Article
Oncology
Hanjing Gao, Zheng Yan, Haiyan Sun, Yanfang Chen
Summary: The study showed that FOXA2 is significantly increased in ESCC tissues, and high expression of FOXA2 promotes ESCC progression by regulating ZEB2 at the transcription level. The results suggest that FOXA2 plays a critical role in ESCC and may be a potential target for ESCC treatment.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Xiaoting Chen, Lanlan Huang, Tingting Yang, Jiexuan Xu, Chengyong Zhang, Zhendong Deng, Xiaorong Yang, Naihua Liu, Size Chen, Shaoqiang Lin
Summary: Recent studies have identified pleiotropic roles of METTL3 in tumor progression, but its specific role in esophageal squamous cell carcinoma (ESCC) is still unclear. Higher METTL3 expression in ESCC tissues was associated with poor prognosis, and it was shown to promote migration and invasion of ESCC cells by regulating GLS2. These findings suggest METTL3/GLS2 signaling as a potential therapeutic target for anti-metastatic strategies against ESCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yingkuan Liang, Qixing Mao, Lin Wang, Wenjie Xia, Bing Chen, Hui Wang, Rutao Li, Lin Xu, Feng Jiang, Gaochao Dong
Summary: The study revealed that circIMMP2L is upregulated in tumor tissues and plasma from ESCC patients, predicting worse survival outcomes. It promotes malignant progression of ESCC by facilitating CtBP1 nuclear retention, serving as a robust biomarker for diagnosis, prognosis, and lymph node metastasis. This extends our understanding of circRNA regulation in gene transcription through epigenetics.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Genetics & Heredity
Adam N. Bennett, Rui Xuan Huang, Qian He, Nikki P. Lee, Wing-Kin Sung, Kei Hang Katie Chan
Summary: Esophageal cancer, particularly esophageal squamous cell carcinoma, is a significant challenge globally, with high incidence and mortality rates. The limited number of effective therapeutic options contributes to the high mortality rate. Repurposing existing drugs approved for other diseases through drug repositioning is a more time and cost-effective strategy. This study identified potential therapeutic drugs for esophageal cancer patients through gene expression analysis and network analysis, including both known drugs like Doxorubicin and potential psychiatric drugs like Venlafaxine.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Yuandong Cao, Aidi Gao, Xiaoqing Li, Han Min, Chao He, Xinchen Sun, Wei-Qun Ding, Jundong Zhou
Summary: TAB182 is identified as a key regulator of radiation sensitivity in ESCC cells, with its downregulation sensitizing cancer cells to ionizing radiation and overcoming radioresistance by interacting with FHL2 to modulate the G2-M checkpoint.
Article
Engineering, Biomedical
Yenan Wu, Haiwei Liang, Aiping Luo, Yong Li, Zhiqiang Liu, Xin Li, Wenxin Li, Kaini Liang, Junyang Li, Zhihua Liu, Yanan Du
Summary: In this study, gelatin-based 3D biomimetic scaffolds mimicking the stiffness and collagen content of esophageal squamous cell carcinoma (ESCC) were established to efficiently enrich ESCC cancer stem cells (CSCs). The effects of scaffold viscoelasticity on ESCC CSCs were thoroughly investigated, and it was found that highly viscous scaffolds better supported the enrichment of ESCC CSCs and the TGF-beta signaling pathway may be involved in regulating ESCC stemness. Compared to 2D cultures, highly viscous scaffolds significantly promoted the clonal expansion of ESCC cells in vitro and tumor formation ability in vivo.
Article
Oncology
Shuwen Xu, Xiaofeng Li, Longfei Li, Yufeng Wang, Chong Geng, Feng Guo, Tao Zhang, Aonan Du, Zhiwei Lu, Hua Hui, Qiang Wang
Summary: The study found that miR-137 was down-regulated in ESCC cells. Upregulation of miR-137 inhibited proliferation, migration, invasion, and EMT of ESCC cells. CTCF activated miR-137 transcription and its downstream targets included EZH2 and PXN.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Shaobo Zhang, Tongyang Gong, Yabin Nan, Riyue Feng, Zhihua Liu, Hongyan Chen
Summary: Esophageal squamous cell carcinoma (ESCC) is a common malignant disease, and MAFB, which is highly expressed in ESCC, may promote tumor development by upregulating IGFBP6, suggesting it as a potential therapeutic target for ESCC.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Immunology
Zongdan Jiang, Jun Wang, Ziyang Shen, Zhenyu Zhang, Shukui Wang
Summary: This study revealed significant differences in microbial diversity between esophageal cancer patients and healthy controls, as well as distinct changes at the genus level. Additionally, esophageal adenocarcinoma patients showed differences in bacterial composition compared to esophagitis patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Guozhen Yang, Xiaodong Su, Yuanheng Huang, Guangyu Luo, Zhiqiang Wang, Peiqiang Cai, Yating Zheng, Ting Bei, Mengli Huang, Yuezong Bai, Haoqiang He, Jin Xiang, Muyan Cai, Jiudi Zhong, Qiyu Guo, Xu Zhang
Summary: Three cycles of neoadjuvant camrelizumab plus nab-paclitaxel and capecitabine increased tumor regression and improved survival outcomes in patients with locally advanced esophageal squamous cell carcinoma. Randomized controlled trials with larger sample sizes and longer follow-up periods are needed to validate these findings.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Yin Yin, Xiao Yu, Riyue Feng, Yang Li, Yahui Zhao, Zhihua Liu
Summary: This study found sex and age biases in esophageal squamous cell carcinoma (ESCC), with the G2/M checkpoint pathway being a potential cause. The results suggest that including G2/M targets in combination therapy may improve the efficacy of ESCC treatment for male patients.
Article
Medicine, General & Internal
Wei Guo, Bolun Zhou, Zhenlin Yang, Xiang Liu, Qilin Huai, Lei Guo, Xuemin Xue, Fengwei Tan, Yin Li, Qi Xue, Shugeng Gao, Jie He
Summary: This study characterized the spatial landscape of different cell subsets within the tumor microenvironment (TME) using single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST). It identified distinct stromal cell populations and their distribution in the TME of esophageal squamous cell carcinoma (ESCC). The study also revealed differences in TME features between metastatic and non-metastatic samples and between the primary and metastatic sites.
Article
Immunology
Zhiping Wang, Mengyan Zhang, Lingyun Liu, Yan Yang, Jianjian Qiu, Yilin Yu, Jiancheng Li
Summary: This study investigates the impact and prognostic significance of exosomal proteins derived from cancer-associated fibroblasts (CAFs) in esophageal squamous cell carcinoma (ESCC). The findings reveal that exosomes derived from CAFs enhance the proliferation, invasion, and migration of esophageal cancer cells. A prognostic signature based on CAFs-derived exosomal proteins is established, and it is found to serve as a reliable biomarker for predicting prognosis and evaluating the immune microenvironment in ESCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Xin-ye Wang, Xia-yu Fu, Hong Yang, Jing Wen, Peng Lin, Jian-hua Fu
Summary: This study explores the characteristics of 4R metastasis and evaluates the clinical value of 4R node dissection in esophageal squamous cell carcinoma (ESCC). The study finds that 4R metastasis is significantly associated with 2R metastasis and pathologic tumor-node-metastasis stage, but performing 4R dissection does not improve overall survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Sheila Coelho Soares-Lima, Isabela Martins Gonzaga, Diego Camuzi, Pedro Nicolau-Neto, Raissa Vieira da Silva, Simone Guaraldi, Maria Aparecida Ferreira, Hector Hernandez-Vargas, Zdenko Herceg, Luis Felipe Ribeiro Pinto
Summary: The study suggests that overexpression of IL6 may play a key role in the carcinogenesis of ESCC, contributing to ESCC development through a homogeneous antiapoptotic signaling via BCL3 overexpression. The study also supports the potential of using BCL3 mRNA expression as a biomarker for ESCC detection.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Matthew A. Sermersheim, Ki Ho Park, Kristyn Gumpper, T. M. Ayodele Adesanya, Kuncheng Song, Tao Tan, Xingcong Ren, Jin-Ming Yang, Hua Zhu
FRONTIERS IN BIOSCIENCE-LANDMARK
(2017)
Article
Biochemistry & Molecular Biology
Yanhong Luo, Jianfeng He, Chunlin Yang, Matthew Orange, Xingcong Ren, Nick Blair, Tao Tan, Jin-Ming Yang, Hua Zhu
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Article
Cell Biology
Ken Chen, Zaicheng Xu, Yukai Liu, Zhen Wang, Yu Li, Xuefei Xu, Caiyu Chen, Tianyang Xia, Qiao Liao, Yonggang Yao, Cindy Zeng, Duofen He, Yongjian Yang, Tao Tan, Jianxun Yi, Jingsong Zhou, Hua Zhu, Jianjie Ma, Chunyu Zeng
SCIENCE TRANSLATIONAL MEDICINE
(2017)
Review
Pharmacology & Pharmacy
Xin An, Cesar Sarmiento, Tao Tan, Hua Zhu
ACTA PHARMACEUTICA SINICA B
(2017)
Review
Chemistry, Multidisciplinary
Jiu-cheng Zhang, Wei-dong Chen, Jean Bustamante Alvarez, Kelly Jia, Lei Shi, Qiang Wang, Ning Zou, Kai He, Hua Zhu
ACTA PHARMACOLOGICA SINICA
(2018)
Article
Cell Biology
Yongqiu Zheng, Zhenzhen Wu, Frank Yi, Matthew Orange, Mingjiang Yao, Bin Yang, Jianxun Liu, Hua Zhu
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Cardiac & Cardiovascular Systems
Zhen Wang, Ken Chen, Yu Han, Hua Zhu, Xinyu Zhou, Tao Tan, Jing Zeng, Jun Zhang, Yukai Liu, Yu Li, Yonggang Yao, Jianxun Yi, Duofen He, Jingsong Zhou, Jianjie Ma, Chunyu Zeng
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2018)
Letter
Biochemistry & Molecular Biology
Sheng Wang, Kristyn Gumpper, Tao Tan, Xianzhang Luo, Hui Guo, Changsheng Ming, Hanying Jiang, Jiangguo Fang, Guang Du, Hua Zhu, Jianjie Ma, Zhishui Chen, Nianqiao Gong
CELL AND BIOSCIENCE
(2018)
Review
Pharmacology & Pharmacy
Yanhong Luo, Hua Zhu, Tao Tan, Jianfeng He
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Qi-wei Jiang, Denis Kaili, Jonaye Freeman, Chong-yang Lei, Bing-chuan Geng, Tao Tan, Jian-feng He, Zhi Shi, Jian-jie Ma, Yan-hong Luo, Heather Chandler, Hua Zhu
ACTA PHARMACOLOGICA SINICA
(2019)
Article
Cardiac & Cardiovascular Systems
T. M. Ayodele Adesanya, Melanie Russell, Ki Ho Park, Xinyu Zhou, Matthew A. Sermersheim, Kristyn Gumpper, Sara N. Koenig, Tao Tan, Bryan A. Whitson, Paul M. L. Janssen, Joy Lincoln, Hua Zhu, Jianjie Ma
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Cell Biology
Zhentao Zhang, Gabriella Shayani, Yanping Xu, Ashley Kim, Yurim Hong, Haiyue Feng, Hua Zhu
Summary: Cardiac fibroblasts are a major contributor to cardiac fibrosis during heart repair processes. This study demonstrates that Gata4 plays a role in regulating the senescence of cardiac fibroblasts. Deletion of Gata4 in cardiac fibroblasts induces senescence, while deletion in cardiomyocytes does not.
Article
Chemistry, Multidisciplinary
Yan-hong Luo, Min Zhu, Dong-gang Wang, Yu-sheng Yang, Tao Tan, Hua Zhu, Jian-feng He
ACTA PHARMACOLOGICA SINICA
(2018)
Article
Chemistry, Multidisciplinary
Bao-yu Peng, Qiang Wang, Yan-hong Luo, Jian-feng He, Tao Tan, Hua Zhu
ACTA PHARMACOLOGICA SINICA
(2018)
Article
Oncology
Zhenguo Liu, Canqiao Luo, Weixiong Yang, Kefeng Wang, Chuang Hu, Jianyong Zou, Hua Zhu, Liwu Fu, Jing Nie, Chao Cheng
CANCER BIOLOGY & THERAPY
(2018)