Article
Pharmacology & Pharmacy
S. Alboni, C. Benatti, C. Colliva, G. Radighieri, J. M. C. Blom, N. Brunello, F. Tascedda
Summary: The study demonstrates that pretreatment with Vortioxetine prevents LPS-induced cognitive memory impairment without affecting acute sickness behavior and anhedonia. Vortioxetine may impact the immune response by affecting the microglia in the hippocampus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Elisabeth Rackles, Michael Witting, Ignasi Forne, Xing Zhang, Judith Zacherl, Simon Schrott, Christian Fischer, Jonathan J. Ewbank, Christof Osman, Axel Imhof, Stephane G. Rolland
Summary: Research shows the existence of organelle-specific retrograde signaling for peroxisomes, which plays an important role in responding to stress and infection, regulating lipid metabolism, immunity, and potentially acting as a protective mechanism.
Article
Plant Sciences
Jie Cheng, Min Chen, Hui-Qi Wan, Xue-Qin Chen, Cheng-Fu Li, Ji-Xiao Zhu, Qing Liu, Guang-Hui Xu, Li-Tao Yi
Summary: The study demonstrated that paeoniflorin exhibits neuroprotective and antidepressant effects in mice by activating neuronal FGF-2/FGFR1 signaling pathway and inhibiting microglial activation in the hippocampus, suggesting its potential therapeutic application for depression.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Sarah Lecordier, Vincent Pons, Serge Rivest, Ayman ElAli
Summary: The study found that multifocal cerebral microinfarcts accelerate the pathological progression of Alzheimer's disease (AD) more potently in young males compared to young females, independently of A beta pathology, via modulation of neurovascular coupling, inflammatory response, and DKK1 expression. These findings suggest that the effects of microinfarcts should be taken into consideration in the diagnosis, prognosis, and therapies of AD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elena Grao-Cruces, Maria C. Millan-Linares, Maria E. Martin-Rubio, Rocio Toscano, Sergio Barrientos-Trigo, Beatriz Bermudez, Sergio Montserrat-de la Paz
Summary: High-density lipoproteins (HDLs) are important for brain health in the central nervous system, but their functions may be compromised in obese patients. Obesity-related metabolic disturbances can reverse the antioxidant and anti-inflammatory properties of HDLs in microglial cells, leading to higher pro-inflammatory cytokine production.
Article
Immunology
Zhaolin Liu, Chenye Shen, Heng Li, Jiabin Tong, Yufei Wu, Yuanyuan Ma, Jinghui Wang, Zishan Wang, Qing Li, Xiaoshuang Zhang, Hongtian Dong, Yufang Yang, Mei Yu, Jian Wang, Renyuan Zhou, Jian Fei, Fang Huang
Summary: Parkinson's disease (PD) is characterized by neuronal degeneration and neuroinflammation. This study found that NLRC5 expression is increased in PD mouse models and in astrocytes, microglia, and neurons exposed to neurotoxic stimuli. NLRC5 deficiency reduced dopaminergic degeneration and inflammation, suppressed NF-kappa B and MAPK signaling pathways, and promoted AKT-GSK-3 beta and AMPK signaling. Furthermore, NLRC5 deficiency increased neuron survival and NF-kappa B and AKT activation. NLRC5 may serve as a marker of glial activation in PD patients.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Neurosciences
Francina Mesquida-Veny, Jose Antonio Del Rio, Arnau Hervera
Summary: In contrast to normal tissue repair, central nervous system (CNS) injuries do not heal properly due to malfunctioning macrophages and microglia, which hinder appropriate axonal regeneration. Recent studies have highlighted the plasticity and complexity of these immune cells, shedding light on their roles in neuronal regeneration. Understanding the molecular mechanisms underlying this complexity is crucial for advancing therapeutic approaches for neuronal injuries.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yang Fan, Yajuan Bi, Haixia Chen
Summary: The study found that treatment with Salidroside (SLDS) can reduce depressive behaviors in stress mice by inhibiting microglial activation and reducing the expression and release of neuroinflammatory cytokines. This suggests that SLDS may be a potential therapeutic approach for treating depression by interfering with microglia-mediated neuroinflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Yan-Ling Liao, Xiao-Yan Zhou, Mu-Huo Ji, Liang-Cheng Qiu, Xiao-Hui Chen, Can-Sheng Gong, Ying Lin, Yan-Hua Guo, Jian-Jun Yang
Summary: The study revealed that the upregulation of S100A9 in sepsis is associated with cognitive impairments, and inhibiting S100A9 can improve learning and memory impairments in sepsis survivors, suggesting a potential therapeutic target for sepsis-associated encephalopathy.
Article
Immunology
Louise M. Ince, Jeffrey S. Darling, Kevin Sanchez, Kiersten S. Bell, Jennifer K. Melbourne, Lourdes K. Davis, Kimberly Nixon, Andrew D. Gaudet, Laura. K. Fonken
Summary: Aging is associated with changes in immune system reactivity. Male rats show cognitive decline and increased neuroinflammatory responses, while females do not. Sex differences play a crucial role in the mechanism of aging.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Kristina G. Witcher, Chelsea E. Bray, Titikorn Chunchai, Fangli Zhao, Shane M. O'Neil, Alan J. Gordillo, Warren A. Campbell, Daniel B. McKim, Xiaoyu Liu, Julia E. Dziabis, Ning Quan, Daniel S. Eiferman, Andy J. Fischer, Olga N. Kokiko-Cochran, Candice Askwith, Jonathan P. Godbout
Summary: Traumatic brain injury can lead to significant neuropsychiatric problems and neurodegenerative pathologies that last for years. This study showed that microglia play a crucial role in acute and chronic stages of TBI, influencing inflammation and neuropathology development, which in turn affect neuronal homeostasis and behavioral outcomes.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Immunology
Cheng-Yi Chang, Chih-Cheng Wu, Jiaan-Der Wang, Jian-Ri Li, Ya-Yu Wang, Shih-Yi Lin, Wen-Ying Chen, Su-Lan Liao, Chun-Jung Chen
Summary: The study demonstrated that DHA exhibits anti-inflammatory, neuroprotective, and antiviral effects against JEV infection by modulating the immune response of microglia and neurons. This suggests that DHA may be a potential candidate for treating neuroinflammation associated with viral infections such as Japanese Encephalitis.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Ruizhuo Chen, Brandy N. Routh, Jillian E. Straetker, Cecily R. Gibson, Aidan S. Weitzner, Kiersten S. Bell, Andrew D. Gaudet, Laura K. Fonken
Summary: The circadian system regulates various physiological processes, and disruption of the circadian clock gene Rev-erb alpha can lead to behavioral changes and neuroinflammation. This study demonstrates that microglia depletion can ameliorate behavioral abnormalities in RKO mice and that male and female RKO mice show different alterations in the neuroimmune system.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Yexiang Du, Min Luo, Yehong Du, Mingliang Xu, Qiuhui Yao, Kejian Wang, Guiqiong He
Summary: Our study demonstrated that liquiritigenin can alleviate Alzheimer's disease symptoms through multiple mechanisms, including reducing neuronal apoptosis, alleviating inflammation response, and promoting microglial type transformation. Furthermore, liquiritigenin may potentially treat AD by decreasing Aβ levels and improving spatial learning and memory.
NEUROTOXICITY RESEARCH
(2021)
Article
Immunology
Jiayuan Wu, Xinqin Xu, Li Zheng, Juanfen Mo, Xiuhui Jin, Yi Bao
Summary: Nilotinib has been shown to suppress microglia-mediated neuroinflammatory response and protect DA neurons from inflammatory damage, suggesting its potential application in further clinical trials.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Ivana Geric, Yulia Y. Tyurina, Olga Krysko, Dmitri V. Krysko, Evelyn De Schryver, Valerian E. Kagan, Paul P. Van Veldhoven, Myriam Baes, Simon Verheijden
Article
Radiology, Nuclear Medicine & Medical Imaging
Lien Beckers, Dieter Ory, Ivana Geric, Lieven Declercq, Michel Koole, Michael Kassiou, Guy Bormans, Myriam Baes
MOLECULAR IMAGING AND BIOLOGY
(2018)
Article
Clinical Neurology
Stephanie De Munter, Dorien Bamps, Ana Rita Malheiro, Ritesh Kumar Baboota, Pedro Brites, Myriam Baes
Article
Biochemistry & Molecular Biology
Mart Bittremieux, Rita M. La Rovere, Haidar Akl, Claudio Martines, Kirsten Welkenhuyzen, Kathia Dubron, Myriam Baes, Ann Janssens, Peter Vandenberghe, Luca Laurenti, Katja Rietdorf, Giampaolo Morciano, Paolo Pinton, Katsuhiko Mikoshiba, Martin D. Bootman, Dimitar G. Efremov, Humbert De Smedt, Jan B. Parys, Geert Bultynck
CELL DEATH AND DIFFERENTIATION
(2019)
Article
Biochemistry & Molecular Biology
Sara Violante, Nihad Achetib, Carlo W. T. van Roermund, Jacob Hagen, Tetyana Dodatko, Frederic M. Vaz, Hans R. Waterham, Hongjie Chen, Myriam Baes, Chunli Yu, Carmen A. Argmann, Sander M. Houten
Article
Cell Biology
Yannick Das, Nele Roose, Lies De Groef, Marc Fransen, Lieve Moons, Paul P. Van Veldhoven, Myriam Baes
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2019)
Article
Immunology
Lien Beckers, Ivana Geric, Stijn Stroobants, Sander Beel, Philip Van Damme, Rudi D'Hooge, Myriam Baes
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Biochemistry & Molecular Biology
Celien Lismont, Janet Koster, Sarah Provost, Myriam Baes, Paul P. Van Veldhoven, Hans R. Waterham, Marc Fransen
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2019)
Article
Endocrinology & Metabolism
Ritesh Kumar Baboota, Abhijit Babaji Shinde, Katleen Lemaire, Marc Fransen, Stefan Vinckier, Paul P. Van Veldhoven, Frans Schuit, Myriam Baes
MOLECULAR METABOLISM
(2019)
Article
Biochemistry & Molecular Biology
Kevin Berendse, Maxim Boek, Marion Gijbels, Nicole N. Van der Wel, Femke C. Klouwer, Marius A. van den Bergh-Weerman, Abhijit Babaji Shinde, Rob Ofman, Bwee Tien Poll-The, Sander M. Houten, Myriam Baes, Ronald J. A. Wanders, Hans R. Waterham
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Article
Multidisciplinary Sciences
Jinuk Kong, Yul Ji, Yong Geun Jeon, Ji Seul Han, Kyung Hee Han, Jung Hyun Lee, Gung Lee, Hagoon Jang, Sung Sik Choe, Myriam Baes, Jae Bum Kim
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Paul P. Van Veldhoven, Evelyn de Schryver, Stephen G. Young, An Zwijsen, Marc Fransen, Marc Espeel, Myriam Baes, Elke Van Ael
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Genetics & Heredity
Muhammad Ali, Shahid Y. Khan, Tony A. Rodrigues, Tania Francisco, Xiaodong Jiao, Hang Qi, Firoz Kabir, Bushra Irum, Bushra Rauf, Asma A. Khan, Azra Mehmood, Muhammad Asif Naeem, Muhammad Zaman Assir, Muhammad Hassaan Ali, Mohsin Shahzad, Khaled K. Abu-Amero, Shehla Javed Akram, Javed Akram, Sheikh Riazuddin, Saima Riazuddin, Michael L. Robinson, Myriam Baes, Jorge E. Azevedo, J. Fielding Hejtmancik, S. Amer Riazuddin
Summary: A novel missense mutation in PEX5 was identified in a large family, resulting in defective import of PTS2 cargo proteins into peroxisomes, leading to congenital cataracts and developmental defects.
Editorial Material
Ophthalmology
Kaat Peperstraete, Myriam Baes, Danielle Swinkels
Summary: Using cell type-specific knockout mice has been a valuable tool for studying the role of genes in specific cells and understanding disease mechanisms. In this study, multiple transgenic mouse models with global or cell type-specific deletion of MFP2 were generated and phenotyped to investigate its association with retinopathy. Unexpectedly, the L7Cre-2 mouse model did not show the expected specificity in generating rod bipolar cell specific knockout mice. Instead, the authors suggest using the independently generated BAC-L7-IRES-Cre mouse line for this purpose.
EXPERIMENTAL EYE RESEARCH
(2023)