Article
Engineering, Multidisciplinary
Sungjun Hwang, Yousoo Han, Douglas J. Gardner
Summary: Bleached Kraft pulp, unbleached Kraft pulp, and old corrugated cardboard pulp are suitable for producing cellulose nanofibril suspensions. Spray drying is a fast, simple, cost-effective, and scalable drying method. Spray-dried cellulose nanofibrils can be used as reinforcing materials in polypropylene matrices. The particle size of cellulose nanofibrils affects the material properties.
COMPOSITES PART B-ENGINEERING
(2024)
Article
Chemistry, Applied
J. Alarcon-Moyano, D. Acuna, S. Matiacevich, L. Caballero, F. Melo, F. Quero, P. Diaz-Calderon
Summary: This study evaluated the physical-chemical properties and structure of cellulose nanocrystals (CNC) dried by two different methods: Spray-Drying (SD) or Freeze-Drying (FD). The results showed that the drying method influenced the size, aspect ratio, and sorption of CNC. However, it did not affect zeta potential, crystallinity, or degradation temperature. The study suggests that the drying method plays a role in modifying the physico-chemical properties of CNC.
FOOD HYDROCOLLOIDS
(2023)
Review
Food Science & Technology
Dian Shofinita, Dianika Lestari, Lienda Aliwarga, Giovanni Arneldi Sumampouw, Sekar Arum Ambarwati, Karen Christine Gunawan, Amarthya Benigna Achmadi
Summary: Drying is a crucial step in coffee production to prevent microbial growth and extend coffee's storage time. Mechanical drying methods have been developed, but they may alter the physicochemical properties and compounds in coffee. Thus, maintaining these factors is vital as they impact the stability, reconstitution, and aroma of coffee, ultimately determining its quality. This review focuses on the effects of spray-drying, freeze-drying, and spray-freeze-drying on coffee's physicochemical properties and discusses their impact on organoleptic properties. Possible advancements such as encapsulation, porous frozen samples, and total solid enhancement of raw materials are highlighted.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Engineering, Chemical
Li Yoke Ho, Yau Yan Lim, Chin Ping Tan, Lee Fong Siow
Summary: This study compared the effects of different drying techniques on the coacervation of xanthone, a poorly aqueous-soluble bioactive compound. Spray drying showed the highest improvement in xanthone solubility, while freeze drying resulted in the highest encapsulation yield. The findings of this study have implications for the food and pharmaceutical industries.
Article
Food Science & Technology
Gulsah Caliskan Koc
Summary: This study investigated the influence of encapsulating agents on the properties of red pepper juice powders, obtaining acceptable powder yield and specific energy consumption values. RPJP + MD exhibited superior properties compared to other powders.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Article
Food Science & Technology
Qingya Zhang, Ao Yang, Weihua Tan, Wenchao Yang
Summary: In this study, propolis microcapsules were developed using a spray-drying technique, with ethanol extract of propolis as the core material and gum arabic and & beta;-cyclodextrin as the shell materials. The microcapsules showed good solubility and antibacterial activity, and have the potential to be used as a sustained-release food additive, preservative, or drug.
Article
Biochemistry & Molecular Biology
Shumin Wang, Yingxuan Xie, Huanhuan Su, Yanran Luo, Mengting Wang, Teng Li, Yuying Fu
Summary: Curcumin solid dispersions (Cur SDs) were prepared using hydroxypropyl methyl cellulose (HPMC) and sodium carboxymethyl cellulose (CMC) at different dosages. The addition of CMC enhanced the characteristic peak shift of curcumin, reduced contact angle, increased surface free energy, and improved the solubility of Cur SDs. The morphology of Cur SDs changed from needle-like to sheet-like with the addition of CMC. The addition of CMC significantly improved the anti-proliferation effect of Cur SDs, enhancing the bioavailability of curcumin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Chulhun Park, Jieyu Zuo, Myung-Chul Gil, Raimar Lobenberg, Beom-Jin Lee
Summary: This study investigated the enhancement of solubility and stability of cannabinoid acids through the formation of inclusion complexes with cyclodextrins. The inclusion complexes showed improved physicochemical and biological performances, making them a promising option for loading lipophilic cannabinoids in drug products derived from cannabis.
Article
Food Science & Technology
Phatthawin Setthaya, Sanchai Jaturasitha, Sunantha Ketnawa, Thanongsak Chaiyaso, Kenji Sato, Rawiwan Wongpoomchai
Summary: This study found that the combination of Alcalase(R) and papain enzymes, along with the spray-drying process, can be used to produce chicken breast hydrolysates with antioxidant properties.
Article
Engineering, Chemical
Ferhan Balci-Torun, Feramuz Ozdemir
Summary: This study aimed to enhance the encapsulation stability of natural strawberry flavour using optimal spray drying conditions, resulting in encapsulates with high yield and solubility. Spray-dried encapsulates were spherical, smooth, and homogeneous, while freeze-dried encapsulates were heterogeneous and spongy. The particle size of spray-dried samples was significantly smaller than freeze-dried samples.
Article
Chemistry, Applied
Annelies E. Blok, Dieuwerke P. Bolhuis, Krassimir P. Velikov, Markus Stieger
Summary: In this study, dried microfibrillated cellulose (MFC) particles were prepared by spray-drying MFC dispersions in a surplus of maltodextrin to prevent degradation of properties. The effect of MFC particle concentration and MFC:maltodextrin ratio on rheological, tribological and sensory texture properties of liquid foods was evaluated. The results showed that low MFC:maltodextrin particles effectively improved rheological properties, thickness, and creaminess of the foods. Therefore, spray-dried MFC particles can be used as a thickener or fat replacer in liquid foods.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Applied
Margarida Faustino, Carla F. Pereira, Joana Dura, Ana Sofia Oliveira, Joana Odila Pereira, Carlos Ferreira, Manuela E. Pintado, Ana P. Carvalho
Summary: This study evaluates the impact of freeze drying and spray drying on the structural, physicochemical, and biological properties of mannans from Saccharomyces cerevisiae. Structural analysis was conducted using FT-IR, PXRD, and SEM, while physicochemical properties were assessed based on sugars, protein, ash and water contents, solubility, and molecular weight distribution. Thermal behavior was analyzed using DSC, and antioxidant activity was measured using DPPH and ABTS assays.
Article
Pharmacology & Pharmacy
Sin Yee Lee, Vincent Ferdinand, Lee Fong Siow
Summary: This study aimed to investigate the effect of drying methods on the properties of chamomile extract powder. The findings showed that convection oven-drying resulted in the highest yield and desirable powder properties, while spray-drying had lower yield and higher moisture content and water activity. Freeze-drying had slightly lower total polyphenol content compared to the other two methods.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Polymer Science
Sungjun Hwang, Colleen C. Walker, Donna Johnson, Yousoo Han, Douglas J. Gardner
Summary: Enzyme-treated cellulose nanofibrils (CNFs) were prepared and spray-dried to investigate their effect on the mechanical properties of composites. The results showed that adding enzyme-treated SDCNFs enhanced the strength of PP and maintained the strength properties.
Article
Food Science & Technology
Vanessa Maldaner, Paulo Carteri Coradi, Marcela Trojahn Nunes, Amanda Muller, Leticia Oliveira Carneiro, Paulo Eduardo Teodoro, Larissa Pereira Ribeiro Teodoro, Joseane Bressiani, Kellen Francine Anschau, Edson Irineu Muller
Summary: Controlling the intermittence time and air-drying temperature is crucial for drying rice, as longer drying time can lead to ruptures in brown rice endosperm and an increase in burned and chalky grains. The longer the drying time, the more significant the effect on rice quality.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Claudia Carbone, Carla Caddeo, Teresa Musumeci
Review
Pharmacology & Pharmacy
Elide Zingale, Alessia Romeo, Salvatore Rizzo, Cinzia Cimino, Angela Bonaccorso, Claudia Carbone, Teresa Musumeci, Rosario Pignatello
Summary: This review focuses on the latest advances in ocular routes of drug administration, particularly after topical application. The use of fluorescent nanoparticles for tracking and biodistribution studies is discussed, along with their potential applications in diagnostics and therapeutics.
Review
Pharmacology & Pharmacy
Elide Zingale, Angela Bonaccorso, Claudia Carbone, Teresa Musumeci, Rosario Pignatello
Summary: The development of nanocrystalline drug technology has shown promising results in improving drug solubility and bioavailability. The use of nanocrystals as carrier-free drug particles has proven to be effective in the treatment of CNS diseases and has potential applications in diagnostic imaging. The clinical effectiveness of nanocrystals is leading to an increasing number of FDA-approved products, particularly for neurological disorders.
Article
Dermatology
Simona Pisanti, Teresa Mencherini, Tiziana Esposito, Valeria D'Amato, Tania Re, Maurizio Bifulco, Rita P. Aquino
Summary: This study critically compares medieval and modern dermocosmetics through the analysis of Trotula de Ruggiero's works. The results highlight Trotula's focus on female care, beauty and well-being, as well as the extraordinary combination of tradition and modernity in her work.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Cell Biology
Irene Paterniti, Alessia Filippone, Irina Naletova, Valentina Greco, Sebastiano Sciuto, Emanuela Esposito, Salvatore Cuzzocrea, Enrico Rizzarelli
Summary: Spinal cord injury (SCI) can cause severe motor dysfunction and nervous system abnormalities. The conjugation of trehalose with l-carnosine (Tre-car) has been found to reduce inflammation in vitro and in vivo models of SCI. Tre-car decreased early inflammatory effects, oxidative stress, and apoptosis, and stimulated the release of neurotrophic factors and influenced Zn2+ homeostasis. Tre-car may be a promising therapeutic agent for treating SCI.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Giovanni Falcone, Sonja Kuth, Aldo R. Boccaccini, Rita P. Aquino, Tiziana Esposito, Paola Russo
Summary: To fully utilize the potential of 3D printing, particularly in the case of semisolid extrusion (SSE), the technological challenges need to be addressed. This study focuses on investigating the physicochemical properties of natural polymers, specifically alginate hydrogel, for 3D printing tablets that are easy to swallow. By adding sorbitol as a plasticizer, the aim is to improve the swallowability of the tablets. Different concentrations of sorbitol solution are evaluated to determine the best composition in terms of printing and technological properties. The results highlight a predictable relationship between the amount of sorbitol loaded and the residual mass of the final platforms.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Maria Rosaria Lauro, Patrizia Picerno, Silvia Franceschelli, Michela Pecoraro, Rita Patrizia Aquino, Rosario Pignatello
Summary: The aim of this work was to develop, prepare, and control Eudraguard(R) spray-drying microparticles to obtain powders with easy handling and a stable dietary supplement containing a polar functional extract from Sorbus domestica L. leaves. The results showed that both Eudraguard(R) products were capable of carrying the extract and improving its antioxidant and alpha-glucosidase inhibition activities, as well as the extract stability and handling.
Article
Pharmacology & Pharmacy
Carmela Tommasino, Giulia Auriemma, Carla Sardo, Carmen Alvarez-Lorenzo, Emilia Garofalo, Silvana Morello, Giovanni Falcone, Rita P. Aquino
Summary: In this study, a PCL/INU-PLA hybrid biomaterial was prepared, which showed improved surface properties, swelling ability, and in vitro biodegradation rate compared to PCL alone. The 3D printed scaffolds exhibited dimensional and structural parameters close to the digital model and showed favorable results in biocompatibility and osteogenic activity tests.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Redouane Lemoui, Patrizia Picerno, Samira Benyahia, Teresa Mencherini, Antonio Vassallo, Maria Francesca Armentano, Labib Noman, Khaled Bouchama, Luca Rastrelli, Rita Patrizia Aquino
Summary: In this study, seven secondary metabolites were isolated and identified from the methanol extract of Stachys brachyclada de Noe ex Coss. leaves. The extract showed inhibition of alpha-glucosidase enzyme, radical scavenging activity, and reduction of oxidative stress level in Human Dermal Fibroblast. Stachysetin was identified as the major compound in the extract.
NATURAL PRODUCT RESEARCH
(2023)
Review
Chemistry, Medicinal
Angela Bonaccorso, Anna Privitera, Margherita Grasso, Sonya Salamone, Claudia Carbone, Rosario Pignatello, Teresa Musumeci, Filippo Caraci, Giuseppe Caruso
Summary: Carnosine, an endogenous dipeptide, has been investigated for its pharmacodynamic profile in various disease models and clinical settings due to its anti-aggregant, antioxidant, and anti-inflammatory activities, as well as its ability to modulate energy metabolism in immune cells. However, the rapid hydrolysis of carnosine by carnosinases, especially at the plasma level, limits its therapeutic use. Therefore, the development of new strategies, such as chemical modification and drug delivery systems, is crucial to increase carnosine bioavailability and site-specific transport to different tissues.
Article
Biology
Chiara Amante, Chiara De Soricellis, Gianni Luccheo, Luigi Luccheo, Paola Russo, Rita Patrizia Aquino, Pasquale Del Gaudio
Summary: The National Institute of Health has found that 80% of chronic infections are linked to biofilms, which contribute to bacterial resistance to antimicrobial agents. A novel mixture composed of N-acetylcysteine (NAC) and various natural ingredients has been developed to enhance NAC's activity against different bacteria and reduce biofilm formation. This mixture has shown increased NAC permeation, fibrinolytic activity, antibiofilm activity, and reduced bacterial adhesion.
Article
Polymer Science
Maria Rosaria Sellitto, Chiara Amante, Rita Patrizia Aquino, Paola Russo, Rosalia Rodriguez-Dorado, Monica Neagu, Carlos A. Garcia-Gonzalez, Renata Adami, Pasquale Del Gaudio
Summary: The use of polysaccharide-based aerogels as drug carriers for wound healing is being explored. Drug-loaded aerogel capsules were produced through prilling in tandem with supercritical extraction. The capsules had a hollow cavity and a thin alginate aerogel layer with good textural properties. These capsules effectively absorbed wound fluid and prolonged drug release due to a formed hydrogel barrier.
Article
Plant Sciences
Tiziana Esposito, Simona Pisanti, Rosanna Martinelli, Rita Celano, Teresa Mencherini, Tania Re, Rita P. Aquino
Summary: This study compared the metabolite profile of Couroupita guianensis bark decoction produced by Amazonian shamans with that obtained under laboratory conditions and investigated their biological properties in wound healing and inflammation. The analysis revealed the presence of polyphenolic compounds and uncommon sulphated derivatives of ellagic acid in the decoction. A new sulphated molecule was identified as the potential active compound responsible for wound healing. The decoction also showed anti-inflammatory effects and potential therapeutic applications in skin diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Francesco Bellia, Valeria Lanza, Irina Naletova, Barbara Tomasello, Valeria Ciaffaglione, Valentina Greco, Sebastiano Sciuto, Pietro Amico, Rosanna Inturri, Susanna Vaccaro, Tiziana Campagna, Francesco Attanasio, Giovanni Tabbi, Enrico Rizzarelli
Summary: A series of copper(II) complexes varying the molecular weight of Hyaluronic acid (Hy, x = 200 or 700 kDa) conjugated with carnosine (Car) were synthesized and characterized. The metal complexes showed excellent Cu, Zn-superoxide dismutase (SOD1) mimicking activity. The presence of non-functionalized Hyaluronic acid OH groups enhanced the scavenger activity of the copper(II) complexes.
Article
Biochemistry & Molecular Biology
Patrizia Picerno, Lucia Crasci, Patrizia Iannece, Tiziana Esposito, Silvia Franceschelli, Michela Pecoraro, Virgilio Giannone, Anna Maria Panico, Rita Patrizia Aquino, Maria Rosaria Lauro, Francisca Rodrigues, Ana Margarida Silva
Summary: This study evaluated the biological and technological activity of a dry aqueous extract from Sicilian almond peels, finding significant antioxidant and metalloproteinase inhibition effects. The use of Eudraguard (R) Natural improved the solubility and release of the extract and protected it from degradation and oxidation, prolonging the shelf life of the final product.
