Molecular trail for the anticancer behavior of a novel copper carbohydrazone complex in BRCA1 mutated breast cancer

Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells

(2016) Veena Somasundaram et al.   BMC CANCER

Increased sensitivity of BRCA defective triple negative breast tumors to plumbagin through induction of DNA Double Strand Breaks (DSB)

(2016) Rakesh Sathish Nair et al.   Scientific Reports

TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer

(2015) Steven J. Isakoff et al.   JOURNAL OF CLINICAL ONCOLOGY

The molecular response of vanadium complexes of nicotinoyl hydrazone in cervical cancers—A possible interference with HPV oncogenic markers

(2014) Rakesh S. Nair et al.   LIFE SCIENCES

Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cellsin vivo

(2012) Sutapa Sinha et al.   INTERNATIONAL JOURNAL OF CANCER

Antioxidant Activities of Plumbagin and Its Cu (II) Complex

(2011) Mingxiong Tan et al.   BIOINORGANIC CHEMISTRY AND APPLICATIONS

Inhibition of Cu2+-mediated generation of reactive oxygen species by the small heat shock protein αB-crystallin: The relative contributions of the N- and C-terminal domains

(2011) Sankaralingam Prabhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Challenges to the Development of New Agents for Molecularly Defined Patient Subsets: Lessons FromBRCA1/2-Associated Breast Cancer

(2011) Susan M. Domchek et al.   JOURNAL OF CLINICAL ONCOLOGY

Role of Metalation in the Topoisomerase IIα Inhibition and Antiproliferation Activity of a Series of α-Heterocyclic-N4-Substituted Thiosemicarbazones and Their Cu(II) Complexes

(2011) Brian M. Zeglis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chitosan–iron oxide nano-composite platform for mismatch-discriminating DNA hybridization for Neisseria gonorrhoeae detection causing sexually transmitted disease

(2010) Renu Singh et al.   BIOSENSORS & BIOELECTRONICS

Cytotoxicity of the traditional chinese medicine (TCM) plumbagin in its copper chemistry

(2009) Zhen-Feng Chen et al.   DALTON TRANSACTIONS

Copper(II) and uranyl(II) complexes with acylthiosemicarbazide: Synthesis, characterization, antibacterial activity and effects on the growth of promyelocytic leukemia cells HL-60

(2009) Madalina Veronica Angelusiu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells

(2009) S. Nazeem et al.   MUTAGENESIS

Drug Resistance Caused by Reversion Mutation

(2008) A. Ashworth   CANCER RESEARCH

Secondary BRCA1 Mutations in BRCA1-Mutated Ovarian Carcinomas with Platinum Resistance

(2008) E. M. Swisher et al.   CANCER RESEARCH

Synthesis and Spectral Studies of Bisthiocarbohydrazone and Biscarbohydrazone of Quinoline-2-carbaldehyde: Crystal Structure of Bis(quinoline-2-aldehyde) Thiocarbohydrazone

(2008) E. Manoj et al.   JOURNAL OF CHEMICAL CRYSTALLOGRAPHY

Iron Chelators of the Dipyridylketone Thiosemicarbazone Class: Precomplexation and Transmetalation Effects on Anticancer Activity

(2008) Paul V. Bernhardt et al.   JOURNAL OF MEDICINAL CHEMISTRY

On the Molecular Mechanism of Drug Intercalation into DNA: A Simulation Study of the Intercalation Pathway, Free Energy, and DNA Structural Changes

(2008) Arnab Mukherjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preparation, magnetic and EPR spectral studies of copper(II) complexes of an anticancer drug analogue

(2008) E. Manoj et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY