Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life

(2017) Pernille Foged Jensen et al.   MOLECULAR & CELLULAR PROTEOMICS

Impact of Antigen Density on the Binding Mechanism of IgG Antibodies

(2017) Maya Hadzhieva et al.   Scientific Reports

Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions

(2016) Erika M. Cook et al.   JOURNAL OF IMMUNOLOGY

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

(2016) Lindsay B. Avery et al.   mAbs

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

(2015) Amita Datta-Mannan et al.   mAbs

Pharmacokinetic properties of IgG and various Fc fusion proteins in mice

(2015) Felix Unverdorben et al.   mAbs

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity

(2015) Yasmina Noubia Abdiche et al.   mAbs

Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics

(2015) Angela Schoch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In-depth analysis of subclass-specific conformational preferences of IgG antibodies

(2015) Xinsheng Tian et al.   IUCrJ

The Fab Conformations in the Solution Structure of Human Immunoglobulin G4 (IgG4) Restrict Access to Its Fc Region

(2014) Lucy E. Rayner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling

(2014) M. Jack Borrok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge

(2014) Bing Li et al.   mAbs

Investigating the Interaction between the Neonatal Fc Receptor and Monoclonal Antibody Variants by Hydrogen/Deuterium Exchange Mass Spectrometry

(2014) Pernille Foged Jensen et al.   MOLECULAR & CELLULAR PROTEOMICS

One Mouse, One Pharmacokinetic Profile: Quantitative Whole Blood Serial Sampling for Biotherapeutics

(2014) Alison P. Joyce et al.   PHARMACEUTICAL RESEARCH

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

(2013) Tilman Schlothauer et al.   mAbs

Are endosomal trafficking parameters better targets for improving mAb pharmacokinetics than FcRn binding affinity?

(2013) Brian Gurbaxani et al.   MOLECULAR IMMUNOLOGY

Embryo-Fetal Transfer of Bevacizumab (Avastin) in the Rat Over the Course of Gestation and the Impact of Neonatal Fc Receptor (FcRn) Binding

(2012) Mitchell Thorn et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences

(2011) W. Wang et al.   DRUG METABOLISM AND DISPOSITION

Whole-Molecule Antibody Engineering: Generation of a High-Affinity Anti-IL-6 Antibody with Extended Pharmacokinetics

(2011) Donna K. Finch et al.   JOURNAL OF MOLECULAR BIOLOGY

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4

(2011) Daniela Bumbaca et al.   mAbs

A Therapeutic Anti-VEGF Antibody with Increased Potency Independent of Pharmacokinetic Half-life

(2010) Y. A. Yeung et al.   CANCER RESEARCH

Importance of Neonatal FcR in Regulating the Serum Half-Life of Therapeutic Proteins Containing the Fc Domain of Human IgG1: A Comparative Study of the Affinity of Monoclonal Antibodies and Fc-Fusion Proteins to Human Neonatal FcR

(2010) Takuo Suzuki et al.   JOURNAL OF IMMUNOLOGY

Enhanced antibody half-life improves in vivo activity

(2010) Jonathan Zalevsky et al.   NATURE BIOTECHNOLOGY

Reduced elimination of IgG antibodies by engineering the variable region

(2010) T. Igawa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Intrachain disulfide bond in the core hinge region of human IgG4

(2010) James W. Bloom et al.   PROTEIN SCIENCE

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Survey of the year 2007 commercial optical biosensor literature

(2008) Rebecca L. Rich et al.   JOURNAL OF MOLECULAR RECOGNITION