Melatonin regulates PARP1 to control the senescence-associated secretory phenotype (SASP) in human fetal lung fibroblast cells

Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c-kit+cardiac progenitor cells by promoting miR-675

(2016) Benzhi Cai et al.   JOURNAL OF PINEAL RESEARCH

Melatonin inhibits tumorigenicity of glioblastoma stem-like cells via the AKT-EZH2-STAT3 signaling axis

(2016) Xueran Chen et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reduces endoplasmic reticulum stress and autophagy in liver of leptin-deficient mice

(2016) Beatriz de Luxán-Delgado et al.   JOURNAL OF PINEAL RESEARCH

Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging

(2016) Ioannis Grammatikakis et al.   Aging-US

Functional Characterization of Long Noncoding RNA Lnc_bc060912 in Human Lung Carcinoma Cells

(2015) Huaxia Luo et al.   BIOCHEMISTRY

HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways

(2015) Chongxi Fan et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reverses H2O2-induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway

(2015) Long Zhou et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

(2015) Hongshan Chen et al.   MOLECULAR CELL

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes

(2015) Zhuo Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long non-coding RNA and chromatin remodeling

(2015) Pei Han et al.   RNA Biology

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Telomere functions grounding on TERRA firma

(2015) Claus M. Azzalin et al.   TRENDS IN CELL BIOLOGY

SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase

(2015) Hengrui Zhu et al.   Cell Reports

HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

(2014) Taranjit Singh Rai et al.   GENES & DEVELOPMENT

A review of melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases

(2014) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

ER Stress Response in Human Cellular Models of Senescence

(2014) Liliana Matos et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A long noncoding RNA protects the heart from pathological hypertrophy

(2014) Pei Han et al.   NATURE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation

(2014) Hongshan Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PARP1 orchestrates variant histone exchange in signal-mediated transcriptional activation

(2013) Amanda O‧Donnell et al.   EMBO REPORTS

Long Noncoding RNAs: Past, Present, and Future

(2013) J. T. Y. Kung et al.   GENETICS

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

PARP-1 and gene regulation: Progress and puzzles

(2013) W. Lee Kraus et al.   MOLECULAR ASPECTS OF MEDICINE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis?

(2013) Amanda Swindall et al.   Cancers

Beyond DNA Repair: Additional Functions of PARP-1 in Cancer

(2013) Alice N. Weaver et al.   Frontiers in Oncology

Redox signaling loops in the unfolded protein response

(2012) Arisa Higa et al.   CELLULAR SIGNALLING

Melatonin suppresses doxorubicin-induced premature senescence of A549 lung cancer cells by ameliorating mitochondrial dysfunction

(2012) Naree Song et al.   JOURNAL OF PINEAL RESEARCH

Inheritance of Silent rDNA Chromatin Is Mediated by PARP1 via Noncoding RNA

(2012) Claudio Guetg et al.   MOLECULAR CELL

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

QKI-Mediated Alternative Splicing of the Histone Variant MacroH2A1 Regulates Cancer Cell Proliferation

(2011) L. Novikov et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells

(2011) Akiko Takahashi et al.   MOLECULAR CELL

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

(2011) R. Navab et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

(2009) Gyula Timinszky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytokine expression and signaling in drug-induced cellular senescence

(2009) Z Novakova et al.   ONCOGENE

Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-9) and effector caspases (casp-3/casp-7) and PARP in UVR-exposed HaCaT keratinocytes

(2008) T. W. Fischer et al.   JOURNAL OF PINEAL RESEARCH

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY