Exploring the anti-proliferative activity of Pelargonium sidoides DC with in silico target identification and network pharmacology

Identification of “Multiple Components-Multiple Targets-Multiple Pathways” Associated with Naoxintong Capsule in the Treatment of Heart Diseases Using UPLC/Q-TOF-MS and Network Pharmacology

(2016) Xianghui Ma et al.   Evidence-based Complementary and Alternative Medicine

Structure Identification and Anti-Cancer Pharmacological Prediction of Triterpenes from Ganoderma lucidum

(2016) Yanyan Shao et al.   MOLECULES

Brain-inspired cheminformatics of drug-target brain interactome, synthesis, and assay of TVP1022 derivatives

(2016) Francisco J. Romero-Durán et al.   NEUROPHARMACOLOGY

Anti-proliferative properties of commercialPelargonium sidoidestincture, with cell-cycle G0/G1arrest and apoptosis in Jurkat leukaemia cells

(2016) Andreia Pereira et al.   PHARMACEUTICAL BIOLOGY

The double-edged sword of AMPK signaling in cancer and its therapeutic implications

(2015) Sang-Min Jeon et al.   ARCHIVES OF PHARMACAL RESEARCH

Activity-guided isolation and identification of the major antioxidant and anticancer compounds from a commercial Pelargonium sidoides tincture

(2015) Andreia Pereira et al.   MEDICINAL CHEMISTRY RESEARCH

Emerging Roles of Focal Adhesion Kinase in Cancer

(2015) Yu-Ling Tai et al.   Biomed Research International

In silico target fishing and pharmacological profiling for the isoquinoline alkaloids of Macleaya cordata (Bo Luo Hui)

(2015) Qifang Lei et al.   Chinese Medicine

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

Systematic Analysis of the Multiple Bioactivities of Green Tea through a Network Pharmacology Approach

(2014) Shoude Zhang et al.   Evidence-based Complementary and Alternative Medicine

Prediction of Multi-Target Networks of Neuroprotective Compounds with Entropy Indices and Synthesis, Assay, and Theoretical Study of New Asymmetric 1,2-Rasagiline Carbamates

(2014) Francisco Durán et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ANN Multiscale Model of Anti-HIV Drugs Activity vs AIDS Prevalence in the US at County Level Based on Information Indices of Molecular Graphs and Social Networks

(2014) Humberto González-Díaz et al.   Journal of Chemical Information and Modeling

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Identification of Proapoptopic, Anti-Inflammatory, Anti-Proliferative, Anti-Invasive and Anti-Angiogenic Targets of Essential Oils in Cardamom by Dual Reverse Virtual Screening and Binding Pose Analysis

(2013) Biplab Bhattacharjee et al.   Asian Pacific Journal of Cancer Prevention

Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer

(2013) Kamal S. Saini et al.   CANCER TREATMENT REVIEWS

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Polypharmacology – Foe or Friend?

(2013) Jens-Uwe Peters   JOURNAL OF MEDICINAL CHEMISTRY

A Network Approach to Wound Healing

(2013) Tomasz Arodz et al.   Advances in Wound Care

A NETWORK VIEW ON PARKINSON'S DISEASE

(2013) Sreedevi Chandrasekaran et al.   Computational and Structural Biotechnology Journal

3D MI-DRAGON: New Model for the Reconstruction of US FDA Drug- Target Network and Theoretical-Experimental Studies of Inhibitors of Rasagiline Derivatives for AChE

(2012) Francisco Prado-Prado et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The mTOR Signalling Pathway in Human Cancer

(2012) Helena Pópulo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The disease and gene annotations (DGA): an annotation resource for human disease

(2012) Kai Peng et al.   NUCLEIC ACIDS RESEARCH

Polypharmacology: drug discovery for the future

(2012) A Srinivas Reddy et al.   Expert Review of Clinical Pharmacology

2D MI-DRAGON: A new predictor for protein–ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins

(2011) Francisco Prado-Prado et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical–protein interactome

(2011) Heng Luo et al.   NUCLEIC ACIDS RESEARCH

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-κB activity and downregulation of PI3K/AKT/small GTPase signals

(2010) Hsieh-Hsun Ho et al.   FOOD AND CHEMICAL TOXICOLOGY

PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach

(2010) Xiaofeng Liu et al.   NUCLEIC ACIDS RESEARCH

Investigation of the influence of EPs® 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses

(2010) Martin Michaelis et al.   PHYTOMEDICINE

Activation of Rap1 Promotes Prostate Cancer Metastasis

(2009) C. L. Bailey et al.   CANCER RESEARCH

ErbB receptors and signaling pathways in cancer

(2009) Nancy E Hynes et al.   CURRENT OPINION IN CELL BIOLOGY

How to visually interpret biological data using networks

(2009) Daniele Merico et al.   NATURE BIOTECHNOLOGY

Involvement of extracellular signal-related kinase signaling in esculetin induced G1 arrest of human leukemia U937 cells

(2008) Shin Hwa Lee et al.   BIOMEDICINE & PHARMACOTHERAPY

Low-power laser irradiation activates Src tyrosine kinase through reactive oxygen species-mediated signaling pathway

(2008) Juntao Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae)

(2008) T. Brendler et al.   JOURNAL OF ETHNOPHARMACOLOGY

Efficacy of an aqueous Pelargonium sidoides extract against herpesvirus

(2008) P. Schnitzler et al.   PHYTOMEDICINE

PI3K/PTEN signaling in tumorigenesis and angiogenesis

(2007) Bing-Hua Jiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS