MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

(2016) Deborah C.I. Goberdhan et al.   Cell Metabolism

Schedule-dependent interaction between anticancer treatments

(2016) Sheng-hong Chen et al.   SCIENCE

The expanding role of mTOR in cancer cell growth and proliferation

(2015) Marie Cargnello et al.   MUTAGENESIS

MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response

(2015) F Mancini et al.   ONCOGENE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

Where is mTOR and what is it doing there?

(2014) Charles Betz et al.   JOURNAL OF CELL BIOLOGY

p70 Ribosomal protein S6 kinase (Rps6kb1): an update

(2014) Farnaz Bahrami-B et al.   JOURNAL OF CLINICAL PATHOLOGY

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

(2013) Q. Liu et al.   CANCER RESEARCH

Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry

(2013) Y. Zhu et al.   GENES & DEVELOPMENT

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Functions of MDMX in the Modulation of the p53-Response

(2011) Kristiaan Lenos et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts

(2011) Kristiaan Lenos et al.   Molecular Cancer

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

(2011) V. Pant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4

(2010) S. Xiong et al.   CANCER RESEARCH

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Puzzling over MDM4–p53 network

(2010) F. Mancini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Rag proteins regulate amino-acid-induced mTORC1 signalling

(2009) Yasemin Sancak et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway

(2009) Francesca Mancini et al.   EMBO JOURNAL

Common corruption of the mTOR signaling network in human tumors

(2009) S Menon et al.   ONCOGENE

Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats

(2008) M. J. Herold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE