Article
Pharmacology & Pharmacy
Caroline A. Arout, Margaret Haney, Evan S. Herrmann, Gillinder Bedi, Ziva D. Cooper
Summary: This study found that acute oral CBD did not consistently demonstrate dose-dependent analgesic effects in healthy noncannabis users, and in fact increased pain in some measures. Future studies should consider using more comprehensive pain assessment paradigms and investigate the analgesic effects of CBD in different populations.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Feng Li, Yanling Qiao, Yuanyuan Chen, Nan Li, Mengxiang Yang, Xiangyu Li, Yi Qiu, Wei Cui, Haowei Shen, Peng Xu, Bin Di
Summary: This study compared the anesthetic, analgesic activity, and abuse liability of the new synthetic drug N-Ethylnorketamine (NENK) with ketamine. The results showed that NENK has lower anesthetic and analgesic activity compared to ketamine, but has significant abuse liability.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
R. Ross MacLean, Elise E. DeVito, Tore Eid, Suprit Parida, Ralitza Gueorguieva, Mehmet Sofuoglu
Summary: This study used a novel double-blind placebo-controlled intravenous nicotine self-administration model to determine the threshold for detecting positive effects of nicotine in young adult smokers. The results showed that a dose of about 0.1 mg of nicotine was needed to detect positive effects, while a higher dose of 0.2 mg was required to produce consistent nicotine reinforcement. These findings support the value of nicotine reinforcement threshold as a tobacco regulatory target.
PSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seong Shoon Yoon, Jaesuk Yun, Bong Hyo Lee, Hee Young Kim, Chae Ha Yang
Summary: Acupuncture at HT7 acupoint can regulate the brain reward function of rats and elevate ICSS thresholds. However, it does not affect the threshold-lowering effects produced by cocaine, indicating that it only effectively regulates the ICSS thresholds in drug-naive rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Michael T. Sapko, Taleen Hanania, Qing Chang, Jonathan C. Javitt
Summary: This study aimed to evaluate the abuse liability of D-cycloserine (DCS) using a self-administration paradigm. The results showed that DCS did not result in self-administration at any of the test doses and had similar behavior to the control group.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Neurosciences
Marion A. Coe, Michelle R. Lofwall, Victoria Vessels, Paul A. Nuzzo, Sharon L. Walsh
Summary: This study found that the NK1 antagonist tradipitant did not significantly attenuate the abuse liability and analgesic effects of oxycodone in opioid-experienced individuals, and had minimal impact on the main effects of oxycodone. This suggests that NK1 antagonists may not be a useful treatment for opioid use disorder.
PSYCHOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
D. F. Altomare, A. Picciariello, A. Di Ciaula, M. Rinaldi, M. De Fazio, P. Portincasa
Summary: Temporary sacral nerve stimulation (SNS) did not have any effect on upper/lower gastrointestinal motility and transit in patients with severe constipation.
TECHNIQUES IN COLOPROCTOLOGY
(2021)
Article
Behavioral Sciences
David N. Velazquez-Martinez, Benita Lizeth Pacheco-Gomez, Ana Laura Toscano-Zapien, Maria Almudena Lopez-Guzman, Daniel Velazquez-Lopez
Summary: Rats work hard for intracranial self-stimulation through effort and time allocation, producing a sigmoidal function of reward magnitude. The study showed that rats adjust response time allocation based on task requirements and accuracy. Additionally, rats integrate response requirements into the reinforcement tradeoff function but not into the discriminative function of ICSS.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychology, Biological
R. Ross MacLean, Tore Eid, Suprit Parida, Ralitza Gueorguieva, Elise E. DeVito, Mehmet Sofuoglu
Summary: The threshold for positive subjective effects of nicotine is 2-4 times lower than its reinforcing threshold in young adult nondependent smokers. Higher abstinence-induced craving and faster nicotine metabolism are associated with greater reinforcement from nicotine. Products that are considered to be subthreshold for reinforcement should be carefully evaluated for their subjective effects.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Irene Puig-Parnau, Soleil Garcia-Brito, Laia Vila-Soles, Andrea Riberas, Laura Aldavert-Vera, Pilar Segura-Torres, Elisabet Kadar, Gemma Huguet
Summary: Curative or fully effective treatments for Alzheimer's disease (AD) are currently unavailable. Electrical stimulation of deep brain areas is proposed as a therapeutic approach. Previous research shows that intracranial self-stimulation (ICSS) targeting the medial forebrain bundle (MFB) improves learning and memory in rats with memory impairment. Based on this, MFB could be a promising target for AD treatment.
Review
Psychology, Multidisciplinary
Ignacio Morgado-Bernal, Pilar Segura-Torres
Summary: Through intracranial self-stimulation (ICSS), rats can enhance implicit and explicit memory, especially in those with poor learning performance. Additionally, ICSS promotes neurogenesis and structural changes in specific hippocampal areas, as well as regulates the expression of genes related to learning and memory.
Article
Neurosciences
Kristyn N. Borrelli, Carly R. Langan, Kyra R. Dubinsky, Karen K. Szumlinski, William A. Carlezon, Elena H. Chartoff, Camron D. Bryant
Summary: H1(+/-) mice displayed a complex intracranial self-stimulation (ICSS) phenotype following MA, showing indications of both blunted reward magnitude and enhanced reward sensitivity specifically in H1(+/-) females.
PSYCHOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Shuo Chen, Liang Liu, Yanmei Li, Hailong Li, Xizhen Sun, Dan Zhu, Qiao Meng, Shukun Yao, Shiyu Du
Summary: This study compared the effects of colonic electrical stimulation and prucalopride on gastrointestinal transit and defecation, showing that both treatments have similar short-term effects on improving gastrointestinal transit and stool consistency, but colonic electrical stimulation outperforms prucalopride in inducing defecation in the short term. Ideal levels of endurance and histocompatibility were observed in animals undergoing colonic electrical stimulation.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, Research & Experimental
Yong-Qing Zhang, Hyun Kyu Min, Eunchong Hong, Eunhye Yu, Sun Mi Gu, Seong Shoon Yoon, Dohyun Lee, Jaejun Lee, Jin Tae Hong, Jaesuk Yun
Summary: The ICSS model was used to evaluate the abuse potential of 18 drugs in mice, and it was found that DAT availability and extracellular dopamine levels in the mPFC and NAc correlated with the ICSS threshold. These findings suggest a relationship between DAT availability-mediated dopamine levels and drug-induced reward-seeking behavior.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Federico G. Gnazzo, Devry Mourra, Christopher A. Guevara, Jeff A. Beeler
Summary: Food restriction enhances both the acquisition and expression of dopamine-reinforced self-stimulation responding, leading to increased response rates.
Article
Pharmacology & Pharmacy
Mohammad Alsalem, Ahmad Altarifi, Heba Kalbouneh, Heba Al-Zer, Belal Azab, Khalid El-Salem
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2016)
Article
Environmental Sciences
Shreen Deeb Nusair, Yousef Sa'id Abu Zarour, Ahmad A. Altarifi
WATER AIR AND SOIL POLLUTION
(2017)
Article
Medicine, Research & Experimental
Ahmad A. Altarifi, Zain Kalha, Saddam F. Kana'an, Mahmoud A. Alfaqih, Mohammad I. Alsalem
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2019)
Article
Immunology
Mohammad Alsalem, Mansour Haddad, Sara A. Aldossary, Heba Kalbouneh, Ahmad Altarifi, Sahar M. Jaffal, Manal A. Abbas, Nour Aldaoud, Khalid El-Salem
INFLAMMOPHARMACOLOGY
(2019)
Article
Psychology, Biological
Khawla Q. Nuseir, Ahmad Y. Altarifi, Alaa Tasslaq, Ahmd Y. Alhusban, Karem H. Alzoubi
PHYSIOLOGY & BEHAVIOR
(2019)
Article
Neurosciences
Mohammad Alsalem, Ahmad Altarifi, Mansour Haddad, Sara A. Aldossary, Heba Kalbouneh, Nour Aldaoud, Tareq Saleh, Khalid El-Salem
Article
Pharmacology & Pharmacy
Karan H. Muchhala, Joanna C. Jacob, William L. Dewey, Hamid Akbarali
Summary: The role of 0-arrestin-2 in opioid tolerance was investigated, showing its involvement in acute, but not chronic tolerance in dorsal root ganglia neurons and in vivo antinociception. These findings suggest that opioid-induced antinociceptive tolerance can develop even without 0-arrestin-2 activation, significantly impacting the clinical utility of biased agonists.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Physiology
Karan H. Muchhala, Joanna C. Jacob, Minho Kang, William L. Dewey, Hamid Akbarali
Summary: Bidirectional interactions between the gut epithelium and commensal bacteria are crucial for maintaining gut homeostasis. Chronic opioid exposure disrupts gut homeostasis through various neuro-immune-epithelial mechanisms, leading to the development of tolerance, a major factor in the current opioid crisis. The differences in molecular mechanisms of opioid tolerance between the enteric and central pain pathways present a significant challenge in managing chronic pain without adverse gastrointestinal effects.
Article
Clinical Neurology
Stanley M. Cheatham, Karan H. Muchhala, Eda Koseli, Joanna C. Jacob, Essie Komla, S. Stevens Negus, Hamid I. Akbarali
Summary: Opioids may exacerbate disease severity in Crohn's disease patients, while NSAIDs have no impact on behavioral depression. Therefore, evaluating the effects of analgesics in models of colonic inflammation-induced depression is crucial.
FRONTIERS IN PAIN RESEARCH
(2021)
Review
Clinical Neurology
Ryan A. Mischel, Karan H. Muchhala, William L. Dewey, Hamid I. Akbarali
Article
Clinical Neurology
Ahmad Altarifi, Mohammad Alsalem, Ayman Mustafa
SCANDINAVIAN JOURNAL OF PAIN
(2019)
Article
Neurosciences
Samar Abdo, Khawla Q. Nuseir, Ahmad A. Altarifi, Moussa Barqawi, Nehad M. Ayoub, Tareq L. Mukkatash
Article
Dentistry, Oral Surgery & Medicine
Ayman G. Mustafa, Ayssar A. Tashtoush, Othman A. Alshboul, Mohammed Z. Allouh, Ahmad A. Altarifi
INTERNATIONAL JOURNAL OF DENTISTRY
(2019)