Article
Biotechnology & Applied Microbiology
Guangdong Liu, Haihong Li, Wenyang Ji, Haidong Gong, Yan Jiang, Guomin Ji, Guangyao Liu
Summary: Through RNA analysis, we identified four lncRNAs of research value in gliomas, constructed a ceRNA network related to gliomas, and developed a prognostic prediction model.
Article
Immunology
Li -Chong Wang, Yue-Long Wang, Bin He, Yan-Jiang Zheng, Hong-Chi Yu, Zhi-Yong Liu, Rang-rang Fan, Xin Zan, Rui-Chao Liang, Ze-Pei Wu, Xin Tang, Guo-Qing Wang, Jian-Guo Xu, Liang-Xue Zhou
Summary: Immune checkpoint therapy has shown breakthrough in cancer treatment, but its interaction in glioma remains controversial. In this study, we analyzed transcriptome data and conducted immunofluorescence assay to detect the features of immune checkpoints. We found that B7-H3, VISTA, and PD-L1 were associated with overall survival and grade in glioma.
CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Chuantao Zhang, Man Jiang, Na Zhou, Helei Hou, Tianjun Li, Hongsheng Yu, Yuan-De Tan, Xiaochun Zhang
Summary: Using gene differential expression and gene ontology, a set of 26 tumor suppressor genes were identified, with SASH1, STARD13, CBFA2T3, and RECK showing strong tumor suppressor effects, and EXT1, PTCH1, KLK10, and APC demonstrating weak tumor suppressor effects. These genes can be used as specific and sensitive biomarkers for diagnosis of NSCLC cancer.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ssu-Han Chen, Hong-Han Lin, Yao-Feng Li, Wen-Chiuan Tsai, Dueng-Yuan Hueng
Summary: High expression of TRIP13 in gliomas is associated with poor prognosis, potentially influencing tumor development by regulating co-expressed genes related to tumorigenesis and therapeutic resistance. Aberrant expression of TRIP13 may be regulated by mechanisms such as DNA methylation and miRNA targeting, leading to high aneuploidy levels and reduced CD8(+)/Treg ratio, which worsen patient outcomes.
Article
Oncology
Cong Li, Shaoyan Xi, Yingshen Chen, Chengcheng Guo, Ji Zhang, Qunying Yang, Jian Wang, Ke Sai, Jing Zeng, Jing Wang, Zhiqiang Zhang, Chao Ke, Zhongping Chen
Summary: This study aimed to investigate the histopathological characteristics of recurrent gliomas and their clinical significance. The histopathological patterns of recurrent gliomas were found to be related to survival time after reoperation. Primary WHO low-grade or IDH1 mutant gliomas showed a survival benefit mainly on later recurrence.
Article
Cell & Tissue Engineering
Wei Chen, Ming Wu, Si-Tong Cui, Yue Zheng, Zhen Liu, Liang-Sheng Luo
Summary: In this study, it was shown that circ-ITCH is significantly downregulated in glioma and can inhibit cell proliferation and invasion by regulating the miR-106a-5p/SASH1 axis, providing a new molecular target for glioma treatment.
CELL TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Xuanxuan Li, Kuo Kang, Lin Shen, Liangfang Shen, Yangying Zhou
Summary: The biological significance and clinical values of PLINs in gliomas have been demonstrated, suggesting that they may serve as potential biomarkers for regulating the tumor microenvironment and predicting the efficacy of immunotherapy.
Article
Multidisciplinary Sciences
Dongming Yan, Yaping Yu, Qiongwei Ni, Qingwen Meng, Haolin Wu, Shun Ding, Xiaoqian Liu, Caiying Tang, Qibing Liu, Kun Yang
Summary: The upregulation of TBX15 has been observed in various tumors and is known to promote uncontrolled tumor cell proliferation and inhibit apoptosis, thereby accelerating the malignant transformation of tumors. However, the prognostic significance of TBX15 in glioma and its correlation with immune infiltration are still unknown. This study aimed to investigate the prognostic value of TBX15 and its relationship with immune infiltration in glioma, as well as evaluate TBX15 expression in pan-cancer using RNAseq data.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Karina Biserova, Arvids Jakovlevs, Romans Uljanovs, Ilze Strumfa
Summary: Cancer stem cells, particularly in glioblastoma, play a crucial role in tumor resistance to treatment and recurrence. The regulatory mechanisms of glioma stem cells include tumor microenvironment, niche concept, metabolism, immunity, genetics, and epigenetics, which serve as potential targets for future treatments.Understanding the molecular markers and treatment resistance of GSCs in glioblastoma may lead to more effective therapeutic strategies in the future.
Article
Endocrinology & Metabolism
He Liu, Jiao Wang, Tao Luo, Zhiming Zhen, Li Liu, Yalan Zheng, Chaobin Zhang, Xiaofei Hu
Summary: This study investigated the expression and prognostic significance of ITGB2 in glioma. The results showed that ITGB2 can be a potential marker for mesenchymal molecular subtype gliomas and an independent predictive marker of overall survival in malignant glioma patients. In addition, ITGB2 is closely related to glioma immune-related activities. Methylation of ITGB2 negatively regulates its expression in low-grade glioma tissues and can be used to predict the overall survival of low-grade glioma patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Xuejun Yan, Quanwei Zhou, Hecheng Zhu, Weidong Liu, Hongjuan Xu, Wen Yin, Ming Zhao, Xingjun Jiang, Caiping Ren
Summary: CD37 is abnormally expressed in diffuse gliomas and is associated with unfavorable prognosis, potentially exerting its effect by suppressing immune processes. Gliomas with high expression of CD37 have more M2 macrophage and neutrophil infiltration, with lower NK cell abundance.
Article
Multidisciplinary Sciences
Mei Lin, Xiao-Long Zhang, Rui You, You-Ping Liu, Hong-Min Cai, Li-Zhi Liu, Xue-Fei Liu, Xiong Zou, Yu-Long Xie, Ru-Hai Zou, Yi-Nuan Zhang, Rui Sun, Wei-Yi Feng, Hai-Yan Wang, Gui-Hua Tao, Hao-Jiang Li, Wen-Jie Huang, Chao Zhang, Pei-Yu Huang, Jin Wang, Qi Zhao, Qi Yang, Hong-Wan Zhang, Ting Liu, Hui-Feng Li, Xiao-Bing Jiang, Jun Tang, Yang-Kui Gu, Tao Yu, Zhi-Qiang Wang, Lin Feng, Tie-Bang Kang, Zhi-Xiang Zuo, Ming-Yuan Chen
Summary: To understand the metastasis of nasopharyngeal carcinoma, a genomic analysis was conducted on matched blood and tumor samples. Two distinct routes of metastasis were identified, one originating from lymph nodes and the other from primary tumors. The hematogenous route exhibited higher expression of IFN-gamma response genes and exhausted CD8(+) T cells. The hematogenous group showed better progression-free survival and PD-1 immunotherapy response, while the lymphatic group responded better to locoregional radiotherapy.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Xin Guo, Yuelin Zhang, Hengxing Jiao, Xingyu Miao
Summary: PD-L1 expression is significantly associated with low overall survival (OS) in patients with glioblastoma (GBM). However, this result needs to be interpreted with caution and further evaluated in large, multicenter clinical studies with similar baseline data.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikola Jovanovic, Milica Lazarevic, Vladimir J. Cvetkovic, Vesna Nikolov, Jelena Kostic Peric, Milena Ugrin, Sonja Pavlovic, Tatjana Mitrovic
Summary: A single-institution observational study evaluated the prognostic relevance of the methylation status of MGMT in diffuse gliomas. The study found that younger patients with surgically resected gliomas and temozolomide (TMZ) adjuvant chemotherapy had a better prognosis. The chosen method and cut-off value determination for methylation status affected the results. The study recognized MGMT promoter methylation as a positive prognostic factor, but further verification in a larger population is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Zhishuai Ren, Shenqian Ma, Xingbo Cheng, Yuqi Guo, Zhendong Liu
Summary: Studies have shown that TIMELESS is highly expressed in glioma and is closely related to prognosis and clinical characteristics. It can activate multiple pathways in glioma, and small molecule drugs have been predicted to inhibit its function.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2021)
