Article
Pharmacology & Pharmacy
Cheng Zhang, Xuewen Wu, Pengmin Shi, Hongyu Ma, Fei Fang, Qianlang Feng, Shuang Zhao, Ruipu Zhang, Jinyuan Huang, Xinting Xu, Weilie Xiao, Guang Cao, Xu Ji
Summary: In this study, it was found that diterpenoids from the traditional Chinese medicine Callicarpa rubella could effectively inhibit oxidized low-density lipoprotein-induced macrophage foam cell formation by promoting cholesterol efflux, suggesting their potential as drugs for the treatment of atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Meng Du, Liu Yang, Bing Liu, Liuye Yang, Xiaoxiang Mao, Minglu Liang, Kai Huang
Summary: NFAT has been identified as a key regulator in foam cell formation, where NFAT activation leads to inhibition of PPARγ and subsequent reduction of cholesterol uptake, thereby preventing the development of atherosclerosis. Targeting NFAT may offer a potential therapeutic strategy in cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Xiaoqing Guo, Bowei Li, Cheng Wen, Feng Zhang, Xuying Xiang, Lei Nie, Jiaojiao Chen, Ling Mao
Summary: Disordered lipid accumulation in the arterial wall is a hallmark of atherosclerosis. This study investigated the role of triggering receptor expressed on myeloid cells 2 (TREM2) in atherosclerosis using animal models and cell cultures. The results showed that TREM2 promotes the development of atherosclerosis by promoting foam cell formation in vascular smooth muscle cells and macrophages through regulating the expression of the scavenger receptor CD36. These findings suggest that TREM2 may be a potential therapeutic target for the treatment of atherosclerosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Neurosciences
Jacob C. Zbesko, Jessica Stokes, Danielle A. Becktel, Kristian P. Doyle
Summary: Inflammation plays a dual role in the healing process after ischemic stroke, being necessary for tissue homeostasis restoration but also detrimental to neurodegeneration and regeneration. Myeloid cells with a foamy appearance are major immune cells in chronic stroke infarcts, formed due to overwhelmed mechanisms of myelin lipid clearance. Targeting lipid accumulation in these foam cells may be a promising strategy for improving recovery. This review aims to provide an overview of inflammation and foam cell formation in the brain following ischemic stroke and identify potential therapeutic targets.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Fen Gao, Rui Bai, Weiwei Qin, Bin Liang, Zhiming Yang, Huiyu Yang
Summary: Periostin plays a key role in enhancing macrophage foam cell formation induced by Ang II, by suppressing cholesterol efflux, and its expression is regulated by oxLDL and Twist2-mediated transactivation. In patients with atherosclerosis, there is a significant positive correlation between serum periostin and Ang II levels.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Plant Sciences
YuShan Tian, Shanquan Chang, Juntao Xu, Puyang Gong, BoYang Yu, Jin Qi
Summary: Ophiopogonis Radix extract significantly inhibits macrophage foam cell formation and increases antioxidant capacity in macrophage cells. Through the specific active components methylophiopogonanone A and methylophiopogonanone B, Ophiopogonis Radix effectively prevents the development of atherosclerosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sara Franceschelli, Federica De Cecco, Mirko Pesce, Patrizio Ripari, Maria Teresa Guagnano, Arturo Bravo Nuevo, Alfredo Grilli, Silvia Sancilio, Lorenza Speranza
Summary: This study aimed to investigate whether hydroxytyrosol (HT), a phenolic compound with anti-inflammatory and antioxidant properties, can reduce cholesterol accumulation in foam cells derived from THP-1 macrophages, and to explore the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yan Liu, Yan Sun, Xuze Lin, Dai Zhang, Chengping Hu, Jinxing Liu, Yong Zhu, Ang Gao, Hongya Han, Meng Chai, Jianwei Zhang, Yujie Zhou, Yingxin Zhao
Summary: The study demonstrates that PVAT-derived exosomes (EXOs) reduce macrophage foam cell formation by regulating the expression of cholesterol transport proteins, highlighting a novel mechanism by which PVAT protects the vasculature from atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Food Science & Technology
Xue-Lian Chen, Pu-Lin Liang, Ming-Jiong Gong, Ya Xu, Liang Zhang, Xiao-Hui Qiu, Jing Zhang, Zhi-Hai Huang, Wen Xu
Summary: The polyphenol extraction from Syzygium brachythyrsum showed a protective effect in inhibiting foam cell formation and reducing inflammation response, potentially through regulating the expression of related proteins.
Article
Hematology
Joshua A. Dubland, Sima Allahverdian, Katrina J. Besler, Carleena Ortega, Ying Wang, Collin S. Pryma, Kamel Boukais, Teddy Chan, Michael A. Seidman, Gordon A. Francis
Summary: The study found that the inherently low level of LAL in SMCs compared with macrophages is associated with reduced capacity to catabolize atherogenic lipoproteins, which is a mechanism for SMC foam cell formation in atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Microbiology
Yanchen Guo, Yang Chen, Qiumei Wang, Zhiyuan Wang, Lang Gong, Yankuo Sun, Zebu Song, Hao Chang, Guihong Zhang, Heng Wang
Summary: African swine fever (ASF) is a highly contagious disease caused by African swine fever virus (ASFV), which has significant impacts on the domestic pig industry and the global agricultural economy. This study discovered that emodin (EM) and rhapontigenin (RHAG) extracted from Polygonum knotweed can inhibit ASFV replication in porcine alveolar macrophages (PAMs) in a dose-dependent manner. They not only affect virion attachment and internalization, but also inhibit early stages of viral replication.
VETERINARY MICROBIOLOGY
(2023)
Article
Toxicology
Haiyi Yu, Liting Xu, Tenglong Cui, Yu Wang, Baoqiang Wang, Ze Zhang, Ruijun Su, Jingxu Zhang, Rong Zhang, Yanhong Wei, Daochuan Li, Xiaoting Jin, Wen Chen, Yuxin Zheng
Summary: Fine particulate matter (PM) is a major environmental factor contributing to the development of atherosclerosis. This study found that exposure to PM promoted the formation of foam cells, a crucial pathological process in atherosclerosis. Additionally, magnetite nanoparticles were identified as a key toxic component of PM in facilitating foam cell formation.
TOXICOLOGICAL SCIENCES
(2022)
Article
Hematology
Kaori Endo-Umeda, Eunyoung Kim, David G. Thomas, Wenli Liu, Huijuan Dou, Mustafa Yalcinkaya, Sandra Abramowicz, Tong Xiao, Per Antonson, Jan-Ake Gustafsson, Makoto Makishima, Muredach P. Reilly, Nan Wang, Alan R. Tall
Summary: Our study reveals the crucial role of macrophage LXRs in promoting the Trem2 gene expression program and suppressing inflammation in foam cells of atherosclerotic plaques.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Oncology
Yan Qian, Li Xia, Lai Wei, Weiwei Jiang
Summary: The study demonstrated that ART attenuated foam cell formation in ox-LDL-induced macrophages by increasing ABCA1 and ABCG1 expression, reducing cholesterol accumulation, and decreasing the secretion of IL-6 and TNF-alpha. These findings suggest that ART may be a potential drug for treating atherosclerosis by modulating cholesterol metabolism and inflammation levels.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yuze Zhang, Huihui Li, Yonghu Huang, Hong Chen, Haojie Rao, Guoli Yang, Qing Wan, Zekun Peng, John Bertin, Brad Geddes, Michael Reilly, Jean-Luc Tran, Miao Wang
Summary: RIPK1 plays a stage-dependent regulatory role in the development of atherosclerosis, with both pro-atherosclerotic effects and anti-atherosclerotic effects. It is important to consider the impact at different stages during the treatment process.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Immunology
Xiaoyan Xu, Lei Han, Guixian Zhao, Shengjie Xue, Yunzhen Gao, Jun Xiao, Shicheng Zhang, Peng Chen, Zhi-ying Wu, Jianping Ding, Ronggui Hu, Bin Wei, Hongyan Wang
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Chen Zhong, Rongfen Huo, Kuan Hu, Jinlong Shen, Dangsheng Li, Ningli Li, Jianping Ding
JOURNAL OF MOLECULAR RECOGNITION
(2017)
Article
Chemistry, Multidisciplinary
Chao Cheng, Tianlong Zhang, Chunxi Wang, Wenxian Lan, Jianping Ding, Chunyang Cao
CHINESE JOURNAL OF CHEMISTRY
(2018)
Letter
Cell Biology
Hanwen Zhu, Tianlong Zhang, Fang Wang, Jun Yang, Jianping Ding
Article
Multidisciplinary Sciences
Tianlong Zhang, Marie-Pierre Peli-Gulli, Zhen Zhang, Xin Tang, Jie Ye, Claudio De Virgilio, Jianping Ding
Article
Cell Biology
Wenjing Li, Yu Shi, Tianlong Zhang, Jie Ye, Jianping Ding
Article
Biochemistry & Molecular Biology
Pengkai Sun, Tengfei Ma, Tianlong Zhang, Hanwen Zhu, Jianyang Zhang, Yabing Liu, Jianping Ding
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Cell Biology
Pengkai Sun, Yan Liu, Tengfei Ma, Jianping Ding
Article
Cell Biology
Jun Yang, Hanwen Zhu, Tianlong Zhang, Jianping Ding
Summary: The study presents the crystal structures of D-2-hydroxyglutarate dehydrogenase (D-2-HGDH) and analyzes its substrate specificity and catalytic reaction at a molecular level. Insights into the pathogenicity of disease-associated mutations are provided through structural and biochemical data.
Article
Multidisciplinary Sciences
Wenjing Li, Tianlong Zhang, Mingliang Sun, Yu Shi, Xiao-Jie Zhang, Guo-Liang Xu, Jianping Ding
Summary: This study elucidates the molecular mechanism of CMD1-catalyzed C-5-glyceryl-methylcytosine (5gmC) DNA modification. CMD1 exhibits high binding affinities for DNA and moderate substrate preference for DNA containing 5mCpG.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yifan Zhang, Ziyue Chen, Fang Wang, Honghua Sun, Xueliang Zhu, Jianping Ding, Tianlong Zhang
Summary: This study demonstrates that Rab9 utilizes Nde1 as an effector to interact with the dynein motor complex, thereby tethering the late endosomes to the dynein motor for their retrograde transport to the TGN.
Article
Multidisciplinary Sciences
Xin Tang, Yifan Zhang, Guanchao Wang, Chunxiao Zhang, Fang Wang, Jiawen Shi, Tianlong Zhang, Jianping Ding
Summary: The mTORC1 complex is a central regulator of cell growth and metabolism, and SAMTOR functions as a sensor for S-adenosylmethionine (SAM) to regulate mTORC1 activity. In this study, the crystal structures of SAMTOR in its apo form and bound to SAM were determined, revealing the mechanism of SAM sensing and its functional role in mTORC1 signaling.
Article
Biochemistry & Molecular Biology
Guanchao Wang, Xueqian Feng, Jianping Ding
Summary: In this study, the T95R mutation in the IRF4 gene was found to enhance the binding affinity and specificity of the IRF4 protein to DNA, with the highest preference for the noncanonical DNA sequence GATA.
Letter
Cell Biology
Yu Shi, Hui Yang, Jianping Ding
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Letter
Cell Biology
Xueyan Ma, Peixue Li, Peihao Chen, Jinhui Li, Hongling Huang, Chao Wang, Wenjing Li, Jianping Ding, Yun Zhao, Fa-Xing Yu, Xiangbing Qi, Lei Zhang
JOURNAL OF MOLECULAR CELL BIOLOGY
(2018)