Article
Biochemistry & Molecular Biology
Jea Woo Kang, Angela M. Zivkovic
Summary: Eggs are a nutrient-dense food with high-quality protein and micronutrients, but controversies exist over whether they are contraindicated for individuals at risk for cardiovascular disease due to their cholesterol and choline content. The impact of egg cholesterol and choline on plasma concentrations, as well as the complex relationship with gut microbiome, play a significant role in determining the effects of egg intake on individual health. Further clinical studies are needed to identify individuals for whom egg intake may be contraindicated for heart health and those for whom it poses no negative effects on plasma lipid profiles and TMAO concentrations.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Genki Kobayashi, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study investigated the association between LDL cholesterol, HDL cholesterol, and LDL/HDL ratio and the incidence of diabetes, and identified the cut-off values for incident diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Giovanna Revilla, Lidia Cedo, Mireia Tondo, Antonio Moral, Jose Ignacio Perez, Rosa Corcoy, Enrique Lerma, Victoria Fuste, T. Srivinasa Reddy, Francisco Blanco-Vaca, Eugenia Mato, Joan Carles Escola
Summary: Cholesterol is crucial for various functions in endocrine-related cells, including hormone and steroid production. While LDL-cholesterol and HDL-cholesterol were not consistently associated with endocrine-related cancer risk, LDL receptor plays a critical role in endocrine-related tumor cells by enhancing circulating LDL-C uptake.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Environmental Sciences
Eleni Papadopoulou, Alina Nicolescu, Line S. Haug, Trine Hus, Calin Deleanu, Hubert Dirven, Birgitte Lindeman
Summary: This study explores the association between serum PFAS concentrations and lipoprotein subclasses. After adjusting for confounders, the adjusted models found positive associations between several PFASs and cholesterol concentrations in large to medium sized HDL and medium sized LDL particles. Significant associations were observed between certain PFASs and cholesterol in large to medium LDL particle sizes among women. The study also found that most PFASs tended to be associated with a reduction in VLDL particle number and VLDL triglyceride.
ENVIRONMENTAL POLLUTION
(2022)
Article
Clinical Neurology
Zhirong Yang, Duncan Edwards, Stephen Burgess, Carol Brayne, Jonathan Mant
Summary: This study investigated the potential associations between blood LDL-C, HDL-C, and triglycerides and post-stroke dementia. The results showed that higher LDL-C levels were associated with an increased risk of dementia, while lower triglyceride levels were associated with a decreased risk. There was no association between HDL-C levels and dementia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Jennifer Wilcox, Sarah M. Skye, Brett Graham, Allyson Zabell, Xinmin S. Li, Lin Li, Shamanthika Shelkay, Xiaoming Fu, Sarah Neale, Cathy O'Laughlin, Kimberly Peterson, Stanley L. Hazen, W. H. Wilson Tang
Summary: This study showed that daily consumption of 4 eggs did not significantly increase TMAO or platelet reactivity in healthy participants, despite the high choline content in egg yolks. In contrast, choline bitartrate supplements led to a significant increase in both TMAO levels and platelet reactivity.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Genetics & Heredity
Ana Catarina Alves, Beatriz Miranda, Oana Moldovan, Raquel Espirito Santo, Raquel Gouveia Silva, Sandra Soares Cardoso, Luisa Diogo, Monica Seidi, Silvia Sequeira, Mafalda Bourbon
Summary: This study aimed to analyze the association between rare lipid disorders and low LDL or low HDL cholesterol in 7 cases. NGS analysis of genes associated with rare forms of low HDL-c or LDL-c identified genetic variants related to rare lipid disorders. NGS proved to be a fundamental key for genetic testing of rare lipid disorders, helping to find the genetic cause of disease in 6/7 patients with low HDL-c and LDL-c.
FRONTIERS IN GENETICS
(2023)
Article
Engineering, Chemical
Fangyuan Zhang, Brittany Macshane, Ryan Searcy, Zuyi Huang
Summary: Cholesterol is a vital component of eukaryotic cell membranes and serves as a precursor for other molecules in the body. Maintaining cholesterol homeostasis is crucial for human health, as high cholesterol increases the risk of heart disease. Mathematical models can be used to study the best approaches to reducing overall cholesterol levels, providing insights into suitable drug targeting reactions or processes.
Article
Cardiac & Cardiovascular Systems
Vignesh Chidambaram, Lucas Zhou, Jennie Ruelas Castillo, Amudha Kumar, Samuel K. Ayeh, Akshay Gupte, Jann-Yuan Wang, Petros C. Karakousis
Summary: This study found that higher baseline serum cholesterol levels in TB patients were associated with lower risks of all-cause and infection-related mortality, as well as lower levels of inflammatory markers. Body mass index did not modify or confound this association.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Nutrition & Dietetics
Minu S. Thomas, Michael Puglisi, Olga Malysheva, Marie A. Caudill, Maria Sholola, Jessica L. Cooperstone, Maria Luz Fernandez
Summary: The addition of whole eggs to a plant-based diet increases plasma HDL cholesterol, choline, and zeaxanthin in individuals with MetS.
Review
Biochemistry & Molecular Biology
Saeed Aslani, Bahman Razi, Danyal Imani, Keyhan Mohammadi, Tannaz Jamialahmadi, Zeljko Reiner, Amirhossein Sahebkar
Summary: A systematic review and meta-analysis showed that statin therapy effectively lowered levels of total cholesterol, LDL-C, and TG, and increased levels of HDL-C in patients with different CVDs.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Sifan Qian, Shoujiang You, Yaming Sun, Qiuyi Wu, Xianhui Wang, Weiting Tang, Xiaofeng Dong, Chun-feng Liu, Tan Xu, Yongjun Cao, Chongke Zhong
Summary: This study found a significant positive association between elevated fasting remnant cholesterol levels and abnormal cIMT in patients with ischemic stroke, even in patients with optimal LDL cholesterol levels. Future prospective studies are needed to validate these findings and assess the impact of remnant cholesterol-lowering interventions in patients with ischemic stroke.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Oncology
Pik-Fang Kho, Frederic Amant, Daniela Annibali, Katie Ashton, John Attia, Paul L. Auer, Matthias W. Beckmann, Amanda Black, Louise Brinton, Daniel D. Buchanan, Stephen J. Chanock, Chu Chen, Maxine M. Chen, Timothy H. T. Cheng, Linda S. Cook, Marta Crous-Bous, Kamila Czene, Immaculata De Vivo, Joe Dennis, Thilo Doerk, Sean C. Dowdy, Alison M. Dunning, Matthias Duerst, Douglas F. Easton, Arif B. Ekici, Peter A. Fasching, Brooke L. Fridley, Christine M. Friedenreich, Montserrat Garcia-Closas, Mia M. Gaudet, Graham G. Giles, Ellen L. Goode, Maggie Gorman, Christopher A. Haiman, Per Hall, Susan E. Hankinson, Alexander Hein, Peter Hillemanns, Shirley Hodgson, Erling A. Hoivik, Elizabeth G. Holliday, David J. Hunter, Angela Jones, Peter Kraft, Camilla Krakstad, Diether Lambrechts, Loic Le Marchand, Xiaolin Liang, Annika Lindblom, Jolanta Lissowska, Jirong Long, Lingeng Lu, Anthony M. Magliocco, Lynn Martin, Mark McEvoy, Roger L. Milne, Miriam Mints, Rami Nassir, Geoffrey Otton, Claire Palles, Loreall Pooler, Tony Proietto, Timothy R. Rebbeck, Stefan P. Renner, Harvey A. Risch, Matthias Ruebner, Ingo Runnebaum, Carlotta Sacerdote, Gloria E. Sarto, Fredrick Schumacher, Rodney J. Scott, V. Wendy Setiawan, Mitul Shah, Xin Sheng, Xiao-Ou Shu, Melissa C. Southey, Emma Tham, Ian Tomlinson, Jone Trovik, Constance Turman, Jonathan P. Tyrer, David van den Berg, Zhaoming Wang, Nicolas Wentzensen, Lucy Xia, Yong-Bing Xiang, Hannah P. Yang, Herbert Yu, Wei Zheng, Penelope M. Webb, Deborah J. Thompson, Amanda B. Spurdle, Dylan M. Glubb, Tracy A. O'Mara
Summary: This study used Mendelian randomization analysis to investigate the relationship between blood lipids and endometrial cancer risk. Genetically elevated LDL cholesterol levels were associated with reduced risk of endometrial cancer, while higher predicted HDL cholesterol levels were linked to increased risk of non-endometrioid endometrial cancer. Obesity may influence these associations, but triglycerides showed no evidence of involvement in endometrial cancer development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Obstetrics & Gynecology
Maria C. Adank, Anja K. Johansen, Laura Benschop, Sophia P. Van Streun, Anna M. Smak Gregoor, Linn K. L. Oyri, Monique T. Mulder, Eric A. P. Steegers, Kirsten B. Holven, Jeanine E. Roeters van Lennep
Summary: Maternal lipid levels in early pregnancy are positively associated with childhood lipid levels in offspring, independent of maternal BMI and diet. This suggests that gestational lipid levels can be used as an early predictor of children's long-term health.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Multidisciplinary Sciences
Jae-Chan Ryu, Jae-Han Bae, Sang Hee Ha, Boseong Kwon, Yunsun Song, Deok Hee Lee, Bum Joon Kim, Dong-Wha Kang, Sun U. U. Kwon, Jong S. S. Kim, Jun Young Chang
Summary: This study investigated the association between changes in lipid profiles and the risk of in-stent restenosis. The results showed that improvement of HDL-C levels, TC/HDL-C ratio, and LDL-C/HDL-C ratio were associated with a decreased risk of in-stent restenosis.
Review
Physiology
Emily E. Howard, Stefan M. Pasiakos, Christopher N. Blesso, Maya A. Fussell, Nancy R. Rodriguez
FRONTIERS IN PHYSIOLOGY
(2020)
Meeting Abstract
Biochemistry & Molecular Biology
Chelsea Garcia, Courtney Millar, Liya Anto, Frank Nichols, Christopher Blesso
Article
Biochemistry & Molecular Biology
Courtney L. Millar, Christina Jiang, Gregory H. Norris, Chelsea Garcia, Samantha Seibel, Liya Anto, Ji-Young Lee, Christopher N. Blesso
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2020)
Review
Nutrition & Dietetics
Liya Anto, Sarah Wen Warykas, Moises Torres-Gonzalez, Christopher N. Blesso
Review
Biochemistry & Molecular Biology
Chelsea Garcia, Christopher N. Blesso
Summary: Anthocyanins can protect against atherosclerosis and cardiovascular disease by enhancing cellular antioxidant status, counteracting oxidative stress, and inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Nutrition & Dietetics
Richard S. Bruno, Avinash Pokala, Moises Torres-Gonzalez, Christopher N. Blesso
Summary: This article discusses the impact of full-fat dairy consumption on cardiometabolic health, highlighting that full-fat dairy products reduce cardiometabolic risk by improving gut health, reducing inflammation, and managing dyslipidemia.
Article
Biochemistry & Molecular Biology
Courtney L. Millar, Liya Anto, Chelsea Garcia, Mi -Bo Kim, Anisha Jain, Anthony A. Provatas, Robert B. Clark, Ji -Young Lee, Frank C. Nichols, Christopher N. Blesso
Summary: Oral and gut bacteria produce glycine lipids that protect against atherosclerosis by reducing inflammation and macrophage activation. However, high-fat diets lead to a decrease in bacterial glycine lipids, which can worsen the development of atherosclerosis and liver injury.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Nutrition & Dietetics
Minu S. Thomas, Marissa DiBella, Christopher N. Blesso, Olga Malysheva, Marie Caudill, Maria Sholola, Jessica L. Cooperstone, Maria Luz Fernandez
Summary: This study found that intake of eggs significantly increased the plasma levels of lutein and zeaxanthin in subjects with metabolic syndrome. This increase may provide additional protection against oxidative stress, which is a common condition in metabolic syndrome.
Review
Biochemistry & Molecular Biology
Liya Anto, Christopher N. Blesso
Summary: Atherosclerosis is the leading cause of death worldwide, and lifestyle modifications such as diet and exercise are recommended for its prevention. Dietary patterns are strongly associated with the risk of atherosclerosis, and dysbiosis of the gut microbiota and changes in microbial metabolites can influence its progression.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Minu S. Thomas, Christopher N. Blesso, Mariana C. Calle, Ock K. Chun, Michael Puglisi, Maria Luz Fernandez
Summary: There is a clear correlation between gut microbiota, diet, and metabolic outcomes. A diet high in fiber can decrease inflammation and increase insulin sensitivity, while a diet high in fat and sugar can lead to dyslipidemia, insulin resistance, and low-grade inflammation. Unhealthy diets can alter the gut microbiota, disrupt the intestinal barrier, and contribute to the development of metabolic syndrome (MetS), while healthy diets can improve gut barrier function and reduce low-grade inflammation.
METABOLIC SYNDROME AND RELATED DISORDERS
(2022)
Article
Nutrition & Dietetics
Minu S. Thomas, Lindsey Huang, Chelsea Garcia, Junichi R. Sakaki, Christopher N. Blesso, Ock K. Chun, Maria Luz Fernandez
Summary: This study found that adding whole eggs to a plant-based diet does not have adverse effects on inflammation and oxidative stress. On the contrary, eggs seem to provide additional protection against the biomarkers that define metabolic syndrome.
Article
Nutrition & Dietetics
Chelsea Garcia, Liya Anto, Christopher N. Blesso
Summary: This study aimed to explore the effects of milk polar lipids (MPLs) and anhydrous milk fat on colitis disease activity. The results showed that mice fed added MPLs were protected against colitis when on a high-fat diet, while added MPLs during a low-fat diet attenuated disease activity during the induction period but promoted colitis and inflammation in male mice during the recovery period.
Meeting Abstract
Gastroenterology & Hepatology
Anisha Jain, Chelsea Garcia, Liya Anto, Christopher Blesso
Meeting Abstract
Chemistry, Applied
Christopher Blesso
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2021)
Article
Food Science & Technology
Catalina Marin-Echeverri, Manuela Piedrahita-Blandon, Yeisson Galvis-Perez, Christopher N. Blesso, Maria-Luz Fernandez, Vitelbina Nunez-Rangel, Jacqueline Barona-Acevedo
Summary: The chronic consumption of agraz had positive effects on antioxidant status and oxidative stress markers in women with metabolic syndrome, with individual variability in response observed.
CYTA-JOURNAL OF FOOD
(2021)