Article
Rheumatology
Eduardo Martin-Nares, Gabriela Hernandez-Molina
Summary: In patients with IgG4-related disease, a significant number of patients have ANCA positivity, and these patients differ from the ANCA-negative group in terms of clinical and serological features.
Article
Urology & Nephrology
Xiao-Yan Jia, Hui-Yan Xu, Xiao-Yu Jia, Zhao Cui, Ming-Hui Zhao
Summary: Anti-glomerular basement membrane (GBM) disease is a rare but aggressive form of glomerulonephritis, and the prognosis of patients has improved over the past few decades. Serum creatinine and crescent percentage at diagnosis are predictors for kidney outcomes, while positive antineutrophil cytoplasmic antibodies (ANCAs) are predictors for mortality.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Riccardo Capecchi, Domenico Giannese, Diego Moriconi, Angelo G. Bonadio, Federico Pratesi, Cristina Croia, Maria F. Egidi, Ilaria Puxeddu, Antonio G. Tavoni, Paola Migliorini
Summary: IgG4-Related Disease primarily affects the kidneys, potentially leading to tubulointerstitial nephritis or membranous nephropathy. While responsive to steroids, in some cases it can still result in permanent kidney damage.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Peter C. Grayson, Cristina Ponte, Ravi Suppiah, Joanna C. Robson, Anthea Craven, Andrew Judge, Sara Khalid, Andrew Hutchings, Raashid A. Luqmani, Richard A. Watts, Peter A. Merkel
Summary: The revised classification criteria for EGPA demonstrate strong performance characteristics and are validated for use in research.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Clinical Neurology
Michael A. Foster, Sara Collorone, Jacqueline Palace, James Acheson, Ahmed T. Toosy
Summary: This case presents a rare dual diagnosis of sarcoidosis and neuromyelitis optica with aquaporin-4 antibodies in a patient with atypical recurrent optic neuritis. Long-term immunosuppression is required for management, highlighting the importance of identifying the features and cause of atypical optic neuritis.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Urology & Nephrology
Keita Morimoto, Go Kanzaki, Takahito Niikura, Kentaro Koike, Nanae Matsuo, Yukio Maruyama, Nobuo Tsuboi, Takashi Yokoo
Summary: This case describes an older woman who developed ATIN associated with MPO-ANCA following cimetidine treatment. Despite discontinuing cimetidine, renal injury persisted with high MPO-ANCA titers, but improved with oral steroid treatment. This suggests that ANCA-associated ATIN can be caused by cimetidine and emphasizes the importance of serological monitoring and renal biopsy in cases of drug-induced ATIN.
Review
Clinical Neurology
Cheng Xia, Ping Li
Summary: This article reported three cases of IgG4-HP patients coexpressing ANCA. The study found a potential overlap between these two diseases based on the review of relevant literature.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Satoshi Kurahashi, Naohiro Toda, Masaaki Fujita, Katsuya Tanigaki, Jun Takeoka, Hisako Hirashima, Eri Muso, Katsuhiro Io, Takaki Sakurai, Toshiyuki Komiya
Summary: This article reports a case of extra-nodal RDD presenting as acute tubulointerstitial nephritis mimicking IgG4-RD, and discusses the association between RDD and IgG4-RD.
Article
Rheumatology
Peter C. Grayson, Cristina Ponte, Ravi Suppiah, Joanna C. Robson, Anthea Craven, Andrew Judge, Sara Khalid, Andrew Hutchings, Raashid A. Luqmani, Richard A. Watts, Peter A. Merkel
Summary: This study aimed to develop and validate revised classification criteria for EGPA. Through the identification, collection, and analysis of candidate criteria items, a risk score system was established for disease classification in EGPA patients and comparator diseases. The criteria demonstrated strong sensitivity and specificity after validation.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Immunology
Xiao-Ning An, Zhao-Nan Wei, Yin-Yin Xie, Jing Xu, Yan Shen, Li-Yan Ni, Hao Shi, Ping-Yan Shen, Wen Zhang, Yong-Xi Chen
Summary: In this study, the role of CD206(+) mono-macrophages in antineutrophil cytoplasmic antibodies (ANCA) associated glomerulonephritis (AGN) was investigated. The results showed that the proportion of CD206(+) cells was higher in active AGN patients compared to remissive patients, healthy controls, and kidney function adjusted controls. CD206 was highly expressed in different kidney regions of active AGN patients. Further studies demonstrated that MPO ANCA could induce CD206 expression in mono-macrophages and this effect could be reversed by its inhibitor AZD5904.
Article
Virology
Naoko Uno, Ted M. Ross
Summary: The study developed four independent DENV envelope glycoproteins using COBRA methodology to induce broadly neutralizing antibodies against all four serotypes, demonstrating a broad protective immune response in rhesus macaques.
JOURNAL OF VIROLOGY
(2021)
Review
Urology & Nephrology
Mansour Mbengue, Nabila Goumri, Abdou Niang
Summary: IgG4-related disease is a multi-system disorder with unclear pathogenesis, involving genetic and immune factors, where renal involvement may lead to tubulointerstitial nephritis or membranous nephropathy. Early diagnosis and appropriate therapy are crucial due to the risk of irreversible renal failure.
CLINICAL NEPHROLOGY
(2021)
Review
Rheumatology
Ping Li, Yuejia Zhou, Huanyu Liu, Weihua Yin, Jian Li, Minghua Luo
Summary: This is a case report of a 35-year-old man with IgG4-related disease, presenting with initial symptoms of facial edema and recent onset of proteinuria. It took over a year from symptom onset to diagnosis. Treatment with glucocorticoids led to a good prognosis without recurrence.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Jeong-Hoon Lim, Man-Hoon Han, Yong-Jin Kim, Yena Jeon, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Hajeong Lee, Dong Ki Kim, Kyung Chul Moon, Sun-Hee Park
Summary: In Korean AAGN patients, histopathologic and clinicopathologic classifications have predictive value for renal outcomes, especially in the sclerotic class or the high-risk group with higher risk of progression to end-stage kidney disease despite treatment.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Yoshitaka Furuto, Hirotsugu Hashimoto, Akio Namikawa, Teppei Morikawa, Yuko Shibuya
Summary: This article reports a case of IgG4-related membranous nephropathy treated with multitarget therapy and achieved remission.
Article
Urology & Nephrology
Qiu-hua Gu, Megan Huynh, Yue Shi, Xiao-yu Jia, Jie-jian Luo, Tai-jiao Jiang, Zhao Cui, Joshua D. Ooi, A. Richard Kitching, Ming-hui Zhao
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Multidisciplinary Sciences
Jingyuan Xie, Lili Liu, Nikol Mladkova, Yifu Li, Hong Ren, Weiming Wang, Zhao Cui, Li Lin, Xiaofan Hu, Xialian Yu, Jing Xu, Gang Liu, Yasar Caliskan, Carlo Sidore, Olivia Balderes, Raphael J. Rosen, Monica Bodria, Francesca Zanoni, Jun Y. Zhang, Priya Krithivasan, Karla Mehl, Maddalena Marasa, Atlas Khan, Fatih Ozay, Pietro A. Canetta, Andrew S. Bomback, Gerald B. Appel, Simone Sanna-Cherchi, Matthew G. Sampson, Laura H. Mariani, Agnieszka Perkowska-Ptasinska, Magdalena Durlik, Krzysztof Mucha, Barbara Moszczuk, Bartosz Foroncewicz, Leszek Paczek, Ireneusz Habura, Elisabet Ars, Jose Ballarin, Laila-Yasmin Mani, Bruno Vogt, Savas Ozturk, Abdulmecit Yildiz, Nurhan Seyahi, Hakki Arikan, Mehmet Koc, Taner Basturk, Gonca Karahan, Sebahat Usta Akgul, Mehmet Sukru Sever, Dan Zhang, Domenico Santoro, Mario Bonomini, Francesco Londrino, Loreto Gesualdo, Jana Reiterova, Vladimir Tesar, Claudia Izzi, Silvana Savoldi, Donatella Spotti, Carmelita Marcantoni, Piergiorgio Messa, Marco Galliani, Dario Roccatello, Simona Granata, Gianluigi Zaza, Francesca Lugani, GianMarco Ghiggeri, Isabella Pisani, Landino Allegri, Ben Sprangers, Jin-Ho Park, BeLong Cho, Yon Su Kim, Dong Ki Kim, Hitoshi Suzuki, Antonio Amoroso, Daniel C. Cattran, Fernando C. Fervenza, Antonello Pani, Patrick Hamilton, Shelly Harris, Sanjana Gupta, Chris Cheshire, Stephanie Dufek, Naomi Issler, Ruth J. Pepper, John Connolly, Stephen Powis, Detlef Bockenhauer, Horia C. Stanescu, Neil Ashman, Ruth J. F. Loos, Eimear E. Kenny, Matthias Wuttke, Kai-Uwe Eckardt, Anna Koettgen, Julia M. Hofstra, Marieke J. H. Coenen, Lambertus A. Kiemeney, Shreeram Akilesh, Matthias Kretzler, Lawrence H. Beck, Benedicte Stengel, Hanna Debiec, Pierre Ronco, Jack F. M. Wetzels, Magdalena Zoledziewska, Francesco Cucca, Iuliana Ionita-Laza, Hajeong Lee, Elion Hoxha, Rolf A. K. Stahl, Paul Brenchley, Francesco Scolari, Ming-hui Zhao, Ali G. Gharavi, Robert Kleta, Nan Chen, Krzysztof Kiryluk
NATURE COMMUNICATIONS
(2020)
Article
Urology & Nephrology
Beining Wang, Jia Xiaoyu, Xiaojuan Yu, Zhao Cui, Minghui Zhao
Summary: Post-ESWL anti-GBM disease is a rare complication that should be taken seriously, presenting similar clinical features to classic anti-GBM disease, including fever, hematuria, and RPGN. Although the exact pathogenesis remains unclear, early diagnosis and treatment are crucial.
Article
Biochemistry & Molecular Biology
Elena N. Pokidysheva, Harald Seeger, Vadim Pedchenko, Sergei Chetyrkin, Carsten Bergmann, Dale Abrahamson, Zhao Wei Cui, Eric Delpire, Fernando C. Fervenza, Aaron L. Fidler, Agnes B. Fogo, Ariana Gaspert, Maik Grohmann, Oliver Gross, George Haddad, Raymond C. Harris, Clifford Kashtan, A. Richard Kitching, Johan M. Lorenzen, Stephen McAdoo, Charles D. Pusey, Marten Segelmark, Alicia Simmons, Paul A. Voziyan, Timo Wagner, Rudolf P. Wuethrich, Ming-Hui Zhao, Sergei P. Boudko, Andreas D. Kistler, Billy G. Hudson
Summary: A unique genetic variant of collagen IV alpha 345 was discovered in familial cases of Goodpasture's disease and Alport syndrome, leading to GBM abnormalities and proteinuria in a knock-in mouse model. Crystallography and assembly studies revealed underlying mechanisms of the hexamer, which could potentially be targeted for therapeutic interventions in GBM diseases.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Urology & Nephrology
Cong-Rong Shen, Xiao-Yu Jia, Wentian Luo, Florina Olaru, Zhao Cui, Ming-Hui Zhao, Dorin-Bogdan Borza
Summary: In patients with anti-GBM antibody GN, circulating IgG autoantibodies binding to laminin-521 were found in about one third of patients, but not in healthy controls or patients with other glomerular diseases. Autoreactivity towards laminin-521 was significantly more common in patients with anti-GBM GN and lung hemorrhage than in patients with kidney-limited disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Shuang Gao, Zhao Cui, Xin Wang, Yi-miao Zhang, Fang Wang, Xu-yang Cheng, Li-qiang Meng, Fu-de Zhou, Gang Liu, Ming-hui Zhao
Summary: In a retrospective study of 95 Chinese patients with pMN receiving rituximab therapy, it was found that as an initial treatment, rituximab had a higher remission rate compared to alternative therapy. Severe proteinuria and persistent positivity of anti-PLA2R antibodies were identified as independent risk factors for no-remission.
FRONTIERS IN MEDICINE
(2021)
Letter
Cardiac & Cardiovascular Systems
Shu Fang, Xu-jie Zhou, Zhao Cui, Xiao-juan Yu, Su-xia Wang, Fu-de Zhou
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Urology & Nephrology
Yan-jiao Cheng, Xu-yang Cheng, Yi-miao Zhang, Fang Wang, Xin Wang, Li-qiang Meng, Gang Liu, Zhao Cui, Ming-hui Zhao
Summary: This study suggests that hydroxychloroquine as an adjunctive treatment in patients with primary membranous nephropathy can effectively reduce proteinuria and have a positive impact on antibody reduction. In the long term, the hydroxychloroquine group showed a higher clinical remission rate, and no serious adverse events were observed.
JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Xiao-Yan Jia, Hui-Yan Xu, Xiao-Yu Jia, Zhao Cui, Ming-Hui Zhao
Summary: Anti-glomerular basement membrane (GBM) disease is a rare but aggressive form of glomerulonephritis, and the prognosis of patients has improved over the past few decades. Serum creatinine and crescent percentage at diagnosis are predictors for kidney outcomes, while positive antineutrophil cytoplasmic antibodies (ANCAs) are predictors for mortality.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Yanfen Li, Juntao Yu, Miao Wang, Zhao Cui, Ming-hui Zhao
Summary: This study suggests that anti-PLA2R antibodies may directly induce damage to podocytes through interactions with calcium-dependent proteins, structural damage to cells, and inhibition of cell motility.
Article
Urology & Nephrology
Shuang Gao, Zhao Cui, Ming-hui Zhao
Summary: This study investigates the role of C3a and C3a receptor (C3aR) in the pathogenesis of primary membranous nephropathy (MN). It demonstrates that C3a anaphylatoxin is a crucial effector of complement-mediated podocyte damage in MN, and blocking C3aR may be a potentially viable treatment for this disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Xue-Fen Yang, Xiao-Yu Jia, Xiao-Juan Yu, Zhao Cui, Ming-Hui Zhao
Summary: This study retrospectively reviewed eight patients diagnosed with anti-GBM disease who were treated with rituximab from 2014 to 2020. The results showed that rituximab may be an alternative therapy for patients with severe or refractory anti-GBM disease. After a median follow-up of 34.5 months, kidney function partially recovered or stabilized in 62.5% of the patients, and anti-GBM antibodies remained undetected in all patients during follow-up. No severe adverse effects associated with rituximab were observed.
Article
Cell & Tissue Engineering
Hui-song Zhou, Zhao Cui, Hui Wang, Ting-ting Gao, Liu Wang, Jun Wu, Zu-ying Xiong, Jie Hao, Ming-hui Zhao
Summary: The study suggests that human embryonic stem cell-derived immunity-and-matrix regulatory cells have therapeutic effects on primary membranous nephropathy by regulating T cells and IL-10.
STEM CELL RESEARCH & THERAPY
(2022)
Letter
Medicine, General & Internal
Chenyang Zhao, Zhao Cui, Yimiao Zhang, Fang Wang, Xin Wang, Xuyang Cheng, Liqiang Meng, Gang Liu, Minghui Zhao
CHINESE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Ai-bo Qin, Zi-shan Lin, Su-xia Wang, Hui Wang, Zhao Cui, Fu-de Zhou, Ming-hui Zhao
Summary: This study compared the clinicopathological and ultrastructural features of patients with mercury-associated membranous nephropathy (M-MN) and idiopathic membranous nephropathy (I-MN). The results showed that M-MN patients were younger, achieved complete remission more quickly, and had a lower relapse rate compared to I-MN patients. M-MN patients also exhibited less severe foot process effacement and a higher rate of mesangial electron-dense deposits.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)