The nuclear orphan receptor NR4A1 regulates β1-integrin expression in pancreatic and colon cancer cells and can be targeted by NR4A1 antagonists

Nuclear receptor 4A (NR4A) family – orphans no more

(2016) Stephen Safe et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration

(2016) Erik Hedrick et al.   MOLECULAR AND CELLULAR BIOLOGY

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells

(2016) Erik Hedrick et al.   Oncotarget

Nuclear receptor 4A1 as a drug target for breast cancer chemotherapy

(2015) Erik Hedrick et al.   ENDOCRINE-RELATED CANCER

Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation

(2015) Li Li et al.   Nature Chemical Biology

Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma

(2015) Erik Hedrick et al.   PLoS One

NR4A nuclear receptors are orphans but not lonesome

(2014) Kondababu Kurakula et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Orphan nuclear receptor Nur77 promotes colorectal cancer invasion and metastasis by regulating MMP-9 and E-cadherin

(2014) J.-R. Wang et al.   CARCINOGENESIS

The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells

(2014) Syng-Ook Lee et al.   MOLECULAR CANCER RESEARCH

Diindolylmethane Analogs Bind NR4A1 and Are NR4A1 Antagonists in Colon Cancer Cells

(2014) Syng-Ook Lee et al.   MOLECULAR ENDOCRINOLOGY

Association of CD98, integrin β1, integrin β3 and Fak with the progression and liver metastases of colorectal cancer

(2014) Cuicui Sun et al.   PATHOLOGY RESEARCH AND PRACTICE

Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-β signalling

(2014) FangFang Zhou et al.   Nature Communications

Research Resource: Nuclear Receptors as Transcriptome: Discriminant and Prognostic Value in Breast Cancer

(2013) George E. O. Muscat et al.   MOLECULAR ENDOCRINOLOGY

Minireview: Role Of Orphan Nuclear Receptors in Cancer and Potential as Drug Targets

(2013) Stephen Safe et al.   MOLECULAR ENDOCRINOLOGY

Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway

(2013) Wei-jia Wang et al.   Nature Chemical Biology

Cadherin-17 interacts with α2β1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis

(2013) R A Bartolomé et al.   ONCOGENE

Detection and Clinical Significance of CD44v6 and Integrin-β1 in Pancreatic Cancer Patients using a Triplex Real-Time RT-PCR Assay

(2012) Gang Zhou et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Orphan receptor TR3 is essential for the maintenance of stem-like properties in gastric cancer cells

(2012) Yan-yan Zhan et al.   CANCER LETTERS

Matrix Metalloproteinase-2 Cleavage of the β1 Integrin Ectodomain Facilitates Colon Cancer Cell Motility

(2012) Jakub Kryczka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

 1-Integrin: A Potential Therapeutic Target in the Battle against Cancer Recurrence

(2011) D. Barkan et al.   CLINICAL CANCER RESEARCH

Knockdown of the β1 integrin subunit reduces primary tumor growth and inhibits pancreatic cancer metastasis

(2011) John J. Grzesiak et al.   INTERNATIONAL JOURNAL OF CANCER

The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53

(2011) S-O Lee et al.   ONCOGENE

Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells

(2011) Aaron G. Smith et al.   Pigment Cell & Melanoma Research

Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth

(2010) S.-O. Lee et al.   CANCER RESEARCH

A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro

(2010) Jing-jing Liu et al.   CANCER RESEARCH

Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells

(2010) Hua Wu et al.   FASEB JOURNAL

Minireview: Nuclear Hormone Receptor 4A Signaling: Implications for Metabolic Disease

(2010) Michael A. Pearen et al.   MOLECULAR ENDOCRINOLOGY

PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin β1-ERK1/2 and-MMP2 signaling

(2009) Lirong Peng et al.   Molecular Cancer

Cytosporone B is an agonist for nuclear orphan receptor Nur77

(2008) Yanyan Zhan et al.   Nature Chemical Biology