Brain-specific HIV Nef identified in multiple patients with neurological disease

Predicted coreceptor usage at end-stage HIV disease in tissues derived from subjects on antiretroviral therapy with an undetectable plasma viral load

(2017) S.L. Lamers et al.   INFECTION GENETICS AND EVOLUTION

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity

(2017) A Sami Saribas et al.   Cell Death & Disease

HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy

(2017) Manish K. Gupta et al.   Scientific Reports

On the Physicochemical and Structural Modifications Associated with HIV-1 Subtype B Tropism Transition

(2016) Susanna L. Lamers et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV Maintains an Evolving and Dispersed Population in Multiple Tissues during Suppressive Combined Antiretroviral Therapy in Individuals with Cancer

(2016) Rebecca Rose et al.   JOURNAL OF VIROLOGY

Evolution of Neuroadaptation in the Periphery and Purifying Selection in the Brain Contribute to Compartmentalization of Simian Immunodeficiency Virus (SIV) in the Brains of Rhesus Macaques with SIV-Associated Encephalitis

(2016) Brittany D. Rife et al.   JOURNAL OF VIROLOGY

HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads

(2016) Susanna L. Lamers et al.   JOURNAL OF VIROLOGY

Defective HIV-1 proviruses produce novel protein-coding RNA species in HIV-infected patients on combination antiretroviral therapy

(2016) Hiromi Imamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of dual-tropic HIV-1 using evolved neural networks

(2015) Gary B. Fogel et al.   BIOSYSTEMS

Dysregulation of autophagy by HIV-1 Nef in human astrocytes

(2015) A Sami Saribas et al.   CELL CYCLE

Nef, the shuttling molecular adaptor of HIV, influences the cytokine network

(2015) Zulema Antonia Percario et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Tracking the Emergence of Host-Specific Simian Immunodeficiency VirusenvandnefPopulations RevealsnefEarly Adaptation and Convergent Evolution in Brain of Naturally Progressing Rhesus Macaques

(2015) Susanna L. Lamers et al.   JOURNAL OF VIROLOGY

HIV-1 Nef expression in microglia disrupts dopaminergic and immune functions with associated mania-like behaviors

(2014) Shaona Acharjee et al.   BRAIN BEHAVIOR AND IMMUNITY

Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment

(2014) John Jeff Alvarado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Infection of T Cells and Macrophages Are Differentially Modulated by Virion-Associated Hck: A Nef-Dependent Phenomenon

(2013) Alyssa Cornall et al.   Viruses-Basel

HIV-1 Nef in Macrophage-Mediated Disease Pathogenesis

(2012) Susanna L. Lamers et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Immune Selection In Vitro Reveals Human Immunodeficiency Virus Type 1 Nef Sequence Motifs Important for Its Immune Evasion Function In Vivo

(2012) M. J. Lewis et al.   JOURNAL OF VIROLOGY

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Astrocytic expression of HIV-1 Nef impairs spatial and recognition memory

(2012) Gladys Chompre et al.   NEUROBIOLOGY OF DISEASE

Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix

(2012) Lillian S Kuo et al.   Retrovirology

Independent evolution of macrophage-tropism and increased charge between HIV-1 R5 envelopes present in brain and immune tissue

(2012) Maria P Gonzalez-Perez et al.   Retrovirology

Macrophages and their relevance in Human Immunodeficiency Virus Type I infection

(2012) Herwig Koppensteiner et al.   Retrovirology

Significant Genetic Heterogeneity of the SIVmac251 Viral Swarm Derived from Different Sources

(2011) Samantha L. Strickland et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV-1 Nef Protein Visits B-Cells via Macrophage Nanotubes: A Mechanism for AIDS-Related Lymphoma Pathogenesis?

(2011) Susanna L. Lamers et al.   CURRENT HIV RESEARCH

Nef Performance in Macrophages: The Master Orchestrator of Viral Persistence and Spread

(2011) Yanina Ghiglione et al.   CURRENT HIV RESEARCH

Monocyte Mobilization, Activation Markers, and Unique Macrophage Populations in the Brain: Observations from SIV Infected Monkeys Are Informative with Regard to Pathogenic Mechanisms of HIV Infection in Humans

(2011) Kenneth Williams et al.   Journal of Neuroimmune Pharmacology

HIV-1 Nef Protein Structures Associated with Brain Infection and Dementia Pathogenesis

(2011) Susanna L. Lamers et al.   PLoS One

Structure, dynamics, and Hck interaction of full-length HIV-1 Nef

(2011) Jinwon Jung et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Evidence for Adaptive Evolution at the Divergence Between Lymphoid and Brain HIV-1 nef Genes

(2010) Kevin C. Olivieri et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

HIV-1 phylogenetic analysis shows HIV-1 transits through the meninges to brain and peripheral tissues

(2010) Susanna L. Lamers et al.   INFECTION GENETICS AND EVOLUTION

Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapy

(2010) I Everall et al.   JOURNAL OF NEUROVIROLOGY

CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates

(2010) Lachlan R. Gray et al.   JOURNAL OF NEUROVIROLOGY

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Macrophage signaling in HIV-1 infection

(2010) Georges Herbein et al.   Retrovirology

Nef, macrophages and B cells: a highway for evasion

(2009) Susan Moir et al.   IMMUNOLOGY AND CELL BIOLOGY

HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits

(2009) Weifeng Xu et al.   NATURE IMMUNOLOGY

Distinct Patterns of HIV-1 Evolution within Metastatic Tissues in Patients with Non-Hodgkins Lymphoma

(2009) Marco Salemi et al.   PLoS One

Computational intelligence approaches for pattern discovery in biological systems

(2008) G. B. Fogel   BRIEFINGS IN BIOINFORMATICS

Prediction of R5, X4, and R5X4 HIV-1 Coreceptor Usage with Evolved Neural Networks

(2008) S.L. Lamers et al.   IEEE-ACM Transactions on Computational Biology and Bioinformatics

Changes in the incidence and predictors of human immunodeficiency virus-associated dementia in the era of highly active antiretroviral therapy

(2007) Krishnan Bhaskaran et al.   ANNALS OF NEUROLOGY