Review
Critical Care Medicine
Jonathan A. Black, Virginia S. Pierce, Kavina Juneja, John B. Holcomb
Summary: Trauma remains a leading cause of death, with hemorrhage being the leading preventable cause. In the past 20 years, resuscitation strategies for trauma have significantly changed, moving from large volume crystalloid resuscitation to a 1:1:1 ratio of packed red blood cells, fresh plasma, and platelets.
Article
Surgery
Elaine Cole, Anne Weaver, Lewis Gall, Anita West, Daniel Nevin, Rosel Tallach, Breda O'Neill, Sumitra Lahiri, Shubha Allard, Nigel Tai, Ross Davenport, Laura Green, Karim Brohi
Summary: Recent innovations in trauma major hemorrhage management have led to a significant decrease in mortality rates, although there are still opportunities for improvement. The proportion of trauma patients dying within a short period has decreased, with survivors more likely to be discharged home. Late deaths are now mainly attributed to traumatic brain injury and multiple organ dysfunction.
Article
Surgery
Jennifer M. Gurney, Amanda M. Staudt, Deborah J. Del Junco, Stacy A. Shackelford, Elizabeth A. Mann-Salinas, Andrew P. Cap, Philip C. Spinella, Matthew J. Martin
Summary: This study compared the early mortality rates of patients who received warm fresh whole blood with those who did not. The results showed a significant reduction in 6-hour mortality among the warm fresh whole blood group, with a dose-dependent effect. These findings support the use of warm fresh whole blood for hemorrhage control and call for further research in military and civilian trauma settings.
Article
Critical Care Medicine
David Kauvar, Bryan Cotton, Mansoor Khan, Bruno Perreira, Megan Brenner, Paula Ferrada, Tal Horer, Andrew Kirkpatrick, Carlos Ordonez, Artai Pirouzram, Derek Roberts, Juan Duchesne
Summary: The care of hemorrhaging patients has evolved significantly in civilian trauma care over the past 15 years with the increased use of endovascular techniques. These techniques are now being widely employed to treat major thoracoabdominal arterial injuries and as a supportive adjunct to resuscitation. Emerging endovascular technology offers the opportunity to provide temporary or permanent control of non-compressible torso hemorrhage in combat casualty care.
Article
Critical Care Medicine
Juan Duchesne, Sharven Taghavi, Scott Ninokawa, Charles Harris, Rebecca Schroll, Patrick McGrew, Clifton McGinness, Robert Reily, Chrissy Guidry, Danielle Tatum
Summary: A retrospective study on MTP patients over 12 years at a large trauma center found that despite lower mortality rates with the use of tourniquets and whole blood, overall mortality rates due to hemorrhage have remained unchanged. This suggests that implementing new in-hospital strategies alone may not be sufficient to reduce mortality from bleeding.
Article
Anesthesiology
Maeve Muldowney, Zhinan Liu, Lynn G. Stansbury, Monica S. Vavilala, John R. Hess
Summary: This retrospective study examined ultramassive transfusion cases at a trauma center over an 11-year period and found that the proportion of blood products transfused was associated with mortality. Early identification of coagulopathy and transfusing blood components in appropriate ratios were associated with reduced mortality.
ANESTHESIA AND ANALGESIA
(2023)
Review
Emergency Medicine
Zhe Zhu, Yong Yu, Kairui Hong, Mengqin Luo, Yefang Ke
Summary: This systematic review aims to evaluate the effectiveness of Viscoelastic Hemostatic Assay (VHA)-guided strategy in resuscitating trauma patients by summarizing the published evidence. The results show that while some studies suggest potential benefits of VHA-guided strategy in reducing the need for blood transfusion and mortality, the evidence is still limited.
WORLD JOURNAL OF EMERGENCY SURGERY
(2022)
Article
Surgery
Jason B. Brill, Brian Tang, Gabrielle Hatton, Krislynn M. Mueck, C. Cameron McCoy, Lillian S. Kao, Bryan A. Cotton
Summary: This study investigated the survival benefit of whole blood transfusion in bleeding trauma patients from different populations. The findings revealed that whole blood transfusion is associated with improved survival and decreased overall blood utilization in patients experiencing hemorrhagic shock.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Hematology
Joel Addams, Saman Arbabi, Eileen M. Bulger, Lynn G. Stansbury, Erin E. Tuott, John R. Hess
Summary: The research team successfully developed a whole blood transfusion program, utilizing low-titer group O whole blood in prehospital and in-hospital care, resulting in positive outcomes.
Article
Critical Care Medicine
David Kauvar, Bryan Cotton, Mansoor Khan, Bruno Perreira, Megan Brenner, Paula Ferrada, Tal Horer, Andrew Kirkpatrick, Carlos Ordonez, Artai Pirouzram, Derek Roberts, Juan Duchesne, Sharven Taghavi
Summary: Traumatic hemorrhage is caused by vascular disruption and can be controlled through selective vessel access and vascular flow control. The Circulatory Trauma paradigm views traumatic hemorrhage as injury to the circulatory system, leading to the increasing use of endovascular techniques for treatment.
Article
Critical Care Medicine
Tim W. H. Rijnhout, Femke Noorman, Oscar J. F. van Waes, Michaela van Bohemen, Michael H. J. Verhofstad, Rigo Hoencamp
Summary: This study assessed the knowledge of local massive transfusion protocols (MTP) and transfusion strategy in level 1 trauma centers in the Netherlands. The results showed that the majority of physicians dealing with trauma patients lacked awareness of the exact composition of MTP and there was low consensus regarding transfusion strategy and indication for platelet transfusion.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Medicine, General & Internal
Ross Davenport, Nicola Curry, Erin E. Fox, Helen Thomas, Joanne Lucas, Amy Evans, Shaminie Shanmugaranjan, Rupa Sharma, Alison Deary, Antoinette Edwards, Laura Green, Charles E. Wade, Jonathan R. Benger, Bryan A. Cotton, Simon J. Stanworth, Karim Brohi
Summary: This study aimed to assess whether administering an early and empirical high dose of cryoprecipitate could improve survival in patients with trauma and bleeding. The results showed that this treatment method did not reduce all-cause mortality at 28 days in patients who required activation of a major hemorrhage protocol.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Gastroenterology & Hepatology
Antolin S. Flores, Katherine T. Forkin, Meghan M. Brennan, Sathish S. Kumar, Deborah A. Winegar, Francesco Viola
Summary: This study evaluated the consistency of the Quantra System (with QStat Cartridge) and ROTEM delta device in monitoring coagulation and fibrinolysis in liver transplantation patients. The results showed a strong correlation between the two devices and an overall agreement of 90.3% in detecting fibrinolysis. Therefore, the Quantra System provides comparable information to the ROTEM delta in assessing hemostatic function.
LIVER TRANSPLANTATION
(2023)
Article
Critical Care Medicine
Mitsuaki Kojima, Akira Endo, Atsushi Shiraishi, Tomohisa Shoko, Yasuhiro Otomo, Raul Coimbra
Summary: This study investigated the interaction between plasma-to-RBC ratio and age in trauma patients and found that the association between plasma-to-RBC ratio and in-hospital mortality was clear in non-geriatric patients, but inconclusive in geriatric patients.
JOURNAL OF INTENSIVE CARE
(2022)
Article
Multidisciplinary Sciences
Jennifer S. Breel, Agnes G. C. L. Wensing, Susanne Eberl, Benedikt Preckel, Patrick Schober, Marcella C. A. Muller, Robert J. M. Klautz, Markus W. Hollmann, Henning Hermanns
Summary: This study aims to delineate the specific coagulation patterns and their clinical consequence in patients undergoing cardiac surgery due to infective endocarditis. The findings show significantly altered coagulation profiles in patients with infective endocarditis, with concomitant hyper- and hypocoagulability. The incidence of bleeding complications and transfusion requirements were also increased in patients with endocarditis.
Article
Critical Care Medicine
Marianne E. Nellis, Oliver Karam, Elizabeth Mauer, Melissa M. Cushing, Peter J. Davis, Marie E. Steiner, Marisa Tucci, Simon J. Stanworth, Philip C. Spinella
CRITICAL CARE MEDICINE
(2018)
Article
Critical Care Medicine
Thomas Woolley, Patrick Thompson, Emrys Kirkman, Richard Reed, Sylvain Ausset, Andrew Beckett, Christopher Bjerkvig, Andrew P. Cap, Tim Coats, Mitchell Cohen, Marc Despasquale, Warren Dorlac, Heidi Doughty, Richard Dutton, Brian Eastridge, Elon Glassberg, Anthony Hudson, Donald Jenkins, Sean Keenan, Christophe Martinaud, Ethan Miles, Ernest Moore, Giles Nordmann, Nicolas Prat, Joseph Rappold, Michael C. Reade, Paul Rees, Rory Rickard, Martin Schreiber, Stacy Shackelford, Hakon Skogran Eliassen, Jason Smith, Mike Smith, Philip Spinella, Geir Strandenes, Kevin Ward, Sarah Watts, Nathan White, Steve Williams
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2018)
Article
Cardiac & Cardiovascular Systems
Shelley Hancock, Curtis Froehlich, Veronica Armijo-Garcia, Andrew D. Meyer
Article
Critical Care Medicine
Thomas Woolley, Patrick Thompson, Emrys Kirkman, Richard Reed, Sylvain Ausset, Andrew Beckett, Christopher Bjerkvig, Andrew P. Cap, Tim Coats, Mitchell Cohen, Marc Despasquale, Warren Dorlac, Heidi Doughty, Richard Dutton, Brian Eastridge, Elon Glassberg, Anthony Hudson, Donald Jenkins, Sean Keenan, Christophe Martinaud, Ethan Miles, Ernest Moore, Giles Nordmann, Nicolas Prat, Joseph Rappold, Michael C. Reade, Paul Rees, Rory Rickard, Martin Schreiber, Stacy Shackelford, Hakon Skogran Eliassen, Jason Smith, Mike Smith, Philip Spinella, Geir Strandenes, Kevin Ward, Sarah Watts, Nathan White, Steve Williams
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2018)
Article
Critical Care Medicine
Marianne E. Nellis, Ruchika Goel, Oliver Karam, Melissa M. Cushing, Peter J. Davis, Marie E. Steiner, Marisa Tucci, Simon J. Stanworth, Philip C. Spinella, Warwick Butt, Carmel Delzoppo, Simon Erickson, Elizabeth Croston, Samantha Barr, Elena Cavazzoni, Annick de Jaeger, Marisa Tucci, Mary-Ellen French, Marion Ropars, Lucy Clayton, Srinivas Murthy, Gordon Krahn, Dong Qu, Yi Hui, Mathias Johansen, Anne-Mette Back Jensen, Inge-Lise Jarnvig, Ditte Strange, Muralidharan Jayashree, Mounika Reddy, Jhuma Sankar, U. Vijay Kumar, Rakesh Lodha, Reut Kassif Lerner, Gideon Paret, Ofer Schiller, Eran Shostak, Ovadia Dagan, Yuval Cavari, Fabrizio Chiusolo, Annagrazia Gillis, Anna Camporesi, Martin Kneyber, Suzan Cochius-den Otter, Ellen Van Hemeldonck, John Beca, Claire Sherring, Miriam Rea, Clara Abadesso, Marta Moniz, Saleh Alshehri, Jesus Lopez-Herce, Irene Ortiz, Miriam Garcia, Iolanda Jordan, J. Carlos Flores Gonzalez, Antonio Perez -Ferrer, Ana Pascual-Albitre, Serge Grazioli, Carsten Doell, Peter J. Davis, Ilaria Curio, Andrew Jones, Mark J. Peters, Jon Lillie, Angela Aramburo, Medhat Shabana, Priya Ramachandran, Helena Sampaio, Kalaimaran Sadasivam, Nicholas J. Prince, Hari Krishnan Kanthimathinathan, Ricardo Garcia Branco, Kim L. Sykes, Christie Mellish, Avishay Sarfatti, James Weitz, Ron C. Sanders, Glenda Hefley, Rica Sharon P. Morzov, Barry Markovitz, Anna Ratiu, Anil Sapru, Allison S. Cowl, E. Vincent S. Faustino, Shruthi Mahadevaiah, Fernando Beltramo, Asumthia S. Jeyapalan, Mary K. Cousins, Cheryl Stone, James Fortenberry, Neethi P. Pinto, Chiara Rodgers, Allison Kniola, Melissa Porter, Erin Owen, Kristen Lee, Laura J. Thomas, Melania M. Bembea, Ronke Awojoodu, Daniel Kelly, Kyle Hughes, Zenab Mansoor, Carol Pineda, Phoebe H. Yager, Maureen Clark, Scot T. Bateman, Kevin W. Kuo, Erin F. Carlton, Brian Boville, Mara Leimanis, Marie E. Steiner, Dan Nerheim, Kenneth E. Reniy, Lauren Langford, Melissa Schicker, Marcy N. Singleton, J. Dean Jarvis, Sholeen T. Nett, Shira Getz, James S. Killinger, Meghan Sturhahn, Margaret M. Parker, Liana Harwayne-Gidansky, Laura A. Watkins, Gina Cassel, Adi Aran, Shubhi Kaushik, Andy Y. Wen, Amanda B. Hassinger, Caroline P. Ozment, Candice M. Ray, Michael C. McCrory, Andora L. Bass, Michael T. Bigham, Heather Anthony, Jennifer A. Muszynki, Jill Popelka, Julie C. Fitzgerald, Susan Doney Leonard, Neal J. Thomas, Debbie Spear, Whitney E. Marvin, Arun Saini, Alina Nico West, Jennifer McArthur, Angela Norris, Saad Ghafoor, Ashlea Anderson, Tracey Monjure, Kris Bysani, LeeAnn M. Christie, Laura L. Loftis, Andrew D. Meyer, Robin Tragus, Holly Dibrell, David Rupert, Claudia Delgado-Corcoran, Stephanie Bodily, Douglas Willson, Leslie A. Dervan, Sheila J. Hanson, Scott A. Hagen, Awni M. Al-Subu
PEDIATRIC CRITICAL CARE MEDICINE
(2019)
Article
Critical Care Medicine
Marianne E. Nellis, Ruchika Goel, Oliver Karam, Melissa M. Cushing, Peter J. Davis, Marie E. Steiner, Marisa Tucci, Simon J. Stanworth, Philip C. Spinella, Warwick Butt, Carmel Delzoppo, Simon Erickson, Elizabeth Croston, Samantha Barr, Elena Cavazzoni, Annick de Jaeger, Marisa Tucci, Mary-Ellen French, Marion Ropars, Lucy Clayton, Srinivas Murthy, Gordon Krahn, Dong Qu, Yi Hui, Mathias Johansen, Anne-Mette Baek Jensen, Inge-Lise Jarnvig, Ditte Strange, Muralidharan Jayashree, Mounika Reddy, Jhuma Sankar, U. Vijay Kumar, Rakesh Lodha, Reut Kassif Lerner, Gideon Paret, Ofer Schiller, Eran Shostak, Ovadia Dagan, Yuval Cavari, Fabrizio Chiusolo, Annagrazia Cillis, Anna Camporesi, Martin Kneyber, Suzan Cochius-den Otter, Ellen Van Hemeldonck, John Beca, Claire Sherring, Miriam Rea, Clara Abadesso, Marta Moniz, Saleh Alshehri, Jesus Lopez-Herce, Irene Ortiz, Miriam Garcia, Iolanda Jordan, J. Carlos Flores Gonzalez, Antonio Perez-Ferrer, Ana Pascual-Albitre, Serge Grazioli, Carsten Doell, Peter J. Davis, Ilaria Curro, Andrew Jones, Mark J. Peters, Jon Lillie, Paul A. Wellman, Angela Aramburo, Medhat Shabana, Priya Ramachandran, Helena Sampaio, Kalaimaran Sadasivam, Nicholas J. Prince, Hari Krishnan Kanthimathinathan, Ricardo Garcia Branco, Kim L. Sykes, Christie Mellish, Avishay Sarfatti, James Weitz, Ron C. Sanders, Glenda Hefley, Rica Sharon P. Morzov, Barry Markovitz, Anna Ratiu, Anil Sapru, Allison S. Cowl, E. Vincent S. Faustino, Shruthi Mahadevaiah, Fernando Beltramo, Asumthia S. Jeyapalan, Mary K. Cousins, Cheryl Stone, James Fortenberry, Neethi P. Pinto, Chiara Rodgers, Allison Kniola, Melissa Porter, Erin Owen, Kristen Lee, Laura J. Thomas, Melania M. Bembea, Ronke Awojoodu, Daniel Kelly, Kyle Hughes, Zenab Mansoor, Carol Pineda, Phoebe H. Yager, Maureen Clark, Scot T. Bateman, Kevin W. Kuo, Erin F. Carlton, Brian Boville, Mara Leimanis, Marie E. Steiner, Dan Nerheim, Kenneth E. Remy, Lauren Langford, Melissa Schicker, Marcy N. Singleton, J. Dean Jarvis, Sholeen T. Nett, Shira Gertz, James S. Killinger, Meghan Sturhahn, Margaret M. Parker, Ilana Harwayne-Gidansky, Laura A. Watkins, Gina Cassel, Adi Aran, Shubhi Kaushik, Andy Y. Wen, Amanda B. Hassinger, Caroline P. Ozment, Candice M. Ray, Michael C. McCrory, Andora L. Bass, Michael T. Bigham, Heather Anthony, Jennifer A. Muszynski, Jill Popelka, Julie C. Fitzgerald, Susan Doney Leonard, Neal J. Thomas, Debbie Spear, Whitney E. Marvin, Arun Saini, Jennifer McArthur, Angela Norris, Saad Ghafoor, Ashlea Anderson, Tracey Monjure, Kris Bysani, LeeAnn M. Christie, Laura L. Loftis, Andrew D. Meyer, Robin Tragus, Holly Dibrell, David Rupert, Claudia Delgado-Corcoran, Stephanie Bodily, Douglas Willson, Leslie A. Dervan, Sheila J. Hanson, Scott A. Hagen, Awni M. Al-Subu
PEDIATRIC CRITICAL CARE MEDICINE
(2019)
Article
Hematology
Andrew D. Meyer, Anjana R. Rishmawi, Robin Kamucheka, Crystal Lafleur, Andriy I. Batchinsky, Nigel Mackman, Andrew P. Cap
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Review
Engineering, Biomedical
Sven R. Olson, Catherine R. Murphree, David Zonies, Andrew D. Meyer, Owen J. T. McCarty, Thomas G. Deloughery, Joseph J. Shatzel
Summary: The study reviewed thrombosis and bleeding outcomes in ECMO patients without continuous systemic anticoagulation. Results showed that while the incidence of bleeding and thrombosis was higher, the risk of circuity and patient thrombosis in anticoagulant-free ECMO patients was comparable to those receiving continuous systemic anticoagulation during ECMO.
Article
Multidisciplinary Sciences
Morten Zaar, Maryanne C. Herzig, Chriselda G. Fedyk, Robbie K. Montgomery, Nicolas Prat, Bijaya K. Parida, Carmen Hinojosa-Laborde, Gary W. Muniz, Robert E. Shade, Cassondra Bauer, Wilfred Delacruz, James A. Bynum, Victor A. Convertino, Andrew P. Cap, Heather F. Pidcoke, Nandu Goswami, Nandu Goswami, Nandu Goswami
Article
Hematology
Thomas G. Scorer, Lucy FitzGibbon, Riyaad Aungraheeta, Umang Sharma, Grantham C. Peltier, Colby S. McIntosh, Kristin M. Reddoch-Cardenas, Andrew Meyer, Andrew P. Cap, Andrew D. Mumford
Article
Otorhinolaryngology
Dylan Z. Erwin, Philip D. Heichel, Laura M. Wright, Nira A. Goldstein, Timothy P. McEvoy, Marisa A. Earley, Andrew D. Meyer
Summary: Treating PTH with nebulized TXA may be a safe first-line therapy to reduce the need for operative control of bleeding. The data suggests that a large clinical trial is needed to determine the efficacy of nebulized TXA in mitigating this common and potentially fatal post-operative complication.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Johanna Boutillier, Venetia Cardona, Pascal Magnan, Michael Ogier, Sebastien De Mezzo, Florent Montespan, William Menini, Joel Mosnier, Pierre Naz, Nicolas J. Prat
Summary: Exposure to blast is a major cause of death and disability in recent military conflicts. This study investigates the protective capability of ballistic-proof equipment, focusing on thoracic protective equipment (TPE). The results show that using ceramic hard plates can decrease the severity of blast-induced lung injuries, while using soft body armor may lead to more severe lung injuries. The force and force impulse data obtained from BOPMAN are well correlated with the level of blast-induced lung injury.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Nicolas J. Prat, Andrew D. Meyer, Vittorio Scaravilli, Jeremy Cannon, Leopoldo C. Cancio, Andrew P. Cap, Andriy Batchinsky
Summary: Regional acidification reduces platelet activation and consumption of coagulation factors during ECCO2R.
Review
Physiology
Frederique Dufour-Gaume, Nadira Frescaline, Venetia Cardona, Nicolas J. J. Prat
Summary: Hemorrhage is the leading cause of death in severe trauma injuries. Damage-associated molecular patterns (DAMPs) are released into the intercellular environment when organs or tissues experience prolonged hypoxia. The endothelium plays a significant role in both the release and effects of DAMPs, contributing to immune-inflammatory dysregulation and tissue suffering. This review focuses on the pathophysiological roles of DAMPs and explores emerging therapeutic interventions for severe trauma, aiming to calm the inflammatory response triggered by traumatic hemorrhagic shock.
FRONTIERS IN PHYSIOLOGY
(2023)