Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria

Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria

(2017) Rosauro Varo et al.   MALARIA JOURNAL

Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria

(2017) E. Shabani et al.   PARASITE IMMUNOLOGY

A quantitative brain map of experimental cerebral malaria pathology

(2017) Patrick Strangward et al.   PLoS Pathogens

Magnetic Resonance Imaging of Cerebral Malaria Patients Reveals Distinct Pathogenetic Processes in Different Parts of the Brain

(2017) Sanjib Mohanty et al.   mSphere

Immunity to malaria in an era of declining malaria transmission

(2016) FREYA J. I. FOWKES et al.   PARASITOLOGY

Long-term Behavioral Problems in Children With Severe Malaria

(2016) John Mbaziira Ssenkusu et al.   PEDIATRICS

Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria

(2016) Sarah J. Higgins et al.   Science Translational Medicine

Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial

(2015) Michael T. Hawkes et al.   MALARIA JOURNAL

Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case–control study of Ugandan children

(2015) Robyn E. Elphinstone et al.   MALARIA JOURNAL

Brain Swelling and Death in Children with Cerebral Malaria

(2015) Karl B. Seydel et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury

(2015) Yonas Getachew et al.   TOXICOLOGICAL SCIENCES

Interferon-γ: The Jekyll and Hyde of Malaria

(2015) Thayer King et al.   PLoS Pathogens

Estimates of the changing age-burden of Plasmodium falciparum malaria disease in sub-Saharan Africa

(2014) Jamie T. Griffin et al.   Nature Communications

PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria

(2014) Lena Serghides et al.   PLoS Pathogens

Malaria biology and disease pathogenesis: insights for new treatments

(2013) Louis H Miller et al.   NATURE MEDICINE

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Piecing Together the Puzzle of Severe Malaria

(2013) A. J. Cunnington et al.   Science Translational Medicine

The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

(2013) Emilia Kansanen et al.   Redox Biology

A Phase I First-in-Human Trial of Bardoxolone Methyl in Patients with Advanced Solid Tumors and Lymphomas

(2012) D. S. Hong et al.   CLINICAL CANCER RESEARCH

Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children

(2012) Guicheng Zhang et al.   INFECTION AND IMMUNITY

Oxidative Stress in Malaria

(2012) Sandro Percário et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Triterpenoids

(2012) Robert A. Hill et al.   NATURAL PRODUCT REPORTS

Changing Malaria Epidemiology and Diagnostic Criteria for Plasmodium falciparum Clinical Malaria

(2012) Clémentine Roucher et al.   PLoS One

Neuroimmunological Blood Brain Barrier Opening in Experimental Cerebral Malaria

(2012) Adela Nacer et al.   PLoS Pathogens

The Neuropathology of Fatal Cerebral Malaria in Malawian Children

(2011) Katerina Dorovini-Zis et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

(2011) Arie Neymotin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Interleukin-10 in Malaria: Focusing on Coinfection with Lethal and Nonlethal Murine Malaria Parasites

(2011) Mamoru Niikura et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress

(2011) Michael B. Sporn et al.   JOURNAL OF NATURAL PRODUCTS

The 'hidden' burden of malaria: cognitive impairment following infection

(2011) Sumadhya D Fernando et al.   MALARIA JOURNAL

Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India

(2011) Vidhan Jain et al.   MALARIA JOURNAL

Combinations of Host Biomarkers Predict Mortality among Ugandan Children with Severe Malaria: A Retrospective Case-Control Study

(2011) Laura K. Erdman et al.   PLoS One

Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer

(2010) S. Nagaraj et al.   CLINICAL CANCER RESEARCH

Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease

(2010) Cliona Stack et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transcriptional Regulation of Renal Cytoprotective Genes by Nrf2 and Its Potential Use as a Therapeutic Target to Mitigate Cisplatin-Induced Nephrotoxicity

(2010) L. M. Aleksunes et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

(2010) Arjen M Dondorp et al.   LANCET

Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study

(2010) Gretchen L Birbeck et al.   LANCET NEUROLOGY

A Rapid Murine Coma and Behavior Scale for Quantitative Assessment of Murine Cerebral Malaria

(2010) Ryan W. Carroll et al.   PLoS One

Murine cerebral malaria: the whole story

(2010) Nicholas H. Hunt et al.   TRENDS IN PARASITOLOGY

Use of Peroxisome Proliferator‐Activated Receptor γ Agonists as Adjunctive Treatment forPlasmodium falciparumMalaria: A Randomized, Double‐Blind, Placebo‐Controlled Trial

(2009) Andrea K. Boggild et al.   CLINICAL INFECTIOUS DISEASES

Rosiglitazone Modulates the Innate Immune Response toPlasmodium falciparumInfection and Improves Outcome in Experimental Cerebral Malaria

(2009) Lena Serghides et al.   JOURNAL OF INFECTIOUS DISEASES

Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   JOURNAL OF NEUROCHEMISTRY

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease

(2009) J. BRIAN de SOUZA et al.   PARASITOLOGY

Serum Angiopoietin-1 and -2 Levels Discriminate Cerebral Malaria from Uncomplicated Malaria and Predict Clinical Outcome in African Children

(2009) Fiona E. Lovegrove et al.   PLoS One

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

(2009) Lichuan Yang et al.   PLoS One

Cerebral Malaria in Children Is Associated With Long-term Cognitive Impairment

(2008) C. C. John et al.   PEDIATRICS