Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS

The association between the hypothalamic pituitary adrenal axis and tryptophan metabolism in persons with recurrent major depressive disorder and healthy controls

(2017) F.J.H. Sorgdrager et al.   JOURNAL OF AFFECTIVE DISORDERS

Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression

(2017) Xinnan Zhao et al.   BEHAVIOURAL BRAIN RESEARCH

A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide, suicidal behavior, and major depressive disorder

(2016) Honglei Yin et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Understanding alterations in serotonin connectivity in a rat model of depression within the monoamine-deficiency and the hippocampal-neurogenesis frameworks

(2016) Noam Gordon et al.   BEHAVIOURAL BRAIN RESEARCH

The identification of metabolic disturbances in the prefrontal cortex of the chronic restraint stress rat model of depression

(2016) Lanxiang Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Metabolomic analysis reveals metabolic disturbances in the prefrontal cortex of the lipopolysaccharide-induced mouse model of depression

(2016) Yu Wu et al.   BEHAVIOURAL BRAIN RESEARCH

Developmental minocycline treatment reverses the effects of neonatal immune activation on anxiety- and depression-like behaviors, hippocampal inflammation, and HPA axis activity in adult mice

(2016) Jafar Majidi et al.   BRAIN RESEARCH BULLETIN

Targeted Metabolomic Pathway Analysis and Validation Revealed Glutamatergic Disorder in the Prefrontal Cortex among the Chronic Social Defeat Stress Mice Model of Depression

(2016) Wei Wang et al.   JOURNAL OF PROTEOME RESEARCH

Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

(2016) M-L Wong et al.   MOLECULAR PSYCHIATRY

A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

(2016) D R Goldsmith et al.   MOLECULAR PSYCHIATRY

Hypothalamic Proteomic Analysis Reveals Dysregulation of Glutamate Balance and Energy Metabolism in a Mouse Model of Chronic Mild Stress-Induced Depression

(2016) Chenglong Rao et al.   NEUROCHEMICAL RESEARCH

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(2016) Anand Gururajan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neuropathological relationship between major depression and dementia: A hypothetical model and review

(2016) Helena Kyunghee Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Guanosine and its role in neuropathologies

(2016) Luis E. B. Bettio et al.   Purinergic Signalling

Signaling pathways underlying the antidepressant-like effect of inosine in mice

(2016) Filipe Marques Gonçalves et al.   Purinergic Signalling

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(2016) Christian Otte et al.   Nature Reviews Disease Primers

The contribution of hypothalamic neuroendocrine, neuroplastic and neuroinflammatory processes to lipopolysaccharide-induced depressive-like behaviour in female and male rats: Involvement of glucocorticoid receptor and C/EBP-β

(2015) Miroslav Adzic et al.   BEHAVIOURAL BRAIN RESEARCH

The antioxidant properties of salicylate derivatives: A possible new mechanism of anti-inflammatory activity

(2015) Rosivaldo S. Borges et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Depressive-like behavior induced by tumor necrosis factor-α is attenuated by m-trifluoromethyl-diphenyl diselenide in mice

(2015) César Augusto Brüning et al.   JOURNAL OF PSYCHIATRIC RESEARCH

PLS/OPLS models in metabolomics: the impact of permutation of dataset rows on the K-fold cross-validation quality parameters

(2015) Mohamed N. Triba et al.   Molecular BioSystems

Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and “depressed” mice exposed to chronic mild stress

(2015) A. Franceschelli et al.   NEUROSCIENCE

Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics

(2015) Robin Ortiz et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Glia in the cytokine-mediated onset of depression: fine tuning the immune response

(2015) Wendy K. Jo et al.   Frontiers in Cellular Neuroscience

Serotonin versus catecholamine deficiency: behavioral and neural effects of experimental depletion in remitted depression

(2015) P Homan et al.   Translational Psychiatry

Peripheral blood mononuclear cell-based metabolomic profiling of a chronic unpredictable mild stress rat model of depression

(2014) Juan Li et al.   Molecular BioSystems

Oral administration of inosine produces antidepressant-like effects in mice

(2014) Junko Muto et al.   Scientific Reports

Metabolite Profiling of a NIST Standard Reference Material for Human Plasma (SRM 1950): GC-MS, LC-MS, NMR, and Clinical Laboratory Analyses, Libraries, and Web-Based Resources

(2013) Yamil Simón-Manso et al.   ANALYTICAL CHEMISTRY

Dysfunctional Glutamatergic and γ-Aminobutyric Acidergic Activities in Prefrontal Cortex of Mice in Social Defeat Model of Depression

(2013) Pandichelvam Veeraiah et al.   BIOLOGICAL PSYCHIATRY

Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial

(2013) R. N. Feng et al.   DIABETOLOGIA

Is there an association between peripheral immune markers and structural/functional neuroimaging findings?

(2013) Thomas Frodl et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Platelet uptake of GABA and glutamate in patients with bipolar disorder

(2012) Simona Daniele et al.   BIPOLAR DISORDERS

Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities

(2012) Jonathan Savitz et al.   BRAIN BEHAVIOR AND IMMUNITY

Cytoskeleton of cortical astrocytes as a target to proline through oxidative stress mechanisms

(2012) Samanta Oliveira Loureiro et al.   EXPERIMENTAL CELL RESEARCH

Plasma Metabonomics as a Novel Diagnostic Approach for Major Depressive Disorder

(2012) Peng Zheng et al.   JOURNAL OF PROTEOME RESEARCH

Meta-analyses Indicate Associations between Neuroendocrine Activation, Deactivation in Neurotrophic and Neuroimaging Markers in Depression after Stroke

(2012) Kate Noonan et al.   Journal of Stroke & Cerebrovascular Diseases

Identification and Validation of Urinary Metabolite Biomarkers for Major Depressive Disorder

(2012) Peng Zheng et al.   MOLECULAR & CELLULAR PROTEOMICS

Peripheral and cerebral metabolic abnormalities of the tryptophan–kynurenine pathway in a murine model of major depression

(2010) Anthony Laugeray et al.   BEHAVIOURAL BRAIN RESEARCH

Reversal of myo-inositol metabolic level in the left dorsolateral prefrontal cortex of rats exposed to forced swimming test following desipramine treatment: an in vivo localized 1H-MRS study at 4.7 T

(2010) Sang-Young Kim et al.   MAGNETIC RESONANCE IMAGING

Study of plasma metabolic profiling and biomarkers of chronic unpredictable mild stress rats based on gas chromatography/mass spectrometry

(2010) Zhen-Yu Li et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

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(2010) Hua-Cheng Yan et al.   Neuroscience Bulletin

A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder

(2009) Rushaniya A. Khairova et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Intracerebroventricular injection of L-proline and D-proline induces sedative and hypnotic effects by different mechanisms under an acute stressful condition in chicks

(2008) K. Hamasu et al.   AMINO ACIDS

Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress

(2008) Yan Ni et al.   FEBS LETTERS

Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder

(2008) M J Lan et al.   MOLECULAR PSYCHIATRY

Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole

(2008) M Banasr et al.   MOLECULAR PSYCHIATRY

Interferon-α effects on diurnal hypothalamic–pituitary–adrenal axis activity: relationship with proinflammatory cytokines and behavior

(2008) C L Raison et al.   MOLECULAR PSYCHIATRY

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE