Article
Biochemistry & Molecular Biology
Muganti Rajah Kumar, Swee Keong Yeap, Han Chung Lee, Nurul Elyani Mohamad, Muhammad Nazirul Mubin Aziz, Melati Khalid, Mas Jaffri Masarudin, Adam Thean Chor Leow, Janna Ong Abdullah, Noorjahan Banu Alitheen
Summary: The study found that Kefir B in kefir water exhibited the highest antioxidant and anti-apoptotic activities, providing significant cell protection and maintaining cellular morphology. The results suggest that kefir water can exert its antioxidative, anti-apoptotic, and neuroprotective effects through upregulating enzymes like SOD and catalase.
Article
Medicine, Research & Experimental
Praveen Kumar Issac, Ajay Guru, Manikandan Velayutham, Raman Pachaiappan, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Ki Choon Choi, Ramasamy Harikrishnan, Jesu Arockiaraj
Summary: The study demonstrated that morin provides neuroprotection in zebrafish larvae by restoring antioxidant enzyme activity and reducing lipid peroxidation to alleviate oxidative stress-induced cellular apoptosis and ROS levels. This mechanism enhances cellular antioxidant defense and could be a novel strategy for combating oxidative stress.
Article
Biochemistry & Molecular Biology
Zi-Long Song, Yanan Hou, Feifei Bai, Jianguo Fang
Summary: Oxidative stress plays a role in the development of neurodegenerative diseases, and targeting oxidative stress is a promising strategy for treatment. Small molecules that interfere with cellular redox-regulating machinery, such as compounds 9b and 9c, show neuroprotective effects by upregulating antioxidant genes through the Nrf2 pathway, making them potential candidates for further development as neuroprotective agents.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Carlota Suarez-Barrio, Susana del Olmo-Aguado, Eva Garcia-Perez, Luis Fernandez-Vega-Cueto, Andres Fernandez-Vega Cueto, Begona Baamonde-Arbaiza, Luis Fernandez-Vega, Jesus Merayo-Lloves
Summary: Age-related macular degeneration (AMD) can lead to the degeneration of retinal cells and vision loss, and long-term exposure to blue light may exacerbate the progression of AMD. Plasma rich in growth factors (PRGF) has been shown to enhance cell antioxidant pathways, protect photoreceptors from blue light damage, and promote cell autophagy.
Article
Nutrition & Dietetics
Reny Pratiwi, Chanin Nantasenamat, Waralee Ruankham, Wilasinee Suwanjang, Virapong Prachayasittikul, Supaluk Prachayasittikul, Kamonrat Phopin
Summary: The study revealed that the plant sterol stigmasterol has the potential to protect neuronal cells from oxidative stress damage, maintaining intracellular reactive oxygen species levels and preventing oxidative stress-induced cell death.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Cassie L. L. Rayner, Steven E. E. Bottle, Alexander P. P. Martyn, Nigel L. L. Barnett
Summary: Oxidative stress plays a major role in progressive neurodegenerative diseases and could be a key target for novel preventative and therapeutic strategies. The antioxidant DCTEIO has shown efficacy in protecting retinal neurocells and reducing inflammation and oxidative stress. These findings suggest that DCTEIO has potential as a neuroprotectant for degenerative diseases of the central nervous system.
NEUROCHEMICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Edwiges de Fatima de Oliveira, Alodia Brasil, Anderson Manoel Herculano, Matheus A. Rosa, Bruno Duarte Gomes, Fernando Allan de Farias Rocha
Summary: Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia, which can lead to microvascular damage in the retina causing diabetic retinopathy. This study aimed to evaluate the potential protective effect of acai on retinal function in mice with induced diabetes. The results showed that treatment with acai prevented a significant decrease in visual electrophysiological responses in diabetic animals.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Nagaram Prabha, Ajay Guru, Ramasamy Harikrishnan, Mansour K. Gatasheh, Ashraf Atef Hatamleh, Annie Juliet, Jesu Arockiaraj
Summary: This study evaluated the neuroprotective and antioxidant ability of a short peptide, RW20, and demonstrated its prominent antioxidant activity. Therefore, RW20 may be developed as a potent therapeutic agent against oxidative stress-induced neurodegenerative diseases.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Review
Engineering, Chemical
Md. Habibur Rahman, Johny Bajgai, Ailyn Fadriquela, Subham Sharma, Thuy Trinh Thi, Rokeya Akter, Seong Hoon Goh, Cheol-Su Kim, Kyu-Jae Lee
Summary: Oxidative stress and neuroinflammatory stress play a role in neurological disorders, and molecular hydrogen has emerged as a potential therapeutic agent. While most neurological problems are currently incurable, the administration routes and potential effectors of H-2 hold promise for prevention and treatment. However, more research is needed to evaluate the direct target molecules of H-2.
Article
Biochemistry & Molecular Biology
Sarah Naguib, Carlisle R. R. DeJulius, Jon R. R. Backstrom, Ameer A. A. Haider, John M. M. Ang, Andrew M. M. Boal, David J. J. Calkins, Craig L. L. Duvall, Tonia S. S. Rex
Summary: EPO-R76E activates the NRF2/ARE pathway, leading to increased expression of antioxidant proteins and providing neuroprotection.
Review
Neurosciences
Luciana Cristina B. Fernandes, Ianara Mendonca Costa, Marco Aurelio M. Freire, Francisca Overlania V. Lima, Francisca Idalina Neta, Eudes Euler de Souza Lucena, Rodrigo Dias Alves, Jose Rodolfo Lopes P. Cavalcanti, Francisco Irochima Pinheiro, Eduardo Pereira de Azevedo, Carlos Ibere A. Freitas, Fausto Pierdona Guzen
Summary: The study reveals that essential oils have positive effects on neurological disorders such as anxiety, dementia, oxidative stress, cerebral ischemia, and oxidative toxicity, showing potential as alternative agents in the treatment of neurological disorders.
CURRENT NEUROPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Yasin Zamanian, Rosario Mireya Romero Parra, Afsaneh Soltani, Malgorzata Kujawska, Yasser Fakri Mustafa, Ghaidaa Raheem, Lateef Al-Awsi, Holya A. Lafta, Niloofar Taheri, Mahsa Heidari, Maryam Golmohammadi, Gholamreza Bazmandegan
Summary: Parkinson's disease (PD) is a prevalent neurodegenerative condition characterized by impaired motor function due to the progressive deterioration of nigrostriatal dopaminergic neurons. Current therapy solutions for PD are ineffective and may have adverse effects. Natural polyphenols, particularly resveratrol (RES), have been found to offer neuroprotection against PD by reducing oxidative stress and upregulating Nrf2. This review examines the molecular mechanisms underlying RES activity and its effects in both in vitro and in vivo PD models, providing scientific evidence for its neuroprotective properties.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Agriculture, Multidisciplinary
Rosario Cazares-Camacho, J. Abraham Dominguez-Avila, Humberto Astiazaran-Garcia, Marcelino Montiel-Herrera, Gustavo A. Gonzalez-Aguilar
Summary: The study suggests that mango has potent neuroprotective properties against diabetes-induced oxidative stress, and can be an alternative to prevent and treat biochemical alterations caused by diabetes.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Pharmacology & Pharmacy
Ibrahim Bulama, Suleiman Nasiru, Abubakar Bello, Abdullahi Yahaya Abbas, Jinjiri Ismail Nasiru, Yusuf Saidu, Musa Samaila Chiroma, Mohamad Aris Mohd Moklas, Che Norma Mat Taib, Ali Waziri, Bilbis Lawal Suleman
Summary: This study evaluated the antioxidative neuroprotective property and learning and memory-enhancing effects of dimethyl sulfoxide (DMSO) in a rat model after traumatic brain injury (TBI). The results showed that DMSO improved learning and memory, locomotor function, and decreased anxiety in rats with induced TBI. Additionally, DMSO decreased oxidative stress and S100B levels, while increasing the activity of antioxidant enzymes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Md Sadikul Islam, Ha-Young Shin, Yeo-Jin Yoo, Ryunhee Kim, Young-Jin Jang, Md Rashedunnabi Akanda, Hyun-Jin Tae, In-Shik Kim, Dongchoon Ahn, Byung-Yong Park
Summary: Olanzapine has neuroprotective effects through downregulating complement component-related genes and MAPKs expression, upregulating SOD expression, reducing ROS generation, and regulating apoptosis-related protein expression.
Editorial Material
Virology
Bharat Bhusan Subudhi, Subhasis Chattopadhyay, Soma Chattopadhyay
Article
Pharmacology & Pharmacy
Sangeeta Kumari, Vikas Sharma, Rahul Tiwari, Jay Prakash Maurya, Bharat Bhusan Subudhi, Dhirodatta Senapati
Summary: Metastatic prostate cancer (mCaP) is a major cause of cancer-related death in men worldwide. Androgen receptor (AR) drives disease progression and androgen deprivation therapy (ADT) is the preferred treatment. Loss of tumor suppressor protein p53, which is commonly seen in aggressive prostate cancer, impacts the efficacy of ADT and AR inhibitors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Praful Kumar Majhi, Samir Sayyad, Pratyush Mishra, Sainath Kamte, Rajanikant Sahu, Goutam Ghosh, Bharat Bhusan Subudhi
Summary: Dextromethorphan (DM) and its metabolite dextrorphan (DX) have diverse pharmacodynamics, but further validation in different preclinical models and correlation with relevant pharmacokinetics data is needed. A new method using solid-phase extraction, liquid chromatographic separation, and mass spectrometric detection was developed for low sample volumes. This method allowed for the simultaneous quantification of DM and DX in rat plasma and yielded accurate pharmacokinetic parameters.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Pharmacology & Pharmacy
Rasmita Dash, Madhulika Yadav, Jyotirmaya Biswal, Anshuman Chandra, Vijay Kumar Goel, Tripti Sharma, Shakti Ketan Prusty, Sujata Mohapatra
Summary: Conjugate drugs are being widely studied for their potential in improving the properties of drugs. A new conjugate derivative (AT-CU) of atorvastatin and curcumin was synthesized and evaluated in terms of its physical and therapeutic properties. Chitosan-modified PLGA nanoparticles were prepared and showed improved drug encapsulation efficiency and reduced burst release. In vivo studies further confirmed the effectiveness of the ideal formulation in treating atherosclerosis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Rasmita Dash, Jyotirmaya Biswal, Madhulika Yadav, Tripti Sharma, Sujata Mohapatra, Shakti Ketan Prusty
Summary: This study aimed to overcome solubility issues of atorvastatin (AC) and curcumin (CUR) by synthesizing atorvastatin-curcumin conjugate (AC-CUR) and evaluating its synergistic action on inflammation. The AC-CUR conjugate was successfully synthesized and found to increase solubility by approximately 2 folds. In vivo testing revealed that the new conjugate molecule exhibited excellent biopharmaceutical properties and improved anti-inflammatory efficacy, suggesting that AC-CUR nanogel could be an efficient platform for inflammation treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Nishigandha Sa, P. Tejaswani, Sweta Priyadarshini Pradhan, Khider Ali Alkhayer, Anindita Behera, Pratap Kumar Sahu
Summary: Diabetes is a chronic metabolic disorder that causes complications due to oxidative stress and cell damage. Plant-derived phytomolecules with super-antioxidant properties show promise in treating diabetes. Metal nanoparticles, synthesized using a green approach, exhibit significant anti-diabetic and antioxidant activities in a diabetic rat model.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sweta Priyadarshini Pradhan, P. Tejaswani, Nishigandha Sa, Anindita Behera, Rajesh Kumar Sahoo, Pratap Kumar Sahu
Summary: The present study investigates the efficacy of antidiabetic drug VLD and antioxidant VE against STZ-induced diabetic cognitive impairment. To enhance the efficacy of VLD, gold nanoparticles are conjugated with VLD for targeted brain delivery. The treatment with drug-conjugated Au NPs improves cognitive functions and shows neuroprotective action against diabetes-induced cognitive impairment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Vara Prasada Rao Regu, Dhananjay Behera, Sai Prathyusha Sunkara, Vinit Gohel, Shyamalendu Tripathy, Ranjit Prasad Swain, Bharat Bhusan Subudhi
Summary: Metformin, a commonly used anti-diabetic medication, has anti-inflammatory properties. This study developed a gel formulation of metformin for topical ocular application, aiming to manage inflammation associated with diabetes. The optimized formulation showed sustained release and demonstrated potential as a safe alternative to steroids for managing ocular inflammation.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Cell Biology
Sweta Priyadarshini Pradhan, Pratap Kumar Sahu, Anindita Behera
Summary: Alzheimer's disease (AD) and type-II diabetes mellitus (DM) are mutually related chronic neurodegenerative disorders. Chronic DM increases the risk for AD due to insulin resistance and cognitive dysfunction. Repurposing of antidiabetic drugs and nanotechnological interventions show promise in the prevention and treatment of AD. This review explores the cellular and molecular pathophysiologies of AD and type-II DM, the use of in vivo DM models in AD studies, and the potential of antidiabetic drugs and nanodelivery systems for AD treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biology
Anshuman Sahu, Mahendra Gaur, Nimai Charan Mahanandia, Enketeswara Subudhi, Ranjit Prasad Swain, Bharat Bhusan Subudhi
Summary: Monkeypox virus outbreak has spread to 82 non-endemic countries and poses a serious threat due to high mortality in vulnerable populations. Identification of potential inhibitors is challenging due to limited knowledge about the virus's lifecycle. However, publicly available genomes of mpox virus can be used to identify druggable targets and conduct virtual screening for potential inhibitors.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Neurosciences
Anindita Behera, Sweta Priyadarshini Pradhan, P. Tejaswani, Nishigandha Sa, Swagata Pattnaik, Pratap Kumar Sahu
Summary: Diabetes mellitus leads to cognitive dysfunction due to insulin deficiency. Hesperidin, a bioflavonoid, has poor solubility and a short half-life. To overcome these limitations, hesperidin was conjugated with gold, selenium, and core-shell bimetallic nanoparticles. The synthesized nanoparticles showed neuroprotective effects in a rat model of cognitive dysfunction induced by streptozotocin. Among the nanoparticles, the bimetallic Se@Au-HSP NPs exhibited the strongest neuroprotective action. Hesperidin-conjugated bimetallic nanoparticles could be a potential alternative for neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Anindita Behera, Nishigandha Sa, Sweta Priyadarshini Pradhan, Sunsita Swain, Pratap Kumar Sahu
Summary: Nanotechnology is being applied in various biomedical fields, such as lifestyle diseases and neurodegenerative diseases. Metal nanoparticles are widely used as drug delivery systems due to their enhanced physicochemical properties. This review article discusses the neuroprotective and neurotoxic effects of different metal nanoparticles on Alzheimer's disease, as well as their biocompatibility for brain targeting. It also analyzes the need for new drug delivery systems and offers guidance for researchers in brain-targeted drug delivery for Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Dibyajyoti Uttameswar Behera, Mahendra Gaur, Maheswata Sahoo, Enketeswara Subudhi, Bharat Bhusan Subudhi
Summary: The study aimed to find an FDA-approved efflux inhibitor as an adjuvant to colistin. The research identified argatroban as a potential bacterial efflux inhibitor that enhanced susceptibility to colistin.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Sunita Mishra, Shakti Ketan Prusty, Pratap Kumar Sahu, Debajyoti Das
Summary: This study evaluated the efficacy of Azilsartan against aluminium chloride induced Alzheimer's disease (AD). The results showed that both Azilsartan and Telmisartan significantly improved cognitive dysfunction, enhanced antioxidant status, and reduced A beta production. However, the protective effect of Azilsartan was found to be slightly weaker than Telmisartan.
CURRENT ISSUES IN PHARMACY AND MEDICAL SCIENCES
(2023)
