A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells

Genetic regulation of the RUNX transcription factor family has antitumor effects

(2017) Ken Morita et al.   JOURNAL OF CLINICAL INVESTIGATION

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

(2016) Anuradha Illendula et al.   EBioMedicine

Antibacterial activities against rice bacterial leaf blight and tomato bacterial wilt of 2-mercapto-5-substituted-1,3,4-oxadiazole/thiadiazole derivatives

(2015) Pei Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells

(2015) Xiongwei Cai et al.   Cell Stem Cell

A small-molecule inhibitor of the aberrant transcription factor CBF -SMMHC delays leukemia in mice

(2015) A. Illendula et al.   SCIENCE

Estrogen Defines the Dorsal-Ventral Limit of VEGF Regulation to Specify the Location of the Hemogenic Endothelial Niche

(2014) Kelli J. Carroll et al.   DEVELOPMENTAL CELL

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

(2014) Nicholas Kwiatkowski et al.   NATURE

An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

(2014) M. R. Mansour et al.   SCIENCE

Prognosis and monitoring of core-binding factor acute myeloid leukemia: current and emerging factors

(2014) Nicolas Duployez et al.   Expert Review of Hematology

Attenuation of AML1-ETO cellular dysregulation correlates with increased leukemogenic potential

(2013) R. C. DeKelver et al.   BLOOD

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

(2013) Susumu Goyama et al.   JOURNAL OF CLINICAL INVESTIGATION

A stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesis

(2013) Xiao-Jian Sun et al.   NATURE

Addiction of t(8;21) and inv(16) Acute Myeloid Leukemia to Native RUNX1

(2013) Oren Ben-Ami et al.   Cell Reports

Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia

(2012) Takaomi Sanda et al.   CANCER CELL

Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer

(2012) Cornelia Johanna Franziska Scheitz et al.   EMBO JOURNAL

New insights into the role of Runx1 in epithelial stem cell biology and pathology

(2012) Cornelia Johanna Franziska Scheitz et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBF  interaction

(2012) L. Cunningham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis

(2011) Kentson Lam   Frontiers in Bioscience-Landmark

Runx1 Loss Minimally Impacts Long-Term Hematopoietic Stem Cells

(2011) Xiongwei Cai et al.   PLoS One

Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesis

(2010) L. Li et al.   BLOOD

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

(2010) Nicola K. Wilson et al.   Cell Stem Cell

Structure of the AML1-ETO NHR3–PKA(RIIα) Complex and Its Contribution to AML1-ETO Activity

(2010) Takeshi Corpora et al.   JOURNAL OF MOLECULAR BIOLOGY

The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology

CBF  is critical for AML1-ETO and TEL-AML1 activity

(2009) L. Roudaia et al.   BLOOD

Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity

(2009) S. Park et al.   BLOOD

Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

(2009) K. Cullion et al.   BLOOD

Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program

(2009) M. Hoogenkamp et al.   BLOOD

Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis

(2009) B. Jacob et al.   BLOOD

Hematopoietic Stem Cell Development Is Dependent on Blood Flow

(2009) Trista E. North et al.   CELL

Mouse models of human AML accurately predict chemotherapy response

(2009) J. Zuber et al.   GENES & DEVELOPMENT

Genetic Tests To Evaluate Prognosis and Predict Therapeutic Response in Acute Myeloid Leukemia

(2009) Margaret L. Gulley et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

The Osteogenic Transcription Factor Runx2 Controls Genes Involved in Sterol/Steroid Metabolism, Including Cyp11a1 in Osteoblasts

(2009) Nadiya M. Teplyuk et al.   MOLECULAR ENDOCRINOLOGY

Transforming activity of AML1-ETO is independent of CBFβ and ETO interaction but requires formation of homo-oligomeric complexes

(2009) Colin Kwok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Runx2 Regulates G Protein-coupled Signaling Pathways to Control Growth of Osteoblast Progenitors

(2008) Nadiya M. Teplyuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY