Article
Agriculture, Dairy & Animal Science
Hui Xu, Xuexia Bai, Yu Li, Jiajia Li, Yong Meng, Zhiqiang Xu, Jianqing Tang, Yan Lu, Yahong Huang
Summary: Freshwater biodiversity crisis has attracted significant attention due to the destruction of freshwater ecosystems. Drought, as an important factor contributing to this crisis, is still poorly understood. In this study, we examined the immune function, histopathology, and metabolism of crayfish under drought conditions using flow cytometry, hematoxylin-eosin staining, and untargeted metabolomics. The results demonstrate that drought suppresses immune function, disrupts the balance of oxidative and antioxidative systems, and induces tissue damage and metabolic changes in crayfish.
Review
Chemistry, Multidisciplinary
Chenyang Zhang, Xin Wang, Jiangfeng Du, Zhanjun Gu, Yuliang Zhao
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Review
Chemistry, Inorganic & Nuclear
Nahyun Kwon, Dayeh Kim, K. M. K. Swamy, Juyoung Yoon
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play crucial roles in human life, but overproduction can lead to cell damage and diseases. Researchers have developed fluorescent and luminescent probes based on metal-coordinated systems to detect and image these active species, providing valuable tools for studying their roles in signaling and pathology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Jiaxue Liu, Boyan Jia, Zhibo Li, Wenliang Li
Summary: Applying reactive polymer materials sensitive to biological stimuli has attracted extensive research interest. The application of reactive oxygen species (ROS)-responsive polymers as drug-delivery systems in organisms has received much attention due to the special physiological effects of ROS on tumors or inflammation. The research progress of ROS-responsive polymers and their application in recent years were summarized and analyzed in this paper. From the perspective of nanoparticle drug delivery systems, multi-responsive delivery systems, and ROS-responsive hydrogels, the future development trends in this field were discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qinyuan He, Xian Zhang, Xiaojun Yang
Summary: Beta-cypermethrin (8-CYP), a commonly used insecticide, has potential toxicity and adverse effects on the health of animals and humans. Our research found that 8-CYP exposure leads to defective nuclear maturation of porcine oocytes through abnormal spindle assembly and chromosome alignment. It also disrupts cytoplasmic maturation by affecting cortical granules, endoplasmic reticulum, and mitochondrial integrity, leading to increased reactive oxygen species and apoptosis. Supplementation with glutathione mitigates the meiotic defects induced by 8-CYP exposure by regulating ROS levels.
Review
Chemistry, Multidisciplinary
Gabriel T. Huynh, Vidhishri Kesarwani, Julia A. Walker, Jessica E. Frith, Laurence Meagher, Simon R. Corrie
Summary: The combination of nanomaterials and fluorescent detection offers new opportunities for monitoring oxygen and ROS in biological systems, improving optical properties and interactions with cells and media, and providing ratiometric sensing robust to environmental drift.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Patryk Szymaszek, Patrycja Sroda, Malgorzata Tyszka-Czochara, Anna Chachaj-Brekiesz, Tomasz Swiergosz, Joanna Ortyl
Summary: Here we report the synthesis of a novel fluorescent probe P182 for quantitative measurement of H2O2. This fluorometric probe displays a fluorescence turn-on response in the presence of H2O2. It offers good performances in terms of sensitivity and response time, and shows non-toxic activity for in vivo studies. This study provides research on molecular fluorescence probe for the detection of H2O2.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Yi-Ching Lin, Yi-Giien Tsai, Yu-Chih Lin, Chia-Hong Kuo, Mei-Lan Tsai, Chao-Hung Kuo, Wei-Ting Liao
Summary: Acrylamide promoted mitochondria-specific ROS generation, increased gene expression of mitochondrial respiratory chain complex II SDHA, induced histone modifications and upregulated PINK1 expression, leading to a macrophage M2 polarization shift in THP-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wei Guo, Yadi Xing, Xiumei Luo, Fuguang Li, Maozhi Ren, Yiming Liang
Summary: Reactive oxygen species (ROS) are crucial regulators in both plant and human cells, serving as messengers in multiple pathways. While they play a beneficial role in growth and development, excessive ROS can cause oxidative stress and damage cellular functions. This review highlights the current research and mechanisms of ROS in both kingdoms, emphasizing their interactions with other substances and proposing potential opportunities for novel therapeutic strategies and agricultural advancements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Marc Herb, Alexander Gluschko, Michael Schramm
Summary: Reactive oxygen species (ROS) play important roles in cellular processes but can also lead to diseases, their effects depending on cell type and ROS production conditions. Cellular redox balance, like cell pH and calcium levels, is tightly controlled, with evidence showing that cells regulate ROS production by controlling activation and localization factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hee Jin Jung, Dong Chan Choi, Sang Gyun Noh, Heejeong Choi, Inkyu Choi, Il Young Ryu, Hae Young Chung, Hyung Ryong Moon
Summary: Thirteen (Z)-2-(substituted benzylidene)benzimidazothiazolone analogs were synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. Among these compounds, compounds 1-3 displayed stronger tyrosinase inhibitory activity and could inhibit melanin production through different pathways.
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Biochemistry & Molecular Biology
Daiana Romina Peralta, Juan Vicente Farizano, Natalia Bulacio Gil, Natalia Soledad Corbalan, Maria Fernanda Pomares, Paula Andrea Vincent, Conrado Adler
Summary: Siderophores, such as enterobactin, have been found to have roles beyond iron acquisition, including regulating copper toxicity and protecting against oxidative stress. Enterobactin shows a bimodal effect on copper toxicity depending on its concentration, acting both protectively and harmfully.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Luisa M. Sandalio, Aurelio M. Collado-Arenal, Maria C. Romero-Puertas
Summary: Plant peroxisomes are dynamic organelles participating in a variety of metabolic processes and cell responses to the environment. This review focuses on the interactions and effects of reactive species such as ROS, RNS, CRS, and SRS in peroxisomes, as well as their role in regulating the redox/ROS homeostasis and plasticity of peroxisomes. The review also highlights the important role of H2O2-dependent peroxisomal retrograde signaling and discusses the specific peroxisomal footprint.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)