Article
Cell Biology
Reichelle X. Yeo, Pieter J. Dijkstra, Flavia G. De Carvalho, Fanchao Yi, Maria F. Pino, Steven R. Smith, Lauren M. Sparks
Summary: This study assessed the impact of aerobic training on mitochondrial metabolism of human skeletal muscle cells, and found that aerobic training can improve skeletal muscle mitochondrial capacity without affecting mitochondrial content.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Patrick M. Schaefer, Komal Rathi, Arrienne Butic, Wendy Tan, Katherine Mitchell, Douglas C. Wallace
Summary: Primary mitochondrial diseases are metabolic disorders caused by mutations in mitochondrial and nuclear DNA genes. This study found that endurance exercise may be beneficial for some mitochondrial disorders but not for others. Gene expression analysis identified key pathways involved in the exercise response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Physiology
Daniele A. Cardinale, Kasper D. Gejl, Kristine G. Petersen, Joachim Nielsen, Niels Ortenblad, Filip J. Larsen
Summary: Intensified exercise training can temporarily impair mitochondrial respiration in elite athletes, but can also up-regulate antioxidative response proteins and slightly activate mitochondrial biogenesis. Despite the temporary impairment in mitochondrial respiratory function, physical performance improves in the days following the intense training period.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mathias Flensted-Jensen, Martin Gram, Flemming Dela, Jorn Wulff Helge, Steen Larsen
Summary: In this study involving 12 sedentary obese individuals at risk of developing T2D, it was found that high intensity interval training (HIT) significantly decreased ROS production, increased antioxidant protein levels, and improved mitochondrial respiratory capacity within a short period of time. These findings suggest that a relatively small amount of HIT can effectively enhance antioxidant status and lower oxidative stress in muscle cells, potentially protecting against the development of cardiovascular disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mingjun Zhang, Shumao Cui, Bingyong Mao, Qiuxiang Zhang, Jianxin Zhao, Xin Tang, Wei Chen
Summary: In this study, it was discovered that gastrodin can alleviate exercise-induced fatigue in male mice. Gastrodin preserves glycogen levels in muscles and liver, increases superoxide dismutase activity, and decreases levels of malondialdehyde, blood lactate, and blood urea nitrogen. Additionally, gastrodin activates the AMPK and Nrf2/HO-1 pathways and regulates the composition of intestinal flora. These findings suggest that gastrodin can be an effective functional food for mitigating exercise-induced fatigue.
Article
Cell Biology
Edmund Battey, Regula Furrer, Jacob Ross, Christoph Handschin, Julien Ochala, Matthew J. Stroud
Summary: PGC-1α plays a critical role in myonuclear accretion during adaptation to endurance training, especially in larger muscle fibers. Myonuclear accretion in PGC-1α mKO mice is slightly affected with increasing fiber size, but is significantly altered in trained larger fibers compared to sedentary mice, highlighting the importance of PGC-1α in myonuclear accretion in these fibers.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Oliver Baum, Felicitas A. M. Huber-Abel, Martin Fluck
Summary: This study investigated the relationship between nNOS expression and capillarity in the TA muscle of mice undergoing treadmill training. The results showed that both mRNA and protein levels of nNOS were up-regulated after 28 days of treadmill training. Additionally, ZsGreen1-positive fibers in the nNOS-transfected TA muscle of trained mice exhibited higher immunofluorescence for nNOS and more capillary contacts around MHC-IIb fibers compared to ZsGreen1-negative fibers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Philip M. Batterson, Erin M. McGowan, Harrison D. Stierwalt, Sarah E. Ehrlicher, Sean A. Newsom, Matthew M. Robinson
Summary: Aerobic training promotes substrate oxidation by remodeling the quantity and quality of skeletal muscle mitochondria. Short-term high-intensity interval training (HIIT) reveals changes to mitochondrial respiration and regulatory pathways. HIIT increases mitochondrial respiration for various substrates and induces gene transcripts and respiratory function, indicating remodeling of mitochondria within 2 weeks.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Geriatrics & Gerontology
Jan Spaas, Richie P. Goulding, Charly Keytsman, Lena Fonteyn, Jack van Horssen, Richard T. Jaspers, Bert O. Eijnde, Rob C. I. Wust
Summary: Patients with multiple sclerosis (MS) have lower exercise tolerance due to reduced skeletal muscle oxidative phenotype. However, skeletal muscle mitochondria seem resistant to the effects of exercise training, suggesting that other physiological systems may be driving the improvements in exercise capacity following exercise training in MS.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Physiology
Elisabeth Skoglund, Per Stal, Tommy R. Lundberg, Thomas Gustafsson, Per A. Tesch, Lars -Eric Thornell
Summary: This study compared muscle morphology in three advanced aging cohorts, including a unique cohort of lifelong endurance athletes. The findings suggest that lifelong endurance training is associated with higher muscle oxidative capacity, even in individuals over the age of 80.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Maria Apostolopoulou, Lucia Mastrototaro, Sonja Hartwig, Dominik Pesta, Klaus Strassburger, Elisabetta de Filippo, Tomas Jelenik, Yanislava Karusheva, Sofiya Gancheva, Daniel Markgraf, Christian Herder, K. Sreekumaran Nair, Andreas S. Reichert, Stefan Lehr, Karsten Mussig, Hadi Al-Hasani, Julia Szendroedi, Michael Roden
Summary: The study found that 12 weeks of high-intensity interval training can improve insulin sensitivity in males, but individuals with insulin resistance showed different alterations in metabolism and inflammatory signals. Changes in the proteome of SEVs might influence the metabolic response to exercise training in humans.
Article
Biochemistry & Molecular Biology
Julia Villarroel, Ida Donkin, Camille Champion, Remy Burcelin, Romain Barres
Summary: Accumulating evidence suggests the existence of a tissue microbiota, which plays a role in regulating the physiological function of tissues. A study conducted on healthy male individuals found that endurance training specifically remodels the bacterial DNA profile of skeletal muscle, but not blood.
Review
Physiology
Ian A. J. Darragh, Lorraine O'Driscoll, Brendan Egan
Summary: Exercise factors are a key area of research, potentially influencing acute exercise metabolism and adaptation to exercise training. Exercise training may alter the resting profile of circulating exercise factors, some of which may be transported as small EVs in circulation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Camilla Bean, Matteo Audano, Tatiana Varanita, Francesca Favaretto, Marta Medaglia, Marco Gerdol, Lena Pernas, Fabio Stasi, Marta Giacomello, Stephanie Herkenne, Maheswany Muniandy, Sini Heinonen, Emma Cazaly, Miina Ollikainen, Gabriella Milan, Alberto Pallavicini, Kirsi H. Pietilainen, Roberto Vettor, Nico Mitro, Luca Scorrano
Summary: The study demonstrates that the mitochondrial cristae biogenesis protein Opa1 plays a role in cell-autonomous adipocyte browning through the regulation of the urea cycle. The findings suggest a potential therapeutic strategy for obesity and highlight the connection between the urea cycle and adipocyte browning.
Article
Neurosciences
Maude Dulac, Jean-Philippe Leduc-Gaudet, Marina Cefis, Marie-Belle Ayoub, Olivier Reynaud, Anwar Shams, Alaa Moamer, Marcos Francisco Nery Ferreira, Sabah Na Hussain, Gilles Gouspillou
Summary: The study found that silencing or overexpressing Drp1 in late middle-aged mice is detrimental to skeletal muscle function and mitochondrial health. Modulating Drp1 expression is unlikely to be a viable approach to counteract the muscle ageing process.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Meeting Abstract
Sport Sciences
Liam F. Fitzgerald, Julia D. Miehm, Miles F. Bartlett, Erica L. Hartman, Ben J. Hoffmann, Michael A. Busa, Richard E. A. van Emmerik, Jane A. Kent
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2017)
Letter
Physiology
Susie Chung, Michael D. Nelson
JOURNAL OF APPLIED PHYSIOLOGY
(2018)
Article
Clinical Neurology
Sumire Sato, Jongil Lim, Jules D. Miehm, John Buonaccorsi, Caitlin Rajala, Farnaz Khalighinejad, Carolina Ionete, Jane A. Kent, Richard E. A. van Emmerik
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Clinical Neurology
Sumire Sato, John Buonaccorsi, Jules D. Miehm, Jongil Lim, Caitlin Rajala, Farnaz Khalighinejad, Carolina Ionete, Jane A. Kent, Richard E. A. van Emmerik
Summary: Foot-tap performance and plantar cutaneous sensitivity differed between MS subtypes. Lower walking performance was associated with lower foot-tapping and plantar cutaneous sensitivity in the RRMS but not the PMS group.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Meeting Abstract
Sport Sciences
Jules D. Miehm, Sumire Sato, John Buonaccorsi, Caitlin Rajala, Jongil Lim, Farnaz Khalighinejad, Carolina Ionete, Jane A. Kent, Richard E. A. van Emmerik
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Article
Multidisciplinary Sciences
Liam F. Fitzgerald, Margaret M. Ryan, Miles F. Bartlett, Jules D. Miehm, Jane A. Kent
Article
Clinical Neurology
Jules D. Miehm, John Buonaccorsi, Jongil Lim, Sumire Sato, Caitlin Rajala, Julianna Averill, Farnaz Khalighinejad, Carolina Ionete, Stephanie L. Jones, Jane A. Kent, Richard E. A. van Emmerik
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2020)
Meeting Abstract
Sport Sciences
Julia D. Miehm, Julianna L. Averill, Jongil Lim, John Buonaccorsi, Carolina Ionete, Jane A. Kent, Richard van Emmerik
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2018)
