The role of IL-23 and the IL-23/TH 17 immune axis in the pathogenesis and treatment of psoriasis
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The role of IL-23 and the IL-23/TH
17 immune axis in the pathogenesis and treatment of psoriasis
Authors
Keywords
-
Journal
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
Volume 31, Issue 10, Pages 1616-1626
Publisher
Wiley
Online
2017-06-27
DOI
10.1111/jdv.14433
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the continuous treatment of patients with moderate to severe psoriasis: Results from the phase III, double-blinded, placebo- and active comparator–controlled VOYAGE 1 trial
- (2017) Andrew Blauvelt et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the treatment of patients with moderate to severe psoriasis with randomized withdrawal and retreatment: Results from the phase III, double-blind, placebo- and active comparator–controlled VOYAGE 2 trial
- (2017) Kristian Reich et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Tildrakizumab versus placebo or etanercept for chronic plaque psoriasis (reSURFACE 1 and reSURFACE 2): results from two randomised controlled, phase 3 trials
- (2017) Kristian Reich et al. LANCET
- Psoriasis and Psoriatic Arthritis: Flip Sides of the Coin?
- (2016) W Boehncke ACTA DERMATO-VENEREOLOGICA
- A prospective phase III, randomized, double-blind, placebo-controlled study of brodalumab in patients with moderate-to-severe plaque psoriasis
- (2016) K.A. Papp et al. BRITISH JOURNAL OF DERMATOLOGY
- First-in-human study to assess guselkumab (anti-IL-23 mAb) pharmacokinetics/safety in healthy subjects and patients with moderate-to-severe psoriasis
- (2016) Yanli Zhuang et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Targeting CD8+ T cells prevents psoriasis development
- (2016) Paola Di Meglio et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a
- (2016) Ka Lun Cheung et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization
- (2016) Juhan Yoon et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Keratinocyte-Derived IL-17E Contributes to Inflammation in Psoriasis
- (2016) Luisa Senra et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Secukinumab long-term safety experience: A pooled analysis of 10 phase II and III clinical studies in patients with moderate to severe plaque psoriasis
- (2016) Peter C.M. van de Kerkhof et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease
- (2016) Fusheng Zhou et al. NATURE GENETICS
- Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis
- (2016) Kenneth B. Gordon et al. NEW ENGLAND JOURNAL OF MEDICINE
- IL-12 protects from psoriasiform skin inflammation
- (2016) Paulina Kulig et al. Nature Communications
- Ponesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseases
- (2016) Daniele D’Ambrosio et al. Therapeutic Advances in Chronic Disease
- Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture
- (2015) Philip E. Stuart et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial
- (2015) K. Papp et al. BRITISH JOURNAL OF DERMATOLOGY
- Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis
- (2015) Philip J. Mease CURRENT OPINION IN RHEUMATOLOGY
- New and emerging biologic therapies for moderate-to-severe plaque psoriasis: mechanistic rationales and recent clinical data for IL-17 and IL-23 inhibitors
- (2015) Anthony A. Gaspari et al. Dermatologic Therapy
- Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions
- (2015) Dhavalkumar D. Patel et al. IMMUNITY
- Humanized anti–IFN-γ (HuZAF) in the treatment of psoriasis
- (2015) Jamie L. Harden et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Anti–IL-23A mAb BI 655066 for treatment of moderate-to-severe psoriasis: Safety, efficacy, pharmacokinetics, and biomarker results of a single-rising-dose, randomized, double-blind, placebo-controlled trial
- (2015) James G. Krueger et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The immunogenetics of Psoriasis: A comprehensive review
- (2015) Jamie L. Harden et al. JOURNAL OF AUTOIMMUNITY
- An autoimmune “attack” on melanocytes triggers psoriasis and cellular hyperplasia
- (2015) James G. Krueger JOURNAL OF EXPERIMENTAL MEDICINE
- Melanocyte antigen triggers autoimmunity in human psoriasis
- (2015) Akiko Arakawa et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Association with Genetic Variants in the IL-23 and NF-κB Pathways Discriminates between Mild and Severe Psoriasis Skin Disease
- (2015) Pernilla Nikamo et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Psoriasis
- (2015) Wolf-Henning Boehncke et al. LANCET
- Clinical improvement in psoriasis with specific targeting of interleukin-23
- (2015) Tamara Kopp et al. NATURE
- TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26
- (2015) Stephan Meller et al. NATURE IMMUNOLOGY
- IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases
- (2015) Michele W L Teng et al. NATURE MEDICINE
- Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis
- (2015) Mark Lebwohl et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Phase 2 Trial of Guselkumab versus Adalimumab for Plaque Psoriasis
- (2015) Kenneth B. Gordon et al. NEW ENGLAND JOURNAL OF MEDICINE
- Variation in genes involved in the immune response and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial
- (2015) Danyelle A. Winchester et al. PROSTATE
- Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci
- (2015) Lam C. Tsoi et al. Nature Communications
- Risk of Serious Infection With Biologic and Systemic Treatment of Psoriasis
- (2015) Robert E. Kalb et al. JAMA Dermatology
- Patient Preferences for Biologicals in Psoriasis: Top Priority of Safety for Cardiovascular Patients
- (2015) Marthe-Lisa Schaarschmidt et al. PLoS One
- Immunology of Psoriasis
- (2014) Michelle A. Lowes et al. Annual Review of Immunology
- The Role of Interleukin-17A in Psoriatic Disease
- (2014) Silvano Adami et al. BIODRUGS
- Guselkumab (an IL-23–specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis
- (2014) Howard Sofen et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage
- (2014) G. L. Stritesky et al. JOURNAL OF IMMUNOLOGY
- Interleukin 17A: Toward a new understanding of psoriasis pathogenesis
- (2014) Charles W. Lynde et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Oral ponesimod in patients with chronic plaque psoriasis: a randomised, double-blind, placebo-controlled phase 2 trial
- (2014) Andrea Vaclavkova et al. LANCET
- Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation
- (2014) Lorena Riol-Blanco et al. NATURE
- Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials
- (2014) Richard G. Langley et al. NEW ENGLAND JOURNAL OF MEDICINE
- IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms
- (2014) H.-L. Ha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis
- (2014) Roberto Lande et al. Nature Communications
- Psoriasis
- (2014) P. Di Meglio et al. Cold Spring Harbor Perspectives in Medicine
- Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from 5 years of follow-up
- (2013) K.A. Papp et al. BRITISH JOURNAL OF DERMATOLOGY
- The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions
- (2013) Roderick J. Hay et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Genetic insights into common pathways and complex relationships among immune-mediated diseases
- (2013) Miles Parkes et al. NATURE REVIEWS GENETICS
- Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis Identifies Seven Shared Susceptibility Loci
- (2012) David Ellinghaus et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
- (2012) Wolfgang Hueber et al. GUT
- Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis
- (2012) Kim A. Papp et al. NEW ENGLAND JOURNAL OF MEDICINE
- New IBD genetics: common pathways with other diseases
- (2011) C. W. Lees et al. GUT
- Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis
- (2011) A. M. Lin et al. JOURNAL OF IMMUNOLOGY
- Foxp3+ Regulatory T Cells of Psoriasis Patients Easily Differentiate into IL-17A-Producing Cells and Are Found in Lesional Skin
- (2011) H. Jorn Bovenschen et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- A Phase III, Randomized, Controlled Trial of the Fully Human IL-12/23 mAb Briakinumab in Moderate-to-Severe Psoriasis
- (2011) Kenneth B. Gordon et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Psoriasis and Other Complex Trait Dermatoses: From Loci to Functional Pathways
- (2011) Francesca Capon et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Guidelines of care for the management of psoriasis and psoriatic arthritis
- (2011) Alan Menter et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans
- (2011) Paola Di Meglio et al. PLoS One
- Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis
- (2010) G. Tonel et al. JOURNAL OF IMMUNOLOGY
- IL-23-Mediated Psoriasis-Like Epidermal Hyperplasia Is Dependent on IL-17A
- (2010) H. L. Rizzo et al. JOURNAL OF IMMUNOLOGY
- A Subpopulation of CD163-Positive Macrophages Is Classically Activated in Psoriasis
- (2010) Judilyn Fuentes-Duculan et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Integrative Responses to IL-17 and TNF-α in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in Psoriasis
- (2010) Andrea Chiricozzi et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Association analyses identify six new psoriasis susceptibility loci in the Chinese population
- (2010) Liang-Dan Sun et al. NATURE GENETICS
- Genome-wide association analysis identifies three psoriasis susceptibility loci
- (2010) Philip E Stuart et al. NATURE GENETICS
- Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis
- (2010) Ulrike Hüffmeier et al. NATURE GENETICS
- Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
- (2009) Dipyaman Ganguly et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Skin and Peripheral Lymph Node Invariant NKT Cells Are Mainly Retinoic Acid Receptor-Related Orphan Receptor t+ and Respond Preferentially under Inflammatory Conditions
- (2009) J.-M. Doisne et al. JOURNAL OF IMMUNOLOGY
- Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis
- (2009) L. van der Fits et al. JOURNAL OF IMMUNOLOGY
- The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis
- (2009) Antonella Di Cesare et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- European S3-Guidelines on the systemic treatment of psoriasis vulgaris
- (2009) D Pathirana et al. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
- Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways
- (2009) Rajan P Nair et al. NATURE GENETICS
- A protective function for interleukin 17A in T cell–mediated intestinal inflammation
- (2009) William O'Connor Jr et al. NATURE IMMUNOLOGY
- Psoriasis
- (2009) Frank O. Nestle et al. NEW ENGLAND JOURNAL OF MEDICINE
- Investigation of association of the IL12B and IL23R genes with psoriatic arthritis
- (2008) Charlotte Filer et al. ARTHRITIS AND RHEUMATISM
- CD4 T cells: fates, functions, and faults
- (2008) J. Zhu et al. BLOOD
- Identification of ZNF313 / RNF114 as a novel psoriasis susceptibility gene
- (2008) Francesca Capon et al. HUMAN MOLECULAR GENETICS
- Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens
- (2008) Meredith M. Curtis et al. IMMUNOLOGY
- Polymorphisms of the IL12B and IL23R Genes Are Associated with Psoriasis
- (2008) Rajan P. Nair et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Functional Characterization of IL-17F as a Selective Neutrophil Attractant in Psoriasis
- (2008) Hideaki Watanabe et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Guidelines of care for the management of psoriasis and psoriatic arthritis
- (2008) Alan Menter et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
- (2008) Craig L Leonardi et al. LANCET
- Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
- (2008) Kim A Papp et al. LANCET
- A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses
- (2008) Elisabetta Volpe et al. NATURE IMMUNOLOGY
- A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci
- (2008) Ying Liu et al. PLoS Genetics
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search