Article
Chemistry, Multidisciplinary
Zhiduo Sun, Weiyun Zhang, Zhichao Ye, Li Yuan, Manli Fu, Xiaoming Liu, Huageng Liang, Heyou Han
Summary: This study presents the design of a novel nanocarrier DNAH for the treatment of bladder cancer, utilizing photothermal therapy to overcome the bladder mucosal barrier and enhance drug penetration. The results demonstrate the potential inhibition of bladder tumor growth by DNAH, leading to improved survival time in mice.
Article
Chemistry, Multidisciplinary
Ying Huang, Lei Wang, Zhiyang Cheng, Biyu Yang, Jiahui Yu, Yi Chen, Wei Lu
Summary: The novel Mal-glu-SN38 prodrug showed selective delivery of SN38 to tumour sites and enhanced efficacy. With slower plasma clearance, increased drug exposure over time, and enhanced accumulation at the tumour site, Mal-glu-SN38 significantly delayed tumour growth after multiple doses, leading to an impressive reduction or even disappearance of tumours without observable side effects in 67% of mice.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Hanhee Cho, Man Kyu Shim, Suah Yang, Sukyung Song, Yujeong Moon, Jinseong Kim, Youngro Byun, Cheol-Hee Ahn, Kwangmeyung Kim
Summary: This study proposes a new approach for drug design in cancer therapy, utilizing a prodrug that can be activated by cathepsin B-overexpressed tumor cells. The prodrug selectively releases doxorubicin, a potent antitumor drug, in the tumor microenvironment, while minimizing toxicity to normal tissues. This promising strategy may have significant implications for effective and safe chemotherapy.
Review
Biotechnology & Applied Microbiology
Zongheng Wang, Miaomiao Xiao, Fangliang Guo, Yue Yan, Hong Tian, Qianshi Zhang, Shuangyi Ren, Liqun Yang
Summary: Cancer poses a serious threat to human health, with few cases having a complete cure. Nano-drug delivery systems based on biodegradable polyesters have gained widespread attention for their potential in offering high bioavailability, effective encapsulation, controlled release, and minimal toxicity. Poly (epsilon-caprolactone) (PCL), poly (lactic-co-glycolic acid) (PLGA), and polylactic acid (PLA) are commonly used carriers in these systems. This paper comprehensively reviews the recent advancements and limitations of these materials as nano-carriers for delivering chemotherapeutic drugs and suggests future research directions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ying Fu, Shuyan Yang, Yuning Liu, Jian Liu, Qizhi Wang, Fengyan Li, Xiuzhuan Shang, Yuou Teng, Na Guo, Peng Yu
Summary: A novel nano-drug delivery system based on targeting ligand modified albumin is shown to inhibit tumor growth and metastasis, offering a promising chemotherapy approach.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Engineering, Environmental
Han Luo, Jianyong Sheng, LinLin Shi, Xiaoyu Yang, Jitang Chen, Tianhao Peng, Qibing Zhou, Jiangling Wan, Xiangliang Yang
Summary: The one-step Fenton method offers a unique and green solution to produce protein NPs, which demonstrated promising antitumor efficacy, pharmacokinetic profiles, and safety. This approach is applicable not only to BSA NPs but also to other proteins, providing a novel strategy for effective drug delivery carrier production in biomedical applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Lan Yang, Xiao He, Zhiying Zeng, Jiakun Tang, Dongmei Qi, Huijie Ma, Hui Chen, Xinghai Ning, Xuli Feng
Summary: This study presents a nucleus-targeted synergistic chemo-photodynamic therapy using the self-assembly of chlorin e6 (Ce6) and doxorubicin (DOX), which demonstrates enhanced cellular uptake and accumulation in the nucleus, leading to improved therapeutic efficacy for cancer treatment. The introduction of clickable dibenzocyclooctyne (DIBO) functionalized lysine (D-K) and crosslinkers enables efficient self-assembly of the nanodrugs, showing great potential for nucleus-specific drug delivery strategies.
Review
Chemistry, Multidisciplinary
Yishen Mao, Caifeng Zou, Yongjian Jiang, Deliang Fu
Summary: Erythrocytes have shown promising potential as drug delivery systems for cancer therapy, particularly in cancer enzyme therapy, delivering chemotherapeutic agents, combining with nanoparticles, and other potential anti-cancer agents for gene or immune therapy. The translation of this novel delivering system from lab to clinical practice is currently underway, with some carriers already in clinical trials and showing promising outcomes. Erythrocyte-derived drug delivery systems may play a crucial role in future cancer management.
CHINESE CHEMICAL LETTERS
(2021)
Article
Engineering, Biomedical
Haijing Qu, Han Chen, Wei Cheng, Yanjun Wang, Yangyang Xia, Linghao Zhang, Buyong Ma, Rong Hu, Xiangdong Xue
Summary: We propose a supramolecular assembly strategy to enhance drug loading, tumor targeting, and delivery simplicity for hydrophilic drugs. By co-assembling with other drugs, we validate the effectiveness of this strategy and demonstrate its application in anti-tumor activities.
ACTA BIOMATERIALIA
(2023)
Article
Polymer Science
Wanda Celentano, Stefania Ordanini, Riccardo Bruni, Luca Marocco, Pietro Medaglia, Andrea Rossi, Stefano Buzzaccaro, Francesco Cellesi
Summary: Well-defined amphiphilic PCL-PEG copolymers with complex molecular architectures were synthesized using ROP and ATRP. These copolymers were used to produce self-assembled nanoparticles for drug encapsulation, with the ability to tune self-assembly, particle size, and drug loading by designing specific macromolecular architectures.
EUROPEAN POLYMER JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Hilda Amekyeh, Enas Alkhader, Rayan Sabra, Nashiru Billa
Summary: This review discusses the potential use of CUR-NPs in cancer treatment. CUR incorporation into nanoparticles enhances its pharmaceutical and therapeutic significance, improving solubility, absorption, bioavailability, stability, plasma half-life, targeted delivery, and anticancer effect. Promising anticancer activity suggests the potential application of CUR-NPs, but clinical reports are limited. Further clinical trials are needed to ensure effective translation into clinical applications.
Article
Pharmacology & Pharmacy
Agata Noelia Traverso, David Jose Fragale, Diego Luis Viale, Octavio Garate, Pablo Torres, Gaston Valverde, Alejandro Berra, Ana Vanesa Torbidoni, Juan Sebastian Yakisich, Mariano Grasselli, Martin Radrizzani
Summary: In this study, a two-step procedure for preparing biohybrid nanoparticles with a hydrophobic quantum dot core and a multilayer coating of human serum albumin is reported. These nanoparticles, decorated with proteins like human serum albumin or human transferrin, retained their fluorescent properties and showed no corona effect in the presence of serum. They were selectively taken up by lung cancer and neuroblastoma cells but not by non-cancerous cells or differentiated neurons. Moreover, digitoxin-loaded transferrin-decorated nanoparticles specifically reduced the number of lung cancer cells. Finally, the in vivo uptake of these biohybrid nanoparticles by retinal cells in mice demonstrated their excellent targeting and traceability.
Article
Oncology
Xi Yang, Lingnan Zheng, Ling Gao, Lingyun Zhang, Jinlan He, Yuanfeng Wei, Jia You, Huawei Li, Cheng Yi, Han Luo
Summary: A platform based on fibrin gel (Fgel) loaded with cisplatin (CDDP) was developed to be implanted into the tumor bed after surgery combined with concurrent radiation therapy for the prevention of postoperative cancer recurrence and metastasis. The local and sustained release of CDDP from Fgel enhanced the antitumor efficacy of radiation therapy with lower systemic toxicity. This approach showed therapeutic benefits in mouse models of breast cancer, anaplastic thyroid carcinoma, and osteosarcoma.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Nanoscience & Nanotechnology
Guolong Gu, Chen Chen, Shichao Zhang, Bo Yin, Jianxin Wang
Summary: A novel strategy of delivering nitric oxide (NO) for cancer chemotherapy was proposed using prodrug dimer self-assembly nanoparticles of NO donors, which significantly improved drug loading and delivery efficiencies, ultimately inducing tumor cell apoptosis. This approach opened up a new avenue for cancer chemotherapy and laid a theoretical basis for clinical translation of NO-based gas chemotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Reza Pashaei-Sarnaghi, Faezeh Najafi, Ameneh Taghavi-Kahagh, Mehdi Salami-Kalajahi, Hossein Roghani-Mamaqani
Summary: In this study, poly(amidoamine) dendrimer with ethylenediamine core up to the fourth generation was synthesized and conjugated to different amounts of 7-(carboxymethoxy)-4-methylcoumarin. Under UV light irradiation, the crosslinked dendrimer-coumarin samples showed smaller particle sizes compared to non-crosslinked samples, with release behavior being influenced by increasing coumarin moieties.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Yuxiang Wang, Jing Chen, Rumeng Duan, Rong Gu, Weiran Wang, Jinhui Wu, Huibo Lian, Yiqiao Hu, Ahu Yuan
Summary: In situ tumor vaccination is achieved through the integration of Phy@PLGdH nanosheets, which enhances radiation therapy-induced immunogenic cell death. The nanosheets exhibit improved radiosensitization and tumor penetrability, while Phy-mediated PPP intervention amplifies the oxidative stress and DNA damage caused by PLGdH-sensitized radiation therapy. This results in effective immunogenic cell death and enhanced immunogenicity of irradiated tumor cells. Furthermore, Phy@PLGdH-sensitized radiation therapy successfully triggers a robust CD8(+)-T-cell-dependent antitumor immune response, which enhances checkpoint blockade immunotherapies against primary and metastatic tumors.
ADVANCED MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Jinbiao Li, Dandan Li, Wenjing Lu, Jinhui Wu, Hong Dong
Summary: This study proposed and verified a detailed GC method for the analysis of S-(+)-ECH impurities in (S)-oxiracetam. The method has the advantages of fast, convenience, and low cost, providing a reference method for quality control.
CURRENT PHARMACEUTICAL ANALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Huanhuan Chen, Yunfei Guo, Zhewei Zhang, Wenxuan Mao, Chenying Shen, Wei Xiong, Yingfang Yao, Xiaozhi Zhao, Yiqiao Hu, Zhigang Zou, Jinhui Wu
Summary: The hydrogen-producing hydrogel made of living Chlorella and bacteria within a cell-impermeable casing can continuously produce hydrogen for 60 hours, selectively reduce highly toxic ·OH and ONOO- species, and reduce inflammation. Studies have shown that the microbe-hydrogel dressing can promote cell proliferation and diabetic wound healing by almost 50% at day 3. This symbiotic algae-bacteria hydrogel demonstrates excellent biocompatibility and reactive oxygen species scavenging capabilities, suggesting great promise for clinical use.
Article
Engineering, Biomedical
Wenguang Wang, Haiheng Xu, Qingsong Ye, Feng Tao, Ian Wheeldon, Ahu Yuan, Yiqiao Hu, Jinhui Wu
Summary: Flagellated bacteria coated with antigen-adsorbing polymer nanoparticles and injected into tumours in mice after radiotherapy elicit systemic antitumour effects by transporting antigens to the tumour's periphery. This finding highlights the potential of leveraging bacteria to enhance dendritic cell activation and improve in situ cancer vaccination strategies.
NATURE BIOMEDICAL ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Lihong Gu, Feng Zhang, Jinhui Wu, Yuzheng Zhuge
Summary: Liver fibrosis is a reversible disease caused by various liver injuries, which can lead to severe complications. Traditional pharmacotherapy has limitations, while nanotechnology has shown great potential in liver fibrosis treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Medicine, Research & Experimental
Yuchen Wang, Chenxuan Zhao, Yang Liu, Chao Wang, Haojie Jiang, Yiqiao Hu, Jinhui Wu
Summary: This Review introduces recent advances in tumor therapy targeted on the CD47-SIRP alpha axis, including various methods such as antibodies, fusion proteins, small molecules, gene therapy, cell therapy, and drug delivery systems. Inhibition of the CD47-SIRP alpha axis can restore the phagocytic function of macrophages and exert anti-tumor effects. Additionally, the Review summarizes approaches to avoid anemia, a common side effect of CD47-SIRP alpha inhibition, and provides ideas for clinical translation.
MOLECULAR PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Haoran Wang, Honghui Liu, Yunfei Guo, Wenjing Zai, Xianghui Li, Wei Xiong, Xiaozhi Zhao, Yingfang Yao, Yiqiao Hu, Zhigang Zou, Jinhui Wu
Summary: Research has shown that using Chlorella in combination with photodynamic therapy (PDT) can enhance local tumor killing, improve the hypoxic and immunosuppressive microenvironment, increase the anti-tumor effect and immune response, and generate a stronger anti-tumor immune memory effect.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Yue Yu, Zhusheng Huang, Qian Chen, Zhicheng Zhang, Haojie Jiang, Rong Gu, Yitao Ding, Yiqiao Hu
Summary: In this study, self-assembled carrier-free nanoscale coordination polymers MFe-NCPs were constructed, which enhanced low-dose iron-induced immunogenic ferroptosis and boosted the therapeutic effect of immune checkpoint blockade therapy.
Article
Medicine, Research & Experimental
Wenguang Wang, Xingli Wang, Feng Tao, Kaiyuan Hu, Junying Zhang, Jinhui Wu, Linjun You, Weijun Zhao
Summary: In this study, O-2@PFC@FHA NPs were developed to deliver oxygen safely and specifically to tumors, thereby relieving tumor hypoxia. The combination of radiotherapy with O-2@PFC@FHA NPs resulted in almost threefold therapeutic improvement compared with radiotherapy alone, without causing obvious systemic toxicity.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Yang Liu, Yuchen Wang, Chao Wang, Tiejun Dong, Haiheng Xu, Yunfei Guo, Xiaozhi Zhao, Yiqiao Hu, Jinhui Wu
Summary: A strategy of hijacking endogenous products of biological events is established to assemble functional intracellular nanoparticles, enhancing targeted drug delivery and inhibiting tumor growth.
Article
Chemistry, Multidisciplinary
Qian Chen, Jing Chen, Qingqing Zhang, Peizheng Yang, Rong Gu, Hao Ren, Yue Dai, Shiqian Huang, Jinhui Wu, Xudong Wu, Yiqiao Hu, Ahu Yuan
Summary: Radiation therapy has the potential to induce immunogenic cell death in tumor cells, leading to in situ vaccination and systemic antitumor immune responses. However, there are limitations to using radiation therapy alone, such as insufficient X-ray deposition and an immunosuppressive microenvironment. To overcome these limitations, researchers developed AmGd-NPs, nanoscale coordination particles that could enhance immunogenic cell death, improve phagocytosis, and promote antigen presentation when combined with radiation therapy. AmGd-NPs also inhibited CD73 activity and promoted a proinflammatory tumor microenvironment, leading to potent in situ vaccination and boosted antitumor immune responses.
Article
Chemistry, Multidisciplinary
Haiheng Xu, Shuqin Xiong, Yiyun Chen, Qingsong Ye, Nan Guan, Yiqiao Hu, Jinhui Wu
Summary: By engineering tumor-targeting bacteria, researchers achieved precise tumor hemorrhage, leading to a change in the immunosuppressive phenotype of tumor-associated macrophages and improving the efficacy of antitumor therapy.
ADVANCED MATERIALS
(2023)
Review
Medicine, Research & Experimental
Qingsong Ye, Deyuan Zheng, Kaiyuan Chen, Jinhui Wu
Summary: Ischemia or hypoxia can cause pathological changes in tissue metabolism and function, leading to various diseases. Timely and effective blood resuscitation or improvement of hypoxia is crucial for disease treatment. However, the development of stable, non-toxic, and immunologically inert oxygen carriers is necessary due to limitations such as blood shortages and the risk of infections. Hemoglobin and perfluorocarbon-based oxygen carriers have been widely studied, and this paper reviews their development and applications as blood substitutes or oxygen carriers in hypoxic diseases. The design of oxygen carriers, their characteristics, and future research prospects are also discussed to provide a reference for further studies.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Haiheng Xu, Shuqin Xiong, Yiyun Chen, Qingsong Ye, Nan Guan, Yiqiao Hu, Jinhui Wu
Summary: This study found that inducing tumor hemorrhage using tumor-targeting bacteria can temporarily change the phenotype of macrophages, potentially improving the effectiveness of antitumor therapy.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Biomaterials
Cheng Wang, Haoran Wang, Lifeng Luo, Shaoju Gan, Yingfang Yao, Qinhua Wei, Jinhui Wu, Ahu Yuan, Yiqiao Hu, Congping Wu, Zhigang Zou
Summary: In this study, a high-energy radiation-based photocatalysis method called radiocatalysis was proposed, and a TiO2-coated lanthanide pyrosilicate scintillator (LnPS@TiO2) was prepared as the radiocatalytic material. This method can effectively kill cancer cells and cause long-term DNA damage. The research expands the application range of photocatalysis and has significant implications for tumor treatment.
BIOMATERIALS SCIENCE
(2022)