期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 139, 期 8, 页码 3065-3071出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.6b12254
关键词
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资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- GreenCentre Canada
- University of Alberta
High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized alpha-phenoxy and related amides at room temperature under 4 atm H-2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution.
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