Review
Immunology
Liangliang Meng, Yingtian Wei, Yueyong Xiao
Summary: Chemical ablation involves injecting chemical agents directly into solid tumors to kill cells and is currently used for palliative treatment. The effectiveness of different drugs has been clinically tested, but their diffusion and concentration limit their efficacy. Immunotherapy shows potential, but low patient response rates and immune-related adverse effects restrict its clinical applications. Intratumoral immunotherapy addresses these issues, but its efficacy alone is uncertain. This study focuses on the research of immunosuppressive tumor microenvironment with chemoablation and intratumoral immunotherapy, aiming to propose a new concept of intratumoral chemo-immunoablation that enhances the systemic anti-tumor immune response while reducing adverse drug effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Long Zhang, Yining Zhang, Xu Wang, Yi Zhou, Ji Qi, Linbo Gu, Qiu Zhao, Rutong Yu, Xiuping Zhou
Summary: A Trojan-horse-like nanoparticle system was designed to target and treat glioblastoma, a type of brain tumor. The system effectively crossed the blood-brain barrier and stimulated the immune environment to enhance chemotherapy efficacy without causing noticeable side effects.
Article
Chemistry, Multidisciplinary
Yupeng Wang, Jie Yu, Zhijian Luo, Qiankun Shi, Guanglong Liu, Fan Wu, Zhizhang Wang, Yubin Huang, Dongfang Zhou
Summary: An engineered biomimetic nano-RBC system utilizing hemoglobin is developed to deliver chemotherapy drugs and oxygen, effectively reprogramming the tumor immunosuppressive microenvironment. This strategy targets tumor-associated macrophages and alleviates tumor hypoxia, enhancing the antitumor immune response and inhibiting tumor metastasis and recurrence.
ADVANCED MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Jiabao Ling, Yanzhou Chang, Zhongwen Yuan, Qi Chen, Lizhen He, Tianfeng Chen
Summary: This study proposes a feasible therapeutic strategy for depleting lactate and reconstructing an immunosuppressive tumor microenvironment using Se-containing nanosheets, which can restore the potent tumor-killing activity of macrophages, thereby amplifying the effects of TAM-based antitumor immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Shiyang Wu, Dan Liu, Wenpan Li, Baohui Song, Chunlin Chen, Dawei Chen, Haiyang Hu
Summary: Tumor-associated fibroblasts play a crucial role in tumor progression and response to therapy in the immunosuppressive tumor microenvironment. By delivering silybin using nano liposomes, the study successfully altered the tumor immune microenvironment and enhanced the anti-tumor immune response. Combining an immunogenic cell death inducer, liposomal doxorubicin, further improved treatment efficacy and prolonged survival duration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Oncology
Maria Perez-Lanzon, Vincent Carbonnier, Pierre Cordier, Fatima Domenica Elisa De Palma, Adriana Petrazzuolo, Christophe Klein, Floriane Arbaretaz, Khady Mangane, Gautier Stoll, Isabelle Martins, Helene Fohrer Ting, Juliette Paillet, Sophie Mouillet-Richard, Delphine Le Corre, Wenjjin Xiao, Marine Sroussi, Chantal Desdouets, Pierre Laurent-Puig, Jonathan Pol, Carlos Lopez-Otin, Maria Chiara Maiuri, Guido Kroemer
Summary: The study successfully established a new breast cancer cell line B6BC, which can be transplanted in C57BL/6 mice and mimics the extravasation of GFP-tagged cancer cells in blood circulation. B6BC-derived tumors are resistant to PD-1 immunotherapy but show good response to ER antagonists and anthracycline-based chemotherapy, suggesting potential new treatment strategies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Hongjuan Zhao, Yatong Li, Haiyu Shi, Mengya Niu, Dan Li, Zhenzhong Zhang, Qianhua Feng, Yi Zhang, Lei Wang
Summary: In this study, reactive oxygen species (ROS) responsive prodrug nanoparticles (DHCRJ) were developed for metabolic enhanced chemo-immunotherapy against triple-negative breast cancer (TNBC). DHCRJ reduced oxidative stress and lactate accumulation, reshaped the immunosuppressive tumor microenvironment, and enhanced tumor immunogenicity through the synergistic effect of DOX prodrugs and JQ1. This strategy significantly suppressed tumor growth and metastasis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Environmental
Afeng Yang, Xia Dong, Yun Bai, Shupei Sheng, Yan Zhang, Tianjun Liu, Dunwan Zhu, Feng Lv
Summary: The study introduced a doxorubicin/CpG self-assembled nanoparticles prodrug and dendritic cells (DC) co-laden hydrogel system for cancer chemo-assisted immunotherapy. The combination effectively induced a strong CTL killing effect, increased effector T cell infiltration, alleviated the immunosuppressive microenvironment, and maximized the immune effect for improving chemo-assisted immunotherapy. The fluorescence imaging tracking provided insight into the in vivo process of immune cells, chemotherapeutic drugs, and immune adjuvants for efficient therapy guidance.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Biomedical
Rui Yang, Mengsi Zhan, Zhijun Ouyang, Honghua Guo, Jiao Qu, Jindong Xia, Mingwu Shen, Xiangyang Shi
Summary: The microfluidic synthesis of artesunate (ART)-loaded polydopamine (PDA)/iron (Fe) nanocomplexes (NCs) coated with fibronectin (FN) was reported in this study. These multifunctional Fe-PDA@ART/FN NCs exhibit desired properties for tumor therapy with improved chemodynamic therapy (CDT) and immunogenic cell death, and can be guided through magnetic resonance (MR) imaging. The developed FDRF NCs are considered an advanced nanomedicine formulation for chemo-chemodynamic-immune therapy of different tumor types under MR imaging guidance.
MATERIALS TODAY BIO
(2023)
Article
Engineering, Biomedical
Xiaoyu Zhou, Enhui Ma, Yingying Zhang, Yujuan Xing, Wenbei Xu, Liang Chen, Hong Zhou, Xinran Zhang, Canran Jiang, Kai Xu, Hong Wang, Shaohui Zheng
Summary: This study proposes a photothermal conversion strategy based on nanomotors to achieve deep tumor penetration, targeted delivery to tumor-associated macrophages (TAMs), and enhanced tumor immunotherapy. Under near-infrared (NIR) laser activation, the nanomotors can effectively and rapidly deliver the drug to TAMs, promoting TAM reprogramming and T cell activation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Jiulong Zhang, Xiaoyan Sun, Mengdan Xu, Xiufeng Zhao, Chunrong Yang, Kexin Li, Fan Zhao, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao
Summary: In this study, a tumor-associated macrophage (TAM) membrane-camouflaged nanodecoy containing a self-amplifying reactive oxygen species (ROS)-sensitive prodrug nanoparticle was developed for inducing immunogenic cell death (ICD) and depleting TAMs. This nanodecoy effectively activated antitumor immune response and showed great potential for cancer immunotherapy.
ACTA BIOMATERIALIA
(2022)
Article
Oncology
Qian Zhao, Xue Zhang, Qiang Ma, Nuo Luo, Zhulin Liu, Renyuan Wang, Yong He, Li Li
Summary: Long-term survival benefit has been observed in non-small cell lung cancer patients treated with immune checkpoint inhibitors, but whether patients with EGFR-activating mutations can benefit from these inhibitors is still controversial. This case highlights the importance of comprehensive detection of PD-L1 expression, driver gene status, and tumor immune microenvironment in predicting treatment efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Dipti Thakkar, Shalini Paliwal, Bhushan Dharmadhikari, Siyu Guan, Lillian Liu, Shreya Kar, Nikhil K. Tulsian, Joshua J. Gruber, Leah DiMascio, Konrad H. Paszkiewicz, Piers J. Ingram, Jerome D. Boyd-Kirkup
Summary: This study developed the first Fc-independent anti-VISTA antibody HMBD-002, which reverses VISTA-induced immune suppression by blocking the functional domain of VISTA. The antibody has a neutralizing, non-depleting effect, effectively inhibiting tumor growth and enhancing T cell activity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Chen Zhao, Ronald N. Germain
Summary: Multiplex imaging is a valuable tool for studying the interactions among immune cells, stroma, and malignant cells within the tumor microenvironment. It holds significant promise for discovering biomarkers and therapeutic targets. However, challenges exist in study design, experiment optimization, and data analysis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Rui Tang, Hongye He, Xiaohong Lin, Nianhong Wu, Li Wan, Qiaoqi Chen, Yaqin Hu, Chen Cheng, Yuting Cao, Xun Guo, Ying Zhou, Xialin Xiong, Min Zheng, Qi Wang, Faqi Li, Yang Zhou, Pan Li
Summary: Combining high-intensity focused ultrasound (HIFU) with immunomodulation can effectively treat solid tumors and stimulate anti-tumor immune response to inhibit tumor recurrence and metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Chemistry, Analytical
Xinyi Luo, Yingying Xue, Enguo Ju, Yu Tao, Mingqiang Li, Li Zhou, Chongguang Yang, Jianhua Zhou, Jiasi Wang
Summary: Early and accurate diagnosis of viruses is critical for control of the pandemic. In this study, a new gene RNA detection platform was developed for quantitative detection of viral RNA with high sensitivity and specificity.
ANALYTICA CHIMICA ACTA
(2022)
Article
Engineering, Biomedical
Miao Fan, Huifang Liu, Hongyu Yan, Ruijun Che, Yi Jin, Xinjian Yang, Xiaohan Zhou, Hua Yang, Kun Ge, Xing-Jie Liang, Jinchao Zhang, Zhenhua Li
Article
Biotechnology & Applied Microbiology
Wentao Dang, Wei-Chih Chen, Enguo Ju, Yanteng Xu, Kai Li, Haixia Wang, Kun Wang, Shixian Lv, Dan Shao, Yu Tao, Mingqiang Li
Summary: In this study, 3D printed hydrogel scaffolds incorporating Gel-SA-CuO were developed for efficient inhibition of postoperative liver cancer recurrence. CuO nanoparticles released Cu2+ to produce ROS and served as photothermal agents to generate heat, enhancing the tumor inhibition through Fenton-like reaction and inducing ferroptosis via GSH depletion.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Hongyu Yan, Miao Fan, Huifang Liu, Tingshan Xiao, Dandan Han, Ruijun Che, Wei Zhang, Xiaohan Zhou, June Wang, Chi Zhang, Xinjian Yang, Jinchao Zhang, Zhenhua Li
Summary: The release of hydrogen by photosynthetic bacteria can disrupt the balance of oxidative stress, stimulate immune response, and increase the infiltration of immune cells. Hydrogen therapy induced by live photosynthetic bacteria effectively kills tumor cells without up-regulating PD-L1, thereby preventing tumor immune escape.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Zhenzhen Wang, Kristen D. Popowski, Dashuai Zhu, Blanca Lopez de Juan Abad, Xianyun Wang, Mengrui Liu, Halle Lutz, Nicole De Naeyer, C. Todd DeMarco, Thomas N. Denny, Phuong-Uyen C. Dinh, Zhenhua Li, Ke Cheng
Summary: Researchers have developed an inhalable and room-temperature-stable virus-like particle COVID-19 vaccine that induces systemic and mucosal immune responses in small animals. The vaccine, consisting of a recombinant SARS-CoV-2 receptor-binding domain conjugated to lung-derived exosomes, enhanced the retention of the receptor-binding domain in the respiratory airway and lungs, and cleared SARS-CoV-2 pseudovirus in mice. In hamsters, the vaccine attenuated severe pneumonia and reduced inflammatory infiltrates after a challenge with live SARS-CoV-2.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Clinical Neurology
Yuan Xing Chen, Han Jun Sun, Xue Tao Mu, Chao Jiang, Hui Bing Wang, Qing Hua Zhang, Yuan Yi Qu, Jian Li, Ling Ling Zhou, Long Zhu Zhao, Ning Yu, Qing Sun
Summary: This study analyzed the clinical characteristics of 6 patients with intracranial tumors who only presented with positional vertigo to avoid misdiagnosis. All patients experienced positional vertigo and accompanying nystagmus induced by changes in head position or posture.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Wentao Dang, Yuqin Wang, Wei-Chih Chen, Enguo Ju, Rachel L. Mintz, Yue Teng, Lili Zhu, Kun Wang, Shixian Lv, Hon Fai Chan, Yu Tao, Mingqiang Li
Summary: A 3D printed hydrogel scaffold is developed for sustained release of drugs, enabling postoperative synergistic cancer therapy. The therapeutic efficiency can be adjusted by altering the amount of drugs and copper ions. The combination of chemotherapy and chemodynamic therapy induces apoptosis and ferroptosis of cancer cells. Results show that the hydrogel scaffold effectively inhibits tumor growth, offering a new strategy for preventing postoperative cancer recurrence.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Mengran Peng, Enguo Ju, Yanteng Xu, Yuqin Wang, Shixian Lv, Dan Shao, Haixia Wang, Yu Tao, Yue Zheng, Mingqiang Li
Summary: Chemodynamic therapy using a core-shell nanoplatform with dual-responsive disassembly that self-supplies H2O2 and undergoes an autocatalytic Fenton reaction has been developed. The platform releases Fe(III) and tannic acid (TA) under ATP and low pH conditions, which can generate self-supplied H2O2. The Fenton reaction between Fe(II) and H2O2 produces highly toxic hydroxyl radicals (& BULL;OH) for efficient chemodynamic therapy.
NPG ASIA MATERIALS
(2022)
Article
Environmental Sciences
Tong Wu, Jie Ding, Le Zhong, Yi-Lin Zhao, Han-Jun Sun, Ji-Wei Pang, Lei Zhao, Shun-Wen Bai, Nan-Qi Ren, Shan-Shan Yang
Summary: In this study, the long-term effects of Zn(II) stress on SNDPR performance were investigated. The results showed that Zn(II) stress at 1 and 5 mg L-1 could enhance nitrogen removal. The highest removal efficiencies of ammonia nitrogen, total nitrogen, and phosphorus were observed at Zn(II) concentration of 5 mg L-1. The abundance of functional genes also reached its peak at 5 mg L-1 Zn(II). The findings suggest that Zn(II) stress can improve the efficiency of wastewater treatment.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Environmental
Meng-Qi Ding, Shan-Shan Yang, Jie Ding, Zhi-Rong Zhang, Yi-Lin Zhao, Wei Dai, Han-Jun Sun, Lei Zhao, Defeng Xing, Nanqi Ren, Wei-Min Wu
Summary: The biodegradation of low-density polyethylene (LDPE) foam by Tenebrio molitor and Tenebrio obscurus larvae was examined with different co-diets. The presence of co-diets enhanced LDPE consumption and degradation, and different diet types influenced gut microbial diversity, metabolic pathways, and functions. Wheat bran or corn flour co-diets showed the highest effectiveness for larval development and LDPE degradation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Youqiang Fang, Xing Luo, Yanteng Xu, Zheng Liu, Rachel L. Mintz, Haiyang Yu, Xuan Yu, Kai Li, Enguo Ju, Haixia Wang, Zhaohui Tang, Yu Tao, Mingqiang Li
Summary: An implantable sandwich-structured dual-drug depot is developed to sequentially trigger a self-intensified starvation therapy and hypoxia-induced chemotherapy. The outer layers are 3D-printed with a calcium-crosslinked mixture ink, while the inner layer is a patch of electrospun fibers loaded with TPZ. The released drugs destroy blood vessels, inhibit angiogenesis, and induce cytotoxicity, effectively inhibiting tumor recurrence and metastasis.
Article
Microbiology
Jungang Lan, Yeqing Wang, Shusheng Yue, Duo Xu, Yinan Li, Xiangyu Peng, Jiao Hu, Enguo Ju, Shanping He, Tingting Li
Summary: KSHV causes both latent and lytic infections, and PEL is a B-cell lymphoma that is predominantly latently infected by KSHV. Inhibiting FoxO proteins can induce KSHV lytic replication and result in massive cell death in PEL.
Article
Multidisciplinary Sciences
Chunxiong Zheng, Qingguo Zhong, Ke Yi, Huimin Kong, Fangfang Cao, Chenya Zhuo, Yanteng Xu, Run Shi, Enguo Ju, Wantong Song, Yu Tao, Xiaoyuan Chen, Mingqiang Li
Summary: Equipping multiple functionalities on adoptive effector cells is essential for superior antitumor efficacy in solid tumors. However, current cell engineering technologies cannot achieve this in a single step due to differences in the spatial distributions of targets within a cell. In this study, a core-shell anti-phagocytosis-blocking repolarization-resistant membrane-fusogenic liposome (ARMFUL) is proposed to achieve one-step multiplexing cell engineering. This allows for the customization of multimodal cellular functions, enhancing adoptive cell therapy.
Article
Engineering, Biomedical
Hongyan Wei, Fenfang Li, Tiantian Xue, Haixia Wang, Enguo Ju, Mingqiang Li, Yu Tao
Summary: This study demonstrated that the tetrahedral DNA (TDN) nanoplatform efficiently delivered liver-specific miR122 to human mesenchymal stem cells (hMSCs), inducing their differentiation into functional hepatocyte-like cells (HLCs), suggesting a new approach for cell-based therapy in acute liver failure.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Enguo Ju, Mengran Peng, Yanteng Xu, Yuqin Wang, Feng Zhou, Haixia Wang, Mingqiang Li, Yue Zheng, Yu Tao
Summary: In this study, a microneedle patch loaded with MnO2/Cu2O nanosheets and combretastatin A4 was designed for the enhanced therapy of cutaneous squamous cell carcinoma (cSCC). The patch effectively delivered drugs locally to the tumor sites and the MnO2/Cu2O exhibited both photothermal conversion and glucose oxidase (GOx)-mimicking activity. This work opens up new avenues for constructing multimodal treatment for efficient therapy of skin cancers.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)