Doxycycline-inducible and astrocyte-specific HIV-1 Tat transgenic mice (iTat) as an HIV/neuroAIDS model

HIV-1 Tat Promotes Lysosomal Exocytosis in Astrocytes and Contributes to Astrocyte-mediated Tat Neurotoxicity

(2016) Yan Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Tat Induces Unfolded Protein Response and Endoplasmic Reticulum Stress in Astrocytes and Causes Neurotoxicity through Glial Fibrillary Acidic Protein (GFAP) Activation and Aggregation

(2016) Yan Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression

(2016) Pejman Rahimian et al.   Journal of Neuroinflammation

HIV Tat Impairs Neurogenesis through Functioning As a Notch Ligand and Activation of Notch Signaling Pathway

(2016) Y. Fan et al.   JOURNAL OF NEUROSCIENCE

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

Central HIV-1 Tat exposure elevates anxiety and fear conditioned responses of male mice concurrent with altered mu-opioid receptor-mediated G-protein activation and β-arrestin 2 activity in the forebrain

(2016) Yun K. Hahn et al.   NEUROBIOLOGY OF DISEASE

Exposure to HIV-1 Tat in brain impairs sensorimotor gating and activates microglia in limbic and extralimbic brain regions of male mice

(2015) Jason J. Paris et al.   BEHAVIOURAL BRAIN RESEARCH

Mechanisms of HIV-1 Tat Neurotoxicity via CDK5 Translocation and Hyper-Activation: Role in HIV-Associated Neurocognitive Disorders

(2015) Jerel Fields et al.   CURRENT HIV RESEARCH

Conditional Tat Protein Brain Expression in the GT-tg Bigenic Mouse Induces Cerebral Fractional Anisotropy Abnormalities

(2015) Amanda Carey et al.   CURRENT HIV RESEARCH

Chronic HIV-1 Tat and HIV Reduce Rbfox3/NeuN: Evidence for Sex- Related Effects

(2015) Yun Hahn et al.   CURRENT HIV RESEARCH

STAT3 and Its Phosphorylation are Involved in HIV-1 Tat-Induced Transactivation of Glial Fibrillary Acidic Protein

(2015) Yan Fan et al.   CURRENT HIV RESEARCH

Didehydro-Cortistatin A Inhibits HIV-1 Tat Mediated Neuroinflammation and Prevents Potentiation of Cocaine Reward in Tat Transgenic Mice

(2015) Sonia Mediouni et al.   CURRENT HIV RESEARCH

HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase

(2015) Ferdous Kadri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders

(2015) J. Fields et al.   JOURNAL OF NEUROSCIENCE

Neuropathology of HAND With Suppressive Antiretroviral Therapy: Encephalitis and Neurodegeneration Reconsidered

(2015) Benjamin B. Gelman   Current HIV/AIDS Reports

Progesterone protects normative anxiety-like responding among ovariectomized female mice that conditionally express the HIV-1 regulatory protein, Tat, in the CNS

(2014) Jason J. Paris et al.   HORMONES AND BEHAVIOR

Effects of HIV-1 Tat on Enteric Neuropathogenesis

(2014) J. Ngwainmbi et al.   JOURNAL OF NEUROSCIENCE

Chronic Central Nervous System Expression of HIV-1 Tat Leads to Accelerated Rarefaction of Neocortical Capillaries and Loss of Red Blood Cell Velocity Heterogeneity

(2014) Jharon N. Silva et al.   MICROCIRCULATION

Reduction of pyramidal and immature hippocampal neurons in pediatric simian immunodeficiency virus infection

(2014) Kimberly Curtis et al.   NEUROREPORT

Effects of chronic HIV-1 Tat exposure in the CNS: heightened vulnerability of males versus females to changes in cell numbers, synaptic integrity, and behavior

(2013) Yun Kyung Hahn et al.   Brain Structure & Function

Effects of Conditional Central Expression of HIV-1 Tat Protein to Potentiate Cocaine-Mediated Psychostimulation and Reward Among Male Mice

(2013) Jason J Paris et al.   NEUROPSYCHOPHARMACOLOGY

Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein

(2013) T. P. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anxiety-like behavior of mice produced by conditional central expression of the HIV-1 regulatory protein, Tat

(2013) Jason J. Paris et al.   PSYCHOPHARMACOLOGY

Synaptic Dysfunction in the Hippocampus Accompanies Learning and Memory Deficits in Human Immunodeficiency Virus Type-1 Tat Transgenic Mice

(2012) Sylvia Fitting et al.   BIOLOGICAL PSYCHIATRY

Modeling HIV-associated neurocognitive disorders in mice: new approaches in the changing face of HIV neuropathogenesis

(2012) L. B. Jaeger et al.   Disease Models & Mechanisms

Morphine efficacy is altered in conditional HIV-1 Tat transgenic mice

(2012) Sylvia Fitting et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neurovirological Correlation With HIV-Associated Neurocognitive Disorders and Encephalitis in a HAART-Era Cohort

(2012) Benjamin B. Gelman et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Platelet-Derived Growth Factor-BB Restores Human Immunodeficiency Virus Tat-Cocaine-Mediated Impairment of Neurogenesis: Role of TRPC1 Channels

(2012) H. Yao et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation and Synaptic Loss

(2012) Jagadeesh S. Rao et al.   NEUROCHEMICAL RESEARCH

The National NeuroAIDS Tissue Consortium Brain Gene Array: Two Types of HIV-Associated Neurocognitive Impairment

(2012) Benjamin B. Gelman et al.   PLoS One

Conditional Tat protein expression in the GT-tg bigenic mouse brain induces gray matter density reductions

(2012) Amanda N. Carey et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse

(2011) Amanda N. Carey et al.   BEHAVIOURAL BRAIN RESEARCH

Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at  -opioid receptor-expressing glia

(2011) S. Zou et al.   BRAIN

RETRACTED ARTICLE: Increased neuroinflammatory and arachidonic acid cascade markers, and reduced synaptic proteins, in brain of HIV-1 transgenic rats

(2011) Jagadeesh Sridhara Rao et al.   Journal of Neuroinflammation

Interactive Comorbidity between Opioid Drug Abuse and HIV-1 Tat

(2010) Sylvia Fitting et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of Egr-1 Expression in Astrocytes by HIV-1 Tat: New Insights into Astrocyte-Mediated Tat Neurotoxicity

(2010) Yan Fan et al.   Journal of Neuroimmune Pharmacology

Human Immunodeficiency Virus-1 Tat Activates Calpain Proteases via the Ryanodine Receptor to Enhance Surface Dopamine Transporter Levels and Increase Transporter-Specific Uptake and Vmax

(2010) S. W. Perry et al.   JOURNAL OF NEUROSCIENCE

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Nuclear Factor-Kappa B Family Member RelB Inhibits Human Immunodeficiency Virus-1 Tat-Induced Tumor Necrosis Factor-Alpha Production

(2010) Michelle Kiebala et al.   PLoS One

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders

(2009) Nicholas P. Whitney et al.   JOURNAL OF NEUROCHEMISTRY

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

(2008) David Wheeler et al.   BRAIN

HIV-1 Tat and morphine have interactive effects on oligodendrocyte survival and morphology

(2008) Kurt F. Hauser et al.   GLIA