Low copy numbers of complement C4 and homozygous deficiency of C4A may predispose to severe disease and earlier disease onset in patients with systemic lupus erythematosus

A comprehensive evaluation for the treatment of lupus nephritis

(2017) Evangelia Zampeli et al.   JOURNAL OF AUTOIMMUNITY

GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region

(2014) D L Armstrong et al.   GENES AND IMMUNITY

Investigation of Complement Component C4 Copy Number Variation in Human Longevity

(2014) Friederike Flachsbart et al.   PLoS One

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner

(2013) Priyadarshini Chatterjee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Genetically Determined Partial Complement C4 Deficiency States Are Not Independent Risk Factors for SLE in UK and Spanish Populations

(2012) Lora Boteva et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Linking complement and anti-dsDNA antibodies in the pathogenesis of systemic lupus erythematosus

(2012) Brendan M. Giles et al.   IMMUNOLOGIC RESEARCH

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

HLA-DR1001 presents “altered-self” peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets

(2010) Eddie A. James et al.   ARTHRITIS AND RHEUMATISM

Effects of C4 null alleles and homoduplications on quantitative expression of C4A and C4B

(2010) A. HAMMOND et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Current advances in lupus genetic and genomic studies in Asia

(2010) YJ Yuan et al.   LUPUS

Genetic susceptibility to systemic lupus erythematosus in the genomic era

(2010) Yun Deng et al.   Nature Reviews Rheumatology

Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells

(2009) B. Gullstrand et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Genetic studies of systemic lupus erythematosus in Asia: where are we now?

(2009) I Kim et al.   GENES AND IMMUNITY

Molecular basis of complete complement C4 deficiency in two North-African families with systemic lupus erythematosus

(2009) Y L Wu et al.   GENES AND IMMUNITY

Great genotypic and phenotypic diversities associated with copy-number variations of complement C4 and RP-C4-CYP21-TNX (RCCX) modules: A comparison of Asian-Indian and European American populations

(2009) Kapil Saxena et al.   MOLECULAR IMMUNOLOGY

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

(2008) Michelle M. A. Fernando et al.   PLoS Genetics