Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases

Reactive oxygen species (ROS) and their impact in neurodegenerative diseases: literature landscape analysis

(2020) Andy Wai Kan Yeung et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular hydrogen protects against oxidative stress-induced RAW 264.7 macrophage cells through the activation of Nrf2 and inhibition of MAPK signaling pathway

(2020) Rahima Begum et al.   Molecular & Cellular Toxicology

Neurodegeneration by oxidative stress: a review on prospective use of small molecules for neuroprotection

(2020) Ekta Singh et al.   MOLECULAR BIOLOGY REPORTS

Oxidative Stress in Neurodegenerative Diseases: From Preclinical Studies to Clinical Applications

(2020) Andrea Tarozzi   Journal of Clinical Medicine

Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System

(2020) Md. Abdul Hannan et al.   Frontiers in Molecular Neuroscience

Molecular hydrogen application in stroke: bench to bedside.

(2020) Lei Huang et al.   CURRENT PHARMACEUTICAL DESIGN

Neuroprotective Effect of Antioxidants in the Brain

(2020) Kyung Hee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hydrogen: A Novel Option in Human Disease Treatment

(2020) Mengling Yang et al.   Oxidative Medicine and Cellular Longevity

Hydralazine Protects Nigrostriatal Dopaminergic Neurons From MPP+ and MPTP Induced Neurotoxicity: Roles of Nrf2-ARE Signaling Pathway

(2019) Xingfang Guo et al.   Frontiers in Neurology

Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes

(2019) Tyler W. LeBaron et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Gut Microbiota in Neurological Disorders

(2019) Marta Grochowska et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment

(2018) Kiyomi Nishimaki et al.   Current Alzheimer Research

Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance

(2018) Chen Hou et al.   FREE RADICAL RESEARCH

Hydrogen gas inhalation during ex vivo lung perfusion of donor lungs recovered after cardiac death

(2018) Seokjin Haam et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway

(2018) Jia Yuan et al.   JOURNAL OF SURGICAL RESEARCH

Dual Gas Treatment With Hydrogen and Carbon Monoxide Attenuates Oxidative Stress and Protects From Renal Ischemia-Reperfusion Injury

(2018) T. Nishida et al.   TRANSPLANTATION PROCEEDINGS

The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats

(2018) Ping Zhou et al.   JOURNAL OF RADIATION RESEARCH

Randomized, double-blind, multicenter trial of hydrogen water for Parkinson's disease

(2018) Asako Yoritaka et al.   MOVEMENT DISORDERS

Molecular hydrogen (H2): Potential in mitigating oxidative stress-induced cardiotoxicity

(2018) Branislav Kura et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

(2018) Farzane Sivandzade et al.   Redox Biology

Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection

(2017) Hirohisa Ono et al.   Journal of Stroke & Cerebrovascular Diseases

Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition

(2017) Carolyn Hollands et al.   Molecular Neurodegeneration

Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial

(2017) Tomoyoshi Tamura et al.   Trials

Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice

(2017) Ching-Pin Lin et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

(2017) Li Ge et al.   Oncotarget

Does H2 Alter Mitochondrial Bioenergetics via GHS-R1α Activation?

(2017) Sergej M. Ostojic   Theranostics

Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection

(2017) Hirohisa Ono et al.   Journal of Stroke & Cerebrovascular Diseases

A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics

(2016) Asako Yoritaka et al.   BMC Neurology

MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis

(2016) Bing Han et al.   FEBS Journal

Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia

(2016) Kenji Imai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis

(2016) Yunan Gao et al.   MEDIATORS OF INFLAMMATION

Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model

(2016) Naofumi Tamaki et al.   Oxidative Medicine and Cellular Longevity

Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy

(2016) Lin Yang et al.   Open Medicine

Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators

(2016) Katsuya Iuchi et al.   Scientific Reports

Molecular hydrogen: An inert gas turns clinically effective

(2015) Sergej M. Ostojic   ANNALS OF MEDICINE

Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells

(2015) Chih-Li Lin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents

(2015) Sayaka Sobue et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

Global neurotrauma research challenges and opportunities

(2015) Andrés M. Rubiano et al.   NATURE

Molecular Hydrogen Suppresses Reactive Astrogliosis Related to Oxidative Injury during Spinal Cord Injury in Rats

(2014) Fang-Ting Liu et al.   CNS Neuroscience & Therapeutics

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia–reperfusion

(2014) Yukio Mano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydrogen protects auditory hair cells from cisplatin-induced free radicals

(2014) Yayoi S. Kikkawa et al.   NEUROSCIENCE LETTERS

Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury

(2014) Kenji Dohi et al.   PLoS One

Role of autophagy in prion protein-induced neurodegenerative diseases

(2013) H. Yao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo

(2013) Tomohiro Kawamura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Neonatal Exposure to Sevoflurane in Mice Causes Deficits in Maternal Behavior Later in Adulthood

(2013) Yumiko Takaenoki et al.   ANESTHESIOLOGY

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hydrogen Inhalation Ameliorated Mast Cell–Mediated Brain Injury After Intracerebral Hemorrhage in Mice

(2013) Anatol Manaenko et al.   CRITICAL CARE MEDICINE

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effects of hydrogen-rich saline on ulcerative colitis rat model

(2013) Jinghu He et al.   JOURNAL OF SURGICAL RESEARCH

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

Delayed Neurovascular Dysfunction Is Alleviated by Hydrogen in Asphyxiated Newborn Pigs

(2013) Orsolya Oláh et al.   Neonatology

Oxidative stress in schizophrenia patients treated with long-acting haloperidol decanoate

(2013) Marija Bošković et al.   PSYCHIATRY RESEARCH

Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages

(2013) Hong-Guang Chen et al.   International Journal of Surgery

Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice

(2013) Akio Matsumoto et al.   Scientific Reports

Coadministration of Hydrogen Gas as Part of the Carrier Gas Mixture Suppresses Neuronal Apoptosis and Subsequent Behavioral Deficits Caused by Neonatal Exposure to Sevoflurane in Mice

(2012) Ryuji Yonamine et al.   ANESTHESIOLOGY

Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs

(2012) Y. Zhou et al.   NEUROSCIENCE

Molecular Hydrogen Reduces LPS-Induced Neuroinflammation and Promotes Recovery from Sickness Behaviour in Mice

(2012) Stefan Spulber et al.   PLoS One

Inhalation of hydrogen gas attenuates left ventricular remodeling induced by intermittent hypoxia in mice

(2011) Tetsuya Hayashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress

(2011) Yasuhiro Terasaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

(2011) Mathias Jucker et al.   ANNALS OF NEUROLOGY

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases

(2011) Shigeo Ohta   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Beneficial effects of hydrogen gas against spinal cord ischemia–reperfusion injury in rabbits

(2011) Yi Huang et al.   BRAIN RESEARCH

Hydrogen-Rich Saline Protects Against Acute Lung Injury Induced by Extensive Burn in Rat Model

(2011) Yong Fang et al.   Journal of Burn Care & Research

Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice

(2011) Cristian A Lasagna-Reeves et al.   Molecular Neurodegeneration

Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease

(2011) Cai Wang et al.   NEUROSCIENCE LETTERS

Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice

(2011) Naomi Kamimura et al.   Obesity

Hydrogen protects vestibular hair cells from free radicals

(2010) Akiko Taura et al.   ACTA OTO-LARYNGOLOGICA

APOE genotype and verbal memory recovery during and after emergence from post-traumatic amnesia

(2010) E. Noé et al.   BRAIN INJURY

Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress

(2010) Xituan Ji et al.   BRAIN RESEARCH

Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress

(2010) Jian Li et al.   BRAIN RESEARCH

Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus

(2010) Yupin Li et al.   CYTOTECHNOLOGY

Recent advances in hydrogen research as a therapeutic medical gas

(2010) Chien-Sheng Huang et al.   FREE RADICAL RESEARCH

Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice

(2010) Yeunhwa Gu et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

The Potential Cardioprotective Effects of Hydrogen in Irradiated Mice

(2010) Liren QIAN et al.   JOURNAL OF RADIATION RESEARCH

Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats

(2010) Fei Wang et al.   JOURNAL OF SURGICAL RESEARCH

Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice

(2010) Qu Liu et al.   LIVER INTERNATIONAL

A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial

(2010) M. Nakayama et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats

(2010) Chengwen Chen et al.   NEUROCHEMICAL RESEARCH

Hydrogen gas reduced acute hyperglycemia-enhanced hemorrhagic transformation in a focal ischemia rat model

(2010) C.H. Chen et al.   NEUROSCIENCE

Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs

(2010) Ying Lin et al.   NEUROSCIENCE LETTERS

Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs

(2010) Ferenc Domoki et al.   PEDIATRIC RESEARCH

Different Susceptibility to the Parkinson's Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1

(2010) Nadia G. Innamorato et al.   PLoS One

The extra-hypothalamic actions of ghrelin on neuronal function

(2010) Zane B. Andrews   TRENDS IN NEUROSCIENCES

Behavior and Development in Children and Age at the Time of First Anesthetic Exposure

(2009) Cor J. Kalkman et al.   ANESTHESIOLOGY

Hydrogen gas is ineffective in moderate and severe neonatal hypoxia–ischemia rat models

(2009) Gerald A. Matchett et al.   BRAIN RESEARCH

Oral hydrogen water prevents chronic allograft nephropathy in rats

(2009) Jon S. Cardinal et al.   KIDNEY INTERNATIONAL

Hydrogen protects auditory hair cells from free radicals

(2009) Yayoi S. Kikkawa et al.   NEUROREPORT

Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease

(2009) Yuan Fu et al.   NEUROSCIENCE LETTERS

Hydrogen in Drinking Water Reduces Dopaminergic Neuronal Loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mouse Model of Parkinson's Disease

(2009) Kyota Fujita et al.   PLoS One

Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice

(2008) Yasunori Sato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice

(2008) Ikuroh Ohsawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroprotective effects of hydrogen saline in neonatal hypoxia–ischemia rat model

(2008) Jianmei Cai et al.   BRAIN RESEARCH

Inherent safety key performance indicators for hydrogen storage systems

(2008) Gabriele Landucci et al.   JOURNAL OF HAZARDOUS MATERIALS

Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice

(2008) Kazufumi Nagata et al.   NEUROPSYCHOPHARMACOLOGY

Hydrogen therapy reduces apoptosis in neonatal hypoxia–ischemia rat model

(2008) Jianmei Cai et al.   NEUROSCIENCE LETTERS

Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance

(2008) Sizuo Kajiyama et al.   NUTRITION RESEARCH