A Smart Nano-Prodrug Platform with Reactive Drug Loading, Superb Stability, and Fast Responsive Drug Release for Targeted Cancer Therapy

Treatment of Malignant Brain Tumor by Tumor-Triggered Programmed Wormlike Micelles with Precise Targeting and Deep Penetration

(2016) Lijuan Zeng et al.   ADVANCED FUNCTIONAL MATERIALS

Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy

(2016) Ping Zhong et al.   BIOMACROMOLECULES

Melanoma Cells Block PEDF Production in Fibroblasts to Induce the Tumor-Promoting Phenotype of Cancer-Associated Fibroblasts

(2016) Nkechiyere G. Nwani et al.   CANCER RESEARCH

Redox-Hypersensitive Organic Nanoparticles for Selective Treatment of Cancer Cells

(2016) Wei Zhang et al.   CHEMISTRY OF MATERIALS

cRGD-functionalized reduction-sensitive shell-sheddable biodegradable micelles mediate enhanced doxorubicin delivery to human glioma xenografts in vivo

(2016) Yaqin Zhu et al.   JOURNAL OF CONTROLLED RELEASE

Robust, tumor-homing and redox-sensitive polymersomal doxorubicin: A superior alternative to Doxil and Caelyx?

(2016) Yan Zou et al.   JOURNAL OF CONTROLLED RELEASE

Self-crosslinkable and intracellularly decrosslinkable biodegradable micellar nanoparticles: A robust, simple and multifunctional nanoplatform for high-efficiency targeted cancer chemotherapy

(2016) Yan Zou et al.   JOURNAL OF CONTROLLED RELEASE

Emerging Frontiers in Drug Delivery

(2016) Mark W. Tibbitt et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oligo(lactic acid)n-Paclitaxel Prodrugs for Poly(ethylene glycol)-block-poly(lactic acid) Micelles: Loading, Release, and Backbiting Conversion for Anticancer Activity

(2016) Yu Tong Tam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Building nanostructures with drugs

(2016) Wang Ma et al.   Nano Today

Erratum: Corrigendum: Recent advances in the construction of antibody–drug conjugates

(2016) Vijay Chudasama et al.   Nature Chemistry

RGD-decorated redox-responsive d-α-tocopherol polyethylene glycol succinate–poly(lactide) nanoparticles for targeted drug delivery

(2016) Yuanyuan Guo et al.   Journal of Materials Chemistry B

Facile Generation of Tumor-pH-Labile Linkage-Bridged Block Copolymers for Chemotherapeutic Delivery

(2015) Chun-Yang Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Supramolecular Nanoparticles Constructed by DOX-Based Prodrug with Water-Soluble Pillar[6]arene for Self-Catalyzed Rapid Drug Release

(2015) Yu Cao et al.   CHEMISTRY OF MATERIALS

Temperature-Sensitive Polymersomes for Controlled Delivery of Anticancer Drugs

(2015) Fei Liu et al.   CHEMISTRY OF MATERIALS

Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+ human breast tumor xenografts

(2015) Yinan Zhong et al.   JOURNAL OF CONTROLLED RELEASE

Tumor-Targeting Co-Delivery of Drug and Gene from Temperature-Triggered Micelles

(2015) Seog-Jin Seo et al.   MACROMOLECULAR BIOSCIENCE

Targeted PRINT Hydrogels: The Role of Nanoparticle Size and Ligand Density on Cell Association, Biodistribution, and Tumor Accumulation

(2015) Kevin G. Reuter et al.   NANO LETTERS

Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation

(2015) Marina Talelli et al.   Nano Today

Redox-responsive cellulose-based thermoresponsive grafted copolymers and in-situ disulfide crosslinked nanogels

(2015) Kaiwan Rahimian et al.   POLYMER

Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer

(2015) Caina Xu et al.   Small

Investigating the Impact of Nanoparticle Size on Active and Passive Tumor Targeting Efficiency

(2014) Edward A. Sykes et al.   ACS Nano

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ring-Opening Polymerization of Prodrugs: A Versatile Approach to Prepare Well-Defined Drug-Loaded Nanoparticles

(2014) Jinyao Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy

(2014) Yinan Zhong et al.   BIOMACROMOLECULES

Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin

(2014) Mingqiang Li et al.   BIOMATERIALS

An overview of clinical and commercial impact of drug delivery systems

(2014) Aaron C. Anselmo et al.   JOURNAL OF CONTROLLED RELEASE

Progress of drug-loaded polymeric micelles into clinical studies

(2014) Horacio Cabral et al.   JOURNAL OF CONTROLLED RELEASE

Targeted Theranostic Platinum(IV) Prodrug with a Built-In Aggregation-Induced Emission Light-Up Apoptosis Sensor for Noninvasive Early Evaluation of Its Therapeutic Responses in Situ

(2014) Youyong Yuan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polymer Micro- and Nanocapsules as Biological Carriers with Multifunctional Properties

(2014) Anna Musyanovych et al.   MACROMOLECULAR BIOSCIENCE

Dual Redox and Thermoresponsive Double Hydrophilic Block Copolymers with Tunable Thermoresponsive Properties and Self-Assembly Behavior

(2014) Nicky Chan et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Passive versus Active Tumor Targeting Using RGD- and NGR-Modified Polymeric Nanomedicines

(2014) Sijumon Kunjachan et al.   NANO LETTERS

Cyclic RGD targeting nanoparticles with pH sensitive polymer–drug conjugates for effective treatment of melanoma

(2014) Xingang Guan et al.   RSC Advances

Cyclic RGD-Linked Polymeric Micelles for Targeted Delivery of Platinum Anticancer Drugs to Glioblastoma through the Blood–Brain Tumor Barrier

(2013) Yutaka Miura et al.   ACS Nano

Patient-reported outcomes from EMILIA, a randomized phase 3 study of trastuzumab emtansine (T-DM1) versus capecitabine and lapatinib in human epidermal growth factor receptor 2-positive locally advanced or metastatic breast cancer

(2013) Manfred Welslau et al.   CANCER

A facile approach for dual-responsive prodrug nanogels based on dendritic polyglycerols with minimal leaching

(2013) Xuejiao Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Supramolecular Nanostructures Formed by Anticancer Drug Assembly

(2013) Andrew G. Cheetham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diphenyl Phosphate as an Efficient Acidic Organocatalyst for Controlled/Living Ring-Opening Polymerization of Trimethylene Carbonates Leading to Block, End-Functionalized, and Macrocyclic Polycarbonates

(2013) Kosuke Makiguchi et al.   MACROMOLECULES

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

NIR Photoresponsive Crosslinked Upconverting Nanocarriers Toward Selective Intracellular Drug Release

(2013) Yanmei Yang et al.   Small

Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability

(2013) Kirsten Achilles Poon et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Well-Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values andcis-Diols

(2012) Yuanpei Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody–drug conjugate in development for the treatment of HER2-positive cancer

(2012) Sandhya Girish et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

(2012) Nazila Kamaly et al.   CHEMICAL SOCIETY REVIEWS

Design of polymeric nanoparticles for biomedical delivery applications

(2012) Mahmoud Elsabahy et al.   CHEMICAL SOCIETY REVIEWS

Biodegradable polymeric micelles for targeted and controlled anticancer drug delivery: Promises, progress and prospects

(2012) Chao Deng et al.   Nano Today

Design of Multifunctional Micelle for Tumor-Targeted Intracellular Drug Release and Fluorescent Imaging

(2011) Weiwei Wang et al.   ADVANCED MATERIALS

Decoration of polymeric micelles with cancer-specific peptide ligands for active targeting of paclitaxel

(2011) Mostafa Shahin et al.   BIOMATERIALS

RGD-based active targeting of novel polycation liposomes bearing siRNA for cancer treatment

(2011) Norihito Yonenaga et al.   JOURNAL OF CONTROLLED RELEASE

Cyclic RGD conjugated poly(ethylene glycol)-co-poly(lactic acid) micelle enhances paclitaxel anti-glioblastoma effect

(2010) Changyou Zhan et al.   JOURNAL OF CONTROLLED RELEASE

Organocatalysis: Opportunities and Challenges for Polymer Synthesis

(2010) Matthew K. Kiesewetter et al.   MACROMOLECULES

Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells

(2009) Yu-Ling Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin

(2009) Huanli Sun et al.   BIOMATERIALS

Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection

(2009) J. Andrew MacKay et al.   NATURE MATERIALS

Polymer-drug conjugates: Recent development in clinical oncology

(2008) Chun Li et al.   ADVANCED DRUG DELIVERY REVIEWS

Degradable Disulfide Core-Cross-Linked Micelles as a Drug Delivery System Prepared from Vinyl Functionalized Nucleosides via the RAFT Process

(2008) Ling Zhang et al.   BIOMACROMOLECULES

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY