Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 35, Issue 7, Pages 752-757Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201300852
Keywords
atom transfer radical polymerization; double hydrophilic block copolymer; LCST; self-assembly; thiol-disulfide degradation
Categories
Funding
- NSERC
- Canada Research Chair (CRC) Award
- NSERC Undergraduate Summer Research Award (USRA)
- FQRNT
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The synthesis, tunable thermoresponsive properties, and self-assembly of dual redox and thermoresponsive double hydrophilic block copolymers having pendant disulfide linkages (DHBCss) are reported. Well-defined DHBCss composed of a hydrophilic poly(ethylene oxide) block and a dual thermo- and reduction-responsive random copolymer block containing pendant disulfide linkages are synthesized by atom transfer radical polymerization. Their lower critical solution temperature (LCST) transitions are adjusted through modulating pendant hydrophobic-hydrophilic balance with disulfide-thiol-sulfide chemistry. Further, these DHBCss derivatives are converted to disulfide-crosslinked nanogels at temperatures above LCST through temperature-driven self-assembly and in situ disulfide crosslinking. They exhibit enhanced colloidal stability and further reduction-responsive degradability, thus demonstrating versatility of dual thermo- and reduction-responsive smart materials. image
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