An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints

Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice

(2010) Monique C. de Waard et al.   ACTA NEUROPATHOLOGICA

Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy

(2010) Sander M. Botter et al.   AGE

Accelerated aging of intervertebral discs in a mouse model of progeria

(2010) Nam Vo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice

(2009) Yuichiro Matsui et al.   ARTHRITIS AND RHEUMATISM

Oxidative Stress Inhibits Insulin-like Growth Factor-I Induction of Chondrocyte Proteoglycan Synthesis through Differential Regulation of Phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK Signaling Pathways

(2009) Weihong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ageing populations: the challenges ahead

(2009) Kaare Christensen et al.   LANCET

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix

(2009) R.F. Loeser   OSTEOARTHRITIS AND CARTILAGE

Connective tissue growth factor expression in human intervertebral disc: implications for angiogenesis in intervertebral disc degeneration

(2008) R Ali et al.   BIOTECHNIC & HISTOCHEMISTRY

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

(2008) Leonard Guarente   CELL

Cellular effects of long wavelength UV light (UVA) in mammalian cells

(2008) T. J. McMillan et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics

(2008) Cristina Ruiz-Romero et al.   MOLECULAR & CELLULAR PROTEOMICS

Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan

(2007) Laura J. Niedernhofer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Reactive nitrogen and oxygen species in interleukin-1-mediated DNA damage associated with osteoarthritis

(2007) C.M. Davies et al.   OSTEOARTHRITIS AND CARTILAGE