Impact of S-sulfocysteine on fragments and trisulfide bond linkages in monoclonal antibodies

S-Sulfocysteine simplifies fed-batch processes and increases the CHO specific productivity via anti-oxidant activity

(2016) Caroline Hecklau et al.   JOURNAL OF BIOTECHNOLOGY

A high-throughput hydrophilic interaction liquid chromatography coupled with a charged aerosol detector method to assess trisulfides in IgG1 monoclonal antibodies using tris(2-carboxyethyl)phosphine reaction products: Tris(2-carboxyethyl)phosphine-oxide and tris(2-carboxyethyl)phosphine-sulfide

(2016) Christopher Cornell et al.   JOURNAL OF CHROMATOGRAPHY A

Factors that determine stability of highly concentrated chemically defined production media

(2015) Rebecca E. McCoy et al.   BIOTECHNOLOGY PROGRESS

Trisulfide Modification Impacts the Reduction Step in Antibody–Drug Conjugation Process

(2013) Katherine Cumnock et al.   BIOCONJUGATE CHEMISTRY

Controlling trisulfide modification in recombinant monoclonal antibody produced in fed-batch cell culture

(2012) Rashmi Kshirsagar et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quality attributes of recombinant therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach

(2012) Alex Eon-Duval et al.   BIOTECHNOLOGY PROGRESS

Reexamination of the Role of Interplay between Glutathione and Protein Disulfide Isomerase

(2011) Anna-Kaisa Lappi et al.   JOURNAL OF MOLECULAR BIOLOGY

Hydrogen sulfide: its production, release and functions

(2010) Hideo Kimura   AMINO ACIDS

Characterization of trisulfide modification in antibodies

(2010) Sheng Gu et al.   ANALYTICAL BIOCHEMISTRY

Effect of inducible co-overexpression of protein disulfide isomerase and endoplasmic reticulum oxidoreductase on the specific antibody productivity of recombinant Chinese hamster ovary cells

(2010) Chaya Mohan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Evidence for Trisulfide Bonds in a Recombinant Variant of a Human IgG2 Monoclonal Antibody

(2009) Pavlo Pristatsky et al.   ANALYTICAL CHEMISTRY