Review
Chemistry, Multidisciplinary
Pritam Ghosh, Priyabrata Banerjee
Summary: This article provides a comprehensive review of the application of covalent organic frameworks (COFs) in drug delivery. COFs, constructed with lightweight organic scaffolds, offer advantages such as easy synthesis and tunable properties, making them suitable candidates for drug delivery. The review focuses on the encapsulation and decapsulation of drugs by COFs and their delivery in biological media, including live cells. COFs show promising potential for multiple drug encapsulation/decapsulation in biological media and could be contenders for clinical applications.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Andrey Sviridov, Svetlana Mazina, Anna Ostapenko, Alexander Nikolaev, Victor Timoshenko
Summary: As-prepared mesoporous silicon nanoparticles were synthesized and explored as a sonosensitizer in aqueous media under low-intensity ultrasound. The nanoparticles showed acceptable colloidal stability and sonosensitization due to their mixed oxide-hydride coating. The experimental results proved that nanoparticle-sensitized cavitation bubbles could cause bacterial lysis and death, making these nanoparticles beneficial for mild antibacterial therapy and treatment of liquid media.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Infectious Diseases
Rajwinder Kaur, Kirandeep Kaur, Mohammad H. Alyami, Damanpreet Kaur Lang, Balraj Saini, Mohammad F. Bayan, Balakumar Chandrasekaran
Summary: The nature of microorganisms and the efficiency of antimicrobials have exhibited a significant interdependent change in their dynamics in recent decades. Metals and metallic compounds have gained popularity as they have been found effective against various microbial strains. A structured search of research and review papers, as well as other sources such as patents and Clinicaltrials.gov, was conducted for this review. Different microbes and their species and strains were found to be sensitive to metal-carrying formulations, effectively inhibiting growth, multiplication, and biofilm formation. Silver, copper, gold, iron, and gallium were identified as metals with antimicrobial properties. Membrane disruption, oxidative stress, and interaction with proteins and enzymes were identified as primary microbicidal processes.
Article
Plant Sciences
Nadana Sabapathi, Srinivasan Ramalingam, Kandasamy Nagarajan Aruljothi, Jintae Lee, Selvaraj Barathi
Summary: The biosynthesis of silver nanoparticles using Cassia auriculate flower extract as the reducing and stabilizing agent was analyzed in this study. The Cassia auriculate-silver nanoparticles (Ca-AgNPs) obtained were characterized by various spectroscopic and microscopic techniques. The Ca-AgNPs showed efficient antimicrobial activity and excellent free radical scavenging activity. Additionally, they exhibited moderate cytotoxicity against breast cancer cells. The flower extract-mediated synthesis approach offers a cost-efficient, eco-friendly, and easy alternative to conventional methods of silver nanoparticle synthesis.
Article
Pharmacology & Pharmacy
Sukumar Uday Kumar, Huaijun Wang, Arsenii V. Telichko, Arutselvan Natarajan, Thierry Bettinger, Samir Cherkaoui, Tarik F. Massoud, Jeremy J. Dahl, Ramasamy Paulmurugan
Summary: The study demonstrates a novel approach to precisely control the delivery of therapeutic miRNAs and genes in tumors using ultrasound-mediated cavitation, showing promising therapeutic potential for TNBC and HCC. Significant increases in delivery and reduction in tumor growth were observed in both tumor models, indicating the efficacy of this combined therapeutic strategy for future cancer therapy.
ADVANCED THERAPEUTICS
(2021)
Editorial Material
Pharmacology & Pharmacy
Guillermo Martinez, Juan Vazquez, Belen Begines, Ana Alcudia
Summary: The field of medicine is advancing rapidly due to the progress in emerging areas such as nanomedicine, regenerative medicine, and personalized medicine. These areas have led to the development of novel drug delivery systems, biocompatible scaffolds, and personalized medicine, which have improved treatment efficacy, reduced side effects, and increased convenience in medication.
Review
Biochemistry & Molecular Biology
Hongyu Gao, Nan Wu, Nini Wang, Jie Li, Jie Sun, Qiang Peng
Summary: This article provides a comprehensive understanding of the biological functions of chitosan in treating oral diseases, such as antimicrobial, anticancer, and remineralization activities. Chitosan-based therapeutic systems have been widely used in treating typical oral diseases, including dental caries, endodontic diseases, periodontal diseases, oral cancer, oral and maxillofacial surgery, and oral mucosal diseases. The concerns and possible solutions of the clinical use of chitosan are also discussed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Eduardo Lanzagorta Garcia, Marija Mojicevic, Dusan Milivojevic, Ivana Aleksic, Sandra Vojnovic, Milena Stevanovic, James Murray, Olivia Adly Attallah, Declan Devine, Margaret Brennan Fournet
Summary: Curcumin and triangular silver nanoplates (TSNP) incorporated bacterial cellulose (BC) films are highly effective antimicrobial materials with low toxicity. These films inhibit the growth of Escherichia coli and Staphylococcus aureus without causing significant harm to human cells and model organisms. The combination of curcumin and TSNP with BC has great potential for clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Shoubei Gao, Kai Liu, Xianbing Ji, Yanshuai Cui, Ruyu Li, Guanglong Ma, Yongqiang Zhang, Longgang Wang
Summary: This paper presents a novel colorimetric method for the detection of hydroquinone based on a peroxidase-like Pd nanozyme. The vancomycin-stabilized palladium nanoparticles (Van-Pd-n NPs) were prepared using vancomycin as a biological template. Van-Pd-2 NPs showed excellent biocompatibility and peroxidase-like activity, making them a promising candidate for the colorimetric detection of hydroquinone.
Article
Chemistry, Multidisciplinary
Nusrat Sharmin, Chengheng Pang, Izumi Sone, James Leon Walsh, Cecilia Gorriz Fernandez, Morten Sivertsvik, Estefania Noriega Fernandez
Summary: Eco-friendly nanocomposite films based on SA were synthesized for potential food packaging applications, showing superior mechanical properties and antimicrobial activity. The formation of AgNPs and their effects on solution viscosity and shear-thinning behavior were confirmed through various tests, highlighting the potential of these films in food packaging industry.
Article
Chemistry, Multidisciplinary
Madalina Elena David, Rodica Mariana Ion, Ramona Marina Grigorescu, Lorena Iancu, Alina Maria Holban, Florin Iordache, Adrian Ionut Nicoara, Elvira Alexandrescu, Raluca Somoghi, Sofia Teodorescu, Anca Irina Gheboianu
Summary: This study focuses on the synthesis of TiO2-decorated multi-walled carbon nanotubes and their incorporation into cellulose acetate-collagen films to obtain a new biomaterial with potential biomedical applications and improved antimicrobial activity. The results show that the presence of the nanocomposites enhances and maintains the antimicrobial activity of the wound dressings, and the obtained films exhibit good biocompatibility.
Article
Engineering, Environmental
Ling Cai, Xinyi Zhu, Hongjie Ruan, Jing Yang, Wei Wei, Yuan Wu, Liuzhu Zhou, Huijun Jiang, Minghui Ji, Jin Chen
Summary: Due to antibiotic misuse, the emergence of drug-resistant pathogenic microbes has raised concern for public health. This study successfully encapsulated curcumin-reduced and stabilized silver nanoparticles (C-Ag NPs) into electrospun nanofiber membranes composed of polyvinyl alcohol (PVA) cross-linked with citric acid (CA), which demonstrated desirable biocompatibility and broad-spectrum antimicrobial activities. The constructed nanofibrous scaffolds exhibited a homogeneously distributed and sustained release of C-Ag NPs, resulting in a significant killing effect against Escherichia coli, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), and Candida albicans, mediated by reactive oxygen species (ROS) generation. Transcriptomic analysis revealed that PVA/CA/C-Ag disrupted carbohydrate and energy metabolism and bacterial membranes, suggesting its potential in overcoming bacterial resistance and eradicating drug-resistant pathogenic microbes in various applications.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Physical
A. Young Lee, Seon Ae Hwangbo, Mun Seok Jeong, Tae Geol Lee
Summary: In this study, a facile and eco-friendly reduction method for mass production of reduced graphene oxide (rGO) was proposed. The sonicated rGO showed comparable carbon-to-oxygen atomic ratio and electrical conductance to commercially available rGO. This method has the potential to contribute to the active utilization of rGO in next-generation industrial products with lower environmental and energy impacts.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Sheril Ann Mathew, Stephen Arumainathan
Summary: The study successfully crosslinked chitosan and gelatin without the use of a crosslinking agent, resulting in the synthesis of nanocomposites in three different ratios. The nanocomposites exhibited excellent biodegradability, biocompatibility, adhesion, and absorption properties, making them suitable for drug delivery applications. Of particular significance is the sustained release of dopamine in a neutral medium achieved using the crosslinked chitosan and gelatin, without the presence of a crosslinker. The nanocomposites also demonstrated favorable antioxidant and antibacterial activity.
Article
Spectroscopy
Kais Daoudi, Soumya Columbus, Bruno P. Falca, Rui N. Pereira, Suzana B. Peripolli, Krithikadevi Ramachandran, Hassen Hadj Kacem, Anis Allagui, Mounir Gaidi
Summary: In this study, AgNPrs/SiNPs hybrid arrays were fabricated for sensitive detection of biomolecules using SERS. SiNPs with different sizes and phosphorous doping concentrations were synthesized in nonthermal plasma. The hybrid arrays exhibited substantial amplification of the fingerprint bands of R6G and showed high stability and reproducibility. They also enabled DNA detection with a lower limit of detection, making them a reliable and cost-effective biosensing platform.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Materials Science, Biomaterials
Maxim B. Gongalsky, Daniela A. Muftieva, Jukka K. S. Saarinen, Antti Isomaki, Nikolay V. Pervushin, Gelina S. Kopeina, Leena J. Peltonen, Clare J. Strachan, Boris Zhivotovsky, Helder A. Santos, Liubov A. Osminkina
Summary: Coherent anti-Stokes Raman scattering (CARS) is a powerful optical method for rapid visualization of biological objects. In this study, efficient nonresonant CARS imaging of silicon nanoparticles (SiNPs) in human cells was demonstrated. SiNPs can be visualized without specific labels due to their high third-order nonlinear susceptibility. CARS microscopy provides localization of SiNPs within biological structures at the cellular level and can be used to monitor various bioprocesses.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Engineering, Biomedical
Liubov A. Osminkina, Svetlana N. Agafilushkina, Ekaterina A. Kropotkina, Nikolay Yu Saushkin, Ivan Bozhev, Sergei S. Abramchuk, Jeanne Samsonova, Alexandra S. Gambaryan
Summary: New research demonstrates the antiviral effectiveness of porous silicon nanoparticles against various pathogenic human viruses, showing potential for universal viral sorbents and disinfectants.
BIOACTIVE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
D. Yakimchuk, U. Prigodich, S. E. Demyanov, J. Ustarroz, H. Terryn, K. Baert, S. A. Khubezhov, D. Tishkevich, A. Trukhanov, V Sivakov, E. Yu Kaniukov
Summary: Template synthesis is a method for obtaining nanostructures with predetermined shapes and sizes. This study successfully created silver nanostructures with complex geometry by changing only the pore volume of the template without altering other chemical kinetic conditions, and the growth mechanism of these nanostructures was examined and discussed in detail.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Materials Science, Multidisciplinary
D. A. Koyuda, S. S. Titova, U. A. Tsurikova, I. S. Kakuliia, E. Parinova, O. A. Chuvenkova, R. G. Chumakov, A. M. Lebedev, S. Kannykin, L. A. Osminkina, S. Yu Turishchev
Summary: A controlled change in the composition and electronic structure of porous silicon nanoparticles by varying the drying conditions is proposed in this study. Two types of nanoparticles were obtained from mechanically milled porous silicon films through air or freeze-drying processing. The surface morphology and structure of the obtained nanoparticles were investigated. The specific local environment and electronic structure of silicon atoms in the studied powders were probed using synchrotron ultrasoft X-ray absorption near edge structure spectroscopy technique.
Article
Chemistry, Physical
Tingsen Ming, Benjamin Dietzek-Ivansic, Xiaoju Lu, Xiaohua Zuo, Vladimir Sivakov
Summary: This study investigates the effects of decorating highly n-doped silicon nanowires with silver nanoparticles on hydrogen generation. The results show that the presence of silver nanoparticles can enhance the efficiency of hydrogen generation, and the decorated silicon nanowires can maintain their morphology after hydrogen release.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Pharmacology & Pharmacy
E. Tolstik, M. B. Gongalsky, J. Dierks, T. Brand, M. Pernecker, N. V. Pervushin, D. E. Maksutova, K. A. Gonchar, J. V. Samsonova, G. Kopeina, V. Sivakov, L. A. Osminkina, K. Lorenz
Summary: This study evaluated the effectiveness of drug delivery, release, and toxicity of pSiNPs nanocontainers in colon cancer cells and cardiac cells. The results demonstrated that pSiNPs effectively loaded and localized the drug within cells, and showed good tolerance and potential protective effects against toxicity in cardiac cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Anna A. Valyaeva, Anastasia A. Zharikova, Eugene Sheval
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an unprecedented global public health emergency, with COVID-19 ranging from mild symptoms to multiorgan failure. Understanding the cellular tropism of SARS-CoV-2 is crucial to comprehend its transmission and the severe outcomes of COVID-19. Single-cell RNA-seq data has been used to predict cellular tropism, although not all susceptible cells may be infected in COVID-19 patients.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Andrey V. Bykov, Tatiana A. Shestimerova, Mikhail A. Bykov, Liubov A. Osminkina, Alexey N. Kuznetsov, Victoria E. Gontcharenko, Andrei V. Shevelkov
Summary: By using X-ray crystal structure analysis, Raman and diffuse reflectance spectroscopies, and quantum chemical calculations, we synthesized a new polyiodoantimonate (HpipeH(2))(2)[Sb2I10](I-2) and investigated its crystal and electronic structure. We found that the compound has a 3D structure with a complex pattern of covalent bonds and non-covalent interactions, which provides a narrow band gap of 1.41 eV. This compound shows potential as a versatile tool for optimizing the band gap of light-harvesting materials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Sergey Turishchev, Alexander Schleusener, Olga Chuvenkova, Elena Parinova, Poting Liu, Maxim Manyakin, Sergei Kurganskii, Vladimir Sivakov
Summary: The composition, atomic and electronic structure of a silicon nanowire array coated with tin oxide were studied. The results showed that tin-oxide nanocrystals of 20 nm in size formed a continuous and highly developed surface with a complex phase composition. The use of photoemission electron microscopy in XANES mode revealed that the entire SiNW surface is covered with a tin(IV) oxide layer and traces of tin(II) oxide and metallic tin phases.
Article
Chemistry, Multidisciplinary
Poting Liu, Alexander Schleusener, Gabriel Zieger, Arne Bochmann, Matthijs A. van Spronsen, Vladimir Sivakov
Summary: Tin-containing layers with different degrees of oxidation are uniformly distributed along the length of silicon nanowires formed by a top-down method. The electronic and atomic structure of the obtained layers is investigated using nondestructive X-ray absorption spectroscopy. The distribution effect of tin-containing phases in the nanostructured silicon matrix is demonstrated, and the amount and distribution of tin-containing phases can be varied and controlled by adjusting the geometric parameters.
Article
Chemistry, Multidisciplinary
Maria G. Chernysheva, Andrey G. Popov, Mikhail G. Dzianisik, Alexander V. Egorov, Tolganay B. Egorova, Alexander V. Gopin, Artem A. Mitrofanov, Gennadii A. Badun
Summary: Hydrogen treatment is a popular method for surface modification of nanodiamonds. In this study, atomic hydrogen treatment of the functionalized surface was used to gently increase its hydrophobicity and maintain its overall composition. The corresponding mechanism was revealed through a combination of theoretical and experimental methods.
MENDELEEV COMMUNICATIONS
(2023)
Article
Microscopy
Daria M. Potashnikova, Tatiana N. Sotnikova, Olesya M. Shirokova, Oleg V. Zayratyants, Elena Yu. Vasilieva, Eugene V. Sheval
Summary: Recent studies have shown that cilia impairment is a common pathological feature of SARS-CoV-2-infected bronchial epithelial cells, but this has mainly been observed in cultured cells and animal models. In this study, the researchers used autopsy material and transmission electron microscopy to observe cilia impairment in infected bronchial epithelial cells directly. They found that only a small number of infected cells showed cilia impairment, while the majority of bronchial cells in the autopsy material had undisturbed ciliary layers. This suggests that most bronchial cells in infected patients do not die directly from the virus.
ULTRASTRUCTURAL PATHOLOGY
(2023)
Article
Chemistry, Multidisciplinary
A. V. Gopin, V. K. Dolgova, A. V. Severin, E. A. Logutenkova
Summary: The sorption parameters of yttrium ions on different textural organization hydroxyapatite samples were studied. Higher maximum adsorbed amount was observed in porous microparticles synthesized by the enzymatic method, while the sorption process was faster in lamellar nanoparticles. The sorption kinetics followed a pseudo-second-order model. The isotope exchange between sorbed and dissolved yttrium was studied using the Y-90 label, which occurred in several stages including the exchange of available yttrium on the surface and the slower exchange of yttrium in the pore space of microparticles in HAP(e).
RUSSIAN CHEMICAL BULLETIN
(2023)
Article
Physics, Multidisciplinary
K. A. Gonchar, I. V. Bozh'ev, O. A. Shalygina, L. A. Osminkina
Summary: Due to their unique structural and physical properties, silicon nanowires show great potential in various fields such as electronics, photovoltaics, photonics, sensors, and biomedicine. Among the available methods for synthesizing silicon nanowires, metal-assisted chemical etching is currently one of the most cost-effective approaches. This study uses gold nanoparticles as a catalyst to synthesize silicon nanowires by metal-assisted chemical etching of crystalline silicon. The resulting nanowires have a diameter of about 100 nm, consisting of a crystalline core of about 50 nm in diameter, coated with a SiO2 shell about 25 nm thick, and with silicon nanocrystals at the interface.
