Glucolipotoxicity in Pancreatic β-Cells

β-cell mass in people with type 2 diabetes

(2010) Jae-Hyoung Cho et al.   Journal of Diabetes Investigation

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Deletion of GPR40 Impairs Glucose-Induced Insulin Secretion In Vivo in Mice Without Affecting Intracellular Fuel Metabolism in Islets

(2009) T. Alquier et al.   DIABETES

Glucose regulation of islet stress responses and β-cell failure in type 2 diabetes

(2009) J. C. Jonas et al.   DIABETES OBESITY & METABOLISM

Suppression of Peroxisome Proliferator-Activated Receptor γ-Coactivator-1α Normalizes the Glucolipotoxicity-Induced Decreased BETA2/NeuroD Gene Transcription and Improved Glucose Tolerance in Diabetic Rats

(2009) Ji-Won Kim et al.   ENDOCRINOLOGY

Liver X Receptor Agonists Augment Human Islet Function through Activation of Anaplerotic Pathways and Glycerolipid/Free Fatty Acid Cycling

(2009) Takeshi Ogihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Small-Molecule Agonists of G Protein-Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice

(2008) C. P. Tan et al.   DIABETES

Loss of beta-cells with fibrotic islet destruction in type 2 diabetes mellitus

(2008) Ji-Won Kim   Frontiers in Bioscience-Landmark

The islet β-cell: fuel responsive and vulnerable

(2008) Christopher J. Nolan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM