Review
Immunology
Bo Yu, Yalong Zhang, Tianyu Wang, Jiayu Guo, Chenyang Kong, Zhongbao Chen, Xiaoxiong Ma, Tao Qiu
Summary: The mitogen-activated protein kinase (MAPK) signaling pathway, which can be triggered by various growth factors, cytokines, and hormones, plays a crucial role in regulating cellular activities such as cell proliferation, motility, and differentiation. It has been extensively studied in the context of inflammation and tumor development. Hepatic ischemia-reperfusion injury (HIRI) is a common pathological phenomenon occurring during surgical procedures like lobectomy and liver transplantation, characterized by severe inflammatory reaction following ischemia and reperfusion. This review mainly focuses on discussing the roles of p38, ERK1/2, JNK in the MAPK family, as well as TAK1 and ASK1 in the MAPKKK family, in HIRI, aiming to identify effective treatments for HIRI.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Neurosciences
Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu Lu
Summary: The abnormal increase of NR6A1 in the hippocampus impairs the CREB-BDNF signaling cascade, leading to the development of depression-like behaviors. Genetic knockdown of NR6A1 can prevent stress-induced depression-like behaviors.
Article
Biochemistry & Molecular Biology
Tao Shi, Daan M. K. van Soest, Paulien E. Polderman, Boudewijn M. T. Burgering, Tobias B. Dansen
Summary: Oxidizing conditions trigger activation of the p53 tumor suppressor, with contributions from both SAPK signaling and DNA damage signaling pathways depending on the type of oxidant used. Modulating oxidative signaling could potentially stimulate p53 without inducing collateral DNA damage, thus limiting mutation accumulation in both healthy and tumor tissues.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Caroline Barau, Shirin Leick, Claudio Caccia, Lolita Portal, Valerio Leoni, Philippe Le Corvoisier, Didier Morin, Bijan Ghaleh, Sandrine Pons
Summary: Exercise can provide cardioprotection against myocardial infarction by restoring pro-survival pathways and increasing resistance of mitochondrial permeability transition pore. Oxysterols, specifically 7 beta-hydroxycholesterol, play a role in the inactivation of these pathways. Regular exercise enhances the RISK pathway and decreases 7 beta-hydroxycholesterol concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
In Gyoung Ju, Eugene Huh, Namkwon Kim, Seungmin Lee, Jin Gyu Choi, Jongki Hong, Myung Sook Oh
Summary: This study showed that Artemisiae Iwayomogii Herba (AIH) attenuates neuroinflammation by regulating the NF-kappa B and MAPK pathways, and it may be used for treating neurological diseases. The inhibitory effects of AIH on microglia-mediated neuroinflammation and NLRP3 inflammasome formation were demonstrated both in vitro and in a mouse model.
Article
Cell Biology
Chong Gao, Meiling Wu, Qiaohui Du, Jiagang Deng, Jiangang Shen
Summary: This study found that naringin promotes adult hippocampal neurogenesis and improves depression-like behaviors by regulating the BDNF/TrkB/CREB signaling pathway. The results showed that naringin enhances the proliferation of neural stem/progenitor cells and accelerates neuronal differentiation, and its antidepressant and anxiolytic effects are attributed to enhanced hippocampal neurogenesis via activating CREB signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Virology
Shilin Gong, Xianhui Hao, Yanhong Bi, Chenchen Yang, Wenjing Wang, Houfack K. Mickael, Yike Zhang, Shuangfeng Chen, Zhongyao Qian, Fen Huang, Daqiao Wei, Wenhai Yu
Summary: HEV infection significantly inhibits the cAMP-PKA-CREB and PI3K-AKT-mTOR signaling pathways, but not the Ras-Raf-MEK-ERK pathway. Elevated estrogen levels and highly activated ER alpha during pregnancy exacerbate HEV replication. This exacerbation further inhibits ER alpha expression and suppresses cAMP-PKA-CREB and PI3K-AKT-mTOR signaling pathways.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Genetics & Heredity
Mark C. Wilkes, Aya Shibuya, Kathleen M. Sakamoto
Summary: Blood cell development is regulated through intrinsic gene regulation and local factors, with signaling pathways involving various kinases. Many cytokines are synthesized and regulated by these pathways, which act both upstream and downstream of the erythropoiesis process. There is still much to be discovered about the nuanced network of kinases responsible for appropriate induction of, and response to, these cytokines.
Article
Cell Biology
Rekha Koravadi Narasimhamurthy, Daicy Andrade, Kamalesh Dattaram Mumbrekar
Summary: This review discusses the neurotoxic effects of pesticides on the human nervous system, focusing on the activation of the CREB signaling pathway and gene expression regulation, as well as the impact of pesticides on these processes. This is of great importance for further understanding pesticide neurotoxicity and identifying therapeutic targets.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Neurosciences
Xin-Ling Wang, Wilf Gardner, Shu-Yan Yu, Tsvetan Serchov
Summary: Several studies have linked adenosine receptors, circadian clockwork, and mood regulation in major depressive disorder. This article reviews the advances in this area and proposes that adenosine receptor signaling regulates circadian gene expression, which may contribute to the pathogenesis of mood disorders. The convergent point of these signaling pathways is summarized, and a potential final common pathogenetic mechanism in depression involving Homer1a expression, regulated by both CREB and circadian clock genes, is put forward.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chunmei Yang, Lulu Zhang, Huakun Huang, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Yanran Huang, Xiaoji Luo, Jinyong Luo
Summary: The study demonstrates that Alantolactone (ALT) exhibits anti-osteosarcoma activity by inhibiting cell proliferation, migration, and invasion, promoting apoptosis, and arresting the cell cycle. These effects are possibly mediated through the suppression of Wnt/beta-catenin and MAPKs signaling pathways.
Article
Biochemistry & Molecular Biology
Emilio M. Serrano-Lopez, Teresa Coronado-Parra, Consuelo Marin-Vicente, Zoltan Szallasi, Victoria Gomez-Abellan, Maria Jose Lopez-Andreo, Marcos Gragera, Juan C. Gomez-Fernandez, Ruben Lopez-Nicolas, Senena Corbalan-Garcia
Summary: PKC comprises a family of serine/threonine protein kinases involved in multiple signaling pathways controlling cell proliferation, survival, and differentiation. Inhibition of PKC alpha gene expression in breast cancer cells identified a set of down-regulated proteins and oncogenic kinases, suggesting an oncogenic role for PKC alpha in this specific cancer model. The study also provides insights into the signaling mode of PKC alpha and suggests potential targeted cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Wuyun Lv, Yu Xiao, Zhe Xu, Hong Jiang, Qi Tong, Zhengyi Wang
Summary: The role of paxillin in signal pathways in phytopathogenic fungi is not well understood. This study reveals that MoPax1 activates MAP kinase signaling pathways and autophagy through its interaction with MoMka1, and plays an important role in appressorium-mediated plant infection by the rice blast fungus.
Article
Behavioral Sciences
Zheng Liu, Jianli Yang, Qing Fang, Hua Shao, Dalu Yang, Junfang Sun, Lizhi Gao
Summary: The study found that miR-199a-5p expression levels were significantly increased in the cerebrospinal fluids and serums of depression patients as well as in the hippocampus of chronic unpredictable mild stress (CUMS) mice. However, the expressions of WNT2, p-CREB, and BDNF were inhibited. In addition, the miR-199a-5p inhibitor enhanced certain behaviors associated with depression in CUMS mice, and this effect was attenuated by knockdown of WNT2.
BRAIN AND BEHAVIOR
(2021)
Article
Cell Biology
Jelena Ostojic, Young-Sil Yoon, Tim Sonntag, Billy Nguyen, Joan M. Vaughan, Maxim Shokhirev, Marc Montminy
Summary: The cyclic AMP pathway promotes melanocyte differentiation by activating CREB and CRTC1-3. In melanoma cells, CRTC3 deficiency leads to impaired differentiation and melanosome maturation. CRTC3 interacts with CREB to stimulate OCA2 expression, affecting pigmentation and melanoma risk, and is activated by ERK1/2 signaling.
Article
Cell Biology
Clarissa Ribeiro Bastos, Janaina Xavier, Laisa Camerini, Samantha Seibt Dewes, Fernanda Pedrotti Moreira, Carolina David Wiener, Karen Jansen, Manuella Pinto Kaster, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Jean Pierre Oses, Luis Valmor Portela, Diogo Rizzato Lara, Luciana Tovo-Rodrigues, Gabriele Ghisleni
Summary: The polymorphisms in the CACNA1C gene are associated with changes in BDNF levels, which may explain the association between CACNA1C and psychiatric disorders. Specifically, the A-allele of rs4765913 is associated with lower BDNF levels in women, while the AA haplotype is associated with lower BDNF levels in women and higher BDNF levels in men.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Review
Nutrition & Dietetics
Madson C. Caminha, Adriana B. Moreira, Filipe C. Matheus, Debora K. Rieger, Julia D. Moreira, Eduardo M. Dalmarco, Izabel G. Demarchi, Katia Lin
Summary: A systematic review found that the ketogenic diet may help reduce the number and severity of migraine attacks, but the evidence on its effectiveness is still inconclusive.
Review
Nutrition & Dietetics
Maiara Cristina Lima, Mariana Papini Gabiatti, Julia Dubois Moreira, Leticia Carina Ribeiro, Mariana dos Santos Lunardi, Katia Lin, Debora Kurrle Venske
Summary: This systematic review evaluated the effects of the ketogenic diet (KD) on cognitive function in patients with pharmacoresistant epilepsy. Some studies found improvements in cognitive function attributed to KD, but there were contradictory results. Currently, it is inconclusive whether KD promotes improvements in cognitive function in epilepsy patients.
Article
Clinical Neurology
Anderson Camargo, Ana Clara N. C. Torra, Ana Paula Dalmagro, Ana Paula Valverde, Bruna R. Kouba, Daiane B. Fraga, Eloise C. Alves, Ana Lucia S. Rodrigues
Summary: Ketamine enhances resilience against stress-induced depressive-like behavior and has prophylactic effects against depressive- and anxiety-like behaviors. AZD6765, a low-trapping NMDA receptor antagonist, does not show the same prophylactic efficacy as ketamine. Ketamine prevents stress-induced depressive-like behavior and anxiety-related self-grooming alterations, possibly through its effect on 4E-BP1-related synaptic protein synthesis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Bruna R. Kouba, Anderson Camargo, Joana Gil-Mohapel, Ana Lucia S. Rodrigues
Summary: Major depressive disorder and anxiety disorders are common and disabling conditions. Symptoms of depression and anxiety often overlap, making diagnosis and treatment challenging. Vitamin D deficiency is associated with increased risk of these disorders, and vitamin D has potential antidepressant and anxiolytic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Gilciane Ceolin, Susana Cararo Confortin, Antonio Augusto Moura da Silva, Cassiano Ricardo Rech, Eleonora d'Orsi, Debora Kurrle Rieger, Julia Dubois Moreira
Summary: This study found that physical activity has a direct effect on serum 25(OH)D, and body fat composition has a small contribution as a mediator in this relationship.
NUTRITION RESEARCH
(2022)
Review
Behavioral Sciences
Anderson Camargo, Ana Lucia S. Rodrigues
Summary: This article reviews the recent findings on the ability of guanosine to produce rapid-acting antidepressant-like effects and provides an overview of the molecular mechanisms underlying its antidepressant actions. The neurobiological mechanisms underlying guanosine's ability to enhance the antidepressant effects elicited by ketamine are also discussed. This review opens new perspectives for the use of guanosine alone or in combination with ketamine for the management of treatment-resistant depression.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Biochemistry & Molecular Biology
Cristine De Paula Nascimento-Castro, Elisa C. Winkelmann-Duarte, Gianni Mancini, Priscilla Gomes Welter, Evelini Placido, Marcelo Farina, Joana Gil-Mohapel, Ana Lucia S. Rodrigues, Andreza Fabro de Bem, Patricia S. Brocardo
Summary: Huntington's disease is a genetic neurodegenerative disease that affects motor, psychiatric, and cognitive functions. Recent evidence suggests that the emotional and cognitive deficits observed in patients with HD might be associated with hippocampal dysfunction. In this study using a HD mouse model, researchers found that mice in the late symptomatic stage exhibited depressive-like behavior and cognitive deficits. Additionally, they observed degenerative changes in the hippocampal dentate gyrus, including the presence of dark neurons and structural alterations in the rough endoplasmic reticulum and Golgi apparatus.
Article
Biochemistry & Molecular Biology
Anderson Camargo, Luis E. B. Bettio, Priscila B. Rosa, Julia M. Rosa, Glorister A. Alte, Ana Lucia S. Rodrigues
Summary: This study reveals the antidepressant-like effect of Guanosine and the modulation of A(1)R and A(2A)R in its antidepressant action. Guanosine interacts with A(1)R and A(2A)R at the adenosine binding site.
PURINERGIC SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Benildo Sousa Cavada, Messias Vital Oliveira, Vinicius Jose Silva Osterne, Vanir Reis Pinto-Junior, Francisco William Viana Martins, Cornevile Correia-Neto, Ronald Feitosa Pinheiro, Rodrigo Bainy Leal, Kyria Santiago Nascimento
Summary: Poor lifestyle choices and genetic predisposition contribute to the increase in cancer cases, such as breast cancer. The development of new strategies for early detection and treatment options is needed to improve survival rates. Glycans on cancer cell surfaces serve as efficient tumor cell markers and can be recognized by lectins. Plant lectins have potential applications in diagnosing and treating breast cancer by detecting and sorting glycans in healthy and malignant cells. Furthermore, lectins can be utilized in various ways, such as mapping differentially expressed glycans, histochemistry/cytochemistry analysis, lectin arrays, chromatographic matrices, drug delivery, and biosensing.
Article
Biochemistry & Molecular Biology
Ingrid A. V. Wolin, Ana Paula M. Nascimento, Rodrigo Seeger, Gabriela G. G. Poluceno, Alfeu Zanotto-Filho, Claudia B. B. Nedel, Carla I. I. Tasca, Sarah Elizabeth Gomes Correia, Messias Vital Oliveira, Vanir Reis Pinto-Junior, Vinicius Jose Silva Osterne, Kyria Santiago Nascimento, Benildo Sousa Cavada, Rodrigo Bainy Leal
Summary: Glioblastoma multiforme (GBM) is a highly aggressive type of glioma, and the study evaluated the antitumor capacity of the lectin DrfL on glioma cell cultures. DrfL induced morphological changes and cytotoxic effects in glioma cell cultures, and its action was dependent on interaction with glycans and required a carbohydrate recognition domain (CRD). DrfL inhibited tumor cell migration, adhesion, proliferation, and survival, while not affecting primary astrocytes.
GLYCOCONJUGATE JOURNAL
(2023)
Article
Clinical Neurology
German Josuet Lapo-Talledo, Jorge Andres Talledo-Delgado, Diego Portalanza, Ana Lucia S. Rodrigues, Aline Siteneski
Summary: Suicide rates and choice of suicide method have increased in Ecuador after natural disasters such as earthquakes and the COVID-19 confinement. Hanging accounted for the majority of suicide cases in the country. The province most severely affected by the 2016 earthquake saw an increased suicide rate.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Bruna R. Kouba, Ana Clara N. C. Torra, Anderson Camargo, Ana Lucia S. Rodrigues
Summary: Vitamin D-3 has shown antidepressant-like responses in mice, possibly through increasing BDNF levels and synaptic protein synthesis.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Anderson Camargo, Ana P. Dalmagro, Glorister A. Alte, Ana Lucia B. Zeni, Carla I. Tasca, Ana Lucia S. Rodrigues
Summary: This study investigated the antidepressant-like and neuroprotective effects of guanosine and ketamine in mice and found that both substances showed protective effects against glutamate-induced damage. The combination of guanosine and ketamine exhibited enhanced antidepressant-like effects and increased glutamine synthetase activity and GLT-1 levels. The findings suggest that guanosine has potential as a treatment for depression and should be further studied.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Endocrinology & Metabolism
Bruna R. Kouba, Anderson Camargo, Ana Lucia S. Rodrigues
Summary: Alzheimer's disease is primarily caused by neuroinflammation, as evidenced by the co-localization of amyloid-beta plaques with activated glial cells and increased levels of inflammatory cytokines. Current pharmacological treatments are challenging, hence compounds with anti-inflammatory and antioxidant properties are being explored as potential therapies. Vitamin D, due to its neuroprotective effects and high prevalence of deficiency, has emerged as a promising candidate. This review highlights the antioxidant and anti-inflammatory properties of vitamin D, and its potential effects on the neuroinflammatory process in Alzheimer's disease.
METABOLIC BRAIN DISEASE
(2023)