NEUROCHEMISTRY
- Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology
- (2008) Stephan Schilling et al. NATURE MEDICINE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started