Review
Cell Biology
Maurycy Jankowski, Maryam Farzaneh, Farhoodeh Ghaedrahmati, Milad Shirvaliloo, Arash Moalemnia, Magdalena Kulus, Hanna Ziemak, Mikolaj Chwarzynski, Piotr Dziegiel, Maciej Zabel, Hanna Piotrowska-Kempisty, Dorota Bukowska, Pawel Antosik, Paul Mozdziak, Bartosz Kempisty
Summary: It is widely recognized that long non-coding RNAs (lncRNAs) play a crucial role in the regulation of mesenchymal stem cells (MSCs) differentiation. Additionally, microRNAs (miRNAs) and lncRNAs have important impacts on the function and differentiation of MSCs. By examining public databases, we have collected the latest discoveries in human stem cell research and compiled clinical studies focused on MSC applications. The therapeutic potential of miRNAs and lncRNAs in MSCs provides exciting prospects for precision therapies and personalized treatments. These findings lay a solid foundation for further exploring the regenerative potential of MSCs.
Review
Chemistry, Multidisciplinary
Santiago Correa, Abigail K. Grosskopf, Hector Lopez Hernandez, Doreen Chan, Anthony C. Yu, Lyndsay M. Stapleton, Eric A. Appel
Summary: Advances in hydrogel technology have led to diverse applications in medicine and environmental engineering, providing solutions for various diseases and medical conditions. Collaboration across disciplines is essential for the development of contemporary hydrogels to accomplish complex biological tasks in different fields.
Article
Medicine, Research & Experimental
Kasra Moeinabadi-Bidgoli, Amirhesam Babajani, Ghasem Yazdanpanah, Behrouz Farhadihosseinabadi, Elham Jamshidi, Soheyl Bahrami, Hassan Niknejad
Summary: Cell-based therapy and stem cell-based regenerative medicine are new approaches for treating degenerative diseases, but face challenges in clinical practice. Preconditioning methods could improve the outcomes of stem cell therapy by enhancing cell resistance against the host environment and improving various biological aspects of cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Cell & Tissue Engineering
Shilpa Sharma, Sathish Muthu, Madhan Jeyaraman, Rajni Ranjan, Saurabh Kumar Jha
Summary: With advancements in tissue engineering and regenerative medicine, biological products, particularly adipose tissue, have gained attention for their regenerative and immunomodulatory potential. Progenitor cells within adipose tissue are crucial for regeneration, and the use of adipose tissue by-products shows promising results in clinical applications.
WORLD JOURNAL OF STEM CELLS
(2021)
Review
Immunology
Peishan Li, Qianmin Ou, Songtao Shi, Changshun Shao
Summary: Mesenchymal stem/stromal cells (MSCs) are widely distributed in the body and can be used for the treatment of autoimmune diseases and other chronic disorders. Dental stem cells (DSCs) have remarkable immunomodulatory properties and have therapeutic effects on systemic inflammatory diseases. MSCs derived from nondental tissues, such as the umbilical cord, also show benefits in the management of periodontitis in preclinical studies.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Cell Biology
Meryem Ouzin, Gesine Kogler
Summary: Mesenchymal stromal cells are widely used in regenerative medicine and translational research, but their heterogeneity and the lack of understanding of their molecular mechanisms pose challenges for clinical applications. This review focuses on the heterogeneity aspects related to tissue source and developmental origin, emphasizing the importance of generating homogeneous products for clinical use.
Article
Biology
Shuo Huang, Min Jin, Nan Su, Lin Chen
Summary: Bone has a strong regenerative capacity driven by reparative cells such as skeletal stem cells and their descendants, playing critical roles in bone development, maintenance, and injury healing. However, the identity and functional roles of skeletal stem cells remain controversial due to technological difficulties and cell heterogeneity. There has been a biased view for many years that bone marrow is the main source of reparative cells for bone repair.
BIOLOGICAL REVIEWS
(2021)
Article
Oncology
Chenghai Li, Hua Zhao, Bin Wang
Summary: While a large body of research has shown the dual role of MSCs in tumor growth and inhibition, studies on the contribution of MSCs to tumorigenesis are rare. MSCs can increase cancer stem cell population, generate cancer precursors, and induce epithelial-mesenchymal transition. Understanding the developmental origin and tissue-resident native MSCs is crucial for grasping MSCs' contribution to cancer cell origin.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Qiong Wu, Shuangli He, Yu Zhu, Shiming Pu, Zuping Zhou
Summary: This study demonstrated the effectiveness of adipose-derived stromal/stem cells (ASCs) in treating obesity and aging in aged mice. ASCs treatment led to significant weight loss, improved organ function, increased antioxidant capacity, enhanced lipid metabolism, and reduced inflammation in old mice. The positive effects of ASCs suggest their potential as primary antiaging and antiobesity agents for the elderly.
Review
Cell Biology
Yi Fan, Chen Cui, Peiran Li, Ruiye Bi, Ping Lyu, Yanxi Li, Songsong Zhu
Summary: Research has identified a novel stem cell niche in condylar cartilage, containing fibrocartilage stem cells (FCSCs) that play a crucial role in the development and regeneration of fibrocartilage. Understanding the properties of FCSCs may inform the development of promising biological strategies for the treatment of TMD in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Bo Li, Yigan Wang, Yi Fan, Takehito Ouchi, Zhihe Zha, Longjiang Li
Summary: This article summarizes the characteristics of the newly discovered cranial stem cell population SuSCs, including their location, self-renewal ability, multipotency, contribution to injury repair, as well as the signaling pathways and molecular mechanisms associated with the regulation of SuSCs.
Review
Cell Biology
Shengnan Yang, Peipei Liu, Yale Jiang, Zai Wang, Huaping Dai, Chen Wang
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with unknown causes, and currently the only medications that can slow down the progression of the disease and improve survival rate are pirfenidone and nintedanib. The use of mesenchymal stem cells (MSCs) provides a new hope for treating interstitial lung disease, but optimal treatment protocols are still lacking.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Shiying Niu, Yueying Zhang
Summary: RILI, a common complication of radiotherapy, lacks effective therapeutic strategies. Studies show that MSCs can enhance tissue regeneration, modulate inflammatory response, and inhibit fibrotic cytokines, providing new potential therapeutic options for RILI.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Alfonso Eirin, Yu Meng, Xiang-Yang Zhu, Yongxin Li, Ishran M. Saadiq, Kyra L. Jordan, Hui Tang, Amir Lerman, Andre J. van Wijnen, Lilach O. Lerman
Summary: Obesity alters the miRNA expression profile and size of human adipose mesenchymal stem/stromal cell-derived extracellular vesicles (EVs), reducing their capacity to repair injured cells and modulate important injury pathways in recipient cells. These observations may guide the development of novel strategies to improve healing and repair in obese individuals.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hantae Jo, Sofia Brito, Byeong Mun Kwak, Sangkyu Park, Mi-Gi Lee, Bum-Ho Bin
Summary: MSCs play a key role in promoting repair of damaged and aging skin by increasing cell proliferation, neovascularization, collagen and elastic fiber production. iPSC-derived MSCs are considered advanced MSCs for cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Khlood Ahmed, Yuichiro Arima, Noriaki Tabata, Masanobu Ishii, Ryota Sato, Takayoshi Yamashita, Kenshi Yamanaga, Hitoshi Takizawa, Seiji Hokimoto, Daisuke Sueta, Satoshi Araki, Koichiro Fujisue, Seiji Takashio, Kazuteru Fujimoto, Hideki Shimomura, Ryusuke Tsunoda, Toyoki Hirose, Koji Sato, Koichi Kikuta, Naritsugu Sakaino, Shinichi Nakamura, Nobuyasu Yamamoto, Toshiyuki Matsumura, Ichiro Kajiwara, Shinji Tayama, Tomohiro Sakamoto, Koichi Nakao, Shuichi Oshima, Eiichiro Yamamoto, Kenji Sakamoto, Koichi Kaikita, Kenichi Matsushita, Kenichi Tsujita
Summary: This study aimed to evaluate the impact of stroke on the prognosis of patients with underlying ischemic heart disease (IHD) who underwent percutaneous coronary intervention (PCI) treatment. The study revealed that stroke patients were older and had more comorbidities compared to stroke-free patients. Patients with stroke had a higher incidence of clinical events and a poorer prognosis, highlighting the urgent need for comprehensive prevention of cardiovascular and cerebrovascular diseases.
Article
Cardiac & Cardiovascular Systems
Koichiro Fujisue, Eiichiro Yamamoto, Daisuke Sueta, Masafumi Takae, Taiki Nishihara, Takashi Komorita, Hiroki Usuku, Kenshi Yamanaga, Miwa Ito, Tadashi Hoshiyama, Hisanori Kanazawa, Seiji Takashio, Yuichiro Arima, Satoshi Araki, Hirofumi Soejima, Koichi Kaikita, Kenichi Matsushita, Kenichi Tsujita
Summary: This study demonstrated for the first time the elevated levels of sPD-L1 in patients with CAD and its significant association with ACS.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Seiji Takashio, Toshihiro Yamada, Masato Nishi, Mami Morioka, Akira Fujiyama, Naoya Nakashima, Kyoko Hirakawa, Shinsuke Hanatani, Hiroki Usuku, Eiichiro Yamamoto, Mitsuharu Ueda, Kenichi Matsushita, Kenichi Tsujita
Summary: This study found that female patients with ATTRwt-CM were diagnosed at an older age, had higher levels of B-type natriuretic peptide, less hypertrophic echocardiography results, preserved left ventricular ejection fraction, weaker cardiac uptake of the Tc-99m-PYP tracer, and were more susceptible to moderate to severe aortic stenosis.
JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tadashi Hoshiyama, Hitoshi Sumi, Shozo Kaneko, Yusei Kawahara, Miwa Ito, Hisanori Kanazawa, Seiji Takashio, Eiichiro Yamamoto, Kenichi Matsushita, Kenichi Tsujita
Summary: Placement of CWMS in the coronary sinus without fluoroscopic guidance is feasible, safe, and effective in reducing radiation exposure during catheter ablation.
JOURNAL OF ARRHYTHMIA
(2022)
Article
Peripheral Vascular Disease
Koichiro Fujisue, Eiichiro Yamamoto, Daisuke Sueta, Yuichiro Arima, Kyoko Hirakawa, Noriaki Tabata, Masanobu Ishii, Miwa Ito, Kenshi Yamanaga, Shinsuke Hanatani, Tadashi Hoshiyama, Hisanori Kanazawa, Seiji Takashio, Satoshi Araki, Hiroki Usuku, Taishi Nakamura, Hirofumi Soejima, Koichi Kaikita, Hiroaki Kawano, Kenichi Matsushita, Kenichi Tsujita
Summary: This study found that royal jelly may have antiatherogenic effects by improving vascular endothelial function. It also enhanced liver function in healthy volunteers.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Review
Cardiac & Cardiovascular Systems
Kenichi Matsushita, Sunao Kojima, Kyoko Hirakawa, Noriaki Tabata, Miwa Ito, Kenshi Yamanaga, Koichiro Fujisue, Tadashi Hoshiyama, Shinsuke Hanatani, Daisuke Sueta, Hisanori Kanazawa, Seiji Takashio, Yuichiro Arima, Satoshi Araki, Hiroki Usuku, Satoru Suzuki, Eiichiro Yamamoto, Taishi Nakamura, Hirofumi Soejima, Koichi Kaikita, Kenichi Tsujita
Summary: This study explores the paradoxical association between overweight/obesity and survival benefits in patients with heart failure (HF) and coronary artery disease (CAD). The results suggest that the effects of overweight/obesity on in-hospital mortality differ depending on the severity of HF.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Hiroki Usuku, Eiichiro Yamamoto, Daisuke Sueta, Momoko Noguchi, Tomohiro Fujisaki, Koichi Egashira, Mami Morioka, Takashi Komorita, Fumi Oike, Koichiro Fujisue, Shinsuke Hanatani, Yuichiro Arima, Seiji Takashio, Seitaro Oda, Hiroaki Kawano, Kenichi Matsushita, Mitsuharu Ueda, Hirotaka Matsui, Kenichi Tsujita
Summary: This study investigated the significance of left ventricular apical sparing in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). The results showed that approximately half of ATTRwt-CM patients did not exhibit left ventricular apical sparing at diagnosis. The relative apical longitudinal strain index (RapLSI) of ATTRwt-CM significantly changed over time, emphasizing the importance of repeated two-dimensional speckle tracking analysis for suspected ATTR-CM patients.
IJC HEART & VASCULATURE
(2022)
Article
Cardiac & Cardiovascular Systems
Seiji Takashio, Teiji Kato, Hikaru Tashima, Hiroki Irie, Yoshihiro Komohara, Tetsuya Oguni, Kei Morikawa, Naoto Kuyama, Noriaki Tabata, Shinsuke Hanatani, Eiichiro Yamamoto, Kenichi Matsushita, Mitsuharu Ueda, Kenichi Tsujita
Summary: Amyloid deposition was frequently observed in the tenosynovium removed during carpal tunnel release (CTR) in elderly men with carpal tunnel syndrome (CTS). Cardiac screening was found to be useful for the early diagnosis of cardiac amyloidosis (CA) in CTR patients with amyloid deposition.
CIRCULATION JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Yusei Kawahara, Hisanori Kanazawa, Seiji Takashio, Yuichiro Tsuruta, Hitoshi Sumi, Takuya Kiyama, Shozo Kaneko, Miwa Ito, Tadashi Hoshiyama, Kyoko Hirakawa, Masanobu Ishii, Noriaki Tabata, Kenshi Yamanaga, Koichiro Fujisue, Shinsuke Hanatani, Daisuke Sueta, Yuichiro Arima, Satoshi Araki, Hiroki Usuku, Taishi Nakamura, Eiichiro Yamamoto, Hirofumi Soejima, Kenichi Matsushita, Hiroaki Kawano, Kenichi Tsujita
Summary: This study aimed to identify factors leading to future pacing device implantation (PDI) and the necessity of prophylactic PDI or implantable cardioverter-defibrillator (ICD) implantation in ATTR-CM patients. A retrospective study was conducted on 114 wild-type ATTR-CM and 50 hereditary ATTR-CM patients to compare patient backgrounds with and without future PDI and examine the incidence of PDI in each conduction disturbance. The study found that specific factors were significantly associated with future PDI in both ATTRwt-CM and ATTRv-CM patients.
Article
Cardiac & Cardiovascular Systems
Seiji Takashio, Mami Morioka, Masanobu Ishii, Kei Morikawa, Kyoko Hirakawa, Shinsuke Hanatani, Fumi Oike, Hiroki Usuku, Masafumi Kidoh, Seitaro Oda, Eiichiro Yamamoto, Kenichi Matsushita, Mitsuharu Ueda, Kenichi Tsujita
Summary: This study aimed to evaluate the clinical course and therapeutic effect of tafamidis in patients with ATTR-CM. It found that tafamidis treatment significantly improved outcomes, reducing all-cause mortality and hospitalization due to heart failure. High-sensitivity cardiac troponin T may be a useful biomarker for evaluating the therapeutic effect of tafamidis.
Article
Cardiac & Cardiovascular Systems
Nobuhiro Nakanishi, Koichi Kaikita, Masanobu Ishii, Naoto Kuyama, Noriaki Tabata, Miwa Ito, Kenshi Yamanaga, Koichiro Fujisue, Tadashi Hoshiyama, Hisanori Kanazawa, Shinsuke Hanatani, Daisuke Sueta, Seiji Takashio, Yuichiro Arima, Satoshi Araki, Hiroki Usuku, Taishi Nakamura, Eiichiro Yamamoto, Hirofumi Soejima, Kenichi Matsushita, Kenichi Tsujita
Summary: This study retrospectively analyzed 300 patients who underwent percutaneous coronary intervention (PCI) and found that high bleeding risk scores were associated with low thrombogenicity, high bleeding risk, and bleeding events after PCI.
CARDIOVASCULAR INTERVENTION AND THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Masanobu Ishii, Kenichi Tsujita, Tomohisa Seki, Masafumi Okada, Kazumi Kubota, Kenichi Matsushita, Koichi Kaikita, Naohiro Yonemoto, Yoshio Tahara, Takanori Ikeda
Summary: Younger females with OHCA in public locations face disparities in receiving bystander CPR and public access defibrillation. This study investigates the association between sex, age, and the rate of receiving these interventions and neurological outcomes in OHCA patients. The results suggest significant sex- and age-based differences in bystander CPR, public access defibrillation, and neurological outcomes in Japan, highlighting the importance of increased use of these interventions, especially for younger females.
Article
Medicine, General & Internal
Kenichi Matsushita, Junnosuke Ito, Aoi Isaka, Satoshi Higuchi, Toshinori Minamishima, Konomi Sakata, Toru Satoh, Kyoko Soejima
Summary: This study demonstrates that echocardiographic assessment of elevated left atrial pressure based on the 2016 ASE/EACVI guidelines is clinically valid for predicting readmission in patients with heart failure.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Peripheral Vascular Disease
Shuhei Miyazaki, Koichiro Fujisue, Kenshi Yamanaga, Daisuke Sueta, Hiroki Usuku, Noriaki Tabata, Masanobu Ishii, Shinsuke Hanatani, Tadashi Hoshiyama, Hisanori Kanazawa, Seiji Takashio, Yuichiro Arima, Satoshi Araki, Eiichiro Yamamoto, Kenichi Matsushita, Kenichi Tsujita
Summary: This study found a significant association between higher sPD-L1 levels and future cardiovascular events in patients with CAD.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Cardiac & Cardiovascular Systems
Kenichi Matsushita, Toshinori Minamishima, Konomi Sakata, Toru Satoh, Kyoko Soejima
Summary: This study compared the prognostic utility of lateral and septal mitral annular early diastolic velocity (e') in patients with acute decompensated heart failure. The results indicated that lateral e' was more reliable than septal e' in predicting 90-day mortality.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Medicine, Research & Experimental
Marijn A. Scheijde-Vermeulen, Lennart A. Kester, Liset Westera, Bastiaan B. J. Tops, Friederike A. G. Meyer-Wentrup
Summary: This study aimed to evaluate the feasibility of integrating state-of-the-art sequencing techniques and flow cytometry into the diagnostic workup of pediatric lymphoma. The results showed that this integration is not only feasible but also provides additional diagnostic information.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Enrico Berrino, Sara Erika Bellomo, Anita Chesta, Paolo Detillo, Alberto Bragoni, Amedeo Gagliardi, Alessio Naccarati, Matteo Cereda, Gianluca Witel, Anna Sapino, Benedetta Bussolati, Gianni Bussolati, Caterina Marchi
Summary: Formalin-fixed paraffin-embedded (FFPE) samples are crucial for tissue-based analysis in precision medicine, but the quality of these samples can affect the reliability of sequencing data. The use of acid-deprived fixatives guarantees the highest DNA preservation and sequencing performance, enabling more complex molecular profiling of tissue samples.
LABORATORY INVESTIGATION
(2024)
Article
Medicine, Research & Experimental
Roope A. Kallionpaa, Sirkku Peltonen, Kim My Le, Eija Martikkala, Mira Jaaskelainen, Elnaz Fazeli, Pilvi Riihila, Pekka Haapaniemi, Anne Rokka, Marko Salmi, Ilmo Leivo, Juha Peltonen
Summary: This study investigated the immune microenvironment of cutaneous neurofibromas (cNFs) in patients with neurofibromatosis 1 (NF1). The results showed that cNFs have substantial populations of T cells and macrophages, which may be tumor-specific. T cell populations in cNFs were found to be different from those in the skin, and cNFs exhibited lower expression of proteins related to T cell-mediated immunity compared to the skin.
LABORATORY INVESTIGATION
(2024)