Article
Chemistry, Analytical
Wenyao Zhang, Kaixin Zheng, Yang Ye, Jiali Ji, Xiaoyu Cheng, Sailing He
Summary: A pipette-tip-enabled digital nucleic acid analyzer for high-performance COVID-19 testing is demonstrated in this study. By using digital LAMP technology, the ORF1a/b gene can be amplified without the need for a thermal cycler, allowing for the generation of monodisperse microdroplets with benchtop centrifugation. The method offers a significant improvement in sensitivity over nondigital techniques and compares favorably to commercial dLAMP platforms, showing potential for large-scale applications of ultrasensitive digital nucleic acid analyzers.
ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Jia Ning, Yulin Lei, Hong Hu, Chenhui Gai
Summary: This review focuses on the development of surface acoustic wave-enabled acoustic drop ejection (SAW-ADE) technology, which can eject droplets from liquids without touching the sample. The article provides an overview of the technology, discusses influencing factors, and introduces its application scenarios. The optimization of SAW-ADE systems for specific applications is crucial.
Review
Materials Science, Biomaterials
Yu Gao, Apresio K. Fajrial, Tao Yang, Xiaoyun Ding
Summary: Surface acoustic waves (SAW) are sound waves traveling on the surface of an elastic material, offering robust control of acoustic energy and versatility. Integration of SAW with modern lab-on-a-chip technology has found numerous applications in micro/nanosystems, particularly in the field of biomaterials where SAW technology provides exceptional opportunities for research and manipulation at small scales.
BIOMATERIALS SCIENCE
(2021)
Article
Environmental Sciences
Yuming Zeng, Siyi Shen, Zhiwei Xu
Summary: Feature extraction and recognition of underwater targets were studied using a millimeter wave (mmWave) radar. The continuous wavelet transform (CWT) method showed better detection performance, and the mmWave radar accurately detected even weak water surface acoustic wave (WSAW) signals. The experiments demonstrated the potential of mmWave radar for cross-medium detection and recognition of underwater targets.
Article
Chemistry, Analytical
Umar Farooq, Xiufang Liu, Wei Zhou, Muhammad Hassan, Lili Niu, Long Meng
Summary: This method utilizes the collision between nanowires and cells to induce cell lysis efficiently, with advantages of low power consumption, fast processing, reusability, and minimal sample consumption. Ni coated Ag-nanowires show promise for applications in point of care diagnostics.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Electrical & Electronic
Junjie Huang, Zhihao Zhu, Yu Zhang, Juan Tu, Xiasheng Guo, Dong Zhang
Summary: This paper presents the fabrication and performance of a glass-based centrifuge using acoustic methods. By controlling the driving voltage and solvent recipe, efficient enrichment of particles and cells with different diameters can be achieved. This centrifuge shows great potential in the enrichment of micro- and nanoparticles as well as rare samples.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Review
Chemistry, Analytical
Kerstin Laenge
Summary: Milk and dairy products are commonly regulated foods. Acoustic sensor devices have been used for milk analysis, including the determination of physical parameters and the detection of analytes and microorganisms. By using different coating and testing formats, the devices are able to meet different analytical demands and legal limits.
Article
Multidisciplinary Sciences
Roel Botter, Kaixuan Ye, Yvan Klaver, Radius Suryadharma, Okky Daulay, Gaojian Liu, Jasper van den Hoogen, Lou Kanger, Peter van der Slot, Edwin Klein, Marcel Hoekman, Chris Roeloffzen, Yang Liu, David Marpaung
Summary: This study demonstrates advanced control of backward SBS in multilayer Si3N4 waveguides and achieves acoustic waveguiding by optimizing the separation between waveguides. The enhanced SBS gain is utilized to realize a high-rejection microwave photonic notch filter. This opens up a path to achieving Brillouin-based photonic circuits in a standard, low-loss Si3N4 platform.
Article
Engineering, Electrical & Electronic
Xiangrong Li, Qiulin Tan, Li Qin, Lei Zhang, Xiaorui Liang, Xiawen Yan
Summary: The study introduced a surface acoustic wave sensor coating with MoS2/GO nano composite, which exhibited high humidity sensitivity and thermal stability. The sensor showed excellent performance at different humidity levels, making it suitable for applications in medical care, environmental monitoring, and cultural relic preservation.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Chemistry, Multidisciplinary
Pan Fu, Pei-Nan Ni, Bo Wu, Xian-Zhi Pei, Qiu-Hua Wang, Pei-Pei Chen, Chen Xu, Qiang Kan, Wei-Guo Chu, Yi-Yang Xie
Summary: Metasurface polarization optics consisting of birefringent nano-antennas can be integrated with VCSEL platforms to achieve compact control over the phase and polarization properties of the laser. These integrated vector beams have the potential to revolutionize optical communications, laser manipulation, information encryption, and quantum optics by bypassing the need for multiple optical components and offering versatile functionalities.
ADVANCED MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Serge Ismael Zida, Yue-Der Lin, Yit Lung Khung
Summary: The development of rapid biosensing platforms is crucial for disease detection and clinical biomarker analysis. Among the various biosensing technologies, surface acoustic wave (SAW) biosensors stand out due to their simple manufacturing requirements and wide operating frequency range. SAW devices have been successfully utilized for detecting important bioactive targets and some designs are already commercially available.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Article
Chemistry, Analytical
Yuan Ning, Menglun Zhang, Hongxiang Zhang, Xuexin Duan, Yi Yuan, Buohua Liu, Wei Pang
Summary: This study explores the mechanism of a new acoustic micro-ejector using a Lamb wave transducer array, which can stably generate picoliter droplet jetting through a combination of acoustic pressure waves and acoustic streaming. Experimental results demonstrate that the ejector can continuously produce uniform small water droplets at a high rate, thanks to a large liquid height window and high ejection stability, making it suitable for demanding biochemical applications.
Article
Engineering, Electrical & Electronic
Jingui Qian, Habiba Begum, Joshua E-Y Lee
Summary: We have developed a hybrid device that combines acoustofluidic localization and resonator-based mass sensing techniques for in-situ analysis in a mu L droplet. Our research demonstrates the capability of acoustofluidic manipulation on a resonator chip using an elliptic plate resonator (EPR). The device focuses particles on the EPR using acoustic tweezers to improve detection efficiency. The EPR has high liquid-phase quality factor (Q) and low motional resistance (R-m), allowing the detection of focused particles in liquid.
IEEE ELECTRON DEVICE LETTERS
(2022)
Article
Biochemical Research Methods
Hemin Pan, Deqing Mei, Chengyao Xu, Shuo Han, Yancheng Wang
Summary: This study presents a novel approach of acoustic tweezers, using bisymmetric coherent acoustic tweezers to modulate the shape of acoustic pressure fields. The experimental tests demonstrate the capability of precise, contactless, and biocompatible cluster manipulation of particles and cells, and the device also allows for rapid switching, shape regulation, and directional translation. This technique shows great potential in the fields of targeted cellular assembly, biological 3D printing, and targeted release of drugs.
Article
Physics, Applied
Zhi-Lei Zhang, Shi-Feng Li, Xin Li, Xin-Ye Zou, Jian-Chun Cheng
Summary: This study introduces an acoustic gradient metasurface with phase modulation that converts propagating waves into surface bounded waves for energy concentration, forming standing waves under normal incidence. By placing piezoelectric composite sheets in antinode regions for acoustic energy harvesting, the output voltage maintains the same phase.
APPLIED PHYSICS LETTERS
(2022)
Article
Biochemical Research Methods
Jason Brenker, Katja Henzler, Camelia N. Borca, Thomas Huthwelker, Tuncay Alan
Summary: This paper presents an X-ray compatible microfluidic platform for in situ characterization of chemical reactions at synchrotron light sources. The new approach with polydimethylsiloxane (PDMS) microfluidic channels sandwiched between ultrathin, X-ray transparent silicon nitride observation windows and rigid substrates demonstrates easy to implement techniques to probe reacting solutions and study their reactions in real-time. This platform has the advantages of being suitable for high energy and tender X-rays, operable in a vacuum environment, and robust enough for continuous scanning with high spatial and time resolution.
Article
Acoustics
Amir Pourabed, Jason Brenker, Tayyaba Younas, Lizhong He, Tuncay Alan
Summary: This paper presents an acoustically actuated microfluidic mixer that uses resonators to rapidly homogenise liquid solutions and synthesise nanoparticles. The system can effectively mix fluids at high flow rates and successfully synthesise nanoparticles with specific sizes and PDI.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Kamal Prakash Prasanna Ravindran Nair, Thulya Chakkumpulakkal Puthan Veettil, Bayden R. Wood, Debjani Paul, Tuncay Alan
Summary: The identification of biomarkers from blood plasma is crucial for diagnostic tests. Haemoprocessor, a portable and robust open-fluidic system, utilizes Travelling Surface Acoustic Waves (TSAW) to separate plasma and red blood cells. Spectroscopy and analysis confirmed the quality and integrity of the plasma separation, validating the potential of Haemoprocessor as a platform for cell enrichment and plasma separation.
Article
Multidisciplinary Sciences
Wai Hoe Chin, Ciaren Kett, Oren Cooper, Deike Museler, Yaqi Zhang, Rebecca S. Bamert, Ruzeen Patwa, Laura C. Woods, Citsabehsan Devendran, Denis Korneev, Joe Tiralongo, Trevor Lithgow, Michael J. McDonald, Adrian Neild, Jeremy J. Barr
Summary: The majority of viruses in the gut are bacterial viruses known as bacteriophages, which coevolve with gut bacteria. This study investigated the evolutionary interactions between bacteriophages, bacterial hosts, and the mammalian gut mucosa. The researchers found that bacteriophages can evolve in response to a mammalian-derived mucosal environment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemical Research Methods
Bryan Ang, Ankush Sookram, Citsabehsan Devendran, Vincent He, Kellie Tuck, Victor Cadarso, Adrian Neild
Summary: Surface acoustic wave (SAW) driven devices often use polymeric microfluidic channels with low acoustic impedance mismatch to the fluid in contact for precise control of the wave field. This work demonstrates the successful implementation of integrating a glass insert at the ceiling of the PDMS microfluidic channel in a SAW activated nanosieve, resulting in a significant increase in flow rate and maintenance of high capture efficiencies. The glass-inserted device allows for processing larger volume samples, overcoming a main limitation of these devices.
Article
Chemistry, Analytical
Bryan Ang, Ruhollah Habibi, Ciaren Kett, Wai Hoe Chin, Kellie L. Tuck, Adrian Neild, Victor J. Cadarso
Summary: Microfluidic concentration technology can detect low concentrations of bacteria in samples, making it suitable for time-sensitive situations such as clinical settings and food quality control. By using a packed bed of micro-particles activated by surface acoustic waves, bacteria can be efficiently captured and recovered for further analysis.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Materials Science, Multidisciplinary
Mohammad Mosarof Hossain, Babar Shabbir, Jingying Liu, Zhichen Wan, Sumeet Walia, Qiaoliang Bao, Tuncay Alan, Sudha Mokkapati
Summary: Bisphenol A exposure is associated with increased risk of various diseases. Monitoring BPA exposure is important for human healthcare. A microfluidic device based on MoS2 field-effect transistor has been developed to detect biomolecules at low concentrations. The functionalized MoS2 FET sensors show high sensitivity and can detect BPA concentration as low as 1 pg mL(-1).
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Nanoscience & Nanotechnology
Kajal Sharma, Shipra Pandey, Hariharan Sekar, Tuncay Alan, Venkat Gundabala
Summary: In this study, curcumin loaded alginate microfibers were generated using microfluidic technique and their efficacy in combination therapy (blue light + curcumin) against drug resistant Staphylococcus aureus (S. aureus) was evaluated. The results showed that the curcumin loaded microfibers exhibited good antibacterial activity and effectively eliminated biofilms formed by multidrug resistant S. aureus.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ali-Reza Shokouhi, Yaping Chen, Hao Zhe Yoh, Jason Brenker, Tuncay Alan, Takahide Murayama, Koukou Suu, Yasuhiro Morikawa, Nicolas H. Voelcker, Roey Elnathan
Summary: A non-viral electroactive nanoinjection (ENI) platform is developed to efficiently deliver and express CAR genes in primary human T cells, with high transfection efficiency and minimal cellular perturbation. The ENI-transfected CAR-T cells show effective suppression of lymphoma cell growth, demonstrating the platform's potential for ex vivo cell engineering in CAR-T cell therapy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Vincent He, Victor J. Cadarso, Susanne Seibt, Ben J. Boyd, Adrian Neild
Summary: In this study, a microfluidic approach was used to prepare different aqueous and lipid droplets and induce phase transformations in the liquid medium. The results showed that when the lipid droplets and aqueous droplets coalesced, distinct structures with different compositions formed on the two sides of the merged droplet. Through diffusion limited interface, water molecules gradually hydrated the lipid portion, leading to a series of phase transformations. This study provides a new approach for studying the kinetics of phase transformations and identifying non-equilibrium phases in droplet-based lyotropic liquid systems.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Nastaran Meftahi, Maciej Adam Surmiak, Sebastian O. Fuerer, Kevin James Rietwyk, Jianfeng Lu, Sonia Ruiz Raga, Caria Evans, Monika Michalska, Hao Deng, David P. McMeekin, Tuncay Alan, Doojin Vak, Anthony S. R. Chesman, Andrew J. Christofferson, David A. Winkler, Udo Bach, Salvy P. Russo
Summary: Organic-inorganic perovskite solar cells (PSCs) have the potential to become the next-generation, cost-effective solar panels due to their competitive cost and high efficiency. However, their poor stability is a major drawback. A new subset of PSCs called quasi-two-dimensional Ruddlesden-Popper PSCs (quasi-2D RP PSCs) has shown improved photostability and resilience to environmental conditions. In this study, a combinatorial, machine learning enhanced high-throughput perovskite film fabrication and optimization approach is proposed to accelerate the search for new quasi-2D RP PSCs. By using spin-coating free robotic fabrication processes, perovskite films with different compositions are produced, and their performance data is used to train a machine learning model for materials optimization and design. The ML-optimized quasi-2D RP perovskite films achieved solar cells with power conversion efficiencies of up to 16.9%.
ADVANCED ENERGY MATERIALS
(2023)
Correction
Chemistry, Multidisciplinary
Shu Huang, Chuang Feng, Edwin L. H. Mayes, Bicheng Yao, Zijun He, Sajjad Asadi, Tuncay Alan, Jie Yang
Article
Nanoscience & Nanotechnology
Kajal Sharma, Shipra Pandey, Hariharan Sekar, Tuncay Alan, Venkat Gundabala
Summary: In this study, curcumin loaded alginate microfibers were generated using the microfluidic technique. The efficacy of a combined therapy (blue light + curcumin) against drug resistant Staphylococcus aureus biofilm was assessed. The results showed that the curcumin loaded alginate microfibers exhibited good eradication activity against drug resistant S. aureus biofilms under blue light irradiation.
ACS APPLIED BIO MATERIALS
(2023)
Meeting Abstract
Infectious Diseases
Y. Zhang, J. Zhao, Y. Lin, M. Han, Y. Zhu, J. Lu, A. Neild, A. Demarco, J. Li
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Biochemical Research Methods
Amir Pourabed, Thulya Chakkumpulakkal Puthan Veettil, Citsabehsan Devendran, Prasanna Nair, Bayden R. Wood, Tuncay Alan
Summary: Malaria, a life-threatening disease transmitted by infected mosquitoes, requires better diagnostic platforms to improve detection sensitivity and reduce processing times and costs. With the use of an acoustically actuated microfluidic mixer, blood cell lysis can be enhanced, leading to increased efficiency in releasing hemoglobin into plasma. The combination of acoustofluidic/spectroscopic approach shows promise for point-of-care blood diagnosis, especially in detecting neonatal and congenital malaria.