Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors
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关键词
Succinate dehydrogenase, Complex I of the electron transport chain, Mitochondrial respiration, Reductive glutamine metabolism, Pyruvate carboxylase, C metabolic flux analysis, Paraganglioma, Gastrointestinal stromal tumors, Leigh syndrome, Ataxia, Leukodystrophy, SDH mutations
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