Article
Multidisciplinary Sciences
Joon-Yung Cha, Jeongsik Kim, Song Yi Jeong, Gyeong-Im Shin, Myung Geun Jia, Ji-Won Hwang, Laila Khaleda, Xueji Liao, Gyeongik Ahn, Hee-Jin Park, Dong Young Kim, Jose M. Pardo, Sang Yeol Lee, Dae-Jin Yun, David E. Somers, Woe-Yeon Kim
Summary: The circadian clock is a timekeeping and homeostatic system that can compensate for variable salt levels in the environment. Our study revealed that the plasma membrane Na+/H+ antiporter SOS1 functions as a salt-specific circadian clock regulator through its interaction with GIGANTEA (GI) in a salt-dependent manner. SOS1 stabilizes the protein level of GI to maintain a proper clock period under saline conditions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Eunju Kwon, Deepak Pathak, Pawan Dahal, Sudarshan Tandukar, Hyun Suk Jung, Woe-Yeon Kim, Dong Young Kim
Summary: This study reports the purification of GI monomer and the crystal structure of the GI/LKP2 complex. The crystal structure reveals that the C-terminal of GI possesses a rigid structure formed by stacking hydrophobic α-helices, and the LOV domain of LKP2 binds to the middle region of GI. The results provide structural insights into the regulation of the circadian clock and photoperiodic flowering by GI and ZTL/LKP2/FKF1.
Letter
Plant Sciences
James Ronald, Anthony J. Wilkinson, Seth J. Davis
Summary: The sub-nuclear localization of EARLY FLOWERING3 gene responds to changes in ambient temperature.
Article
Biochemistry & Molecular Biology
Hee Jin Park, Francisco M. Gamez-Arjona, Marika Lindahl, Rashid Aman, Irene Villalta, Joon-Yung Cha, Raul Carranco, Chae Jin Lim, Elena Garcia, Ray A. Bressan, Sang Yeol Lee, Federico Valverde, Clara Sanchez-Rodriguez, Jose M. Pardo, Woe-Yeon Kim, Francisco J. Quintero, Dae-Jin Yun
Summary: The protein SOS3/CBL4 acts as a Ca2+- and S-acylation-dependent regulator that controls flowering time in a saline environment through the selective stabilization of GIGANTEA in the nucleus, while degradation of GIGANTEA in the cytosol releases SOS2 to achieve salt tolerance. SOS3 interacts with photoperiodic flowering components GIGANTEA and FLAVIN-BINDING, KELCH REPEAT, F-BOX1, and participates in the transcriptional complex that regulates CO and FLOWERING LOCUS T under salinity. Thus, SOS3 connects two signaling networks to co-regulate the stress response and flowering time.
Article
Multidisciplinary Sciences
Yasuhiro Umemura, Nobuya Koike, Yoshiki Tsuchiya, Hitomi Watanabe, Gen Kondoh, Ryoichiro Kageyama, Kazuhiro Yagita
Summary: Circadian clocks are suppressed during early embryonic stages and pluripotent stem cells in mammals, but gradually emerge during ontogenesis. The expression of CLOCK/BMAL1 affects the oscillation of the segmentation clock, which controls somitogenesis in the early developmental stage.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Zein Eddin Bader, Min Jae Bae, Akhtar Ali, Junghoon Park, Dongwon Baek, Dae-Jin Yun
Summary: Plants use their circadian clock to adapt to daily challenges, such as water scarcity. The circadian clock component GIGANTEA (GI) promotes the process of drought escape (DE), which accelerates flowering. GI up-regulates the gene FT, an inducer of flowering. A recent study discovered a new mechanism in which GI and the protein ENHANCED EM LEVEL collaborate to activate ABA biosynthesis during drought stress.
PLANT SIGNALING & BEHAVIOR
(2023)
Editorial Material
Biochemistry & Molecular Biology
Michael J. Rust
Summary: The study on circadian clock suggests that it can function even in non-growing cells using minimal components from cyanobacteria. The findings indicate the potential evolution of the circadian clock to adapt to different cellular conditions.
Review
Cell Biology
Ana R. Neves, Tania Albuquerque, Telma Quintela, Diana Costa
Summary: There is clear evidence of the correlation between circadian rhythm dysregulation and disease origin/development, and clock-related therapies have emerged as significant progress in the clinical field.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Urology & Nephrology
Sho Hasegawa, Reiko Inagi
Summary: Interactions between organs play a critical role in maintaining body homeostasis. Kidney dysfunction can contribute to dysfunction in distant organs, and several studies have identified key mechanisms underlying this kidney crosstalk with other organs.
NATURE REVIEWS NEPHROLOGY
(2023)
Review
Endocrinology & Metabolism
Si-Ke He, Jia-Hao Wang, Tao Li, Shan Yin, Jian-Wei Cui, Yun-Fei Xiao, Yin Tang, Jia Wang, Yun-Jin Bai
Summary: This article reviews the relationship between circadian rhythm disturbance and kidney stone disease (KSD), summarizing the risk factors and treatment methods. The results indicate that KSD is associated with systemic disorders such as metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis, and some chronotherapies have been proven effective.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Sabrina Klemz, Thomas Wallach, Sandra Korge, Mechthild Rosing, Roman Klemz, Bert Maier, Nicholas C. Fiorenza, Irem Kaymak, Anna K. Fritzsche, Erik D. Herzog, Ralf Stanewsky, Achim Kramer
Summary: In organisms with circadian clocks, the post-translational modifications of clock proteins, particularly phosphorylation, play a crucial role in controlling circadian rhythms. Protein phosphatase 4 (PPP4) and its regulatory subunit PPP4R2 have been identified as critical components in mammals and Drosophila, affecting the circadian system by regulating phosphorylation and transactivation activity of CLOCK/BMAL1.
GENES & DEVELOPMENT
(2021)
Editorial Material
Cell Biology
Ueli Schibler
Summary: Mammalian body cells have cell-autonomous and self-sustained circadian oscillators relying on delayed negative feedback loops in gene expression. Transcriptional activation and repression, as well as post-translational mechanisms like phosphorylation and dephosphorylation, play crucial roles in setting the pace of these timekeepers. The study by Klemz and colleagues in Genes & Development demonstrates how dephosphorylation of BMAL1 by protein phosphatase 4 (PPP4) participates in the modulation of circadian timing.
GENES & DEVELOPMENT
(2021)
Editorial Material
Cell Biology
Zhihui Zhang, Guanghou Shui, Min-Dian Li
Summary: Meal timing can reset cellular circadian clocks in the body, with clocks in different tissues being reset to varying degrees by feeding rhythms, and modulated by the central clock and the liver clock. Tissue-specific regulation and intercellular signaling play essential roles in clock synchronization.
TRENDS IN CELL BIOLOGY
(2021)
Article
Plant Sciences
Yaoyao Huang, Xiaojuan Xing, Yun Tang, Jinyu Jin, Lian Ding, Aiping Song, Sumei Chen, Fadi Chen, Jiafu Jiang, Weimin Fang
Summary: This study reveals that CmERF110 interacts with CmFLK to regulate flowering time and affect circadian clock-related genes in chrysanthemum. These findings provide evidence for the evolutionary conservation of the flowering regulation pathway in chrysanthemum.
PLANT CELL AND ENVIRONMENT
(2022)