Journal
LANGMUIR
Volume 33, Issue 17, Pages 4346-4355Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.7b00185
Keywords
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Funding
- National Science Foundation for Distinguished Young Scholars [21425417]
- Natural Science Foundation of China [21274101]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Polycationic polymers have been widely used as antimicrobial materials because of their broad spectrum activity and potential use as new antibiotics. Herein, we report the synthesis of polyanionic antimicrobial membranes by in situ photo-cross-linking of a sulfate based anionic monomer, followed by cation-exchange with organic (quaternary ammonium or imidazolium) or metal (Ag+, Cu2+, Fe3+, Zn2+, Na+, K+) cations. The resultant polyanionic membranes show high and broad spectrum antibacterial activities against both bacteria (Escherichia coli, Staphylococcus aureus) and fungi (Candida albicans ). In addition, the polyanionic antimicrobial membranes efficiently inhibited the formation of biofilms by SC5314 and its crk1 gene deleted (Delta crk1) C. albicans strains. Furthermore, the synthesized polyanionic membranes exhibit good blood compatibility, low cytotoxicity and long-term antibacterial stability, demonstrating safe antimicrobial materials in the application of healthcare.
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