Increased sensitivity of BRCA defective triple negative breast tumors to plumbagin through induction of DNA Double Strand Breaks (DSB)
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Increased sensitivity of BRCA defective triple negative breast tumors to plumbagin through induction of DNA Double Strand Breaks (DSB)
Authors
Keywords
-
Journal
Scientific Reports
Volume 6, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-05-25
DOI
10.1038/srep26631
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Olaparib Monotherapy in Patients With Advanced Cancer and a GermlineBRCA1/2Mutation
- (2015) Bella Kaufman et al. JOURNAL OF CLINICAL ONCOLOGY
- Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line
- (2014) Bianca Schröder-Heurich et al. BMC CANCER
- Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2
- (2014) A. R. Venkitaraman SCIENCE
- BRCA1 and Oxidative Stress
- (2014) Yong Yi et al. Cancers
- BRCA 1/2-Mutation Related and Sporadic Breast and Ovarian Cancers: More Alike than Different
- (2014) Melissa Burgess et al. Frontiers in Oncology
- Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway
- (2012) Jing Li et al. ACTA PHARMACOLOGICA SINICA
- Structure activity relationship of plumbagin in BRCA1 related cancer cells
- (2012) Thasni K.A. et al. MOLECULAR CARCINOGENESIS
- DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway
- (2012) M A Kang et al. Cell Death & Disease
- FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage
- (2012) Young Min Chung et al. Nature Communications
- p53-Dependent BRCA1 Nuclear Export Controls Cellular Susceptibility to DNA Damage
- (2011) J. Jiang et al. CANCER RESEARCH
- Plumbagin and juglone induce caspase-3-dependent apoptosis involving the mitochondria through ROS generation in human peripheral blood lymphocytes
- (2011) Priya Seshadri et al. FREE RADICAL BIOLOGY AND MEDICINE
- Plumbagin Inhibits Osteoclastogenesis and Reduces Human Breast Cancer-Induced Osteolytic Bone Metastasis in Mice through Suppression of RANKL Signaling
- (2011) B. Sung et al. MOLECULAR CANCER THERAPEUTICS
- Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells
- (2011) A. G. Patel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sensitivity and Acquired Resistance of BRCA1;p53-Deficient Mouse Mammary Tumors to the Topoisomerase I Inhibitor Topotecan
- (2010) S. A.L. Zander et al. CANCER RESEARCH
- Secondary mutations of BRCA1/2 and drug resistance
- (2010) Kiranjit K. Dhillon et al. CANCER SCIENCE
- 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
- (2010) Samuel F. Bunting et al. CELL
- Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia
- (2009) Tae Gen Son et al. JOURNAL OF NEUROCHEMISTRY
- Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo
- (2009) Kai-Hong Xu et al. LEUKEMIA RESEARCH
- Plumbagin, a Medicinal Plant–Derived Naphthoquinone, Is a Novel Inhibitor of the Growth and Invasion of Hormone-Refractory Prostate Cancer
- (2008) Moammir H. Aziz et al. CANCER RESEARCH
- The endless tale of non-homologous end-joining
- (2008) Eric Weterings et al. CELL RESEARCH
- Plumbagin-induced apoptosis of human breast cancer cells is mediated by inactivation of NF-κB and Bcl-2
- (2008) Aamir Ahmad et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Plumbagin-induced Apoptosis in Human Prostate Cancer Cells is Associated with Modulation of Cellular Redox Status and Generation of Reactive Oxygen Species
- (2008) Anna A. Powolny et al. PHARMACEUTICAL RESEARCH
- High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
- (2008) S. Rottenberg et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells
- (2007) Clay C.C. Wang et al. CANCER LETTERS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More