Borrelia burgdorferi glycosaminoglycan-binding proteins: a potential target for new therapeutics against Lyme disease

Synthetic oligosaccharides can replace animal-sourced low–molecular weight heparins

(2017) Yongmei Xu et al.   Science Translational Medicine

HtrA, a Temperature- and Stationary Phase-Activated Protease Involved in Maturation of a Key Microbial Virulence Determinant, Facilitates Borrelia burgdorferi Infection in Mammalian Hosts

(2016) Meiping Ye et al.   INFECTION AND IMMUNITY

Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis

(2016) Edgar Sanchez et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Flow-Tolerant Adhesion of a Bacterial Pathogen to Human Endothelial Cells Through Interaction With Biglycan

(2016) Jemiina Salo et al.   JOURNAL OF INFECTIOUS DISEASES

Biomechanics of Borrelia burgdorferi Vascular Interactions

(2016) Rhodaba Ebady et al.   Cell Reports

Surface Proteoglycans as Mediators in Bacterial Pathogens Infections

(2016) Beatriz García et al.   Frontiers in Microbiology

Lyme borreliosis

(2016) Allen C. Steere et al.   Nature Reviews Disease Primers

Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete

(2015) Yi-Pin Lin et al.   CELLULAR MICROBIOLOGY

Glycosaminoglycan binding byBorrelia burgdorferiadhesin BBK32 specifically and uniquely promotes joint colonization

(2015) Yi-Pin Lin et al.   CELLULAR MICROBIOLOGY

Middle region of theBorrelia burgdorferisurface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection

(2015) Xiuli Yang et al.   CELLULAR MICROBIOLOGY

Modulation of Sickle Red Blood Cell Adhesion and its Associated Changes in Biomarkers by Sulfated Nonanticoagulant Heparin Derivative

(2015) Abdulelah Alshaiban et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Borrelia burgdorferi HtrA: evidence for twofold proteolysis of outer membrane protein p66

(2015) James L. Coleman et al.   MOLECULAR MICROBIOLOGY

Suppression of pancreatic cancer by sulfated non-anticoagulant low molecular weight heparin

(2014) Thangirala Sudha et al.   CANCER LETTERS

Identification of Lysine Residues in the Borrelia burgdorferi DbpA Adhesin Required for Murine Infection

(2014) Danielle E. Fortune et al.   INFECTION AND IMMUNITY

Anti-metastasis efficacy and safety of non-anticoagulant heparin derivative versus low molecular weight heparin in surgical pancreatic cancer models

(2014) REEM ALYAHYA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Strain-Specific Variation of the Decorin-Binding Adhesin DbpA Influences the Tissue Tropism of the Lyme Disease Spirochete

(2014) Yi-Pin Lin et al.   PLoS Pathogens

Glycosaminoglycans in infectious disease

(2013) Eyal Kamhi et al.   BIOLOGICAL REVIEWS

The HtrA protease ofBorrelia burgdorferidegrades outer membrane protein BmpD and chemotaxis phosphatase CheX

(2013) James L. Coleman et al.   MOLECULAR MICROBIOLOGY

Borrelia burgdorferi BbHtrA degrades host ECM proteins and stimulates release of inflammatory cytokinesin vitro

(2013) Theresa M. Russell et al.   MOLECULAR MICROBIOLOGY

Lyme disease spirochaetes possess an aggrecan-binding protease with aggrecanase activity

(2013) Theresa M. Russell et al.   MOLECULAR MICROBIOLOGY

Illuminating the roles of the Borrelia burgdorferi adhesins

(2013) Jenifer Coburn et al.   TRENDS IN MICROBIOLOGY

Effects of heparosan and heparin on the adhesion and biofilm formation of several bacteria in vitro

(2012) Xiang’e Chen et al.   CARBOHYDRATE POLYMERS

Inhibitory effect of non-anticoagulant heparin (S-NACH) on pancreatic cancer cell adhesion and metastasis in human umbilical cord vessel segment and in mouse model

(2012) Thangirala Sudha et al.   CLINICAL & EXPERIMENTAL METASTASIS

Heparosan-Derived Heparan Sulfate/Heparin-Like Compounds: One Kind of Potential Therapeutic Agents

(2012) Pingli Li et al.   MEDICINAL RESEARCH REVIEWS

Proteoglycan sequence

(2012) Lingyun Li et al.   Molecular BioSystems

Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules

(2012) Tara J. Moriarty et al.   MOLECULAR MICROBIOLOGY

Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes

(2012) Justin D. Radolf et al.   NATURE REVIEWS MICROBIOLOGY

Analysis of an Ordered, Comprehensive STM Mutant Library in Infectious Borrelia burgdorferi: Insights into the Genes Required for Mouse Infectivity

(2012) Tao Lin et al.   PLoS One

Allelic Variation of the Lyme Disease Spirochete Adhesin DbpA Influences Spirochetal Binding to Decorin, Dermatan Sulfate, and Mammalian Cells

(2011) Vivian M. Benoit et al.   INFECTION AND IMMUNITY

Decorin Binding by DbpA and B of Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi Sensu Stricto

(2011) Jemiina Salo et al.   JOURNAL OF INFECTIOUS DISEASES

Therapies from Fucoidan; Multifunctional Marine Polymers

(2011) Janet Helen Fitton   Marine Drugs

Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity

(2011) Jenny A. Hyde et al.   MOLECULAR MICROBIOLOGY

HTRA proteases: regulated proteolysis in protein quality control

(2011) Tim Clausen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins

(2011) Y. Xu et al.   SCIENCE

Characterization of Unique Regions of Borrelia burgdorferi Surface-Located Membrane Protein 1

(2010) X. Yang et al.   INFECTION AND IMMUNITY

A Chromosomally Encoded Virulence Factor Protects the Lyme Disease Pathogen against Host-Adaptive Immunity

(2009) Xiuli Yang et al.   PLoS Pathogens

Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection

(2008) Jon S Blevins et al.   BMC MICROBIOLOGY

Borrelia burgdorferi Lacking DbpBA Exhibits an Early Survival Defect during Experimental Infection

(2008) E. H. Weening et al.   INFECTION AND IMMUNITY

Both Decorin-Binding Proteins A and B Are Critical for the Overall Virulence of Borrelia burgdorferi

(2008) Y. Shi et al.   INFECTION AND IMMUNITY

Biology of Infection with Borrelia burgdorferi

(2008) Kit Tilly et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Lyme borreliosis spirochete Erp proteins, their known host ligands, and potential roles in mammalian infection

(2008) Catherine A. Brissette et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Suramin: Clinical Uses and Structure-Activity Relationships

(2008) Ross McGeary et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Surfen, a small molecule antagonist of heparan sulfate

(2008) M. Schuksz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms Involved in Vascular Interactions of the Lyme Disease Pathogen in a Living Host

(2008) M. Ursula Norman et al.   PLoS Pathogens

Real-Time High Resolution 3D Imaging of the Lyme Disease Spirochete Adhering to and Escaping from the Vasculature of a Living Host

(2008) Tara J. Moriarty et al.   PLoS Pathogens