Linking inter-individual variability to endocrine disruptors: insights for epigenetic inheritance

Maternal H3K27me3 controls DNA methylation-independent imprinting

(2017) Azusa Inoue et al.   NATURE

Stable Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila

(2017) Filippo Ciabrelli et al.   NATURE GENETICS

Associating cellular epigenetic models with human phenotypes

(2017) Tuuli Lappalainen et al.   NATURE REVIEWS GENETICS

Germ line–inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition

(2017) Fides Zenk et al.   SCIENCE

Maternal exposure to di(2-ethylhexyl)phthalate (DEHP) promotes the transgenerational inheritance of adult-onset reproductive dysfunctions through the female germline in mice

(2017) Paola Pocar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Scientific principles for the identification of endocrine-disrupting chemicals: a consensus statement

(2016) Roland Solecki et al.   ARCHIVES OF TOXICOLOGY

Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications

(2016) Qi Chen et al.   NATURE REVIEWS GENETICS

Analysis of a four generation family reveals the widespread sequence-dependent maintenance of allelic DNA methylation in somatic and germ cells

(2016) Aifa Tang et al.   Scientific Reports

N6-methyladenine functions as a potential epigenetic mark in eukaryotes

(2015) Qinmiao Sun et al.   BIOESSAYS

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

(2015) Walfred W.C. Tang et al.   CELL

Trithorax and Polycomb group-dependent regulation: a tale of opposing activities

(2015) S. J. Geisler et al.   DEVELOPMENT

Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome

(2015) Jeremy M. Shea et al.   DEVELOPMENTAL CELL

Bisphenol A Exposure Disrupts Metabolic Health Across Multiple Generations in the Mouse

(2015) Martha Susiarjo et al.   ENDOCRINOLOGY

Environmentally induced epigenetic transgenerational inheritance of sperm epimutations promote genetic mutations

(2015) Michael K Skinner et al.   Epigenetics

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

Elusive inheritance: Transgenerational effects and epigenetic inheritance in human environmental disease

(2015) Suzanne N. Martos et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Multigenerational and transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation?

(2015) Frances Xin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression

(2015) Shaun D. McCullough et al.   TOXICOLOGICAL SCIENCES

Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming

(2015) Khursheed Iqbal et al.   GENOME BIOLOGY

Exposure to Endocrine Disruptor Induces Transgenerational Epigenetic Deregulation of MicroRNAs in Primordial Germ Cells

(2015) Miguel A. Brieño-Enríquez et al.   PLoS One

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

Chromatin and Transcription Transitions of Mammalian Adult Germline Stem Cells and Spermatogenesis

(2014) Saher Sue Hammoud et al.   Cell Stem Cell

Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant

(2014) S. Denissov et al.   DEVELOPMENT

Sexually Dimorphic Effects of Ancestral Exposure to Vinclozolin on Stress Reactivity in Rats

(2014) Ross Gillette et al.   ENDOCRINOLOGY

The evidence for functional non-CpG methylation in mammalian cells

(2014) Vibha Patil et al.   Epigenetics

DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos

(2014) D. M. Messerschmidt et al.   GENES & DEVELOPMENT

Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment

(2014) F. Court et al.   GENOME RESEARCH

Distinctions between transgenerational and non-transgenerational epimutations

(2014) John R. McCarrey   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Exposure to diethylhexyl phthalate (DEHP) results in a heritable modification of imprint genes DNA methylation in mouse oocytes

(2014) Lan Li et al.   MOLECULAR BIOLOGY REPORTS

DNA methylation dynamics of the human preimplantation embryo

(2014) Zachary D. Smith et al.   NATURE

The DNA methylation landscape of human early embryos

(2014) Hongshan Guo et al.   NATURE

Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity

(2014) Sébastien A Smallwood et al.   NATURE METHODS

Pesticide Methoxychlor Promotes the Epigenetic Transgenerational Inheritance of Adult-Onset Disease through the Female Germline

(2014) Mohan Manikkam et al.   PLoS One

Soma-to-Germline Transmission of RNA in Mice Xenografted with Human Tumour Cells: Possible Transport by Exosomes

(2014) Cristina Cossetti et al.   PLoS One

H3K27me and PRC2 transmit a memory of repression across generations and during development

(2014) L. J. Gaydos et al.   SCIENCE

F0 maternal BPA exposure induced glucose intolerance of F2 generation through DNA methylation change in Gck

(2014) Gengqi Li et al.   TOXICOLOGY LETTERS

Accounting for cellular heterogeneity is critical in epigenome-wide association studies

(2014) Andrew E Jaffe et al.   GENOME BIOLOGY

Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine

(2013) MVE Veenendaal et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

FGF Signaling Inhibition in ESCs Drives Rapid Genome-wide Demethylation to the Epigenetic Ground State of Pluripotency

(2013) Gabriella Ficz et al.   Cell Stem Cell

Are we ready to consider transgenerational epigenetic effects in human health risk assessment?

(2013) Rebecca A. Alyea et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Transgenerational Inheritance of Increased Fat Depot Size, Stem Cell Reprogramming, and Hepatic Steatosis Elicited by Prenatal Exposure to the Obesogen Tributyltin in Mice

(2013) Raquel Chamorro-García et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A double take on bivalent promoters

(2013) P. Voigt et al.   GENES & DEVELOPMENT

Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa

(2013) Serap Erkek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells

(2013) Deqing Hu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Susceptibility to stress-induced visceral sensitivity: a bad legacy for next generations

(2013) V. Théodorou   NEUROGASTROENTEROLOGY AND MOTILITY

The human placenta methylome

(2013) D. I. Schroeder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vinclozolin—No transgenerational inheritance of anti-androgenic effects after maternal exposure during organogenesis via the intraperitoneal route

(2013) Steffen Schneider et al.   REPRODUCTIVE TOXICOLOGY

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Bridging the transgenerational gap with epigenetic memory

(2013) Jana P. Lim et al.   TRENDS IN GENETICS

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence

(2012) L. Gordon et al.   GENOME RESEARCH

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

A unique regulatory phase of DNA methylation in the early mammalian embryo

(2012) Zachary D. Smith et al.   NATURE

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Transgenerational Actions of Environmental Compounds on Reproductive Disease and Identification of Epigenetic Biomarkers of Ancestral Exposures

(2012) Mohan Manikkam et al.   PLoS One

Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease

(2012) Eric Nilsson et al.   PLoS One

Transgenerational epigenetic inheritance: Focus on soma to germline information transfer

(2012) Abhay Sharma   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers

(2012) Carlos Guerrero-Bosagna et al.   REPRODUCTIVE TOXICOLOGY

Transgenerational defense induction and epigenetic inheritance in plants

(2012) Liza M. Holeski et al.   TRENDS IN ECOLOGY & EVOLUTION

Prenatal famine exposure, health in later life and promoter methylation of four candidate genes

(2012) M. V. Veenendaal et al.   Journal of Developmental Origins of Health and Disease

Transgenerational Inheritance of an Acquired Small RNA-Based Antiviral Response in C. elegans

(2011) Oded Rechavi et al.   CELL

Expression discordance of monozygotic twins at birth: Effect of intrauterine environment and a possible mechanism for fetal programming

(2011) Lavinia Gordon et al.   Epigenetics

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

(2011) Ryan Lister et al.   NATURE

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

(2011) Gabriella Ficz et al.   NATURE

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

Analysis of DNA Methylation in a Three-Generation Family Reveals Widespread Genetic Influence on Epigenetic Regulation

(2011) Jason Gertz et al.   PLoS Genetics

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

(2010) Laura N. Vandenberg et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome

(2010) R. Shoemaker et al.   GENOME RESEARCH

DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome

(2010) Miina Ollikainen et al.   HUMAN MOLECULAR GENETICS

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa

(2010) Urszula Brykczynska et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetic Transgenerational Actions of Vinclozolin on Promoter Regions of the Sperm Epigenome

(2010) Carlos Guerrero-Bosagna et al.   PLoS One

Specific transgenerational imprinting effects of the endocrine disruptor methoxychlor on male gametes

(2010) Christelle Stouder et al.   REPRODUCTION

A C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory

(2009) David J. Katz et al.   CELL

A Hierarchy of H3K4me3 and H3K27me3 Acquisition in Spatial Gene Regulation in Xenopus Embryos

(2009) Robert C. Akkers et al.   DEVELOPMENTAL CELL

The hologenome theory of evolution contains Lamarckian aspects within a Darwinian framework

(2009) Eugene Rosenberg et al.   ENVIRONMENTAL MICROBIOLOGY

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Distinctive chromatin in human sperm packages genes for embryo development

(2009) Saher Sue Hammoud et al.   NATURE

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm

(2009) Christelle Stouder et al.   REPRODUCTION

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Maternal exposure to anti-androgenic compounds, vinclozolin, flutamide and procymidone, has no effects on spermatogenesis and DNA methylation in male rats of subsequent generations

(2009) Kunifumi Inawaka et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Non-imprinted allele-specific DNA methylation on human autosomes

(2009) Yingying Zhang et al.   GENOME BIOLOGY

Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

(2008) RC Painter et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Hsp90 Affecting Chromatin Remodeling Might Explain Transgenerational Epigenetic Inheritance in Drosophila

(2008) Douglas Ruden et al.   CURRENT GENOMICS

Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation

(2008) Kristi Kerkel et al.   NATURE GENETICS

Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping

(2008) Christoph Bock et al.   NUCLEIC ACIDS RESEARCH

Transgenerational Epigenetic Programming of the Brain Transcriptome and Anxiety Behavior

(2008) Michael K. Skinner et al.   PLoS One

Transgenerational effects of the endocrine disruptor vinclozolin on the prostate transcriptome and adult onset disease

(2008) Matthew D. Anway et al.   PROSTATE

Vinclozolin—The lack of a transgenerational effect after oral maternal exposure during organogenesis

(2008) S SCHNEIDER et al.   REPRODUCTIVE TOXICOLOGY

Transgenerational epigenetic programming of the embryonic testis transcriptome

(2007) Matthew D. Anway et al.   GENOMICS