Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells

Inhibition of HER2-Integrin signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression

(2015) Parul Gupta et al.   Oncotarget

Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma

(2014) V. Fresquet et al.   BLOOD

Cucurbitacin B Induced ATM-Mediated DNA Damage Causes G2/M Cell Cycle Arrest in a ROS-Dependent Manner

(2014) Jiajie Guo et al.   PLoS One

Functional inhibition of BCL2 is needed to increase the susceptibility to apoptosis to SMO inhibitors in diffuse large B-cell lymphoma of germinal center subtype

(2013) Kranthi Kunkalla et al.   ANNALS OF HEMATOLOGY

Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review

(2013) Ou Sha et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cucurbitacin B inhibits the translational expression of hypoxia-inducible factor-1α

(2013) Juan Ma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Trichosanthes kirilowiiEthanol Extract and Cucurbitacin D Inhibit Cell Growth and Induce Apoptosis through Inhibition of STAT3 Activity in Breast Cancer Cells

(2013) Soon Re Kim et al.   Evidence-based Complementary and Alternative Medicine

Non-Hodgkin’s B-cell lymphoma: Advances in molecular strategies targeting drug resistance

(2013) Steve A Maxwell et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Activation of the STAT3 Signaling Pathway Is Associated With Poor Survival in Diffuse Large B-Cell Lymphoma Treated With R-CHOP

(2013) Xin Huang et al.   JOURNAL OF CLINICAL ONCOLOGY

Differential sensitivity of p44/p42-MAPK- and PI3K/Akt-targeted neuroblastoma subtypes to arsenic trioxide

(2013) Meysam Yousefi et al.   NEUROCHEMISTRY INTERNATIONAL

Biological activities and potential molecular targets of cucurbitacins

(2012) Xiuping Chen et al.   ANTI-CANCER DRUGS

Chemical constituents from the fruits ofTrichosanthes kirilowii

(2012) Xue-Mei Fan et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia

(2011) S.-J. Chen et al.   BLOOD

CCL11-CCR3 Interactions Promote Survival of Anaplastic Large Cell Lymphoma Cells via ERK1/2 Activation

(2011) T. Miyagaki et al.   CANCER RESEARCH

Synergistic Apoptosis-Inducing Antileukemic Effects of Arsenic Trioxide andMucuna macrocarpaStem Extract in Human Leukemic Cells via a Reactive Oxygen Species-Dependent Mechanism

(2011) Kuan-Hung Lu et al.   Evidence-based Complementary and Alternative Medicine

Inhibition of Stat3 expression induces apoptosis and suppresses proliferation in human leukemia HL-60 cells

(2011) Jing Zhao et al.   Hematology

Cucurbitacin B suppresses the transactivation activity of RelA/p65

(2011) Hong Ri Jin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: Reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus

(2011) Sumana Dakeng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cucurbitacin: Ancient Compound Shedding New Light on Cancer Treatment

(2011) Dhong Hyun Lee et al.   TheScientificWorldJOURNAL

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562

(2009) Kin Tak Chan et al.   CANCER LETTERS

Cucurbitacin B Induces Apoptosis by Inhibition of the JAK/STAT Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells

(2009) N. H. Thoennissen et al.   CANCER RESEARCH

Bcl-2-family proteins and hematologic malignancies: history and future prospects

(2008) J. C. Reed   BLOOD

Cucurbitacin B has a potent antiproliferative effect on breast cancer cellsin vitroandin vivo

(2008) Naoki Wakimoto et al.   CANCER SCIENCE

Tumour cell survival signalling by the ERK1/2 pathway

(2008) K Balmanno et al.   CELL DEATH AND DIFFERENTIATION

Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer

(2008) Tingyan Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phase II study of arsenic trioxide and ascorbic acid for relapsed or refractory lymphoid malignancies: a Wisconsin Oncology Network study

(2008) JE Chang et al.   HEMATOLOGICAL ONCOLOGY

Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells

(2008) Talin Haritunians et al.   LEUKEMIA RESEARCH